EDC Science Weekly, Nov. 23-30, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: BPA substitutes and early puberty; PCBs, pesticides and miscarriage; risk assessment of PFAS mixtures worldwide; PFAS half-lives in humans.

More science highlights

Events

Webinar Dec. 12: Neuroendocrine disruptors and brain development: Lessons from PCBs [EDC Strategies Partnership]

Webinar Jan. 9: Food Contact Materials: A Road Map to Improved Safety Testing [EDC Strategies Partnership]

More events

Regulations/Policy

Evaluating the efficiency of the 2020 ban of BPA and BPS in thermal papers in Switzerland.

Has Regulatory Action Reduced Human Exposure to Flame Retardants?

Time to improve transparency at Health Canada’s Pest Management Regulatory Agency.

Thallium Pollution from the Lithium Industry Calls for Urgent International Action on Regulations.

Revising the EPA Dilution-Attenuation Soil Screening Model for PFAS.

More EDC policy and regulations open for comment

Methods/Tools/Screening

CatNet: Sequence-based deep learning with cross-attention mechanism for identifying endocrine-disrupting chemicals.

PFΔScreen – an open-source tool for automated PFAS feature prioritization in non-target HRMS data.

Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research.

TKPlate 1.0: An Open-access platform for toxicokinetic and toxicodynamic modelling of chemicals to implement new approach methodologies in chemical risk assessment.

Reproducibility of organ-level effects in repeat dose animal studies.

Recent Advances in Non-Targeted Screening of Compounds in Plastic-Based/Paper-Based Food Contact Materials.

Advancing chemical safety assessment through an omics-based characterization of the test system-chemical interaction.

Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling: A case study with the mycotoxin deoxynivalenol.

Insights in Pharmaceutical Pollution: The Prospective Role of eDNA Metabarcoding.

Current advances in comprehensive omics data mining for oncology and cancer research.

More tools, reports, and resources

Commentaries

Editorial: Endocrine disruptors affecting the human and companion animal endocrine functions – similarities and indicators in ONE Health concept. [intro to a research topic in Frontiers in Endocrinology]

Editorial: Dietary exposures to environmental pollutants: integrated multimedia perspectives. [intro to a research topic in Frontiers in Public Health]

Editorial: Uterine factors associated with fertility impairment. [intro to a research topic in Frontiers in Endocrinology that includes one article on EDCs]

Editorial: Estrogen receptors in endocrine disorders. [intro to a research topic in Frontiers in Endocrinology]

Microplastics and their environmental effects. [intro to a special issue of Environmental Toxicology and Pharmacology]

Pesticide cocktails harm bumblebees in European fields. [News item in Nature]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Endocrine-disrupting chemicals and breast cancer: a meta-analysis. [DDT, PCBs, PFAS, phthalates, etc.]

The Hidden Threat: Endocrine Disruptors and Their Impact on Insulin Resistance. [BPA, phthalates, PFAS, triclosan, etc.]

Research progress on the interference effects of plasticizers on maternal behavior and its potential mechanisms.

Emerging Pollutants in Etiology and Pathophysiology of Polycystic Ovary Syndrome.

Effect of endocrine disruptors on bacterial virulence.

Assessment of five typical environmental endocrine disruptors and thyroid cancer risk: a meta-analysis. [phthalates, BPA, PCBs, PBDEs, metals]

Source, transport, and toxicity of emerging contaminants in aquatic environments: A review on recent studies.

Environmental Toxins and Alzheimer’s Disease: a Comprehensive Analysis of Pathogenic Mechanisms and Therapeutic Modulation.

BPA/Phenols

Effects of Prenatal Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, on Offspring’s Health: Evidence from Epidemiological and Experimental Studies.

Does bisphenol A (BPA) participates in the pathogenesis of Polycystic Ovary Syndrome (PCOS)?

PFAS

Estimation of per- and polyfluoroalkyl substances (PFAS) half-lives in human studies: A systematic review and meta-analysis.

Fluoropolymers as Unique and Irreplaceable Materials: Challenges and Future Trends in These Specific Per or Poly-Fluoroalkyl Substances.

Pesticides

Pesticide-Induced Inflammation at a Glance.

