EDC Science Weekly, Nov. 4 – 10, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Second Annual Forum on Endocrine Disruptors Nov 19-20
Sponsored by the European Commission

Online symposium: Endocrine Disruptors – Reduce the impact on our health Nov 19
Sponsored by HEAL and Belgian Independent Health Insurance Funds

Webinars:

Racial/ethnic Differences in EDC ExposuresNov 12

Environmental reproductive justice: Racial disparities in environmental pollution and chemical exposuresNov 18

Promoting a Culture of Health through Racial Healing and Transformation Nov 19

Superfund Research Program Progress in Research Webinar Part 4: Emerging Exposures Nov 19

Are fluoropolymers really of low concern for human and environmental health and separate from other PFAS? Dec 3

Regulations/Policy

Deregulatory science: Chemical risk analysis in Trump’s EPA.

Regulation of Persistent Chemicals in Hazardous Waste: A Case Study of Washington State (USA).

PM₁₀-bound arsenic emissions from the artistic glass industry in Murano (Venice, Italy) before and after the enforcement of REACH authorisation.

Methods/Tools/Screening

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology.

Application of In Vitro Metabolism Activation in High-Throughput Screening.

Are we forgetting the “proteomics” in multi-omics ecotoxicology?

In silico health effect prioritization of environmental chemicals through transcriptomics data exploration from a chemo-centric view.

Application of an analytical framework for multivariate mediation analysis of environmental data.

Computational identification of preservatives with potential neuronal cytotoxicity.

An improved overall risk probability-based method for assessing the combined health risks of chemical mixtures: an example about mixture of aflatoxin B₁ and microcystin LR by dietary intake.

A consensus approach for estimating health risk: application to inhalation cancer risks.

Opportunities to Understand, Control, and Prevent Exposure to Per- and Polyfluoroalkyl Substances (PFAS): A Guide from the Environmental Health Matters Initiative [via the National Academies]

Commentaries/Conference Summaries

Environmental Issues and Neurological Manifestations Associated with COVID-19 Pandemic: New Aspects of the Disease? [editorial]

Reduction of environmental pollutants for prevention of cardiovascular disease: it’s time to act.

The Helsinki Declaration 2020: Europe that protects.

Reducing the risk of environmental pollutants for preterm infants through blood transfusions. [letter]

In Memoriam: Daniel Wartenberg (1952-2020).

Pyrethroids: How They Affect Human and Animal Health? [editorial]

How air pollution may influence the course of pandemics. [editorial]

Editorial: Air Pollution and Brain Health.

Guidance to Reduce the Cardiovascular Burden of Ambient Air Pollutants: A Policy Statement From the American Heart Association.

Personal-Level Protective Actions Against Particulate Matter Air Pollution Exposure: A Scientific Statement From the American Heart Association.

Air pollution and health: recent advances in air pollution epidemiology to inform the European Green Deal: a joint workshop report of ERS, WHO, ISEE and HEI.

How to wear your baby to work. [by Genoa Warner, EDC researcher]

Reviews

Numerous EDCs

Drinking water pollutants may affect the immune system: concerns regarding COVID-19 health effects.

Cross-species physiological interactions of endocrine disrupting chemicals with the circadian clock.

BPA

Bisphenol A and thyroid hormones: Bibliometric analysis of scientific publications.

The effect of environmental Bisphenol A exposure on breast cancer associated with obesity.

Phthalates

Phthalate Exposure, Adolescent Health, and the Need for Primary Prevention.

The impact of Di-(2-ethylhexyl) Phthalate and Mono(2-ethylhexyl) Phthalate in placental development, function, and pathophysiology.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants and couple fecundability: a systematic review.

Perfluoroalkyl Substances

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field.

A Review of the Applications, Environmental Release, and Remediation Technologies of Per- and Polyfluoroalkyl Substances.

Pesticides

Factors Associated with Honey Bee Colony Losses: A Mini-Review.

The association between diazinon exposure and dyslipidemia occurrence: a systematic and meta-analysis study.

What Socio-Economic and Political Factors Lead to Global Pesticide Dependence? A Critical Review from a Social Science Perspective.

Ecotoxicology of glyphosate and recent advances in its mitigation by adsorption.

Potentially Toxic Elements

Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs.

