EDC Science Weekly, Sept. 29 – Oct. 7, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week (a few days late this week!).

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Oct 12: The Environmental Justice Index: Ranking Cumulative Health Impacts (American Public Health Association)

Oct 13: Children’s Environmental Health Day (Children’s Environmental Health Network)

Webinar Oct. 19: CHE Cafe: Cancer & the Environment (Collaborative on Health and the Environment)

Oct 26-27: Using New Approach Methodologies to Address Variability and Susceptibility Across Populations (National Toxicology Program)

Webinars Oct 7, Nov 4, Nov 18: NIEHS Superfund Research Program (SRP) Climate Change and Health Webinar Series on how climate related events affects human exposures to hazardous substances.

Webinars Oct 28, Nov 4, Dec 2: Webinar series on Reporting Research Results to Communities (NIEHS funded centers)

Regulations/Policy

When Water Quality Crises Drive Change: A Comparative Analysis of the Policy Processes Behind Major Water Contamination Events.

Methods/Tools/Screening

Systematic evidence map (SEM) template: Report format and methods used for the US EPA Integrated Risk Information System (IRIS) program, Provisional Peer Reviewed Toxicity Value (PPRTV) program, and other “fit for purpose” literature-based human health analyses.

Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification. see related Invited Perspective: Key Characteristics as a Starting Point for Improved Hazard Identification of Immunotoxic Agents.

Prioritization of chemicals in food for risk assessment by integrating exposure estimates and new approach methodologies: A next generation risk assessment case study.

Quick and efficient quantitative predictions of androgen receptor binding affinity for screening Endocrine Disruptor Chemicals using 2D-QSAR and Chemical Read-Across.

Tox21-Based Comparative Analyses for the Identification of Potential Toxic Effects of Environmental Pollutants.

Commentaries

Fracking and Childhood Leukemia: New Evidence Supports Greater Residential Setbacks. [Science Selection in EHP]

Dietary Exposure to Toxic Elements and the Health of Young Children: Methodological Considerations and Data Needs.

Welcome to the AJPH Supplement on Ubiquitous Lead: Risks, Prevention-Mitigation Programs, and Emerging Sources of Exposure. [this special issue includes numerous articles on lead]

Reviews

Numerous Chemicals/Mixtures

Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review.

Temporal decline of sperm concentration: role of endocrine disruptors.

Review of in silico studies dedicated to the nuclear receptor family: Therapeutic prospects and toxicological concerns.

A review on management practices, environmental impacts, and human exposure risks related to electrical and electronic waste in Vietnam: findings from case studies in informal e-waste recycling areas.

BPA/Phenols

Bisphenol A-Induced Endocrine Dysfunction and its Associated Metabolic Disorders.

Current progress in treatment technologies for plastic waste (bisphenol A) in aquatic environment: Occurrence, toxicity and remediation mechanisms.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Influences of climate change on long-term time series of persistent organic pollutants (POPs) in Arctic and Antarctic biota.

Perfluoroalkyl Substances

Epidemiology Evidence for Health Effects of 150 per- and Polyfluoroalkyl Substances: A Systematic Evidence Map.

Sustainable conversion of saturated adsorbents (SAs) from wastewater into value-added products: future prospects and challenges with toxic per- and poly-fluoroalkyl substances (PFAS).

Flame Retardants

The interaction mechanisms of co-existing polybrominated diphenyl ethers and engineered nanoparticles in environmental waters: A critical review.

Pesticides

Dinitroaniline herbicides: a comprehensive review of toxicity and side effects on animal non-target organisms.

Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review.

Pesticides monitoring in biological fluids: Mapping the gaps in analytical strategies.

Metals/Metalloids

Transcriptional Responses as Biomarkers of General Toxicity: A Systematic Review and Meta-Analysis on Metal-Exposed Bivalves.

Microplastics/Nanomaterials

Microplastics in ASEAN region countries: A review on current status and perspectives.

Review and Prospects on the Ecotoxicity of Mixtures of Nanoparticles and Hybrid Nanomaterials.

Microplastic diagnostics in humans: “The 3Ps” Progress, problems, and prospects.

Pharmaceuticals/Personal Care Products

Octinoxate as a potential thyroid hormone disruptor – A combination of in vivo and in vitro data.

