EDC Science Weekly, Nov. 3-9, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Steam disinfection of baby items enhances nanoparticle release; PFAS in Chinese grains/cereals; Mixtures of chemicals linked to children’s IQ, IVF outcomes, sex hormone levels, vitamin D levels, and cancer.

More science highlights

Events

Webinar Nov. 9: Development of Biomedical Knowledge Bases for Exposomics [The Human Health Exposure Analysis Resource]

Webinar Nov. 9: Indoor air phthalates and volatile organic compounds in NY nail salons [Philadelphia Regional Center for Children’s Environmental Health]

Webinar Nov. 16: PFAS and Testicular Cancer: A Study of U.S. Air Force Servicemen [EDC Strategies Partnership]

Webinar Nov. 28: Chemical Recycling: A Dangerous Deception [Beyond Plastics and IPEN]

Webinar Nov. 29: Shades of Pink: Breast Cancer, Pinkwashing, and the Importance of Prevention [CHE-Alaska Partnership]

Webinar Nov. 29: Development and Application of NAMs Workflows and Tools [EPA, PETA, Institute for In Vitro Sciences, California Department of Pesticide Regulation]

Webinar Dec. 12: Neuroendocrine disruptors and brain development: Lessons from PCBs [EDC Strategies Partnership]

Conference Jan 22-24, 2024: USA Exposome Symposium: Children’s Health, Environmental Justice, and the Exposome in Nashville TN; posters due Dec. 1 [Mount Sinai Institute for Climate Change, Environmental Health, and Exposomics; Meharry Medical College Institute for Health Disparities, Equity, and the Exposome]

More events

Regulations/Policy

A new paradigm for regulatory sciences.

Lawsuits force changes in U.S. pesticide regs. [News item in Science]

Worldwide risk assessment of phthalates and bisphenol A in humans: The need for updating guidelines.

Also see the new article from Environmental Health News, The chemical industry may have killed a landmark EU chemical policy. Here’s what that means for the US.

Nominations

EPA is requesting nominations for the Science Advisory Board Environmental Justice Science and Analysis Review Panel. Due Nov. 13.

The National Academies of Sciences, Engineering, and Medicine has established a new Roundtable on Plastics and is seeking experts on reducing plastic pollution. Due Dec. 1.

More EDC policy and regulations open for comment

Methods/Tools/Screening

What is in the fish? Collaborative trial in suspect and non-target screening of organic micropollutants using LC- and GC-HRMS.

Priority list of potential endocrine-disrupting chemicals in food chemical contaminants: a docking study and in vitro/epidemiological evidence integration.

Assessing proarrhythmic potential of environmental chemicals using a high throughput in vitro-in silico model with human induced pluripotent stem cell-derived cardiomyocytes.

Implications of biotic factors for toxicity testing in laboratory studies.

Development of a Lymanea stagnalis embryo bioassay for chemicals hazard assessment.

Deep eutectic solvents with solid supports used in microextraction processes applied for endocrine-disrupting chemicals.

Metabolomics 2022 workshop report: state of QA/QC best practices in LC-MS-based untargeted metabolomics, informed through mQACC community engagement initiatives.

More tools, reports, and resources

Commentaries

Artificial intelligence as the new frontier in chemical risk assessment.

Digging into Exposure Disparities: Mapping Lead Service Lines in New York City. [Science Selection in EHP]

Introduction to the “Tracking complex mixtures of chemicals in human- and eco-exposome: the nexus of models, analytics, and toxicity” themed issue.

Educating the Public About Toxic Chemicals that We Unknowingly Consume: A Potential Important Role for the Practicing Pharmacists.

Respiratory Health Risk Assessment of Exposure to Carcinogenic Chemicals: EPA Method. [letter]

Reviews

Numerous Chemicals/Mixtures

Environmental chemicals-induced ROS generation and immunotoxicity: A comprehensive review.

The influence of environmental factors on premature ovarian insufficiency and ovarian aging.

The evolution of endocrine disruptor chemical assessments worldwide in the last three decades.

BPA/Phthalates

A physiologically based pharmacokinetic model of diethyl phthalates in humans.

Parabens/Triclosan/Antimicrobials

Association of triclosan and human infertility: A systematic review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Perspective on halogenated organic compounds.

