EDC Science Weekly, Sept. 25 – Oct. 1, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Oct. 6 webinar: Glyphosate Science: Cancer, neurotoxicity & endocrine disruption [CHE]

Oct. 6 – Nov. 24 course: Plastics, Microplastics, and Human Health [Physician and Scientist Network Addressing Plastics and Health (P-SNAP)]

Oct. 8: Children’s Environmental Health Day [Children’s Environmental Health Network]

Oct. 13 workshop: What can nurses do about toxic chemicals? Toxics 101, Communicating Effectively About the Science and Health Effects & Opportunities for Action [Alliance of Nurses for Healthy Environments (ANHE)]

Oct. 13 Grand Rounds: Growing Up in a Chemical World: Emerging Contaminants and Children’s Health [New England PEHSU and Boston Children’s Hospital]

Oct. 22 webinar: Science for Public Health Policy: Understanding correlation and causation [EDC Strategies Partnership]

Nov. 17 webinar: Reducing EDC Exposures: From informed consumers to policy solutions [EDC Strategies Partnership]

Nov. 17 forum: Health and Chemicals [Food Packaging Forum and NYU Grossman School of Medicine] in conjunction with:

Nov. 16-20 First International Conference: Global Framework on Chemicals [UNEP, in Geneva, Switzerland; register by Sept. 30]

Dec. 15 due date for Call for Papers: Microplastics, Community Health, and Public Health Actions [American Journal of Public Health]

Mar. 31 due date for Call For Papers: The Chemical Safety Knowledge Landscape: Mapping What We Know and What We Need to Know [ACS Publications]

Regulations/Policy

EFSA needs for scientific excellence and regulatory readiness.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

HepaRGTM CYP induction test method augmentation part 1: The GOLIATH Study.

Human placental transfer of xenobiotics in health and disease: New approach methodologies for developmental and reproductive toxicology testing and mathematical modelling.

New approach methodologies for in vitro detection of chemical-induced cholestatic liver injury.

Applicability of NAMs to support a read-across based hazard assessment workflow for systemic toxicity: a conazole case study.

Toxicogenomic signatures in zebrafish embryos provide a resource for mode-of-action-informed ecotoxic hazard screening.

Commentaries

Microplastics and cancer: a looming threat?

Microplastics and Cancer: Still Searching for Causation.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Endocrine-Disrupting Chemicals and Hypertension: Mechanisms and Clinical Implications.

The Oxidative Stress and Inflammatory Metabolic Pathways of Some Environmental Toxicants Inflicting Human Disorders.

Environmental Contaminants and Osteoporosis-Related Outcomes: A Systematic Review and Meta-Analysis.

Bisphenols

Associations between prenatal bisphenol S with gestational age and preterm birth: A systematic review and meta-analysis.

Altered miRNA Expression Due to Bisphenol A Exposure and Associated Health Implications: A Narrative Review.

POPs/PFAS

Exposure to per-and polyfluoroalkyl substances and early-onset cancers.

Review on the Bioaccumulation, Trophic Magnification, and Aquatic Toxicology of PFAS: Perspectives from Molecular Structure.

Emerging PFAS: Current Concerns, Remediation, and Future Perspectives.

From Follicle Development to Fertilization: How PCBs and PFAS May Shape Female Reproductive Health.

The aryl hydrocarbon receptor as a tissue-specific modulator of insulin sensitivity: evidence from conditional deletion studies

Pesticides

Translational Gaps in Assessing the Obesogenic Effects of Herbicides: A Scoping Review.

Association between exposure to pesticides and brain cancer in adults: a systematic review.

Metals/Metalloids

Cumulative and Interactive Effects of Heavy Metal Mixtures Across Neurodegenerative Diseases: A Comparative Review of Alzheimer, Parkinson, Amyotrophic Lateral Sclerosis and Multiple Sclerosis.

Selenium and Iodine as Susceptibility Modifiers of Thyroid Disruption Associated with Metals: An Overview of Human and Experimental Research Data.

Effects of Arsenic and Mercury Exposure on Thyroid Dysfunction: An Evidence-Based Risk Assessment Using the TRAEC Strategy.

Microplastics/Nanomaterials

Vascular effects of micro- and nanoplastics in humans: Systematic review.

Microplastics and nanoplastics in inflammatory bowel disease: Mechanistic plausibility, human evidence and future research priorities.

Microplastics in Human Ovarian Follicular Fluid and Female Fertility.

Microplastics as Emerging Neurotoxins: Brain Accumulation, Neuroinflammation, and Neurodegeneration Risk.

