RSS HEEDS New Science
  • Exposure to chemicals in plastics linked to cancer diagnoses: Study
    There’s an association between higher levels of phenols and per- and polyfluoroalkyl substances, commonly known as PFAS or “forever chemicals,” and previous diagnoses of different types of cancer, researchers from the University of South California found. The study, published in the Journal of Exposure Science and Environmental Epidemiology, looked at data from 10,000 people who […]
  • Estrogenic endocrine disruptor exposure linked to erectile dysfunction in mice
    In young adult male mice, lifelong exposure to an estrogenic endocrine disrupting chemical (EDC) caused changes to erectile tissue function that are indicative of erectile dysfunction, according to a study recently published in Communications Biology.In short: Exposure to the estrogenic drug DES caused erectile tissue dysfunction in the tissues of exposed mice.Directly exposing erectile tissues […]
  • PlastChem: State-of-the-science of hazardous chemicals in plastic
    This new state-of-the science report from the PlastChem project addresses chemicals of concern in plastics and ways to address them.
  • American Heart Association: Children must be protected from health threats of environmental toxics
    The American Heart Association (AHA) recently published a scientific statement in Circulation highlighting evidence that children’s exposure to environmental pollutants may be a key risk factor for developing cardiovascular conditions throughout their lifespan. In short: There’s a well-established association between cardiovascular diseases and exposure to climate change, air pollution and endocrine disrupting chemicals. Early life […]
  • Flame retardant chemicals linked to increased risk of cancer-related death
    Higher exposure to polybrominated diphenyl ethers (PBDEs), a group of dangerous chemicals commonly used as flame retardants, is associated with an increased risk of death from cancer, according to a new study published in JAMA Network Open.In short:U.S. adults with the highest levels of exposure to PBDEs had a nearly 300% increased risk of cancer […]
  • Chemical exposure may reduce the success of weight loss surgery
    Obese adolescents with higher levels of exposure to the toxic chemical DDE are less likely to have successful results after bariatric weight loss surgery, according to a new study published in Obesity. In short: DDE is an environmental pollutant that results from the breakdown of the pesticide DDT, and is considered an obesogen. Adolescents with […]
  • Exploring the link between household chemicals and neurological disorders
    A new study identifies two chemicals in everyday items as potential culprits behind neurological issues.Arianna Johnson reports for Forbes.In short:Researchers pinpoint quaternary ammonium compounds and organophosphate flame retardants in household products as potentially harmful to brain health.These chemicals are implicated in damaging brain cells crucial for nerve protection, possibly contributing to disorders like autism and […]
  • Water treatment policies linked to decrease in arsenic-related cancers
    According to a new study published in Environment International, the frequency of several arsenic-related cancers in Taiwan decreased significantly once the nation began treating their tap water supply to reduce arsenic contamination. In short: Water treatment was associated with reduced occurrences of 5 types of cancers, including certain forms of lung, bladder, and skin cancer. […]
  • Food packaging materials contain large numbers of untested hazardous PFAS
    A recent study published in Environmental Science & Technology points out the large knowledge gaps around the presence of per- and polyfluoroalkyl substances (PFAS) - a group of chemicals associated with severe health issues - in food packaging materials.In short:The study found that 68 types of PFAS have been detected in food packaging materials, including […]
  • Petrochemical exposure linked to health risks
    A recent review highlights the harmful impact of petrochemicals on health, with evidence pointing to an increase in chronic diseases.Liza Gross reports for Inside Climate News.In short:Petrochemical production has surged since the 1950s, correlating with a rise in chronic and deadly diseases.The review calls for reduced reliance on fossil fuels, not only for environmental reasons […]

On This Page:

Also see new EDC Science and our EDC Science Weekly


Reviews and Commentaries on Endocrine Disrupting Chemicals (EDCs)

Articles

Chemicals Used in Plastic Materials: An Estimate of the Attributable Disease Burden and Costs in the United States.
Trasande L, Krithivasan R, Park K, Obsekov V, Belliveau M.  J Endocr Soc. 2024 Jan.

From Wingspread to CLARITY: a personal trajectory.
Soto AM, Schaeberle CM, Sonnenschein C. 
Nat Rev Endocrinol. 2021 Jan 29. 

Endocrine Disruptors: from Scientific Evidence to Human Health Protection
Demeneix B and Slama R.
Report for the European Parliament, 2019.

Scientific Principles for the Identification of Endocrine-Disrupting Chemicals: A Consensus Statement
Solecki R, Kortenkamp A, Bergman Å et al.
Arch Toxicol. 2017 Feb;91(2):1001-1006.

A Proposed Framework for the Systematic Review and Integrated Assessment (SYRINA) of Endocrine Disrupting Chemicals
Vandenberg LN, Ågerstrand M, Beronius A et al.
Environ Health. 2016 Jul 14;15(1):74. 

