EDC Science Weekly, Sept. 11-17, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Sept. 22-23: 2026 Plastics and Human Health Symposium (in NYC with streaming) [NYU Langone Health’s Center for the Investigation of Environmental Hazards (CIEH) and the Food Packaging Forum]

Sept. 24 webinar: PFAS “Forever Chemicals” [Clean Water Action and Children Now]

Sept. 30: Application due date for the HEEDS Lou Guillette Jr. Outstanding Young Investigator Award.

Oct. 1: Application due date for the Seeding Change/Agents of Change cohort.

Oct. 6 webinar: Glyphosate Science: Cancer, neurotoxicity & endocrine disruption [CHE]

Oct. 6 – Nov. 24 course: Plastics, Microplastics, and Human Health [Physician and Scientist Network Addressing Plastics and Health (P-SNAP)]

Oct. 8: Children’s Environmental Health Day [Children’s Environmental Health Network]

Oct. 13 workshop: What can nurses do about toxic chemicals? Toxics 101, Communicating Effectively About the Science and Health Effects & Opportunities for Action [Alliance of Nurses for Healthy Environments (ANHE)]

Oct. 13 Grand Rounds: Growing Up in a Chemical World: Emerging Contaminants and Children’s Health [New England PEHSU and Boston Children’s Hospital]

Dec. 15 due date for Call for Papers: Microplastics, Community Health, and Public Health Actions [American Journal of Public Health]

Mar. 31 due date for Call For Papers: The Chemical Safety Knowledge Landscape: Mapping What We Know and What We Need to Know [ACS Publications]

Regulations/Policy

Regulatory challenges and opportunities on NAMs at ECHA

Regulating What We Cannot Yet Measure? A Scientific Perspective on Polymeric PFASs, Total Fluorine, and the PFAS Fluorine Gap.

Derivation of guidance values under the EU Drinking Water Directive : the case study of trifluoroacetic acid.

Improving consistency in regulatory assessment of repeated-dose toxicity studies: an EFSA checklist-based framework for statistical evaluation.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

Novel and rigorous methods for identifying cancer hazards: The updated Report on Carcinogens Handbook.

Advancing cancer and carcinogenesis research through new approach methodologies

Can Knowledge Counteract Conflict? A Partial Replication Study of PFAS Science Communication.

Commentaries

More Microplastics and Nanoplastics Detected in Patients With Heart Attacks. [News item in JAMA Network]

Underestimated risks of nanoplastics in the ocean.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

World Trade Center Exposure at 25 Years—A Clinical Guide

Molecular Mechanisms of Endocrine-Disrupting Chemicals and Emerging-Pollutant Toxicity in Human Reproduction: From Xenobiotic Exposure to Fertility Impairment and Reproductive Carcinogenesis.

Epidemiologic research on environmental chemical exposures and ovarian and endometrial cancers: a systematic review.

A Perfect Storm of Pollutants: Environmental Mixtures in the Pathogenesis of Atherosclerosis

Bisphenols

Bisphenol S-induced inflammation: a comparative insight on inflammatory pathway activation in zebrafish and rodent models.

Phthalates

Endocrine and cardiovascular consequences of plasticiser exposure: a narrative review from the thyroid- cardiac axis perspective.

PFAS

Kidney Risks Linked to Per- and Polyfluoroalkyl Substance Exposure.

The association between exposure to per- and polyfluoroalkyl substances and the risk of metabolic syndrome in adults: A systematic review and meta-analysis.

Flame Retardants

Current background human exposure to polybrominated diphenyl ethers: a review.

Pesticides

Pesticide exposure during pregnancy and the risk of adverse maternal and fetal outcomes: a systematic review.

Chronic Paraquat Neurotoxicity and Dopaminergic Degeneration: A Mechanistic Review.

Metals/Metalloids

Environmental Arsenic Exposure and Stress-Related Mental Health Disorders: Mechanisms Shaping Stress Vulnerability.

Microplastics/Nanomaterials

Combined Effects of Microplastics and Heavy Metals, Pesticides, and Antibiotics in Zebrafish (Danio rerio): A Critical Review.

