EDC Science Weekly, Oct. 2-8, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Pediatric effects of forever chemicals may last for a long time.
Simultaneous semen and urine biomonitoring of neonicotinoids and associations with semen quality in men
Enhancing infant feeding pathways in a tertiary children’s hospital: a sustainability-focused quality improvement project.
Intra-individual variability of urinary non-persistent chemical concentrations during pregnancy in the ECHO Cohort.

Science summaries and highlights

Events

Happy Children’s Environmental Health Day!

Oct. 13 workshop: What can nurses do about toxic chemicals? Toxics 101, Communicating Effectively About the Science and Health Effects & Opportunities for Action [Alliance of Nurses for Healthy Environments (ANHE)]

Oct. 13 Grand Rounds: Growing Up in a Chemical World: Emerging Contaminants and Children’s Health [New England PEHSU and Boston Children’s Hospital]

Oct. 13 webinar: Integrating children’s environmental health competencies into public heath education and practice [National Environmental Health Association]

Oct. 14 webinar: Unwrapped: How to get plastic off our food [Plastic Pollution Coalition]

Oct. 14 webinar: Reducing children’s environmental health risks in schools [EPA]

Oct. 16 webinar: How much are people willing to pay to avoid chemicals-related health effects? [OCED]

Oct. 20 webinar: Using ‘systems thinking’ to support uptake of new approach methodologies in regulatory decision-making [ECHA]

Oct. 22 webinar: Science for Public Health Policy: Understanding correlation and causation [EDC Strategies Partnership]

Oct. 27 webinar: The ovarian cost of convenience: Phthalate exposure and ovarian function [Merlon]

Nov. 4-5 meeting: Scientific Advisory Committee on Alternative Toxicological Methods Meeting [National Toxicology Program]

Nov. 17 webinar: Reducing EDC Exposures: From informed consumers to policy solutions [EDC Strategies Partnership]

Nov. 17 forum: Health and Chemicals [Food Packaging Forum and NYU Grossman School of Medicine] in conjunction with:

Nov. 16-20 First International Conference: Global Framework on Chemicals [UNEP]

Dec. 15 due date for Call for Papers: Microplastics, Community Health, and Public Health Actions [American Journal of Public Health] and related informational webinar on Oct. 15 at 4:15pm ET.

Mar. 31 due date for Call For Papers: The Chemical Safety Knowledge Landscape: Mapping What We Know and What We Need to Know [ACS Publications]

Regulations/Policy

Guiding Risk Reduction for Breast Cancer-Relevant Chemicals (BC-Chems): Chemical Production Volumes, Sources, Intake Levels, Emissions, and Regulations

Global plastics treaty negotiations and health-care system use of plastics, WHO African Region.

European joint programme HBM4EU – Bridging science and policy: experiences and lessons learned from the key partners in the scientific steering of the initiative.

ECHA writes back: The reasons for rejection of read-across in compliance check decisions by the European Chemicals Agency.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

Mapping ToxCast/Tox21 Assay Endpoints to Key Characteristics of Carcinogens to Support Cancer Hazard Evaluation

Linking nuclear receptor antagonism with neuronal morphology improves detection of developmental neurotoxicants.

Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report.

A high-throughput method to computationally develop candidate adverse outcome pathways in humans: a proof of concept with insecticides and Parkinson’s Disease.

Advancing component-based mixture risk assessment using new approach methodologies: An environmental case study.

Extrapolation steps in quantitative in vitro to in vivo extrapolation to advance in vitro-based chemical risk assessment for human health.

Development of an in vitro chemical hazard screening method using human iPSCs with and without metabolic activation and application to chlorinated paraffins.

PlastiWatch as a Standardized Multi-Parameter Framework for Microplastic Hazard Screening.

Commentaries

Editorial: Climate change, air pollution, and health inequality: vulnerability of marginalized populations.

The Plasticene Paradigm: Microplastics, Gut Dysbiosis, and Food Allergy – A Critical Commentary.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Cytokine and chemokine dysregulation by Endocrine Disrupting Chemicals (EDCs).

Replacement bisphenols, phthalates, and micro-/nanoplastic exposures in human reproductive endocrinology.

