EDC Science Weekly, Oct. 9-15, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Oct. 16 webinar: How much are people willing to pay to avoid chemicals-related health effects? [OCED]

Oct. 20 webinar: Using ‘systems thinking’ to support uptake of new approach methodologies in regulatory decision-making [ECHA]

Oct. 22 webinar: Science for Public Health Policy: Understanding correlation and causation [EDC Strategies Partnership]

Oct. 22 webinar: Knowing what chemicals are in products [Hej!Support]

Oct. 27 webinar: The ovarian cost of convenience: Phthalate exposure and ovarian function [Merlon]

Nov. 4-5 meeting: Scientific Advisory Committee on Alternative Toxicological Methods [National Toxicology Program]

Nov. 5 in-person Boston event: Plastic-Free Future: Protecting People and the Planet [Just Zero & Plastic Free Mass]

Nov. 17 webinar: Reducing EDC Exposures: From informed consumers to policy solutions [EDC Strategies Partnership]

Nov. 17 forum: Health and Chemicals [Food Packaging Forum and NYU Grossman School of Medicine] in conjunction with:

Nov. 16-20 First International Conference: Global Framework on Chemicals [UNEP]

Dec. 7-8 workshop: Plastics, Microplastics, and Plastic Chemicals: Emerging Impacts on Human Heart, Lung, Blood, and Sleep Health [NIEHS and NHLBI]

Dec. 15 due date for Call for Papers: Microplastics, Community Health, and Public Health Actions [American Journal of Public Health] and related informational webinar on Oct. 15 at 4:15pm ET.

Jan. 25, 2027 due date for abstracts: The Microplastics and Nanoplastics Summit, May 9-12, 2027 in Lincoln, Nebraska

Mar. 31, 2027 due date for Call For Papers: The Chemical Safety Knowledge Landscape: Mapping What We Know and What We Need to Know [ACS Publications]

Regulations/Policy

Climate, Toxic Exposures and Work: Linking the Amazon, Africa, and Southern Europe through a COP30 Dialogue.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

Green Sorptive Sampling Coupled With UHPLC-IMS-MS and GC×GC-TOFMS for Characterization of Migrating Substances From Plastic Food Contact Materials.

A bioengineered model of human placental exposure to environmental metals during pregnancy.

Digital Twins in Toxicology: Toward Predictive, Personalized and Real-Time Risk Assessment.

Review of human health exposure assessment frameworks in the United States and development of a unified framework for exposure assessment practitioners.

Editorial: Shaping the future of predictive toxicology: addressing challenges and new approach methodologies.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Environmental Epigenetic Transgenerational Inheritance and Generational Toxicology.

Disruption of the thyroid hormone system and patterns of altered thyroid hormone serum concentrations after chemical exposures in adult rodents – a systematic review.

Exposure to environmental toxicants during pregnancy and placental angiogenic biomarkers: An integrative review.

Endocrine Disruptors, Gut Microbiota, and Type 2 Diabetes: Bridging Mechanisms to Probiotic-Based Therapeutic Approaches.

Early-Life exposure to environmental pollutants and endocrine disruptors: emerging risks and mechanistic insights in maternal, fetal, and child health.

Environmental chemicals in dogs: evidence review and new data linking dietary exposure and reproductive performance.

Land application of sewage sludge as a pathway for emerging contaminants: a comparative review of microplastics, PFAS, and pharmaceuticals.

Bisphenols

Protective effects of naringenin and naringin against bisphenol A-induced male reproductive toxicity: mechanistic and preclinical evidence.

Phthalates

Di(2-ethylhexyl) phthalate (DEHP) exposure during cardiopulmonary bypass: A narrative review of human clinical evidence and future directions.

PFAS

Do alternative PFAS reduce risk or shift it? A critical comparative review of persistence, mobility, bioaccumulation, toxicity, exposure, and safer substitution criteria.

Metals/Metalloids

Toxic Metals and Metalloids Exposure and the Gut-Cardiometabolic Axis: A Narrative Review of Microbiome Dysbiosis, Gut Barrier Dysfunction, and Metabolic Inflammation.

Aluminium as a Metalloestrogen: Toxicological Pathways, Endocrine Disruption and Systemic Health Implications.

Microplastics/Nanomaterials

Maternal Exposure to Microplastics and Nanoplastics: Placental Lipid Metabolic Dysregulation as a Potential Link to Fetal Growth Restriction.

Understanding the complexity of microplastics, antibiotic resistance, and their interaction with human health and ecosystems: a review towards global environmental sustainability.

Polyethylene Microplastics and Cardiometabolic Mitochondrial-Redox Dysfunction in Preclinical Rodent Models: A Systematic Review and Meta-Analysis of Bioenergetic and Oxidative Stress Outcomes Across Target Organs.