Micro- and nanoplastics in periodontitis: mechanistic pathways and clinical implications.

Microplastics and Nanoplastics in Food: Dietary Toxicology Beyond Particle Counts.

Microplastics and Nanoplastics in the Human Diet: Sources of Exposure, Bioavailability, Toxicokinetics, and Systemic Health Effects.

Microplastics-Mediated Gut Microbial Dysbiosis and Cellular Bioenergetic Impairment: A Critical Review.

Micro- and Nanoplastics in the Human Exposome: Environmental Pathways, Kidney Toxicity, and Implications for Public Health Risk Assessment.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal exposure to a mixture of non-persistent endocrine-disrupting chemicals and attention and hyperactivity symptoms in children in the ECHO cohort.

Prenatal bisphenols and ambient air pollutants are differentially associated with early childhood length and weight from birth to 36 months: a multi-domain mixture analysis in a Korean birth cohort.

Association of prenatal co-exposure to OPEs and PAEs with ASD symptom trajectories in preschool children: the modifying role of vitamin D.

Bisphenols

Association between bisphenol A exposure, methylmalonic acid, and cardiovascular disease among adults aged 60 and younger.

Association between urinary bisphenol levels and metabolic syndrome in Korean adults: a cross-sectional study using the fourth Korean National Environmental Health Survey.

Dietary Bisphenol A Exposure and Urinary Bisphenol A Levels During Late Pregnancy: Associations with Inflammatory and Oxidative Stress Biomarkers.

Phthalates

Prenatal exposure to the plasticizer DEHP increases the likelihood of early-life autism and ADHD symptoms through epigenetic programming.

Associations between prenatal phthalate exposure and maternal immune cell profiles across trimesters.

Phthalate and Terephthalate Mixtures, Cardiometabolic Risk Factors, and the Role of Oxidative Stress: Evidence from NHANES 2015-2018.

Human Biomonitoring of Phthalate Exposure and Serum Estradiol Levels in U.S. Adult Males.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations between serum persistent organic pollutants and type 2 diabetes in a multipollutant analysis using repeated measurements in the Tromsø Study

A community-engaged randomized controlled trial assessing the effectiveness of a weight loss aid in reducing the body burden of persistent organic pollutants.

PFAS

Per- and polyfluoroalkyl substances, perceived stress, and miscarriage risk in a cohort of US Black women.

Revealing the Link Between Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Stroke: A Comprehensive Epidemiological and Network Toxicology Perspective.

Association of per- and polyfluoroalkyl substances exposure and type 2 diabetes risk with the mediating role of platelet mitochondrial DNA methylation in the elderly.

Pesticides

Prenatal exposure to neonicotinoid insecticides and childhood allergic disease trajectories: A nationwide risk assessment from the JECS birth cohort.

Environmental Glyphosate Exposure Is Associated with Lower Serum 25-Hydroxyvitamin D Concentrations: A Cross-Sectional Analysis of NHANES 2013-2018.

Association between chronic agricultural pesticide exposure, oxidative stress biomarkers, and acute leukemia risk: a case-control study in southeastern Iran.

Occupational exposure to 2,4-dichlorophenoxyacetic acid (2,4-D) and associated oxidative and genomic biomarkers among soybean farmers: a cross-sectional study.

Metals/Metalloids

Associations of Urinary Lead, Cadmium, and Arsenic Exposure with Obesity-Related Indicators Among School-Aged Children: A Longitudinal Study.

Associations of blood and urinary heavy metals with obesity risk among children: NHANES 2015-2020.

Microplastics/Nanomaterials

Microplastics in Human Thoracic Tissues: Increased Burden in Patients with Lung Malignancy.

Air Pollution

Prenatal exposure to wildfire fine particulate matter and fetal growth outcomes in the United States: Findings from the ECHO Cohort.

Associations of PM_2.5 exposure with diabetes-related mortality for California residents.

Laboratory Studies

Numerous Chemicals/Mixtures

Toxicological assessment of plasticizer mixtures from treated sewage effluent in zebrafish embryos.

Bisphenols

Effects of Tetramethyl Bisphenol F Exposure on Daphnia magna Growth, Reproduction, Locomotor Behavior and Transcriptomic Responses.