Establishing environmental causes of childhood cancer: a view from the IARC Monographs.

Parabens

Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality.

PFAS

Pediatric effects of forever chemicals may last for a long time.

Pesticides

Effects of Glyphosate and Glyphosate-Based Herbicides on the Mammalian Gut Microbiome: A Critical Review.

Neurotoxicity and neurodegenerative disorders caused by pyrethroids: Adverse events, mechanisms of action and therapeutic approaches.

Impact of Pesticides on Vertebrates.

Metals/Metalloids

Multi-metal co-exposure and type 2 diabetes: integrating biomonitoring evidence, inflammatory mechanisms, and a framework for future risk stratification.

Microplastics/Nanomaterials

Environmental impacts of polylactic acid microplastics on terrestrial and aquatic ecosystems: More threatening compared to traditional microplastics?

A critical review on synergistic toxicity: Plastics as “Trojan-Horses” for mercury biomagnification in polar avian predators.

Micro- and nanoplastic exposure and human health.

Microplastics and Nanoplastics as a Novel Cardiovascular Risk Factor: A Narrative Review.

Micro- and nanoplastics as emerging cardiovascular risk factors: a new atherogenic player?

The impact of microplastics on the human reproductive system: a narrative review.

Miscellaneous

Metal-organic frameworks for the treatment of endocrine-disrupting chemicals.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal exposure to nonpersistent endocrine disruptors and early childhood BMI: single pollutant and mixture analyses from the ECHO Program.

PFAS

Placental Transfer of PFAS and Their Sex-Specific Associations With Neonatal Thyroid Hormones in a Chinese Birth Cohort.

Prenatal exposure to Per- and polyfluoroalkyl substances and children’s digit ratios based on Shanghai Minhang Birth Cohort: The role of DNA methylation in the placenta.

Flame Retardants

Gestational exposure to organophosphate esters (OPEs) and adiposity during middle childhood in the MIREC Cohort.

Pesticides

Simultaneous semen and urine biomonitoring of neonicotinoids and associations with semen quality in men

Associations between Mixed Exposure to Neonicotinoids and Their Metabolites in Cerebrospinal Fluid and Biochemical Indicators Relevant to Potential Neurotoxicity.

Chronic lymphocytic leukemia associated with genetic susceptibility and occupational glyphosate exposure: a case report.

Integrated Analysis of Buccal-Cell microRNAs Reveals Molecular Signatures Associated With Chronic Pesticide Exposure in Agricultural Workers.

Metals/Metalloids

Occupational cadmium exposure and endocrine biomarker alterations in male workers: a cross-sectional study.

Association of Mixed Metal Exposures with Cardiovascular Disease: Insights from a Population-Based Study.

Arsenic induced Hippo pathway dysregulation linked to hTERT hypo-methylation in breast cancer patients.

A Tale of Three Siblings: A Cluster of Toxic Neuropathy From a Less Suspected Source. [arsenic]

Air Pollution

Role of Neighborhood Vulnerability and Opportunity in the Association Between Prenatal Air Pollution and Autism-Related Traits in the ECHO Cohort.

Laboratory Studies

Numerous Chemicals/Mixtures

Migration of phthalates and per- and polyfluoroalkyl substances from paper and plastic drinking straws immersed in human saliva: a pilot migration study.

Bisphenols

Bisphenol A Exposure Perturbs the Immune Microenvironment in Alzheimer’s Disease: Insights from Network Toxicology and Single-Cell Transcriptomics.

Network toxicology, molecular docking and molecular dynamics simulations for bisphenol A neurotoxicity in depression pathogenesis.

Developmental bisphenol A exposure alters adipose metabolism and lipid remodeling in female mouse offspring.

Phthalates

Inhalation exposure and uptake modeling of particle-associated phthalate: from respiratory deposition and clearance to organ toxicokinetics.

Prenatal exposure to di-n-butyl phthalate induces testicular atrophy in offspring mice via the PHF10/ROS/apoptosis axis.

Species-Specific molecular mechanisms of DEHP toxicity in earthworms revealed by integrated transcriptomics and metabolomics.