Effect of micro/nano-plastics on environment and recent advances in their detection strategies.

Microplastic Biomonitoring: Global Distribution, Matrix Selection, and Intrinsic and Extrinsic Effects.

Decoding microplastic toxicity on human health: navigating translational challenges using organ-on-chip models.

Miscellaneous

Environmental exposure risk of typical rubber antioxidant 6PPD and its oxidation product 6PPD-Q.

Human Health Studies

Bisphenols

Exploring potential association between bisphenol A exposure and spondyloarthritis: Integrative evidence from molecular analyses and NHANES.

Phthalates

Association of Phthalates with miR-3651, ATP6AP2, and SEC63 Dysregulation in Missed Abortion: Clinical and In Vitro Evidence.

Parabens/Triclosan/Antimicrobials

Associations of Urinary Triclosan Concentrations Across Gestation and Childhood with the Adolescent Gut Microbiome.

PFAS

Untargeted Lipidomics Analysis of Prenatal Per- and Polyfluoroalkyl Substances (PFAS) Exposure and Small-for-Gestational Age (SGA) Delivery: An Exploratory Study in the Atlanta African American Maternal-Child Cohort, 2014-2020.

Early Pregnancy Exposure to Per- and Polyfluoroalkyl Substances and Hypertensive Disorders of Pregnancy: A Cohort Study in China.

Prenatal per- and polyfluoroalkyl substance levels and childhood rubella incidence up to age 6 years: the Japan Environment and Children’s Study.

Sex-Specific Associations Between Per- and Polyfluoroalkyl Substances and the Risk of Type 2 Diabetes: The Role of Genetic Susceptibility and Lipid Metabolism.

Associations of Serum Per- and Polyfluoroalkyl Substances (PFAS) With Epigenetic Age and DNA Methylation in US Airport Firefighters.

Flame Retardants

Prenatal exposure to organophosphate esters (OPEs) and infant attention to faces at age 1 month.

Association between organophosphate esters and incident type 2 diabetes risk: modification by genetic risk and lifestyle.

Pesticides

Cholinesterase Inhibition Thresholds and Neurobehavioral Impairment in Agricultural Workers Exposed to Organophosphate Pesticides.

A Pilot Study to Explore the Application of Silicone Wristband-Based Chemical Exposure Assessment to Kidney Disease Epidemiology in Agricultural Workers.

Microplastics/Nanomaterials

Microplastics detection in freshly harvested human brain tissues of northeast Chinese postmortem donors and their correlation with Alzheimer’s disease- related pathological proteins.

Pharmaceuticals/Personal Care Products

Multiomics Insights Linking Personal Care Products Exposure to Serum Lipid Profiles in Older Adults: The China BAPE Study.

Miscellaneous

Substituted p-phenylenediamines (PPDs) and PPD-quinones in paired blood and urine from early-stage lung cancer patients: Preliminary assessment of associations with typical medical indicators.

Laboratory Studies

Numerous Chemicals/Mixtures

Multiscale Effects of Environmentally Relevant Mixtures Containing Two Estrogenic Endocrine Disruptors, Chlordecone and Propylparaben, in Hydra vulgaris Pallas, 1766.

Biochemical Responses of Mytilus galloprovincialis to Individual and Binary Exposures to PFDoA, Bisphenol A and Tricresyl Phosphate: Exposure and Post-exposure Dynamics.

Bisphenols

Metabolic impact of bisphenol A on retinal pigment epithelium: disturbed energy pathways and antioxidant response in ARPE-19 cells.

Effects of Spirulina nanoparticles on bisphenol A-induced testicular toxicity in male rats: Hormonal, histopathological, and molecular insights.

High Normal dietary casein attenuates bisphenol A-induced multiorgan toxicity in rats: Preservation of renal integrity, glucose homeostasis, and immune surveillance via modulation of oxidative stress, inflammation, and apoptosis.

Phthalates

Potential targets and mechanisms of Di(2-ethylhexyl) phthalate exposure in inducing chronic kidney disease: a multimodal study integrating epidemiology, network toxicology, and Mendelian randomization.

Combining network toxicology with in vitro and in vivo experimental validation to investigate the toxicological mechanisms of phthalate exposure in promoting osteosarcoma.

Elucidation of the potential mechanisms of di-2-ethylhexyl phthalate (DEHP)-associated osteoporosis by integrating network toxicology and in vitro validation.

Mapping DEHP-induced metabolic dysregulation through multi-omics and systems biology: an adverse outcome pathway network approach.

Exposure to an Environmentally Relevant Phthalate Mixture Impairs Ovarian Endothelial Cell Function In Vitro.

Genetic evidence and multi-omics characterization of DEHP-relevant detoxification and metabolic heterogeneity in hepatocellular carcinoma.