Bisphenol A remodels brown adipose tissue via apoptosis, whitening, and inflammatory stress.

Study on the Potential Mechanism of Bisphenol A-induced Human Diabetic Nephropathy Based on Network Toxicology and Molecular Docking

In silico Molecular Docking Analysis of Bioactive Phytoconstituents against Environmental Neurotoxin Bisphenol-A.

Phthalates/Parabens

Embryonic Dibutyl Phthalate Exposure Disrupts Sertoli Cell Glycolipid Metabolism to Drive Premature Spermatogenesis in PND 22 Male Offspring: A Role for the AMPK/Autophagy Axis.

Unveiling the molecular toxicity of plasticizers derived from microplastics (DMP and DEP) in diabetic kidney disease: integrative insights from network toxicology and multi-omics analysis.

New insights into the reproductive endocrine disruption of early-life dimethyl phthalate exposure in female zebrafish (Danio rerio).

Mechanistic insights into di(2-ethylhexyl) phthalate exposure in obstructive sleep apnea: network toxicology and in vitro validation.

Co-exposure to high temperature and mono(2-ethylhexyl) phthalate inhibits mouse antral follicle growth and estradiol synthesis: Phthalate-heat interactions in the ovary.

Identifying targets and mechanisms of endocrine disruptor-induced sex-specific toxicity: Integration of network toxicology and medaka experimental evidence.

Curcumin attenuates DEHP-induced splenic immunotoxicity in chicks: involvement of Mfn2-mtROS-associated mitochondrial homeostasis.

Quercetin alleviates splenic oxidative stress and inflammatory damage induced by long-term exposure to a mixture of phthalates in rats.

Triclosan

Investigation of the molecular mechanism by which triclosan aggravates rheumatoid arthritis using network toxicology.

PFAS

Embryonic exposure to ambient concentrations of PFAS impairs the innate immune response in zebrafish and fathead minnow.

The maternal-to-zygotic transition is a critical window for PFOA-induced disruption of developmental programming.

Toxicity differences between HFPO-TA and PFOA, and combination with PP-MPs: evidence against HFPO-TA as a safe PFOA alternative.

Perfluorodecanoic acid (PFDA) exposure, through stabilizing HIF-1α to induce VEGF/VEGFR2 autocrine signaling, promotes colorectal cancer cell proliferation.

Ferroptosis and Oxidative Stress Are Implicated Perfluorooctane Sulfonate-Elicited Cytotoxicity to Human Umbilical Vein Endothelial Cells.

Integrative network toxicology and molecular docking reveal epigenetic and endocrine-disrupting mechanisms of PFAS in ovarian cancer.

Flame Retardants

Novel brominated flame retardant TBPH upregulates thyroid synthesis markers via S1PR3 and involves IL-10 with atypical JAK-STAT activation.

Exploring the toxicological impact of BDE-209 on neurodegenerative diseases through network toxicology, molecular docking, molecular dynamics simulation and in-vitro study.

Tetrachlorobisphenol A inhibits steroidogenesis in pubertal rat Leydig cells through disruption of copper homeostasis.

Pesticides

Network pharmacological combined with in vivo and in vitro validation reveals the mechanisms of atrazine-induced Parkinson’s disease-related neurotoxicity.

Environmentally relevant concentrations of Roundup® WG affect ovarian maturation-associated parameters and vitellin immunoreactivity in a non-target freshwater decapod.

A single exposure to an organophosphate insecticide disrupts developmental patterns of hippocampal cell proliferation and overall brain size in a migratory songbird.

Metals/Metalloids

Chronic arsenic-fluoride co-exposure impairs spermatogenesis with gut microbiota-associated bile acid and lipid metabolic remodeling.

Arsenic-induced SAM depletion and m⁶A dysregulation contribute to impaired insulin secretion in MIN6 cells.

Microplastics/Nanomaterials

Perinatal exposure to nano-polystyrene: deleterious imprinting on inflammatory bowel diseases.

Polystyrene nanoplastics induce cardiotoxicity by driving myocardial metabolic reprogramming via the SDHA/Succinate/HIF-1α axis.