Human Health Studies

Numerous Chemicals/Mixtures

Cord blood immune profile: Associations with higher prenatal plastic chemical levels.

Longitudinal effects of prenatal exposure to plastic-derived chemicals and their metabolites on asthma and lung function from childhood into adulthood.

Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia.

Environmental Pollutants are Associated with Irritable Bowel Syndrome in a Commercially Insured Cohort of California Residents.

BPA/Phenols

Bisphenol A: Potential Factor of Miscarriage in Women in the Context of the Phenomenon of Neutrophil Extracellular Traps.

Associations of bisphenol F and S, as substitutes for bisphenol A, with cardiovascular disease in American adults.

Association between urinary bisphenol analogue concentrations and lung cancer in adults: A case-control study.

Parabens/Triclosan/Antimicrobials

Triclosan in paired-maternal and cord blood, and their relationships with congenital heart disease of baby.

Perfluoroalkyl Substances

Associations between serum perfluoroalkyl acid (PFAA) concentrations and health related biomarkers in firefighters.

Antibody response to COVID-19 vaccines among workers with a wide range of exposure to per- and polyfluoroalkyl substances.

Association between prenatal exposure to perfluoroalkyl substances and anogenital distance in female neonates.

Comprehensive Exposure Studies of Per- and Polyfluoroalkyl Substances in the General Population: Target, Nontarget Screening, and Toxicity Prediction.

Association between serum levels of TSH and free T4 and per- and polyfluoroalkyl compounds concentrations in pregnant women.

Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with oxidative stress biomarkers during pregnancy.

Maternal Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Male Reproductive Function in Young Adulthood: Combined Exposure to Seven PFAS.

Flame Retardants

Prenatal exposure to organophosphate esters is associated with decreased anogenital distance in offspring.

Pesticides

A more than four-fold sex-specific difference of autism spectrum disorders and the possible contribution of pesticide usage in China 1990-2030.

Metals/Metalloids

Combined exposure to multiple metals on cardiovascular disease in NHANES under five statistical models.

Potential benefits of joint hypothetical interventions on diet, lead, and cadmium on mortality in US adults.

Association of exposure to multiple serum metals with the risk of chronic kidney disease in the elderly: a population-based case-control study.

Air Pollution

Using follicular fluid metabolomics to investigate the association between air pollution and oocyte quality.

Pharmaceuticals/Personal Care Products

Ibuprofen Reduces Testosterone Level in Women With Polycystic Ovary Syndrome.

Benzophenone-3 and antinuclear antibodies in U.S. adolescents and adults ages 12-39 years.

Laboratory Studies

Numerous Chemicals/Mixtures

Apoptotic susceptibility of pancreatic alpha cells to environmentally relevant dose levels of bisphenol-A versus dibutyl phthalate is mediated by HSP60/caspase-3 expression in male albino rats.

Interaction between environmental pollutants and cancer drug efficacy: BPA, BADGE and PFOA reduce vincristine cytotoxicity in acute lymphoblastic leukemia cells.

Defining the Chemical Additives Driving In Vitro Toxicities of Plastics.

Effects of endocrine disrupting chemicals on the expression of RACK1 and LPS-induced THP-1 cell activation (DEP and PFOS)

BPA/Phenols

Ancestral BPA exposure caused defects in the liver of medaka for four generations.

Lactoferrin alleviates spermatogenesis dysfunction caused by bisphenol A and cadmium via ameliorating disordered autophagy, apoptosis and oxidative stress.

Tetrachlorobisphenol A and bisphenol AF induced cell migration by activating PI3K/Akt signaling pathway via G protein-coupled estrogen receptor 1 in SK-BR-3 cells.

Bisphenol A analogues induce a feed-forward estrogenic response in zebrafish.

Cineole regulates Wnt/β-catenin pathway through Nrf2/keap1/ROS to inhibit bisphenol A-induced apoptosis, autophagy inhibition and immunosuppression of grass carp hepatocytes.

Lycopene protects against Bisphenol A induced toxicity on the submandibular salivary glands via the upregulation of PPAR-γ and modulation of Wnt/β-catenin signaling.

Phthalates

N6-methyladenosine modification on Hmbox1 is related to telomere dysfunction in DEHP-induced male reproductive injury.