Review of Rare Earth Elements as Fertilizers and Feed Additives: A Knowledge Gap Analysis.

A review of metal-induced effects on vitamins A, E and D3 in birds.

The adverse impact of cadmium on immune function and lung host defense.

Microplastics/Nanomaterials

Efficiency of Wastewater Treatment Plants (WWTPs) for Microplastic Removal: A Systematic Review.

Microplastics and associated contaminants in the aquatic environment: A review on their ecotoxicological effects, trophic transfer, and potential impacts to human health.

Environmental source, fate, and toxicity of microplastics.

Hepatotoxicity induced by nanomaterials: mechanisms and in vitro models.

Air Pollution

The Relationship Between Air Pollution and Cognitive Functions in Children and Adolescents: A Systematic Review.

Adverse Birth Outcomes Related to NO₂ and PM Exposure: European Systematic Review and Meta-Analysis.

Effects of air pollution particles (ultrafine and fine particulate matter) on mitochondrial function and oxidative stress – Implications for cardiovascular and neurodegenerative diseases.

Working in Smoke:: Wildfire Impacts on the Health of Firefighters and Outdoor Workers and Mitigation Strategies.

Miscellaneous

The Challenge by Multiple Environmental and Biological Factors Induce Inflammation in Aging: Their Role in the Promotion of Chronic Disease.

Human Health Studies

Numerous Chemicals

Associations of urinary concentrations of phthalate metabolites, bisphenol A, and parabens with obesity and diabetes mellitus in a Korean adult population: Korean National Environmental Health Survey (KoNEHS) 2015-2017.

Associations among urinary triclosan and bisphenol A concentrations and serum sex steroid hormone measures in the Canadian and U.S. Populations.

Congenital heart diseases and parental occupational exposure in a Hungarian case-control study in 1997-2002.

BPA

Effects of bisphenol A on cardiovascular disease: An epidemiological study using National Health and Nutrition Examination Survey 2003-2016 and meta-analysis.

Concentrations of bisphenol A and its associations with urinary albumin creatinine ratios across the various stages of renal function.

Phthalates

Early Gestational Exposure to High-Molecular-Weight Phthalates and Its Association with 48-Month-Old Children’s Motor and Cognitive Scores.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effect of postprandial triglycerides on DDT/ppDDE levels in subjects with varying degree of glucose intolerance.

Age at menarche in Seveso daughters exposed in utero to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Perfluoroalkyl Substances

Severity of COVID-19 at elevated exposure to perfluorinated alkylates.

Prenatal exposure to perfluoroalkyl substances and cord plasma lipid concentrations.

Per- and polyfluoroalkyl substances in drinking water and birthweight in the US: A county-level study.

Associations between six common per- and polyfluoroalkyl substances and estrogens in neonates of China.

Pesticides

Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers.

Potentially Toxic Elements

Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles.

Relations of blood lead levels to echocardiographic left ventricular structure and function in preschool children.

Study of Occupational Chromium, Iron, and Nickel Exposure and Amyotrophic Lateral Sclerosis in Denmark.

Periconceptional and prenatal exposure to metal mixtures in relation to behavioral development at 3 years of age.

Environmental exposure to cadmium and risk of thyroid cancer from national industrial complex areas: A population-based cohort study.

Urinary Metals and Adipokines in Midlife Women: The Study of Women’s Health Across the Nation (SWAN).

Maternal and childhood exposure to inorganic arsenic and airway allergy – A 15-Year birth cohort follow-up study.

Effect of gene-environment interaction (arsenic exposure – PON1 Q192R polymorphism) on cardiovascular disease biomarkers in Mexican population.

Air Pollution

Childhood Leukemia in Small Geographical Areas and Proximity to Industrial Sources of Air Pollutants in Three Colombian Cities.

Prenatal Exposure to Specific PM_2.5 Chemical Constituents and Preterm Birth in China: A Nationwide Cohort Study.

Association between exposure to air pollution during intrauterine life and cephalic circumference of the newborn.

Prenatal exposure to particulate air pollution and gestational age at delivery in Massachusetts neonates 2001-2015: A perspective of causal modeling and health disparities.

Association of Ambient air Pollution with risk of preeclampsia during pregnancy: a retrospective cohort study.

