A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Events, Regulations/ Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies
Highlights:
- Prioritizing and Grouping Food Contact Chemicals: From Chaos to Clarity.
- Matrix-Resolved Profiling of the Prenatal Chemical Exposome Reveals Selective Placental Retention and Fetal Transfer.
- Prenatal exposure to PFAS and multimodal structural brain development across childhood.
- Grounding pesticide use intensity and hazards with real-world data: Toward correcting global models in tropical agriculture
Events
Nov. 4-5 meeting: Scientific Advisory Committee on Alternative Toxicological Methods [National Toxicology Program]
Nov. 5 in-person Boston event: Plastic-Free Future: Protecting People and the Planet [Just Zero & Plastic Free Mass]
Nov. 7, 10, or 12: Grassroots advocacy trainings [Beyond Plastics]
Nov. 17 webinar: Reducing EDC Exposures: From informed consumers to policy solutions [EDC Strategies Partnership]
Nov. 17 webinar: Keeping Fracking Out and Reining Fracking In: Protecting Public Health with New Research Data [Catskill Mountainkeeper and NY PSR]
Nov. 17: Health and Chemicals Forum [Food Packaging Forum and NYU Grossman School of Medicine] in conjunction with:
Nov. 16-20 First International Conference: Global Framework on Chemicals [UNEP]
Nov. 17-18: UCSF Industry Documents Library Workshop [UCSF]
Dec. 7-8 workshop: Plastics, Microplastics, and Plastic Chemicals: Emerging Impacts on Human Heart, Lung, Blood, and Sleep Health [NIEHS and NHLBI]
Dec. 15 due date for Call for Papers: Microplastics, Community Health, and Public Health Actions [American Journal of Public Health]
Jan. 25, 2027 due date for abstracts: The Microplastics and Nanoplastics Summit, May 9-12, 2027 in Lincoln, Nebraska
Mar. 31, 2027 due date for Call For Papers: The Chemical Safety Knowledge Landscape: Mapping What We Know and What We Need to Know [ACS Publications]
Regulations/Policy
More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.
Methods/Tools/Screening
Commentaries
Correspondence on “PFAS Toxicity: What’s True, What’s Not, and What Really Matters” and Rebuttal to Correspondence on “PFAS Toxicity: What’s True, What’s Not, and What Really Matters”.
Role of Therapeutic Plasma Exchange in Accelerating the Clearance of Perfluoroalkyl and Polyfluoroalkyl Substances
Reviews/Meta-Analyses
Numerous Chemicals/Mixtures
Gestational Exposure to Endocrine-Disrupting Chemicals and Small Vulnerable Newborns: A Systematic Review and Meta-Analysis Integrating High-Throughput Toxicity Testing with Mechanistic and Kinetic Modeling for Food Chemical Safety Assessment
Natural Products as Protective Modulators of Environmental Pollutant Toxicity Through the Gut-X Axis
Bisphenols/Phthalates
Comparative fish toxicology of perfluorohexanoic acid, hexafluoropropylene oxide dimer acid, and trifluoroacetic acid
Parabens/Triclosan/ Antimicrobials
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
PFAS
Microplastics/Nanomaterials
Microplastics as evolving particle-chemical-microbial interfaces: plastisphere ecology, ecotoxicity, and safety-informed remediation.
Pharmaceuticals/Personal Care Products
Miscellaneous
Human Health Studies
Numerous Chemicals/Mixtures
Bisphenols/Phthalates PFAS in Follicular Fluid, Anti-Müllerian Hormone, and Oocyte Developmental Competence: A Prospective Study in GIVES Seminal Plasma Metabolomics Reveals Potential Metabolic Pathways Linking Organophosphate Flame Retardant Exposure to Impaired Semen Quality
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
PFAS
Flame Retardants
Sex-Specific Associations of Gestational OPE Exposure with Offspring Digit Ratio: A Birth Cohort Study
Pesticides
Metals/Metalloids
Microplastics/Nanomaterials
Air Pollution
Laboratory Studies
Numerous Chemicals/Mixtures
β-Hydroxybutyrate Attenuates Bisphenol-A-Induced Cellular Responses in Ovarian Cancer Cells.