Paraquat (herbicide) as a cause of Parkinson’s Disease.

A Comprehensive Review of the Current Knowledge of Chlorfenapyr: Synthesis, Mode of Action, Resistance, and Environmental Toxicology.

Metals/Metalloids

Contaminant Metals and Cardiovascular Health.

A hypothesis: Potential contributions of metals to the pathogenesis of pulmonary artery hypertension.

Heavy metals, oxidative stress, and the role of AhR signaling.

Does fluoride exposure affect thyroid function? A systematic review and dose-response meta-analysis.

Microplastics/Nanomaterials

(Micro)Plastics Are Toxic Pollutants.

Trophic transfer of nanomaterials and their effects on high-trophic-level predators.

Nanoparticles and neurodegeneration: Insights on multiple pathways of programmed cell death regulated by nanoparticles.

Effects and applications of surfactants on the release, removal, fate, and transport of microplastics in aquatic ecosystem: a review.

Microplastics – A major contaminant in marine macro algal population: Review.

Air Pollution

Evidence Synthesis of Observational Studies in Environmental Health: Lessons Learned from a Systematic Review on Traffic-Related Air Pollution. [see related Invited Perspective: Systematic Review for Environmental Pollutants-A Work in Progress.]

Influence of Air Pollution Exposures on Cardiometabolic Risk Factors: a Review.

Association between Air Pollution and Lipid Profiles.

The impact of air pollution on neurocognitive development: Adverse effects and health disparities.

Pharmaceuticals/Personal Care Products

Effects of prenatal exposure to synthetic sex hormones on neurodevelopment: a biological mechanism. [DES, etc.]

Benzotriazole UV stabilizers (BUVs) as an emerging contaminant of concern: a review.

Degradation of organic UV filters in the water environment: A concise review on the mechanism, toxicity, and technologies.

Tamoxifen in breast cancer and risk of Parkinson’s disease: A meta-analysis.

A review on in silico prediction of the environmental risks posed by pharmaceutical emerging contaminants.

Human Health Studies

Numerous Chemicals/Mixtures

Investigation of the Relationship between Spontaneous Abortion, Serum Pesticides, and Polychlorinated Biphenyl Levels.

Military exposures and Gulf War illness in veterans with and without posttraumatic stress disorder.

Association of Endocrine Disrupting Chemicals With the Metabolic Syndrome Among Women in the Multiethnic Cohort Study. [BPA, parabens, phthalates, triclosan]

BPA/Phenols

Association between Urinary BPA Substitutes and Precocious Puberty among Girls: A Single-Exposure and Mixed Exposure Approach from a Chinese Case-Control Study.

Bisphenol derivatives in cord blood and association between thyroid hormones and potential exposure sources.

Associations of prenatal exposure to bisphenols with BMI growth trajectories in offspring within the first two years: evidence from a birth cohort study in China.

Phthalates

Single- and combined-phthalate exposures are associated with biological ageing among adults.

Associations Between Phthalate, Eosinophil, and Aeroallergen Sensitization in Schoolchildren.

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017-2018.

Long-term exposure to exogenous phthalate, masculinity and femininity trait, and gender identity in children: a Chinese 3-year longitudinal cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Impacts of perinatal dioxin exposure on gaze behavior in 2-year-old children in the largest dioxin-contaminated area in Vietnam.

PFAS

The Influence of Adiposity Levels on the Relation between Perfluoroalkyl Substances and High Depressive Symptom Scores in Czech Adults.

The Association between Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Respiratory Tract Infections in Preschool Children: A Wuhan Cohort Study.

Health and Psychological Concerns of Communities Affected by Per- and Poly-Fluoroalkyl Substances: The Case of Residents Living in the Orange Area of the Veneto Region.

Flame Retardants

Cognitive Performance and Exposure to Organophosphate Flame Retardants in Children: Evidence from a Cross-Sectional Analysis of Two European Mother-Child Cohorts.

Comprehensive analysis of the impact of emerging flame retardants on prostate cancer progression: The potential molecular mechanisms and immune infiltration landscape.

Ex vivo exposure to polybrominated diphenyl ether (PBDE) selectively affects the immune response in autistic children.