Micro- and Nanoplastics as Environmental Stressors: Mechanistic Links Among Gut Dysbiosis, Inflammation, and Systemic Health Effects.

Current Evidence Linking Microplastic Exposure and Reproductive Cancers.

Microplastics in the Female Genital Tract and Fetoplacental Continuum: A Lesion-Based Framework for Pathophysiological Interpretation.

Microplastics and Nanoplastics in Humans: A Critical ADME Appraisal and the Case for Quantitative Risk Assessment.

Ingested microplastics and the gut-brain axis: A systematic review of mechanistic pathways and neurobiological impacts in human and preclinical models.

Microplastics and IgA nephropathy: a novel environmental hypothesis of immune dysregulation.

Micro- and nanoplastics in pediatric health: from placental transfer to neurodevelopmental outcomes.

Microplastics negatively impact ecosystems, human health and cellular proteostasis.

Human Health Studies

Numerous Chemicals/Mixtures

First and second trimester concentrations of environmental phenols in association with gestational weight gain in the ECHO Cohort.

Hair-Based Biomonitoring of Phthalate Metabolites and Triclosan in Childhood: Links with Metabolic and Endocrine Disorders.

Environmental chemical burden in differentiated thyroid cancer.

Mixed exposure to PFAS and OPEs is associated with increased depressive and anxiety symptoms in college freshmen.

Bisphenols

Association and Mechanistic Insights Linking Bisphenol A to Psoriasis: Integrative Analysis of Bulk Transcriptomics, Network Toxicology, Mendelian Randomization and Single‑cell RNA Sequencing.

Bisphenol mixtures and adverse childhood experiences in adolescent depressive symptoms: Interaction effects and sex differences.

Associations of bisphenol A, F and triclosan with serum lipids: the mediating effect of inflammation and oxidative stress.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Childhood serum DDE concentrations and acute lymphoblastic leukemia in a high-exposure region of south-central Mexico.

PFAS

Higher PFAS Exposure Associated with Lower Aldosterone in Pregnant Women – the potential missing link with fetoplacental interaction? The Odense Child Cohort.

Association between per- and polyfluoroalkyl substances exposure and recurrent pregnancy loss: The potential role of oxidative stress and the HIF1α‑GLUT1/VEGFA axis.

Assessing the Impact of Mixed Exposure to 18 PFASs on Dyslipidemia Risk: An Epidemiological Study in Middle-Aged and Elderly Adults.

Serum per- and polyfluoroalkyl substances and prevalent heart disease: cross-sectional analysis of the multi-site study.

Serum legacy and emerging PFAS and lipid biomarkers in patients with chronic coronary syndrome: a cross-sectional human biomonitoring study.

Plasma per- and polyfluoroalkyl substance (PFAS) concentrations in mid-childhood and associations with DNA methylation and epigenetic aging through early adolescence.

Prenatal exposure to perfluorooctane sulfonate and the risk of neurodevelopmental disorders: Perturbation of placenta-brain axis through DNA methylation.

Per- and polyfluoroalkyl substances, seminal plasma metabolome, and sperm telomere length and mitochondrial DNA copy number: a cohort study.

Flame Retardants

Prenatal exposure to organophosphate esters and child cognitive development in the MARBLES prospective cohort.

Pesticides

Evaluation of Liver Biomarker Levels in Farmers Occupationally Exposed to Pesticides: A Cross-Sectional Study.

Occupational Organophosphorus Pesticide Exposure and Metabolic Syndrome: Implications of PPARγ.

Metals/Metalloids

Associations of Plasma Metal Exposure With the Risk and Severity of Acute Coronary Syndrome: Evidence From Epidemiological and Adverse Outcome Pathway Analyses.

Metals and metalloids signatures in early pregnancy suggest cadmium and arsenic as major mixture components associated with gestational diabetes mellitus risk.

Microplastics/Nanomaterials

Microplastic Pollution and Risk of Cancer: A Prospective Study Based on UK Biobank.

Suspected Microplastic-Like Particles Recovered From Paired Human Small Intestine and Large Intestine Specimens: An Exploratory Post-mortem Study.

Air Pollution

Joint effects of air pollution and temperature on glycemia: An exposome analysis in European cohorts.

Second-trimester PM2.5 and PM10 exposure is associated with neonatal metabolome alterations and elevated risk of pregnancy loss: a large-scale matched cohort study with metabolomic profiling.

Laboratory Studies

Numerous Chemicals/Mixtures

Morpho-Functional Effects of Nonylphenol-Steroid Hormone Co-Exposure on Human Prostate PNT1A Cells.