PFAS

Association between exposure to per- and perfluoroalkyl substances (PFAS) and reproductive hormones in human: A systematic review and meta-analysis.

Strategies to improve adsorption and photocatalytic performance of metal-organic frameworks (MOFs) for perfluoroalkyl and polyfluoroalkyl substances (PFASs) removal from water: A review.

A review of innovative approaches for onsite management of PFAS-impacted investigation derived waste.

Flame Retardants

Adverse outcome pathways of PBDEs inducing male reproductive toxicity.

Rethinking the pathway to sustainable fire retardants.

Pesticides

Pesticides and the Microbiome-Gut-Brain Axis: Convergent Pathways in the Pathogenesis of Parkinson’s Disease. [see related, Why the Gut Microbiome Must Be Considered When Evaluating the Impact of Pesticides on Parkinson’s Disease Risk.]

The effects of organic food on human health: a systematic review and meta-analysis of population-based studies.

An Adverse Outcome Pathway for Chemical-induced Parkinson’s disease: Calcium is Key.

A comprehensive review on toxicological mechanisms and transformation products of tebuconazole: Insights on pesticide management.

Postbiotics as Potential Detoxification Tools for Mitigation of Pesticides.

Malathion or diazinon exposure and male reproductive toxicity: a systematic review of studies performed with rodents.

Cellular metabolism and health impacts of dichlorvos: Occurrence, detection, prevention, and remedial strategies-A review.

Metals/Metalloids

Arsenic Exposure and Amyloid Precursor Protein Processing: A Focus on Alzheimer’s Disease.

The Role of microRNAs in Arsenic-Induced Human Diseases: A Review.

Potential Roles of Metals in the Pathogenesis of Pulmonary and Systemic Hypertension.

Microplastics/Nanomaterials

Biomarkers of oxidative stress, inflammation, and genotoxicity to assess exposure to micro- and nanoplastics. A literature review.

Co-exposure of microplastics and heavy metals in the marine environment and remediation techniques: a comprehensive review.

Microplastics as contaminants in the Brazilian environment: an updated review.

Toxicological impacts of microplastics on human health: a bibliometric analysis.

Life-cycle risk assessment of graphene-enabled textiles in fire protection gear.

Pharmaceuticals/Personal Care Products

Toxicity of chemical-based hand sanitizers on children and the development of natural alternatives: a computational approach.

Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review.

The environmental sources of benzophenones: Distribution, pretreatment, analysis and removal techniques.

Human Health Studies

Numerous Chemicals/Mixtures

“Cocktail” of environmental chemicals and early reproductive outcomes of IVF: The insight from paternal and maternal exposure.

Association between Environmental Exposure to Multiclass Organic Pollutants and Sex Steroid Hormone Levels in Women of Reproductive Age.

Mixture of air pollution, brominated flame retardants, polychlorinated biphenyls, per- and polyfluoroalkyl substances, and organochlorine pesticides in relation to vitamin D concentrations in pregnancy.

Association of postnatal exposure to mixture of bisphenol A, Di-n-butyl phthalate and Di-(2-ethylhexyl) phthalate with Children’s IQ at 5 Years of age: Mothers and Children’s environmental health (MOCEH) study.

Association of urinary arsenic, polycyclic aromatic hydrocarbons, and metals with cancers among the female population in the US.

Phthalates

Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort.

Association of mono-2-ethylhexyl phthalate with adverse outcomes in chronic hemodialysis patients.

Parabens/Triclosan/Antimicrobials

Correlation between Triclosan (TCS) exposure and endometriosis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations of polychlorinated biphenyls and organochlorine pesticides with metabolic dysfunction-associated fatty liver disease among Chinese adults: Effect modification by lifestyle.

Short-chain chlorinated paraffin (SCCP) exposure and type 2 diabetes risk: A population-based case-control study in East China.

PFAS

Association of Perfluoroalkyl and polyfluoroalkyl substances (PFASs) exposures and the risk of systemic lupus erythematosus: a case-control study in China.

Flame Retardants

The relationship of organophosphate flame retardants with hyperuricemia and gout via the inflammatory response: An integrated approach.

Prenatal exposure to replacement flame retardants and organophosphate esters and childhood adverse respiratory outcomes.