Association of ambient particle pollution with gestational diabetes mellitus and fasting blood glucose levels in pregnant women from two Chinese birth cohorts.

Association of ambient PM_2·5 exposure with maternal bone strength in pregnant women from Mexico City: a longitudinal cohort study.

Household air pollution and under-five mortality in sub-Saharan Africa: an analysis of 14 demographic and health surveys.

Long-Term Particulate Matter Exposure and Incidence of Arrhythmias: A Cohort Study.

Air pollution and COVID-19 mortality in the United States: Strengths and limitations of an ecological regression analysis.

Air pollution as a contributor to the inflammatory activity of multiple sclerosis.

Climate and air pollution exposure are associated with thyroid function parameters: a retrospective cross-sectional study.

Blood plasma levels of biomarkers of liver status and lipid profile among nail technicians occupationally exposed to low-level mixture of volatile organic compounds.

Association of ambient air pollution with cardiovascular disease risks in people with type 2 diabetes: a Bayesian spatial survival analysis.

Associations of long-term exposure to ambient nitrogen dioxide with indicators of diabetes and dyslipidemia in China: A nationwide analysis.

The associations of air pollution and socioeconomic factors with esophageal cancer in China based on a spatiotemporal analysis.

Comparison of hospitalization and mortality associated with short-term exposure to ambient ozone and PM_2.5 in Canada.

Exposure to PM_2.5 constituents and risk of adult leukemia in Denmark: A population-based case-control study.

Long-term exposure to air pollution and mortality in the Danish population a nationwide study.

Meteorological Condition and Air Pollution Exposure Associated with Vitamin D Deficiency: A Cross-Sectional Population-Based Study in China.

PM_2.5 exposure and DLEC1 promoter methylation in Taiwan Biobank participants.

Long-Term Exposure to Air Pollutants and Cognitive Function in Taiwanese Community-Dwelling Older Adults: A Four-Year Cohort Study.

Population-weighted exposure to air pollution and COVID-19 incidence in Germany.

Pharmaceuticals/Personal Care Products

Diethylstilbestrol exposure during pregnancy with primary clear cell carcinoma of the cervix in an 8-year-old granddaughter: a multigenerational effect of endocrine disruptors?

Miscellaneous

Association of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012-2014).

Global H3K79 di-methylation mediates DNA damage response to PAH exposure in Chinese coke oven workers.

Environmental Risk Factors for Early-Onset Alzheimer’s Dementia and Frontotemporal Dementia: A Case-Control Study in Northern Italy.

Laboratory Studies

BPA/Phenols

Bisphenol S enhances gap junction intercellular communication in ovarian theca cells.

Phthalates

Exposure to dibutyl phthalate impairs lipid metabolism and causes inflammation via disturbing microbiota-related gut-liver axis.

Disturbance of di-(2-ethylhexyl) phthalate in hepatic lipid metabolism in rats fed with high fat diet.

Exposure to mono (2-ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through NLRP3 inflammasome.

Mono-2-ethylhexyl phthalate drives progression of PINK1-parkin-mediated mitophagy via increasing mitochondrial ROS to exacerbate cytotoxicity.

Parabens

Parabens enhance the calcium-dependent testicular mitochondrial permeability transition: Their relevance on the reproductive capacity in male animals.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Bone tissue morphology of rat offspring lactationally exposed to polychlorinated biphenyl 169 and 155.

Perfluoroalkyl Substances

Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblasts.

Multilayered glycoproteomic analysis reveals the hepatotoxic mechanism in perfluorooctane sulfonate (PFOS) exposure mice.

Comparison of zebrafish in vitro and in vivo developmental toxicity assessments of perfluoroalkyl acids (PFAAs).

Exposure to Perfluorooctanoic Acid Induces Cognitive Deficits via Altering Gut Microbiota Composition, Impairing Intestinal Barrier Integrity, and Causing Inflammation in Gut and Brain.

Formation of perfluorocarboxylic acids (PFCAs) during the exposure of earthworms to 6:2 fluorotelomer sulfonic acid (6:2 FTSA).

Flame Retardants

Decabromodiphenyl ethane disturbs hepatic glycolipid metabolism by regulating the PI3K/AKT/GLUT4 and mTOR/PPARγ/RXRα pathway in mice and L02 cells.