Parabens/Triclosan/Antimicrobials

Halogenated Disinfectants Inhibit Human and Rat 17β-Hydroxysteroid Dehydrogenase 1 Activity and Disrupt Estradiol Synthesis: Implications for Endocrine Disruption.

PFAS

Maternal PFOS Exposure Impairs β‑Cell Insulin Secretion and Glucose Tolerance in Rats.

Gestational exposure to per- and polyfluoroalkyl substances drives maternal liver dysfunction through lipid dysregulation and NF-κB/EGFR-STAT3 inflammatory activation.

Sub‑chronic PFOA exposure at human‑relevant increasing doses in male mice: Role of stress‑induced gut barrier disruption in shaping intestinal and hepatic responses under high-dose conditions.

High-Throughput Transcriptomics for Mechanism-Informed Mixture Risk Assessment of Perfluoroalkyl Substances Using Human Biomonitoring Data.

HFPO homologue exposure impairs human sperm function via calcium dyshomeostasis and mitochondrial dysfunction.

Flame Retardants

Revealing the toxicological effects and mechanisms of tris(1-chloro-2-propyl) phosphate exposure on osteoarthritis based on network toxicology, machine learning, and molecular docking.

The Flame Retardant Triphenyl Phosphate Induces Varying Responses in Genetically Diverse Mouse Induced Pluripotent Stem Cells.

Pesticides

Roundup® induces oxidative stress in zebrafish liver cell line (ZF-L): Role of the Nrf pathway and uncoupling proteins.

Atrazine Induces Hepatic Lipid Metabolism Disorder via BMP9/SMAD1/5-Mediated Iron Overload.

Paraquat induced depression-related neurobehavioral abnormalities in zebrafish: Linkage between hepatic SAM biosynthesis and cerebral m⁶A methylation.

Integrated evidence-based assessment of in vitro and in vivo data supports that the effects of phenmedipham in Xenopus laevis are consistent with generalised toxicity rather than thyroid disruption.

Metals/Metalloids

Transcriptomic effects of lead on the differentiation of human embryonic stem cells into ectoderm: implication for adverse pregnancy outcomes and neurodevelopmental disorders.

Transgenerational Effects of Paternal in Utero Arsenic Exposure on MASLD-like Phenotypes.

Microplastics/Nanomaterials

Ferroptosis inhibition by ferrostatin-1 attenuates nanoplastic-induced angiogenesis impairment in zebrafish larvae and human microvascular endothelial cells.

Long-term polystyrene nanoplastic exposure induces membrane phospholipid remodeling in fish skin-derived epithelial cells.

Surface chemistry and size-related particle attributes shape lipidomic responses to polystyrene micro- and nanoplastics in zebrafish liver cells.

Polylactic acid nanoplastics induce kidney injury by activating the TRPM2-mediated mitophagy pathway.

Cellular uptake, Transport, and Inflammatory Responses of Polyethylene Terephthalate (PET) and Polyvinyl Chloride (PVC) Nanoplastics in In Vitro Caco-2 Monoculture/Mucus Model.

Cellular toxicity and apoptosis-related responses to individual and combined exposure to microplastics and perfluorooctane sulfonic acid (PFOS) in Hediste diversicolor coelomocytes.

Pharmaceuticals/Personal Care Products

Enhanced reproductive toxicity following combined exposure to ethinylestradiol and levonorgestrel: evidence of non-additive endocrine disruption in male rats.

Widespread endocrine-disrupting pollutant alters male courtship behavior in a livebearing fish.

Tire Wear Chemicals

Network toxicology, machine learning, single-cell analysis, and molecular docking reveal 6PPD/6PPD-Q-associated atrial fibrillation signatures.

6PPD-Q alters zebrafish neurobehavior by inducing neuroinflammation and inhibiting ERK1/2-CREB-BDNF pathway.

Exposure/Environment Studies

Phthalates

Occurrence, distribution and potential sources of phthalate and non-phthalate plasticizers in maternal and fetal-related biological matrices.

PFAS

Serum PFAS Concentrations Among US Veterans, NHANES 2003-2018.

Occurrence and Fate of PFAS During Conventional and Advanced Wastewater Treatment.

Thyroid hormones in coastal fish species: Associations with PFAS and multi-elemental burdens.

PFAS in the Urban Atmosphere Detected with I‑CIMS and LC-ESI Orbitrap Mass Spectrometer.

Pesticides

Agricultural plastic mulch increases pesticide persistence in soils.

Metals/Metalloids

Seasonal variations in groundwater arsenic occurrence, speciation, and human health risks under contrasting groundwater-level conditions in an arid irrigated aquifer.

Microplastics/Nanomaterials

Intravenous Fluids as a Route of Microplastic and Plasticizer Exposure in U.S. Patients: A Preliminary Assessment.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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