Pesticides

Meconium concentrations of pesticides and risk of hypospadias: a case-control study in Brittany, France.

Occupational exposure to pesticides and endometrial cancer in the Screenwide case-control study.

Retraction Note: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case-control study.

Metals/Metalloids

Effects of heavy metal exposure during pregnancy on birth outcomes.

Sex-specific associations of maternal and childhood urinary arsenic levels with emotional problems among 6-year-age children: Evidence from a longitudinal cohort study in China.

Race/ethnicity and sex differences in the association between area-level arsenic exposure concentration and hepatocellular carcinoma (HCC) incidence rates in Texas. An ecological study.

Associations of blood cadmium and lead concentrations with all-cause mortality in US adults with chronic obstructive pulmonary disease.

Air Pollution

Randomised controlled trial of a behavioural intervention to reduce exposure to PM_2.5 in patients with COPD.

Effect modification of dietary diversity on the association of air pollution with incidence, complications, and mortality of type 2 diabetes: Results from a large prospective cohort study.

Association between birth weight/joint exposure to ambient air pollutants and type 2 diabetes: a cohort study in the UK Biobank.

Long-term exposure to air pollution and risk of Sarcopenia in adult residents of Taiwan: a nationwide retrospective cohort study.

Miscellaneous

Cohort profile update: The Canadian Maternal-Infant Research on Environmental Chemicals Child Development study (MIREC-CD PLUS).

Laboratory Studies

Numerous Chemicals/Mixtures

Comparative evaluation of different chemical agents induced Autism Spectrum Disorder in experimental Wistar rats

BPA/Phenols

Perinatal exposure to bisphenol A impairs cognitive function via the gamma-aminobutyric acid signaling pathway in male rat offspring.

The protective effects of date seeds, in either conventional or nanoformulation, against bisphenol A-induced testicular toxicity: involvement of testicular expression of CYP11A1, Nrf-2 and Bax/Bcl-2 ratio.

Comparison of structure-activity relationship for bisphenol analogs in the inhibition of gonadal 3β-hydroxysteroid dehydrogenases among human, rat, and mouse.

Toxic effects of bisphenol S on mice heart and human umbilical cord endothelial cells.

Developmental Bisphenol S Toxicity in Two Freshwater Animal Models.

Feeding frequency does not interact with BPA exposure to influence metabolism or behaviour in zebrafish (Danio rerio).

Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A-Induced Spermatogenesis Dysfunction.

Exposure to 4-nonylphenol compromises Leydig cell development in pubertal male mice.

Phthalates

Comparative analysis of diisononyl phthalate and di(isononyl)cyclohexane-1,2 dicarboxylate plasticizers in regulation of lipid metabolism in 3T3-L1 cells.

Parabens/Triclosan/Antimicrobials

Metabolic disturbance and transcriptomic changes induced by methyl triclosan in human hepatocyte L02 cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

2-Chloro-3,7,8-tribromodibenzofuran as a new environmental pollutant inducing atypical ultrasonic vocalization in infant mice.

PCB126 impairs human sperm functions by affecting post-translational modifications and mitochondrial functions.

Hexabromocyclododecane (HBCD) induced PANoptosis of chondrocytes via activation of the NLRP3 inflammasome and decreased the exercise ability of mice in vivo.

PFAS

In Vitro Binding Analysis of Legacy-Linear and New Generation-Cyclic Perfluoro-Alkyl Substances on Sex Hormone Binding Globulin and Albumin, Suggests Low Impact on Serum Hormone Kinetics of Testosterone.

Deriving aquatic PNECs of endocrine disruption effects for PFOS and PFOA by combining species sensitivity weighted distributions and adverse outcome pathway networks.

PFOS Impairs Mitochondrial Biogenesis and Dynamics and Reduces Oxygen Consumption in Human Trophoblasts.

Hypoxic and temporal variation in the endocrine disrupting toxicity of perfluorobutanesulfonate in marine medaka (Oryzias melastigma).

Sublethal Toxicity of 17 Per- and Polyfluoroalkyl Substances with Diverse Structures to Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutes.

Flame Retardants

Toxicity of TPhP on the gills and intestines of zebrafish from the perspectives of histopathology, oxidative stress and immune response.