Bisphenols

Perinatal BPA Exposure-Associated Depressive-like Behaviors in Male Offspring May Involve Changes in Autophagy-Related Proteins and GABARAP-GABAAR Interaction.

Unveiling the Molecular Mechanisms of Bisphenol-Induced Olfactory Toxicity in Zebrafish.

Dietary Bisphenol-A Exposure Induces Oxidative Stress-Mediated Developmental Renal Toxicity in Drosophila melanogaster.

Bisphenol F induces intestinal epithelial injury through hsa_circ_0003655-mediated dual-axis disruption of cytoplasmic and organellar calcium homeostasis.

Comparative evaluation of the effects of bisphenol A and/or bisphenol F on oxidative stress and cytokine responses in SH-SY5Y neuroblastoma cells: in silico and in vitro.

Integration of network toxicology and zebrafish models to elucidate bisphenol BP-induced cardiotoxicity.

Integrating network toxicology, molecular modeling, and in vitro experiments to reveal potential targets and mechanism of BPS-induced osteoporosis.

Phthalates

Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate alters the aryl hydrocarbon receptor signaling pathway in the ovary throughout reproductive aging in mice.

The aryl hydrocarbon signaling pathway in the ovary changes throughout reproductive aging and in response to a mixture of phthalates over time in mice.

The protective effects of thymoquinone on the cerebellum and hippocampus of rats treated with diisobutyl phthalate.

Niacin alleviates dibutyl phthalate-induced impairment of porcine oocyte quality.

Modulatory Effects of Zinc and Cystine on Diisononyl Phthalate-Induced Male Reproductive Injury.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Transcriptomic analysis reveals neurobehavioral impairment in zebrafish during early life following environmentally relevant exposure to short-chain chlorinated paraffins.

PFAS

Perfluorooctanesulfonate (PFOS) Precursor Biotransformation Drives Shared Lipidomic Remodeling in HepaRG Cells.

Dermal Permeability of Perfluorohexane Sulfonic Acid (PFHxS) and Perfluorohexanoic Acid (PFHxA) in Varying Vehicles and the Effects on Skin Integrity in a Reconstructed Human Epidermis Model.

PFDoA induces developmental and immune toxicity in zebrafish through ROS-mediated inflammation-apoptosis signaling.

PFOS increases cellular uric acid content and the abundance of URAT1 and GLUT9 in HK-2 cells.

High-Content Genotoxicity Analysis reveals clastogenic effects of low-concentrations per- and polyfluoroalkyl substances mixtures in Human breast epithelial cells.

6:2 Cl-PFESA exposure and non-obstructive azoospermia: Insights from network toxicology and experimental validation.

Integrative Network Toxicology and Experimental Validation Define Mechanisms of Perfluorodecanoic Acid (PFDA) Induced Granulosa Cell Toxicity and Attenuation by Kaempferol in HGrC1 Cells.

Curcumin Opposes Perfluorodecanoic Acid-Induced Adipogenesis Through the PPARγ/C/EBPα Axis in 3T3-L1 Cells.

Multi-Organ Per- and Polyfluoroalkyl Substances Accumulation Reveals Brain-Peripheral Metabolic Coupling and Glucocorticoid-Related Dysregulation in Mice.

The emerging contaminant HFPO-TA impairs hepatic glucose metabolism and induces pparγ-associated lipid metabolic disorders in zebrafish.

Comparative morphological and transcriptomic responses of three estuarine fish species developmentally exposed to environmentally relevant concentrations of PFHxS.

Integrating epidemiology and mechanistic studies links PFAS exposure to ocular diseases and implicates PFOS-associated glaucoma risk through the PI3K/Akt-MMP3 axis.

Flame Retardants

An in Vitro Comparison of the Effects of Tetrabromobisphenol A and Tetrabromobisphenol S on Threshold-Like Hemolysis in Human Erythrocytes.

Developmental exposure to environmentally relevant bisphenol A bis(diphenyl phosphate) impairs host defense and disrupts epidermal immune and barrier responses in Caenorhabditis elegans.

Pesticides

Glyphosate exposure and epigenetic-environmental interactions in ASD: The role of circTiam1.

Individual and Combined Effects of Commercial Glyphosate and Dicamba-Based Herbicide Formulations on Cytotoxicity, Oxidative Stress and Cell Death on Human Intestinal Caco-2 Cells.

Cellular Responses to Acetamiprid in Human Granulosa Cells: Molecular Docking Insights Into PI3K/AKT Signaling Pathway.