Minireview: Endocrine Disruptors: Past Lessons and Future Directions
Schug TT, Johnson AF, Birnbaum LS et al.
Mol Endocrinol. 2016 Aug;30(8):833-47. 

Peer-Reviewed and Unbiased Research, Rather than ‘Sound Science’, Should Be Used To Evaluate Endocrine-Disrupting Chemicals
Trasande L, Vandenberg LN, Bourguignon JP et al.
J Epidemiol Community Health. 2016 Nov;70(11):1051-1056.

Estimating Burden and Disease Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union
Trasande L, Zoeller RT, Hass U et al.
J Clin Endocrinol Metab. 2015 Apr;100(4):1245-55. 

Designing Endocrine Disruption Out of the Next Generation of Chemicals
Schug TT, Abagyan R, Blumberg B et al.
Green Chem. 2013 Jan;15(1):181-198.

Regulatory Decisions on Endocrine Disrupting Chemicals Should Be Based on the Principles of Endocrinology
Vandenberg LN, Colborn T, Hayes TB et al.
Reprod Toxicol. 2013 Jul;38:1-15. 

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses
Vandenberg LN, Colborn T, Hayes TB et al.
Endocr Rev. 2012 Jun;33(3):378-455. 

Firm Human Evidence on Harms of Endocrine-Disrupting Chemicals Was Unlikely To Be Obtainable for Methodological Reasons
Lee DH, Jacobs D.
J Clin Epidemiol. 2019 Mar;107:107-115. 

Collections

Collection: Endocrine Disrupting Chemicals 2019, in The Endocrine Society Thematic Issue of Endocrine Society Journals.

Collection: Endocrine Disruption, in Nature Reviews Endocrinology, 2017.

Research Topic: Endocrine Disruptors and Metabolism, in Frontiers in Endocrinology, 2018-19.

Collection: Challenges in Environmental Health: Closing the Gap between Evidence and Environmental Regulations, in PLOS, 2017.

Publications by The Endocrine Disruption Exchange (TEDX)

Reports

Toxic Chemicals in Everyday Life
U.K. House of Commons Environmental Audit Committee
July 2019

The United Nations: Scientific Knowledge of Endocrine Disrupting Chemicals 
Three reports on EDCs, on identifying EDCs, the environmental effects of EDCs, and global regulatory frameworks.

Fracking Compendium, Sixth Edition
Physicians for Social Responsibility and Concerned Health Professionals of New York released the 6th edition of the Compendium in June 2019.

News

For news items on EDCs, see Environmental Health News

Scientific Society Statements on EDCs and Health

EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals
Gore AC, Chappell VA, Fenton SE et al.
Endocrine Reviews 2015 Dec;36(6):E1-E150. 
Also see:
EDC-2 Executive Summary
The first Endocrine Society Scientific Statement on EDCs (2009)

The International Federation of Gynecology and Obstetrics Opinion on Reproductive Health Impacts of Exposure to Toxic Environmental Chemicals  
Di Renzo GC, Conry JA, Blake J et al.
Int J Gynaecol Obstet. 2015 Dec;131(3):219-25. 

The American College of Obstetricians and Gynecologists: Committee Opinion on Exposure to Toxic Environmental Agents
2013; Reaffirmed 2018

Resources for Clinicians and Health Professionals

There Are Good Clinical, Scientific, and Social Reasons to Strengthen Links Between Biomedical and Environmental Research
Porta M and Vandenberg LN.
J Clin Epidemiol. 2019 Mar 21.

New Approaches to Cope with Possible Harms of Low-Dose Environmental Chemicals
Lee DH and Jacobs DR.
J Epidemiol Community Health. 2019 Mar;73(3):193-197.

Interventions to Address Environmental Metabolism-Disrupting Chemicals: Changing the Narrative to Empower Action to Restore Metabolic Health
Sargis RM, Heindel JJ, Padmanabhan V.
Front Endocrinol (Lausanne). 2019 Feb 4;10:33. 

Evidence of the Possible Harm of Endocrine-Disrupting Chemicals in Humans: Ongoing Debates and Key Issues
Lee DH
Endocrinol Metab (Seoul). 2018 Mar;33(1):44-52. 

The Role of Nutrition in Influencing Mechanisms Involved in Environmentally Mediated Diseases
Hennig B, Petriello MC, Gamble MV et al.
Rev Environ Health. 2018 Mar 28;33(1):87-97.

Developing a Clinical Approach to Air Pollution and Cardiovascular Health
Hadley MB, Baumgartner J, Vedanthan R.
Circulation. 2018 Feb 13;137(7):725-742. 

Disparities in Environmental Exposures to Endocrine-Disrupting Chemicals and Diabetes Risk in Vulnerable Populations [includes a Healthcare Provider Guide on EDCs for clinicians]
Ruiz D, Becerra M, Jagai JS et al.
Diabetes Care. 2018 Jan;41(1):193-205.