Hydroxylated transformation products obtained after UV irradiation of the current-use brominated flame retardants hexabromobenzene, pentabromotoluene, and pentabromoethylbenzene.

Upregulation of oxidative stress by triphenyl phosphate (TPhP) exposure causes antioxidant insult and apoptotic process in Epithelioma papulosum cyprini (EPC) cells.

Organotins

New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation.

Pesticides

Quantitative Metabolism and Urinary Elimination Kinetics of Seven Neonicotinoids and Neonicotinoid-Like Compounds in Humans.

Dienediamine: A Safe Herbicide as Paraquat Surrogate.

Atrazine exposure caused oxidative stress in male rats and inhibited brain-pituitary-testicular functions.

Hexaconazole exposure disrupt acetylcholinesterase, leading to mental illness.

Toxicity assessment and DNA repair kinetics in HEK293 cells exposed to environmentally relevant concentrations of Glyphosate (Roundup® Control Max).

Cytotoxicity, morphological and ultrastructural effects induced by the neonicotinoid pesticide, imidacloprid, using a rat Leydig cell line (LC-540).

Evaluation of neurological behavior alterations and metabolic changes in mice under chronic glyphosate exposure.

Low concentrations of ethylene bisdithiocarbamate pesticides maneb and mancozeb impair manganese and zinc homeostasis to induce oxidative stress and caspase-dependent apoptosis in human hepatocytes.

Cardiac energy metabolism disorder mediated by energy substrate imbalance and mitochondrial damage upon tebuconazole exposure.

Combined toxicity of aflatoxin B1 and tebuconazole to the embryo development of zebrafish (Danio rerio).

Inhibition with simultaneous spontaneous reactivation and aging of acetylcholinesterase by organophosphorus compounds: Demeton-S-methyl as a model.

Metals/Metalloids

Alteration of epigenetic methyl and acetyl marks by postnatal chromium(VI) exposure causes apoptotic changes in the ovary of the F1 offspring.

Microplastics/Nanomaterials

The seasonality of the concentration of endocrine phenolic compounds in the matter attached to the surface of microplastics.

Bioenergetic effects of pristine and ultraviolet-weathered polydisperse polyethylene terephthalate and polystyrene nanoplastics on human intestinal Caco-2 cells.

The male reproductive toxicity after nanoplastics and microplastics exposure: Sperm quality and changes of different cells in testis.

Microplastics exposure promotes the proliferation of skin cancer cells but inhibits the growth of normal skin cells by regulating the inflammatory process.

Phthalate acid ester release from microplastics in water environment and their comparison between single and competitive adsorption.

Gut toxicity of polystyrene microplastics and polychlorinated biphenyls to Eisenia fetida: Single and co-exposure effects with a focus on links between gut bacteria and bacterial translocation stemming from gut barrier damage.

Transcriptomic analysis following polystyrene nanoplastic stress in the Pacific white shrimp, Litopenaeus vannamei.

Photoaged Polystyrene Nanoplastics Result in Transgenerational Reproductive Toxicity Associated with the Methylation of Histone H3K4 and H3K9 in Caenorhabditis elegans.

A new approach to explore the correlation between declarative memory and anxiety in animal models of schizophrenia and microplastic pollution.

Air Pollution

Neurodevelopmental consequences of gestational exposure to particulate matter 10: Ultrasonic vocalizations and gene expression analysis using a bayesian approach.

Pharmaceuticals/Personal Care Products

Isothiazolinone dysregulates the pattern of miRNA secretion: Endocrine implications for neurogenesis.

Long-term effects of embryonic exposure to benzophenone-3 on neurotoxicity and behavior of adult zebrafish.

Miscellaneous

Insight into the negative effect and lipid profile alterations in liver of mice exposed to methylimidazolium ionic liquids, a novel “green” solvent.

Study on reproductive endocrine disturbance and DNA damage mechanism of female Ruditapes philippinarum under Benzo[a]pyrene stress.

Long-term sublethal exposure to polyethylene and tire wear particles: Effects on risk-taking behaviour in invasive and native fish.

Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Exploring the Occurrence of Organic Contaminants in Human Semen through an Innovative LC-HRMS-Based Methodology Suitable for Target and Nontarget Analysis.