Aging Induces Profound Changes in sncRNA in Rat Sperm and These Changes Are Modified by Perinatal Exposure to Environmental Flame Retardant.

Organotins

Structural and functional analysis of the inhibition of equine glutathione transferase A3-3 by organotin endocrine disrupting pollutants.

Pesticides

Epigenome-wide association study for pesticide (Permethrin and DEET) induced DNA methylation epimutation biomarkers for specific transgenerational disease.

Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis.

Melatonin alleviates the deterioration of oocytes and hormonal disorders from mice subjected to glyphosate.

Aqueous chlorination of herbicide metribuzin: Identification and elucidation of “new” disinfection by-products, degradation pathway and toxicity evaluation.

Paraquat Treatment Compromises the Clearance of β-Amyloid and Tau Proteins and Induces Primary Hippocampal Neuronal Cell Death through HSP70, P20S, and TFEB Disruption.

Physiological Analysis and Transcriptome Analysis of Asian Honey Bee (Apis cerana cerana) in Response to Sublethal Neonicotinoid Imidacloprid.

Effects on Ultrastructure, Composition and Specific Surface Area of the Gills of Odontesthes bonariensis Under Subchronic Glyphosate-Based Herbicide Exposure.

Bioaccumulation of pesticide contaminants in tissue matrices of dogs suffering from malignant canine mammary tumors in Punjab, India.

Potentially Toxic Elements

Sex-dependent effects of preconception exposure to arsenite on gene transcription in parental germ cells and on transcriptomic profiles and diabetic phenotype of offspring.

Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish.

Inhibition of red blood cell development by arsenic-induced disruption of GATA-1.

Tissue and sex-specific programming of DNA methylation by perinatal lead exposure: implications for environmental epigenetics studies.

Gestational arsenic exposure and paternal intergenerational epigenetic inheritance.

Methylmercury chloride exposure aggravates proinflammatory mediators and Notch-1 signaling in CD14⁺ and CD40⁺ cells and is associated with imbalance of neuroimmune function in BTBR T⁺ Itpr3tf/J mice.

Identifying conserved polychaete molecular markers of metal exposure: Comparative analyses using the Alitta virens (Annelida, Lophotrochozoa) transcriptome.

Individual and mixture toxicity of chromium and copper in development, oxidative stress, lipid metabolism and apoptosis of Bufo gargarizans embryos.

LncRNA H19-mediated M2 polarization of macrophages promotes myofibroblast differentiation in pulmonary fibrosis induced by arsenic exposure.

Microplastics

Microplastics and their associated organic pollutants from the coastal waters of the central Adriatic Sea (Italy): Investigation of adipogenic effects in vitro.

Biomicroplastics versus conventional microplastics: An insight on the toxicity of these polymers in dragonfly larvae.

Effects of microplastic exposure on the blood biochemical parameters in the pond turtle (Emys orbicularis).

Polyethylene microbeads are more critically toxic to the eyes and reproduction than the kidneys or growth in medaka, Oryzias latipes.

Air Pollution

Notch1-mediated inflammation is associated with endothelial dysfunction in human brain microvascular endothelial cells upon particulate matter exposure.

Pre-pregnancy exposure to fine particulate matter (PM2.5) increases reactive oxygen species production in oocytes and decrease litter size and weight in mice.

Exposure to Traffic-Generated Pollutants Exacerbates the Expression of Factors Associated with the Pathophysiology of Alzheimer’s Disease in Aged C57BL/6 Wild-Type Mice.

Pharmaceuticals/Personal Care Products

Acute and chronic effects of environmental realistic concentrations of simvastatin in Danio rerio: evidences of oxidative alterations and endocrine disruptive activity.

Ibuprofen as an emerging pollutant on non-target aquatic invertebrates: effects on Chironomus riparius.

Pharmacology-informed prediction of the risk posed to fish by mixtures of non-steroidal anti-inflammatory drugs (NSAIDs) in the environment.

Prenatal testosterone exposure induces insulin resistance, uterine oxidative stress and pro-inflammatory status in rats.

Developmental programming: gestational testosterone excess disrupts LH secretion in the female sheep fetus.

Acute, reproductive, and developmental toxicity of essential oils assessed with alternative in vitro and in vivo systems.

Antibiotic drugs alter zebrafish behavior.

