EDC Science Weekly, Nov. 6-12, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

PFAS and Breast Cancer Incidence in the Sister Study and related editorial, PFAS and Estrogen Receptor‑Negative Breast Cancer.
Follicular-fluid neonicotinoid exposure and endometriosis.

Events

Nov. 17 webinar: Reducing EDC Exposures: From informed consumers to policy solutions [EDC Strategies Partnership]

Nov. 17 webinar: Keeping Fracking Out and Reining Fracking In: Protecting Public Health with New Research Data [Catskill Mountainkeeper and NY PSR]

Nov. 17: Health and Chemicals Forum [Food Packaging Forum and NYU Grossman School of Medicine] in conjunction with:

Nov. 16-20 First International Conference: Global Framework on Chemicals [UNEP]

Nov. 17-18: UCSF Industry Documents Library Workshop [UCSF]

Nov. 19 webinar: Systems Thinking and Collaboration for One Health: Bridging Chemicals, Environment and Health in Europe [ECHA]

Nov. 25 webinar: ChemScore 2026 [ChemSec]

Dec. 7-8 workshop: Plastics, Microplastics, and Plastic Chemicals: Emerging Impacts on Human Heart, Lung, Blood, and Sleep Health [NIEHS and NHLBI]

Dec. 15 due date for Call for Papers: Microplastics, Community Health, and Public Health Actions [American Journal of Public Health]

Jan. 25, 2027 due date for abstracts: The Microplastics and Nanoplastics Summit, May 9-12, 2027 in Lincoln, Nebraska

Jan. 26, 2027 due date for course Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO), May 23 – June 6 at Woods Hole.

Mar. 31, 2027 due date for Call For Papers: The Chemical Safety Knowledge Landscape: Mapping What We Know and What We Need to Know [ACS Publications]

Methods/Tools/Screening

An AOP-anchored framework integrating omics-derived potency and PBK simulations to support mechanistic chemical risk assessment.

Synergizing New Approach Methodologies and Artificial Intelligence: Charting the Paradigm Shift Toward Next-Generation Chemical Risk Assessment.

Patient-derived 3d cell models as new approach methodologies: Applications, advances, and challenges for increased-throughput assays.

Cardiovascular Disease Risk Screening for Endocrine-Disrupting Chemicals Based on Machine Learning.

Feminizing effects of environmental estrogens on amphibians and the corresponding assays: A narrative review.

Commentaries

A Trojan horse: micro- and nano-plastics with a bio-corona

Microplastics and dialysis: a new challenge for green nephrology.

Reviews/Meta-Analyses

Bisphenols/Phthalates

Docosahexaenoic Acid and the Gut-Ovarian Axis: A Potential Protective Role Against Environmental Endocrine-Disrupting Chemical-Induced Female Reproductive Toxicity.

Mixture of Plasticizer Chemicals and Child Intelligence: A Weight-of-Evidence and Meta-Analysis-Informed Bayesian Approach in a Cohort with Improved Exposure Assessment.

Phthalates exposure and gastrointestinal health: a comprehensive review of toxic mechanisms and emerging mitigation strategies.

Prenatal exposure to phthalate metabolites and gestational weight gain: A systematic review.

PFAS

PFAS-induced blood-brain barrier dysfunction: A neurovascular perspective.

Per- and polyfluoroalkyl substances (PFAS) release and pollution characteristics: A critical review from a life-cycle perspective.

Flame Retardants

Developmental, Neurobehavioral, and Oxidative Effects of Organophosphate Flame Retardants in Fish: A Dependence-Aware Meta-Analysis and Dose-Response Assessment.

Metals/Metalloids

Association of heavy metal with sperm parameters and sex hormones: A systematic review and meta-analysis of observational studies.

NRF2 signalling in environmental metal and metalloid neurotoxicity: distinguishing stress responses from functional neuroprotection.

Microplastics/Nanomaterials

Unraveling the Multi-Level Toxicity Cascade: Oxidative Stress, Endocrine Disruption, and Epigenetic Inheritance in Micro- and Nanoplastic-Induced Testicular Injury.

Microplastics and colorectal cancer: presence in human colorectal tissues and associations with tumor biology.

Microplastics and kidney health: From environmental exposure to renal toxicity.

Impact of phthalate and microplastic exposure on childhood allergic diseases: A review of epidemiological evidence and mechanisms.

When co-occurrence becomes risk: a SOURCE-FATE-DOSE-EFFECT-DECISION framework for microplastic-PFAS interactions, food-chain transfer, and dietary safety.

Miscellaneous

The 2026 report of the Lancet Countdown on health and climate change: a decade of escalating health harms and a decisive moment for all and related editorial, Climate change and health: 10 years on, what next?

Removal of endocrine disruptors from tap water: a systematic review.