Pesticides

Prenatal and childhood exposure to organophosphate pesticides and functional brain imaging in young adults.

Maternal exposure to pyrethroid insecticides during pregnancy and respiratory allergy symptoms among children participating in the Venda health examination of mothers, babies and their environment (VHEMBE).

Perinatal health effects of herbicides exposures in the United States: the Heartland Study, a Midwestern birth cohort study.

Exploratory analysis of the associations between neonicotinoids insecticides and serum lipid profiles among US adults: A cross-sectional, population-based study.

Associations between urinary glyphosate and diabetes mellitus in the US general adult: a cross-sectional study from NHANES 2013-2016.

Association of urine glyphosate levels with renal injury biomarkers in children living close to major vegetable-producing regions in China.

Associations between dietary pesticide residue mixture exposure and mortality in a population-based prospective cohort of men and women.

Neuroanatomical differences in Latinx children from rural farmworker families and urban non-farmworker families and related associations with pesticide exposure.

Metals/Metalloids

Urinary heavy metals and attention-deficit/hyperactivity symptoms of preschool children: a mixed-exposure analysis.

Exposure to metal mixtures and young children’s growth and development: A biomonitoring-based study in Eastern China.

Prenatal Exposure to Heavy Metals and Adverse Birth Outcomes: Evidence From an E-Waste Area in China.

Association Between Multiple Metal(loid)s Exposure and Blood Lipid Levels: Evidence from a Cross-Sectional Study of Southeastern China.

Air Pollution

Weekly prenatal PM_2.5 and NO₂ exposures in preterm, early term, and full term infants: Decrements in birth weight and critical windows of susceptibility.

Associations of low levels of air pollution with cardiometabolic outcomes and the role of diet quality in individuals with obesity.

Disentangling impacts of multiple pollutants on acute cardiovascular events in New York city: A case-crossover analysis.

Exposure to ambient air toxicants and the risk of amyotrophic lateral sclerosis (ALS): A matched case control study.

Personal exposure of PM_2.5 and metabolic syndrome markers of pregnant women in South Korea: APPO study.

Assessment of health impacts and costs attributable to air pollution in urban areas using two different approaches. A case study in the Western Balkans.

Long-term exposure to PM₁ is associated with increased prevalence of metabolic diseases: evidence from a nationwide study in 123 Chinese cities.

Exposure to air pollution as an environmental determinant of how Sjögren’s disease is expressed at diagnosis.

Fine Particulate Matter Exposure, Genetic Susceptibility, and the Risk of Incident Stroke: A Prospective Cohort Study.

Association between short-term air pollution exposure and perturbation in thyrotropin levels in 1.38 million Chinese women: A national longitudinal analysis, 2014-2019.

Pharmaceuticals/Personal Care Products

Urinary antibiotic levels and risk of overweight/obesity in preschool children: A biomonitoring-based study from eastern China.

Miscellaneous

Associations of Trimester-Specific Exposure to Perchlorate, Thiocyanate, and Nitrate with Childhood Neurodevelopment: A Birth Cohort Study in China.

Laboratory Studies

Numerous Chemicals/Mixtures

Pharmaceuticals and endocrine disrupting compounds modulate adverse effects of climate change on resource quality in freshwater food webs.

BPA/Phenols

Impact of combined chronic exposure to low-dose bisphenol A and fructose on serum adipocytokines and the energy target metabolome in white adipose tissue.

Bisphenol S remodels red blood cell membrane lipids by altering plasma lipid levels, causing the risk of venous thrombosis in SD rats and zebrafish embryos.

Identification of core genes, critical signaling pathways, and potential drugs for countering BPA-induced hippocampal neurotoxicity in male mice.

N-Acetyl-L-Cysteine Ameliorates BPAF-Induced Porcine Sertoli Cell Apoptosis and Cell Cycle Arrest via Inhibiting the ROS Level.

Bisphenol AF Induces Prostatic Dorsal Lobe Hyperplasia in Rats through Activation of the NF-κB Signaling Pathway.

Bisphenol-A disturbs hormonal levels and testis mitochondrial activity, reducing male fertility.

Bisphenol A alters retinal morphology, visually guided behavior, and thyroid hormone levels in zebrafish larvae.