Cyclooxygenase-2-driven oxylipin storm: A mechanistic link between prenatal DINP exposure and gestational chronic inflammation.

Gut-Liver Axis and Multi-Omics Analysis Reveal the Protective Effect and Mechanism of Luteolin against Dibutyl Phthalate Induced liver injury.

Single-cell study of human ovarian response to phthalate exposure reveals glial cell susceptibility and disruption of adhesion and mitochondrial pathways.

Diethyl phthalate exposure promotes colon cancer progression through ALDOC mediated proliferation, epithelial-mesenchymal transition, and ferroptosis resistance.

Parabens/Triclosan/Antimicrobials

Triclosan-induced trophoblast dysfunction is associated with activation of the circKAT6B/miR-204-5p/TCF12-PCDH9 axis during early pregnancy.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Evaluation of Hepatotoxic and Nephrotoxic Effects of Hexachlorobenzene, DDT, and p,p’-DDE in Rats.

PFAS

Perfluorooctanoic acid exposure inhibits round spermatid elongation by impeding ubiquitin-proteasome-mediated chromatin remodeling in mice.

Assessment of Acute Functional Effects of Perfluorooctanoic Acid (PFOA), Heptafluorobutyric Acid (HFBA), and Hexafluoropropylene Oxide Dimer Acid (HFPO-DA) in Human iPSC-Derived Cardiomyocytes Using Multielectrode Arrays.

Predicting Hormesis Effects of GenX in Zebrafish via Interpretable Machine Learning: Insights From SHAP Analysis.

Development of Sex-Specific Physiologically Based Toxicokinetic (PBTK) Models for GenX in Mice and Their Application to Human Health Risk Assessment.

Exposure to PFOS and PFOA through drinking water is associated with greater cigarette smoke-induced COPD-like lung injury and enhanced NF-κB-related inflammatory signaling in mice.

Splenic Toxicity and Gene Expression Alterations Induced by Perfluorobutanesulfonic Acid (PFBS) Ingestion in Sprague Dawley Rats.

Single-nucleus transcriptomics reveals chronic GenX exposure-induced neurotoxicity and predicted alterations in microglia-neuron communication networks in mouse brain.

Flame Retardants

TBBPA facilitates splenic inflammation and pyroptosis by targeting HMGB1.

Pesticides

Developmental and behavioral disruption in zebrafish larvae by mixtures of anatoxin-a and neonicotinoids.

Thiamethoxam Exposure Impairs Neuromuscular Function through Thyroid Hormone-Linked Mitochondrial Dysfunction in Pelophylax nigromaculatus.

Lambda-Cyhalothrin Impairs Learning and Memory in Zebrafish by Disrupting Brain Energy Metabolism Coupled to Neurotransmitter Homeostasis via α-Ketoglutarate Depletion.

Ameliorating effect of α-glycosyl isoquercitrin treatment from gestation on disruption of hippocampal neurogenesis induced by maternal exposure to imidacloprid in rats.

Dietary Cinnamaldehyde Alleviates Chlorpyrifos-Induced Immunotoxicity in Nile Tilapia and Modulates Apoptosis-, Autophagy-, and AKT/mTOR-Related Gene Expression.

Metals/Metalloids

Diabetogenic effects of arsenic exposure in C57BL/6 N mice carrying the human AS3MT gene: the role of sex and exposure window.

Single-cell transcriptomic analysis reveals endothelial mitochondrial dysfunction and synaptic impairment underlying arsenic-induced hippocampal neurotoxicity in mice.

Microplastics/Nanomaterials

Polystyrene Nanoplastics Induce Penile Endothelial Injury via CLDN1 Downregulation: A Novel Mechanism of Nanoplastic Toxicity.

From plastic to pathophysiology: polyethylene (PE) and polyvinyl chloride (PVC) microplastics disrupt fish blood, metabolism, and growth.

Transgenerational and endocrine-disrupting effects of polylactic acid MPs and bisphenol TMC in zebrafish: A sex-specific study.

Co-exposure to polystyrene nanoplastics and di(2-ethylhexyl) phthalate: Effects and mechanistic insights into hepatic lipid metabolism in mice.