Microplastics and nanoplastics-related genes signature predicts prognosis in pancreatic ductal adenocarcinoma and functional validation of interleukin 1 alpha.

UVB-aged polystyrene microplastics induce enhanced stress responses in human proximal tubular cells.

Multi-omics analysis and experiments reveal an association between polystyrene microplastics exposure and colorectal cancer progression.

Synergistic toxicity of additive-functionalized microplastics in zebrafish: Linking intestinal release kinetics to oxidative stress.

Quercetin attenuates polyethylene terephthalate nanoplastic-induced malignant phenotypes linked to APOE stabilization and lipid metabolic reprogramming in prostate cancer.

Microplastic formation during degradation: bioplastics vs conventional plastics.

Probe Cytotoxic and Oxidative Stress Effects of Nanoplastics on Caco-2 Cells: Insights from Raman Spectroscopy and Machine Learning.

Differential immunotoxic effects of UV-aged polypropylene and polyamide microplastics in Ruditapes philippinarum hemocytes: An extracellular trap perspective.

Single-cell and metabolomic profiling reveals brain cellular and metabolic disruptions in pregnant mice exposed to micro- and nanoplastics.

Pharmaceuticals/Personal Care Products

Integrative AOP‑Based Mechanistic Profiling of Organic UV Filters Reveals Shared Endocrine‑Metabolic and Stress-Response Pathways.

Tire Wear Chemicals

6PPDQ exposure enhances susceptibility to ulcerative colitis by disturbing MMP9, PTGS2, and PPARG homeostasis: an integrative network toxicology and in vivo study.

Potential hazard assessment of 6PPD-quinone in the context of ulcerative colitis: network toxicology, machine learning, transcriptomic analysis, and preliminary In vivo validation.

Chronic PPDs/6PPDQ exposure triggers lung injury via MDM2 binding-mediated p53 accumulation and PI3K-AKT signaling repression.

6PPD and 6PPD-Q Induce Mitochondrial Dysfunction in Saccharomyces cerevisiae.

Miscellaneous

Exploring Nonylphenol as a Potential Environmental Contributor to Alzheimer’s Disease: A Hypothesis-Generating Study Integrating Computational Analyses and Experimental Evidence.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Workflow level release of microplastics, nanoplastics, and perfluoroalkyl and polyfluoroalkyl substances during simulated neurovascular interventions.

Temporal variability of emerging contaminants and estrogenic activity in sediments of a tropical coastal lagoon.

Bisphenols

Association between delivery-food consumption frequency and urinary bisphenol concentrations among Korean adults: a nationally representative study (Korean National Environmental Health Survey cycle 5, 2021-2023).

Phthalates

Global phthalate occurrence and risk assessment in drinking water: A comprehensive Bayesian and probabilistic approach.

PFAS

Relative contributions of dietary and drinking water pathways to PFAS exposure in the U.S. population: intake-based and biomonitoring analyses.

Declared versus actual presence of PFAS in cosmetic products: an INCI list analysis and critical appraisal of current regulatory frameworks.

Per- and Polyfluoroalkyl Substances (PFAS) and Metals in Wild and Farmed Oysters of a Minimally Developed Coastal Region in the Southeastern United States.

Pesticides

Beyond legacy pollutants: glacier and snow melt as a relevant source for current-use pesticides in Alpine environments under climate pressure.

Metals/Metalloids

Heavy metal concentrations and inter-metal relationships in commercially available hair dyes of different colours: a chemometric evaluation

Microplastics/Nanomaterials

Plastic and Anthropogenic Particles in the Reproductive Tissues of Feral and Domestic Felines.

Plastic Ingestion and Plastic-Related Chemicals in Northern Fulmars (Fulmarus glacialis): Exploration of Histopathological and Endocrine Alterations.

Characterization of macroplastics ingested by 23% of stranded short-finned pilot whales (Globicephala macrorhynchus) in the Main Hawaiian Islands (2010-2023).

Ocean warming shapes the marine plastisphere: Microbial assembly, vector effects, and biogeochemical feedbacks of microplastics.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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