6PPD-Q: A comprehensive critical review on environmental occurrence, toxicological mechanisms, risk assessment, and mitigating strategies.

Human Health Studies

Numerous Chemicals/Mixtures

Exposure to environmental phenols and growth indicators in adolescents: Epidemiological analysis and mechanistic exploration.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Internal exposure to persistent organic pollutants mixtures and long-term changes in adiposity in women.

PFAS

Per- and Polyfluoroalkyl Substance Exposure and Breast Cancer Incidence in the Sister Study and related editorial, Perfluoroalkyl Substances and Estrogen Receptor‑Negative Breast Cancer: Looking Beyond Traditional Risk Factors.

Per- and poly-fluoroalkyl substances and time-to-pregnancy in two preconception cohort studies.

Prenatal per- and polyfluoroalkyl substances exposure and hypertensive disorders of pregnancy: fetal sex-specific associations.

In utero PFAS exposure measured in the umbilical cord blood and child neurodevelopmental outcomes at 24 months: a prospective birth cohort study.

Hospitalizations due to infections in children after high prenatal exposure to perfluoroalkyl substances from contaminated drinking water in Ronneby, Sweden.

Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Metabolic Signatures, and Intellectual Development in Preschoolers: A Birth Cohort Study.

Per- and polyfluoroalkyl substances exposure is associated with sleep problems in children: Multi-omics evidence.

Associations of per- and polyfluoroalkyl substances (PFAS) with muscle mass and function in women in midlife.

Serum Perfluorooctanoic Acid and Elevated Atherosclerosis Index: NHANES Associations and Exploratory Ceramide-Related Analyses.

Exposure to emerging and legacy PFAS and risks of metabolic dysfunction-associated steatotic liver disease and liver fibrosis in adults living near a semiconductor science park.

Flame Retardants

Association of exposure to the organophosphate flame retardant EHDPP with early pregnancy loss: An integrated case-control, population-based, and computational study.

Cord-serum Organophosphate Flame Retardants and Childhood Allergic Rhinitis: Multi-omics Insights.

Pesticides

Follicular-fluid neonicotinoid exposure and endometriosis: associations with reproductive outcomes and metabolic remodeling.

Cord Serum Neonicotinoid-Related Biomarkers and Neurodevelopment From Early to Middle Childhood.

Metals/Metalloids

Prenatal Fluoride Exposure in Relation to Cognitive and Motor Outcomes in Preschool-Aged Children: The New Hampshire Birth Cohort Study.

Arsenic exposure in association with reproductive hormones, kisspeptin, and age at menarche in European teenagers.

Associations of lifestyle, nutrition, and mixed environmental exposures with bone mineral density in U.S. children and adolescents: A dual-cohort analysis from NHANES 2017-2018.

Microplastics/Nanomaterials

Microplastics in Urinary Calculi: Evidence From Human Urinary Stones.

Air Pollution

Associations of long-term exposure to air pollution with glucose homeostasis biomarkers and diabetes-related comorbidities in people with recent-onset type 1 and type 2 diabetes.

Laboratory Studies

Numerous Chemicals/Mixtures

Exploring the Influence of Chemical Exposures on Breast Cancer Disparities: High-Throughput Transcriptomic Analysis of Normal Breast Cells from Diverse Donors.

Co-exposure to bisphenols promotes the uptake of nanoplastics by colon cancer cells: mechanisms and implications.

Exploring the mechanism of phthalate esters and polycyclic aromatic hydrocarbons on gestational metabolic disorders based on network toxicology and molecular docking.

Bisphenols

Postnatal maternal care normalizes the medial preoptic area DNA methylome following prenatal bisphenol exposure.

Bisphenol A Aggravates Allergic Rhinitis by Impairing Nasal Epithelial Barrier via AKR1B1 Downregulation: Insights from In Silico and Experimental Evidence.

BPA exposure from gestation through the post-weaning period increases susceptibility to allergic airway inflammation in female mouse offspring: Association with reduced mTOR phosphorylation, enhanced autophagy, and Foxp3 promoter methylation.

Exosomes improved oxidative stress and apoptosis in BPA-induced nephrotoxicity in kidney cells through modulation of Nrf2/Keap1 signaling pathway.

LHCGR disruption and downregulation by bisphenol PH impairs ovarian function and establishes a prioritization framework for endocrine disruptors.

Exploring the Potential Mechanisms Linking Bisphenol A Exposure to Atrial Fibrillation: An Integrated Multi-Dimensional Analysis from Network Toxicology to In Vivo Validation.

Phthalates

Molecular mechanisms of diethyl phthalate enhanced invasion in gastric cancer revealed by integrative network toxicology machine learning and in vitro analyses.

Systematic toxicology reveals dioctyl terephthalate as a hazardous agent on autism spectrum disorder-like behaviors: Evidence from network toxicology and zebrafish models.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Multi-omics indicating the risk of organochlorines to liver cancer.