Interaction between mono-(2-ethylhexyl) phthalate and retinoic acid alters Sertoli cell development during fetal mouse testis cord morphogenesis.

Thyroid hormone disruption by bis-(2-ethylhexyl) phthalate (DEHP) and bis-(2-ethylhexyl) adipate (DEHA) in Japanese medaka Oryzias latipes.

In utero di-(2-ethylhexyl) phthalate-induced testicular dysgenesis syndrome in male newborn rats is rescued by taxifolin through reducing oxidative stress.

Dimethyl Fumarate Attenuates Di-(2-Ethylhexyl) Phthalate-Induced Nephrotoxicity Through the Nrf2/HO-1 and NF-κB Signaling Pathways.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A Generic Pharmacokinetic Model for Quantifying Mother-to-Offspring Transfer of Lipophilic Persistent Environmental Chemicals.

Metallothionein gene expression in rat tissues: response to dietary restriction after orally dichlorodiphenyldichloroethylene (DDE) exposure and high-fat feeding.

Kinetics and toxicity of an environmentally relevant mixture of halogenated organic compounds in zebrafish embryo

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances enhance Staphylococcus aureus pathogenicity and impair host immune response.

Flame Retardants

Parental and transgenerational impairments of thyroid endocrine system in zebrafish by 2,4,6-tribromophenol.

Photolytic degradation of novel polymeric and monomeric brominated flame retardants: Investigation of endocrine disruption, physiological and ecotoxicological effects.

Metabolic perturbations in human hepatocytes induced by bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate exposure: Insights from high-coverage quantitative metabolomics.

Transcriptomic sequencing reveals the potential molecular mechanism by which Tetrabromobisphenol A bis (2-hydroxyethyl ether) exposure exerts developmental neurotoxicity in developing zebrafish (Danio rerio).

Pesticides

Dietary myricetin assuages atrazine-mediated hypothalamic-pituitary-testicular axis dysfunction in rats.

Pre-conceptional exposure to glyphosate affects the maternal hepatic and ovarian proteome.

Comparative assessment of individual and mixture chronic toxicity of glyphosate and glufosinate ammonium on amphibian tadpoles: A multibiomarker approach.

Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig cells.

Household prallethrin-based insecticide toxicity on different C. elegans life stage: A possible sign of Huntington Disease.

Gut dysfunction may be the source of pathological aggregation of alpha-synuclein in the central nervous system through Paraquat exposure in mice.

Direct toxicity of the herbicide florasulam against Chlorella vulgaris: An integrated physiological and metabolomic analysis.

Exposure to pyrazosulfuron-ethyl induces immunotoxicity and behavioral abnormalities in zebrafish embryos.

Metals/Metalloids

Annexin A1 Inhibition Facilitates NLRP3 Inflammasome Activation in Arsenic-induced Insulin Resistance in Rat Liver.

Methylmercury-induced DNA methylation-From epidemiological observations to experimental evidence.

Fluoride subacute testicular toxicity in Wistar rats: Benchmark dose analysis for the redox parameters, essential elements and DNA damage.

The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced non-alcoholic fatty liver disease.

Targeted Intracellular Demethylation of Methylmercury Enhances Elimination Kinetics and Reduces Developmental Toxicity in Transgenic Drosophila.

Chronic lead exposure exacerbates hepatic glucolipid metabolism disorder and gut microbiota dysbiosis in high-fat-diet mice.

Microplastics/Nanomaterials

Polystyrene nanoparticles enhance the adverse effects of di-(2-ethylhexyl) phthalate on male reproductive system in mice.

Environmental microplastics exposure decreases antioxidant ability, perturbs gut microbial homeostasis and metabolism in chicken.

Acute exposure to microplastics induces metabolic disturbances and gut dysbiosis in adult zebrafish (Danio rerio).

Microplastics: What happens in the human digestive tract? First evidences in adults using in vitro gut models.

Enhanced heavy metal adsorption on microplastics by incorporating flame retardant hexabromocyclododecanes: Mechanisms and potential migration risks.

Pharmaceuticals/Personal Care Products

Exposure to acetaminophen impairs gametogenesis and fertility in zebrafish (Danio rerio).