Bisphenol A induced neuronal apoptosis and enhanced autophagy in vitro through Nrf2/HO-1 and Akt/mTOR pathways.

Bisphenol A (BPA) exposure aggravates hepatic oxidative stress and inflammatory response under hypertensive milieu – Impact of low dose on hepatocytes and influence of MAPK and ER stress pathways.

Metabolomic analysis reveals the toxicity mechanisms of bisphenol A on the Microcystis aeruginosa under different phosphorus levels.

Phthalates

Mono-2-ethylhexylphthalate (MEHP) is a potent agonist of human TRPA1 channel.

The no-observed-adverse-effect level of phthalates promotes proliferation and cell cycle progression in normal human breast cells.

Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats.

Parabens/Triclosan/Antimicrobials

Effect of Butyl Paraben on Oxidative Stress in the Liver of Mauremys sinensis.

Ethylparaben Toxicity on Cladocerans Daphnia Similis and Ceriodaphnia Silvestrii and Species Sensitivity Analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Use of a Polymeric Implant System to Assess the Neurotoxicity of Subacute Exposure to 2,2′,5,5′-Tetrachlorobiphenyl-4-ol, a Human Metabolite of PCB 52, in Male Adolescent Rats.

PFAS

Survival, Growth, and Reproduction Responses in a Three-Generation Exposure of the Zebrafish (Danio rerio) to Perfluorooctane Sulfonate.

Binding of Per- and Polyfluoroalkyl Substances (PFAS) to the PPARγ/RXRα-DNA Complex.

Evaluating the Effect of Gestational Exposure to Perfluorohexane Sulfonate on Placental Development in Mice Combining Alternative Splicing and Gene Expression Analyses.

Growth Hormones in Broad Bean (Vicia faba L.) and Radish (Raphanus raphanistrum subsp. sativus L.) Are Associated with Accumulated Concentrations of Perfluoroalkyl Substances.

Studying mixture effects on uptake and tissue distribution of PFAS in zebrafish (Danio rerio) using physiologically based kinetic (PBK) modelling.

Flame Retardants

The environmental pollutant BDE-47 modulates immune responses in vitro and in vivo murine models.

Molecular insights into the effects of tetrachlorobisphenol A on puberty initiation in Wistar rats.

Long-Term Tetrabromobisphenol A Exposure Induces Gut Microbiota Imbalance and Metabolic Disorders via the Peroxisome Proliferator-Activated Receptor Signaling Pathway in the Regenerated Gut of Apostichopus japonicus.

Organotins

Toxic Relationships: Prediction of TBT’s Affinity to the Ecdysteroid Receptor of Triops longicaudatus.

Pesticides

Modifying effects of 2,4-D and Glyphosate exposures on gut-liver-adipose tissue axis of diet-induced non-alcoholic fatty liver disease in mice.

2,4-Dichlorophenoxyacetic Acid Induces Degeneration of mDA Neurons In Vitro.

Effect of atrazine on testicular toxicity involves accommodative disorder of xenobiotic metabolizing enzymes system and testosterone synthesis in European quail (Coturnix coturnix).

Exposure to Chlorpyrifos Alters Proliferation, Differentiation and Fatty Acid Uptake in 3T3-L1 Cells.

The ameliorative effect of cerium oxide nanoparticles on chlorpyrifos induced hepatotoxicity in a rat model: Biochemical, molecular and immunohistochemical study.

Effects of environmentally relevant concentrations of niclosamide on lipid metabolism and steroid hormone synthesis in adult female zebrafish.

Assessment of reproductive toxicity in adult zebrafish (Danio rerio) following sublethal exposure to penthiopyrad.

In vitro antiandrogenic effects of the herbicide linuron and its metabolites.

Trifloxystrobin induced developmental toxicity by disturbing the ABC transporters, carbohydrate and lipid metabolism in adult zebrafish.

Typical neonicotinoids and organophosphate esters, but not their metabolites, adversely impact early human development by activating BMP4 signaling.

Long-Lasting Developmental Effects In Rat Offspring After Maternal Exposure To Acetamiprid In The Drinking Water During Gestation.

Determination of biochemical and histopathological changes on testicular and epididymis tissues induced by exposure to insecticide Imidacloprid during postnatal development in rats.