Evaluation of exposure to multiple organic pollutants in riparian communities of the Brazilian Amazon: Screening levels and potential health risks.

Chemicals of Emerging Arctic Concern in north-western Spitsbergen snow: Distribution and sources.

Proposal for priority emerging pollutants in the Nakdong river, Korea: Application of EU watch list mechanisms.

Endocrine-disrupting chemicals in Vietnamese marine fish: Occurrence, distribution, and risk assessment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Chlordecone determination in serum by LC-MS/MS and the importance of low limit of detection.

Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) levels in air and surface sea waters along the Antarctic Peninsula.

Soil properties and organochlorine compounds co-shape the microbial community structure: A case study of an obsolete site.

PFAS

Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption.

Prevalence and Source Tracing of PFAS in Shallow Groundwater Used for Drinking Water in Wisconsin, USA.

Integrated QuEChERS combined with LC-MS/MS for high-throughput analysis of per- and polyfluoroalkyl substances in milk.

Prediction of perfluoroalkyl acids (PFAAs) in homegrown eggs: Insights into abiotic and biotic factors affecting bioavailability and derivation of potential remediation measures.

Investigation of Sources of Fluorinated Compounds in Private Water Supplies in an Oil and Gas-Producing Region of Northern West Virginia.

Quantification of perfluorinated compounds in atmospheric particulate shows potential connection with environmental event.

Per- and polyfluoroalkyl substances (PFAS) in final treated solids (Biosolids) from 190 Michigan wastewater treatment plants.

Flame Retardants

Neural network for evaluation of the impact of the UK COVID-19 national lockdown on atmospheric concentrations of PAHs and PBDEs.

Pesticides

Current-use pesticide exposure pathways in Czech adults and children from the CELSPAC-SPECIMEn cohort.

Environmental pressures and pesticide exposure associated with an increase in the share of plant-based foods in the diet.

Pesticide residues with hazard classifications relevant to non-target species including humans are omnipresent in the environment and farmer residences.

High urinary oxidative DNA damage in wild chimpanzees ranging in proximity of agricultural fields in Sebitoli area, Uganda.

Metals/Metalloids

Combined chronic dietary exposure to four nephrotoxic metals exceeds tolerable intake levels in the adult population of 10 European countries.

Soft Drinks as a Dietary Source of Fluoride Exposure.

Development and Validation of Knowledge Attitudes and Practices Questionnaire (Nu-KAPQ): for the assessment of Knowledge, Attitudes, and Practices Associated with Arsenic.

Compound-specific stable isotopes of amino acids reveal influences of trophic level and primary production sources on mercury concentrations in fishes from the Aleutian Islands, Alaska.

Distribution and trends of mercury in aquatic and terrestrial biota of New York, USA: a synthesis of 50 years of research and monitoring.

Deleterious effects of mercury contamination on immunocompetence, liver function and egg volume in an antarctic seabird.

Microplastics/Nanomaterials

Steam disinfection enhances bioaccessibility of metallic nanoparticles in nano-enabled silicone-rubber baby bottle teats, pacifiers, and teethers.

A macroplastic vulnerability index for marine mammals, seabirds, and sea turtles in Hawai’i.

Impact of flooding on microplastic abundance and distribution in freshwater environment: a review.

Air Pollution

When Space and Time Matter in Environmental Injustice: A Bayesian Analysis of the Association between Socio-economic Disadvantage and Air Pollution in Greater Mexico City.

Toxic Tire Wear Compounds (6PPD-Q and 4-ADPA) Detected in Airborne Particulate Matter Along a Highway in Mississippi, USA.

Pharmaceuticals/Personal Care Products

Comparative risk assessment studies estimating the hazard posed by long-term consumption of PPCPs in river water.

Suspect and Nontarget Screening Reveal the Underestimated Risks of Antibiotic Transformation Products in Wastewater Treatment Plant Effluents.

Miscellaneous

Twenty-four-hour temporal trend of melamine and its derivatives in urine in association with meal consumption: a panel study in Shanghai, China.

Yeast estrogen screen assay applied in the assessment of estrogenic activity removal from dairy cattle wastewater treated by anaerobic digestion.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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