The antipsychotic drug olanzapine altered lipid metabolism in the common carp (Cyprinus carpio L.): Insight from the gut microbiota-SCFAs-liver axis.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Temporal trends in risk of bisphenol A, benzophenone-3 and triclosan exposure among U.S. children and adolescents aged 6-19 years: Findings from the National Health and Nutrition Examination Survey 2005-2016.

Benzophenones, bisphenols and other polychlorinated/phenolic substances in Danish infants and their parents – including longitudinal assessments before and after introduction to mixed diet.

Transcriptome signatures of wastewater effluent exposure in larval zebrafish vary with seasonal mixture composition in an effluent-dominated stream.

Risk from unintentional environmental mixtures in EU surface waters is dominated by a limited number of substances.

BPA/Phenols

Detection of bisphenols in Indian surface water, tap water, and packaged drinking water using dispersive liquid-liquid microextraction: exposure assessment for health risk.

Parabens/Triclosan/Antimicrobials

Analysis of isothiazolinone and paraben preservatives in children’s toy slime in Japan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Breastfed infants’ exposure to polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and dibenzofurans, and per- and polyfluoroalkyl substances: A cross-sectional study of a municipal waste incinerator in China.

The first German total diet study (BfR MEAL Study) confirms highest levels of dioxins and dioxin-like polychlorinated biphenyls in foods of animal origin.

Two Congener-specific Models Estimate PCB TEQ Hazard to American Mink (Neovison vison) Living near a Western New York Creek.

Organochlorine pesticides in therapeutic teas and human health risk assessment.

Temporal trends of persistent organic pollutant contamination in Franciscana dolphins from the Southwestern Atlantic.

Perfluoroalkyl Substances

Transdermal absorption of ¹³C₄-perfluorooctanoic acid (¹³C₄-PFOA) from a sunscreen in a male volunteer – What could be the contribution of cosmetics to the internal exposure of perfluoroalkyl substances (PFAS)?

Time-course trend and influencing factors for per- and polyfluoroalkyl substances in the breast milk of Korean mothers.

Targeted and Suspect Screening of Per- and Polyfluoroalkyl Substances in Cosmetics and Personal Care Products.

Exposure of a single wild boar population in North Rhine-Westphalia (Germany) to perfluoroalkyl acids.

Spatial distribution, compositional profile, sources, ecological and human health risks of legacy and emerging per- and polyfluoroalkyl substances (PFASs) in freshwater reservoirs of Punjab, Pakistan.

Can oral toxicity data for PFAS inform on toxicity via inhalation?

Distribution of legacy and emerging per- and polyfluoroalkyl substances in riverine and coastal sediments of Southeastern North Carolina, USA.

An Integrated Approach for Determination of Total Per- and Polyfluoroalkyl Substances (PFAS).

Pesticides

Neonicotinoid exposure in Tricolored Blackbirds (Agelaius tricolor).

A deeper understanding of system interactions can explain contradictory field results on pesticide impact on honey bees.

Dietary exposure to environmentally relevant pesticide mixtures impairs swimming performance and lipid homeostatic gene expression in Juvenile Chinook salmon at elevated water temperatures.

Toxic effects of detected pyrethroid pesticides on honeybee (Apis mellifera ligustica Spin and Apis cerana cerana Fabricius).

Metals/Metalloids

Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations.

Heavy metals in paired samples of hair and nails in China: occurrence, sources and health risk assessment.

Health Remedies as a Source of Lead, Mercury, and Arsenic Exposure, New York City, 2010-2019.

Pediatric Practitioner Knowledge of Arsenic in Baby Food.

Spatial variations in winter Hg contamination affect egg volume in an Arctic seabird, the great skua (Stercorarius skua).

Microplastics/Nanomaterials

Identification of microplastics in human placenta using laser direct infrared spectroscopy.

Air Pollution

Beyond Particulate Matter Mass: Heightened Levels of Lead and Other Pollutants Associated with Destructive Fire Events in California.

Pharmaceuticals/Personal Care Products

Analysis of usage patterns and probabilistic risk assessment of personal care products in Korea.

44-Year Retrospective Analysis of Ultraviolet Absorbents and Industrial Antioxidants in Seabird Eggs from the Canadian Arctic (1975 to 2019).

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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