Maternal Gestational and Lactational Exposure to Polystyrene Nanoplastics Triggers Vascular Injury and Lipid Deposition in Mouse Offspring.

Microplastic exposure is associated with enhanced PI3K-Akt signaling in DSS-induced colitis: integrated bioinformatics analyses and in vivo validation.

Aged polystyrene nanoplastics induce cardiac developmental toxicity associated with mitochondrial dysfunction in zebrafish larvae.

The impacts of polystyrene nanoplastics on colorectal cancer: Evidence from integrated network toxicity and in vitro approaches.

Bidirectional interplay in the digestive microenvironment: Nanoplastics-mediated enzyme impairment modulates bisphenol analogs desorption.

Deciphering the role of microplastics-related molecular signatures in cervical cancer progression: Transcriptomic analysis and diagnostic model development.

Pharmaceuticals/Personal Care Products

A Health-Protective Screening Threshold for Personal Care Products: Metabolomic and Endocrine Mechanisms of Adolescent Reproductive Toxicity in Zebrafish.

Tire Wear Chemicals

Bioaccumulation, biotransformation and hormesis effects of 6PPD-Q in Eisenia fetida: Impacts on metabolism and gut microbiota.

Impairment of pentose phosphate pathway mediates 6-PPD quinone-induced neurotoxicity by inhibiting NADPH-dependent antioxidant defense.

Comparative glycolipid metabolic toxicities and mechanisms of the rubber-derived contaminants 6PPD and its derivative 6PPD-Q in zebrafish.

Multi-omics analysis reveals oxidative stress-associated alterations in glycerophospholipid metabolism and inflammatory response in 6PPDQ-exposed macrophages.

Exploring the Potential Neurotoxic Links Between 6PPD/6PPD-Q and Parkinson’s Disease Through Network Toxicology and Multi-Dimensional Bioinformatics Analysis.

Miscellaneous

Integrated network toxicology, machine learning, and multi-omics characterization of 2,4-DTBP neurotoxicity.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Intra-individual variability of urinary non-persistent chemical concentrations during pregnancy in the ECHO Cohort.

Identification of occupations at high risk of exposure to environmental pollutants: A biomonitoring study using KoNEHS cycle 4 (2018-2020).

Unveiling typical emerging contaminants in wastewater from printed circuit board industries in South China.

A Multi-State Assessment of Per- and Polyfluoroalkyl Substances (PFAS), Pesticides, and Antibiotic Resistance Genes in White-Tailed Deer (Odocoileus virginianus) of the United States.

Bisphenols

Lactational PBPK modeling of bisphenol A and its analogues: ontogeny-informed estimation of internal exposure in breastfed Korean infants.

Aggregate risk assessment of bisphenols A, S, and F among the general Korean population.

PFAS

Association between seafood consumption and serum polyfluoroalkyl substance concentrations among Korean adolescents: the Korean National Environmental Health Survey (KoNEHS) cycle 5, 2021-2023.

Contamination profiles of legacy and emerging per- and polyfluoroalkyl substances in various vegetable oils collected in Chinese markets.

Emission Characteristics and Risk Assessment of Per- and Polyfluoroalkyl Substance (PFAS) Released from Water-repellent Consumer Spray Products.

Trifluoroacetic acid (TFA) in grain products from the US supermarkets.

Radical chemistry in atmospheric ice analogs forms persistent trifluoroacetic acid.

Pesticides

An Analytical Approach for Human Health Risk Assessment of Dietary Exposure to Pesticide Residues in Potatoes Among Adults and Children/Adolescents.

Metals/Metalloids

Variable Effectiveness of Raw Rice, Cooked Rice, and Water in Recapitulating Dietary Inorganic and Organic Arsenic Exposure in the Health Effects of Arsenic Longitudinal Study.

Microplastics/Nanomaterials

Enhancing infant feeding pathways in a tertiary children’s hospital: a sustainability-focused quality improvement project.

Microplastic and nanoplastic contamination in bottled water.

The hidden hazard in every sip: tackling microplastics in drinking water through detection and mitigation.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!