Short-term exposure to 2,3,6,7-tetrachlorocarbazole induces early serum metabolic disturbance and hepatic lipid remodeling in mice.

PFAS

PFBS exposure alters gut microbial functional potential and colon immune responses: an integrated metagenomic and transcriptomic analysis.

Perfluorononanoic acid impairs intestinal barrier integrity and induces gut microbiome dysbiosis in zebrafish.

PFOA induces ferroptosis in nucleus pulposus cells by driving a sialylation cascade via the ST6GAL1-ASPH-SRC axis.

Parental transmission toxicity of perfluorohexane sulfonates: Compromised reproductive fitness and offspring developmental defects in zebrafish.

Multi-omics integration reveals a gut microbiota-metabolite-immune axis in PFOA-induced intestinal toxicity.

Analyzing per- and polyfluoroalkyl substances (PFAS) in triple-negative breast cancer (TNBC): an integrative transcriptomic and computational study.

Pesticides

Pesticide β-cypermethrin exposure compromises endometrial receptivity during the window of implantation through ERK-MAPK signaling-driven dysregulation of cell-cycle-associated proteins in early-pregnant mice.

Integrated multi-omics identifies PTGDS-enriched mature oligodendrocyte state remodeling in paraquat-associated Parkinson’s disease.

Microplastics/Nanomaterials

Polystyrene microplastic and bisphenol A Co-exposure drives oxidative collapse, neuroendocrine disruption, apoptotic activation, and hepatopancreatic pathology in Pontogammarus maeoticus.

Polystyrene nanoplastics exposure impairs human trophoblast cell functions and induces miscarriage via activating circRHOBTB3/miR-135a/EGR1 axis.

Polylactic acid – and polybutylene adipate terephthalate-microplastics induced differential effects in Daphnia magna.

Comprehensive Organ-specific Assessment of Biomarkers, Histopathological Alterations, Bioaccumulation and Genotoxicity Responses of Mozambique tilapia (Oreochromis mossambicus) exposed to Polyvinyl chloride Microplastics.

Polystyrene nanoplastic exposure exacerbates epileptic vulnerability in SCN1A mutation models.

Sage (Salvia officinalis) attenuates zinc oxide nanoparticle-induced endocrine disruption in male rats.

Immunotoxicity and hepatic transcriptomic responses in zebrafish co-exposed to LDPE microplastics and zinc sulfate.

Acute and long-term effects of titanium-doped polyethylene terephthalate nanoplastics in human bronchial epithelial cells.

Particle type- and morphology-associated neurotoxicity of microplastics and nanoplastics via divergent PPARγ modulation in zebrafish.

Air Pollution

Wildfire-Emitted Particulate Matter Induces Ovarian Hyperandrogenism through Aryl Hydrocarbon Receptor Activation.

Tire Wear Chemicals

The Microbiota-Short-Chain Fatty Acid Axis Mediates 6PPD-Q-Induced Intestinal Damage in Zebrafish at Environmentally Relevant Concentrations.

Miscellaneous

Maternal Exposure to Quaternary Ammonium Disinfectants: Transplacental Transfer and Adverse Effects on Placental Function.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Public Risk Judgments of Endocrine‐Disrupting Chemicals: Psychometric Structure, Exposure Pathways, and Cross‐National Differences

Bisphenols

Occurrence of Bisphenols A and S in Paired Human Skin and Adipose Tissue in Neonatal Males.

Phthalates

Exploring Environmental Influences on Mono(2-Ethylhexyl) Phthalate (MEHP) Exposure in Common Bottlenose Dolphins (Tursiops truncatus) in Sarasota Bay, FL, USA.

PFAS

Evaluating spatiotemporal variation in PFAS contamination and gene expression in oysters in a large wind-driven estuary.

Effectiveness of PFAS remediation strategies on AFFF impacted soils under different climates and soil characteristics.

Uncovering PFAS emissions in wastewater treatment plants through comprehensive assessment of targets, precursors, and unexplained organofluorine.

Pesticides

Dietary exposure to neonicotinoids of the Hong Kong population through a total diet study.

Urban-Rural Contrasts in Parent Neonicotinoid Insecticides and Their Transformation Products: Evidence from A River Jointly Affected by Urban and Agricultural Inputs.

Microplastics/Nanomaterials

Even giant anteaters in remote Brazil have microplastics in their blood.

Air Pollution

Race disparities in total PM_2.5 and wildfire-specific PM_2.5 exposure among disaggregated Asian American, Native Hawaiian, and Pacific Islander groups in California.

Miscellaneous

Estimation of Excess Inhalation Non-Cancer and Cancer Risk From Volatile Organic Compound Mixtures in New York City Nail Salons.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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