Toward NGRA for safer phthalate substitution: An AOP-informed IATA case study integrating AI-based predictions and in vitro NAM evidence for DART prioritization Early-Life Exposure to DBP and DEHP Induces Ultrastructural Testicular Damage and Semen Quality Deterioration Through Modulation of Inhibin-α, Calretinin, and PPAR-γ Expression
Phthalates/DINCH
Exploring the Mechanism of DEHP Promoting Hepatic Fibrosis Based on Network Toxicology by Triggering Lipophagy-Dependent Hepatic Stellate Cell Activation.
Potential Ecological Risks of the Novel Alternative Plasticizer Di(isononyl)cyclohexane-1,2- Dicarboxylate via Metabolic Toxification in Earthworms 6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate Exposure Disrupts the Gut-Liver Axis and Induces Inflammatory-Dominant Hepatotoxicity via Bile Acid-Farnesoid X Receptor Signaling Exposure Routes Shape Per- and Polyfluoroalkyl Substances’ Toxicokinetics and Sex-Specific Bioaccumulation in Thai Tiger Frogs (Hoplobatrachus rugulosus)
Parabens/Triclosan/ Antimicrobials
PFAS
Exposure duration shapes GenX-induced transcriptomics responses in 3D HepG2/C3A spheroids.
Prenatal PFOS impairs offspring cognition via HDAC and translational repression
PFOS and PFHxS Disrupt Forskolin-Induced Syncytialization but Differentially Affect hCGβ Production in BeWo Cells.
The effects of pinealectomy and melatonin on bisphenol a diglycidyl ether (BADGE)-induced hepatotoxicity in rats: involvement of apoptotic, inflammatory, and oxidative mechanisms Environmentally Persistent Pesticides: In Vitro Effects on Human Aromatase Activity and ERα Signaling
Flame Retardants
Organotins
Pesticides
Impact of S-metolachlor, atrazine and their metabolites on the morphological, structural and functional properties of the intestinal barrier.
Arsenic induces hepatic lipid accumulation associated with DNA methylation alterations and oxidative stress in marine medaka (Oryzias melastigma).
Metals/Metalloids
Microplastics/Nanomaterials
The combined toxicity of polystyrene microplastics and glyphosate on Daphnia magna: Physiological and behavioral responses.
Imaging the Adverse Effects of Tire-Derived Contaminants via Coelenterazine-Facilitated Albumin Luminescence In Vivo High-Throughput Identification of PPARγ-Active Chemicals in Riverine Drinking Water Sources: Discover a Novel DEHP Biodegradation Product If you enjoy this newsletter, please feel free to donate here! Thank you!
Tire Wear Chemicals
Chronic exposure to the tire-wear contaminant 6-PPDQ induces senescence-associated biomarkers and neurobehavioral deficits: Involvement of ABL1-p53-autophagy signaling Gut microbiota-associated metabolic alterations contribute to 6PPD-Q-induced intestinal barrier dysfunction in mice
6PPD-Quinone Induces Anxiety-like Behavior in Mice: A Potential Mechanism Shared Across PPD-Quinones.
Perturbation of the Reproductive Endocrine System by Halogenated Nitrophenols via Thyroid Receptor Signaling: Implications for Developmental, Fertility, and Intergenerational Risks in Japanese Medaka
Miscellaneous
Exposure/Environment Studies
Numerous Chemicals/Mixtures
Hepatic expression of oestrogenic response genes in wild male gray snapper (Lutjanus griseus): A biomarker approach for endocrine disruption in the coast of Campeche, Mexico.
Firefighter Turnout Gear and Peri-Governmental Influences
PFAS
Perfluoroalkyl Substances in Breast Milk of Taiwanese Mothers: Postpartum Trends and Determinants of Variation.
Grounding pesticide use intensity and hazards with real-world data: Toward correcting global models in tropical agriculture
Structure-Based Prediction and Ranking of PFAS Groundwater Mobility for EU Drinking Water Regulation
Flame Retardants
Pesticides
Microplastics/Nanomaterials
Pharmaceuticals/Personal Care Products
From EFSA:
Miscellaneous
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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@ googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.