Metformin chlorination byproducts in drinking water exhibit marked toxicities of a potential health concern.

Mixtures

Evaluation of toxicity and estrogenicity in UASB – Treated municipal sewage.

Miscellaneous

Effects of 3,4-dichloroaniline (3,4-DCA) and 4,4′-methylenedianiline (4,4′-MDA) on sex hormone regulation and reproduction of adult zebrafish (Danio rerio).

Exposure/Environment Studies

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Trends of Diverse POPs in Air and Water Across the Western Atlantic Ocean: Strong Gradients in the Ocean but Not in the Air.

Effects on the Liver Transcriptome in Baltic Salmon: Contributions of Contamination with Organohalogen Compounds and Origin of Salmon.

Perfluoroalkyl Substances

Per- and Polyfluoroalkyl Substances in Dust Collected from Residential Homes and Fire Stations in North America.

Per- and Polyfluoroalkyl Substances in the Air Particles of Asia: Levels, Seasonality, and Size-Dependent Distribution.

Occurrence and Distribution of Per- and Polyfluoroalkyl Substances in Tianjin, China: The Contribution of Emerging and Unknown Analogues.

PFAS and Dissolved Organic Carbon Enrichment in Surface Water Foams on a Northern U.S. Freshwater Lake.

Managing Aqueous Film-Forming Foam (AFFF)-Derived PFAS at Department of Defense Sites.

Recent progress in the detection of emerging contaminants PFASs.

Flame Retardants

Exposure and health risk assessment of secondary contaminants closely related to brominated flame retardants (BFRs): Polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs) in human milk in shanghai.

Legacy and alternative flame retardants in typical freshwater cultured fish ponds of South China: Implications for evolving industry and pollution control.

Organotins

How protected are marine protected areas: A case study of tributyltin in Latin America.

Pesticides

Nationwide Biomonitoring of Neonicotinoid Insecticides in Breast Milk and Health Risk Assessment to Nursing Infants in the Chinese Population.

Organophosphate pesticide dose estimation from spot and 24-hr urine samples collected from children in an agricultural community.

Occurrence of pesticides in waters from the largest sugar cane plantation region in the world.

Peer review of the pesticide risk assessment of the active substance Bacillus thuringiensis ssp. aizawai strain ABTS-1857.

Potentially Toxic Elements

Mercury in Dental Amalgam, Online Retail, and the Minamata Convention on Mercury.

Sediment contaminant levels and multibiomarker approach to assess the health of catfish Sciades herzbergii in a harbor from the northern Brazilian Amazon.

Heavy metal pollution and ecological risk assessment in the Maowei sea mangrove, China.

Metal pollution as a potential threat to shell strength and survival in marine bivalves

Microplastics

Microplastics in corals: An emergent threat.

Coping with the “dirt”: brown shrimp and the microplastic threat.

Nylon 6 and nylon 6,6 micro- and nanoplastics: A first example of their accurate quantification, along with polyester (PET), in wastewater treatment plant sludges.

First detection of microplastics in the freshwater of an Antarctic Specially Protected Area.

Air Pollution

Environmental Awareness for Patients with COPD Undergoing Pulmonary Rehabilitation: Is It of Added Value?

Air pollution declines during COVID-19 lockdowns mitigate the global health burden.

Examining PM_2.5 concentrations and exposure using multiple models.

Dynamic model to predict the association between air quality, COVID-19 cases, and level of lockdown.

Pharmaceuticals/Personal Care Products

Occurrence of the main metabolites of the most recurrent pharmaceuticals and personal care products in Mediterranean soils.

Occurrence and fate of pharmaceuticals in a wastewater treatment plant from southeast of Spain and risk assessment.

Mixtures

A margin of safety approach for the assessment of environmentally realistic chemical mixtures in the marine environment based on combined passive sampling and ecotoxicity testing.

Miscellaneous

Heavy is the Head That Wears the Crown: Black Men’s Perspective on Harmful Effects of Black Women’s Hair Product Use and Breast Cancer Risk.

Long-term spatial and temporal trends, and source apportionment of polycyclic aromatic compounds in the Athabasca Oil Sands Region.

Identification of more than 100 new compounds in the wastewater: Fate of polyethylene/polypropylene oxide copolymers and their metabolites in the aquatic environment.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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