An Integrative Toxicological Assessment of the Herbicide Tebuthiuron: Elucidating Biochemical and Behavioral Responses in Developing Zebrafish.

Prenatal Chlorpyrifos Exposure Induces Ovarian Toxicity in Rat Offspring: Modulatory Potential of Curcumin.

Chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol elicit MASLD-related lipid metabolic perturbations in HepG2 cells.

Mixture Effects Investigation of a Thyroid Hormone System-Specific Interaction with Azole Fungicides.

Metals/Metalloids

Arsenic induced alterations in erythrocyte redox balance, morphology, bioenergetics associated with GLUT1 degradation and hexokinase inhibition: Melatonin-mediated cytoprotection-a mechanistic insight.

Microplastics/Nanomaterials

Mixed leachate from polylactic acid food containers exacerbates NAFLD in obese mice at environmentally relevant levels: cAMP-dependent acid lipolysis mechanism.

Combined toxicity of co-exposure to polystyrene nanoplastics and arsenic on the gut-liver axis in mice.

Nanoplastics amplify ciprofloxacin-induced immunotoxicity: Oxidative stress in splenocytes and conformational and functional changes in lysozyme.

Polyvinyl Chloride and Polypropylene Model Nanoplastics Exhibit Distinct Interaction Patterns and Cellular Responses in Human Umbilical Vein Endothelial (HUVECs) Cells.

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High-Fat Diet-Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction.

Double trouble for spermatogenesis: Polystyrene nanoplastics aggravate microcystin-LR toxicity by hijacking mitochondrial function in zebrafish.

An integrated approach to assess the molecular mechanisms and cellular effects of environmentally realistic mixtures of microplastics in Mytilus galloprovincialis.

Potential mechanisms linking polyethylene terephthalate microplastic-associated exposure factors to abnormal biomineralization.

Pharmaceuticals/Personal Care Products

Short-term exposure to diazepam during zebrafish embryogenesis induces intergenerational neurobehavioral disruption later in life.

Tire Wear Chemicals

6PPD-Quinone Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease through Immune-Inflammatory Disruption.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

A suspect and non-target approach to unveil the chemical fingerprint of a multi-environment indoor dust.

From Buildings to the Environment: Flows, Exposure Pathways, and Toxicological Relevance of Tris(2-Chloro-1-Methylethyl) Phosphate (TCPP), Diuron, and Bis(2-(Perfluorohexyl)Ethyl) Phosphate (6:2 diPAP).

Bisphenols

Migration of Bisphenol A (BPA) into PET-Bottled Beverages: A Comprehensive Review and Bibliometric Analysis.

PFAS

Ultrashort-Chain and Short-Chain Per- and Polyfluoroalkyl Substances Are Universal Contaminants in Wines: A Comprehensive Survey of Red, White, Rosé, and Sparkling Samples.

Nationwide Occurrence and Exposure Assessment of PFAS in Australian Tap Drinking Water Using a Citizen Science Sampling Approach.

(Hyper)bioaccumulation of per- and polyfluoroalkyl substances (PFAS) in the flowers and pollen of wild plants: a potential pollinator exposure pathway.

Per- and Polyfluoroalkyl Substances (PFAS) in Michigan: A Novel High-Throughput Method with Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Analysis of 39 PFAS Compounds in Human and Bovine Dried Blood Spots (DBS).

Comparative Analysis of Influent and Effluent Measurements of Per- and Polyfluoroalkyl Substances (PFAS) at Wastewater Treatment Facilities.

Climate-Driven Per- and Polyfluoroalkyl Substances Transfer via Drosophila from Landfills in China: A Hidden Biological Vector under Global Warming.

Flame Retardants

Organophosphate Flame Retardants in Shanghai Indoor Dust: A 2016 Historical Baseline of Seasonal Variability, Microenvironmental Profiles, and Human Exposure.

Temporal Variability of Urinary Organophosphate Flame Retardant Metabolites Among E-Waste Workers in France: A Pilot Study to Inform Occupational Biomonitoring Sampling Design.

Assessing hair for human biomonitoring: comparison of organophosphorus flame-retardant levels in hair, urine and blood from the same individuals.

Metals/Metalloids

Arsenic in Drinking Water and Human Biomonitoring in Eastern Croatia: An Exploratory Environmental Health Study.

Wolf hair for biomonitoring arsenic, selenium, cadmium and lead exposure: a comparative study with internal organs.

Microplastics/Nanomaterials

Microplastics in human ovarian follicular fluid: a pilot Raman spectroscopy study.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!