Metals/Metalloids

Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum.

Microplastics/Nanomaterials

Microplastic Effect Tests Should Use a Standard Heterogeneous Mixture: Multifarious Impacts among 16 Benthic Invertebrate Species Detected under Ecologically Relevant Test Conditions.

Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo.

Effect of Polystyrene Microplastics on the Antioxidant System and Immune Response in GIFT (Oreochromis niloticus).

Vitamin D modulation of brain-gut-virome disorder caused by polystyrene nanoplastics exposure in zebrafish (Danio rerio).

Co-exposure to polystyrene microplastics and cypermethrin enhanced the effects on hepatic phospholipid metabolism and gut microbes in adult zebrafish.

Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics.

Pharmaceuticals/Personal Care Products

Toxicity of Beauty Salon Effluents Contaminated with Hair Dye on Aquatic Organisms.

Miscellaneous

In vivo and in silico toxicity assessment of four common liquid crystal monomers to Daphnia magna: Novel endocrine disrupting chemicals in crustaceans?

Exploring the adverse effects of 1,3,6,8-tetrabromo-9H-carbazole in atherosclerotic model mice by metabolomic profiling integrated with mechanism studies in vitro.

Turning Waste into Treasure: The Full Technological Process and Product Performance Characterization of Flushable Wet Wipes Prepared from Corn Stalk.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Contaminated Sites and Indigenous Peoples in Canada and the United States: A Scoping Review.

Evidence of transboundary movement of chemicals from Mexico to the U.S. in Tijuana River estuary sediments.

BPA/Phenols

Endocrine disrupting bisphenol A, 4-tert-octylphenol and 4-nonylphenol in gonads of long-tailed ducks Clangula hyemalis wintering in the southern Baltic.

Parabens/Triclosan/Antimicrobials

Exposure Profile and Characteristics of Parabens and Alkylphenols in Plasma among Rural Adults in Central China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Unexpectedly high levels and health risks of atmospheric polychlorinated biphenyls in modern mechanical dismantling of obsolete electrical equipment: Investigations in a large integrated e-waste dismantling industrial estate.

Spatiotemporal Trends Spanning Three Decades Show Toxic Levels of Chemical Contaminants in Marine Mammals.

Persistent organic pollutants and chemicals of emerging Arctic concern in the Arctic environment.

PFAS

Worldwide serum concentration-based probabilistic mixture risk assessment of perfluoroalkyl substances among pregnant women, infants, and children.

Nontarget Identification of Novel Per- and Polyfluoroalkyl Substances (PFAS) in Soils from an Oil Refinery in Southwestern China: A Combined Approach with TOP Assay.

Occurrence and risk characterization of per- and polyfluoroalkyl substances in seafood from the Persian Gulf.

Distribution of select per- and polyfluoroalkyl substances at a chemical manufacturing plant.

Characterizing the Movement of Per- and Polyfluoroalkyl Substances in an Avian Aquatic-Terrestrial Food Web.

Trace Level Analysis of Per- and Polyfluorinated Substances in Fish from Various Regions in Switzerland.

Background concentrations and spatial distribution of PFAS in surface waters and sediments of the greater Melbourne area, Australia.

Flame Retardants

Distribution characteristics, source attribution, and health risk assessment of organophosphate esters in indoor and outdoor dust from various microenvironments in Beijing.

Natural and anthropogenic organic brominated compounds in the southwestern Atlantic ocean: Bioaccumulation in coastal and oceanic dolphin species.

The transport and distribution of novel brominated flame retardants (NBFRs) and organophosphate esters (OPEs) in soils and moss along mountain valleys in the Himalayas.

Pesticides

An updated status of currently used pesticide in India: Human dietary exposure from an Indian food basket.

Pesticides in Ethiopian surface waters: A meta-analytic based ecological risk assessment.

Microplastics/Nanomaterials

Identification of microplastics extracted from field soils amended with municipal biosolids.

Microplastics ingestion and endocrine disrupting chemicals (EDCs) by breeding seabirds in the east tropical Atlantic: Associations with trophic and foraging proxies (δ¹⁵N and δ¹³C).

Quantification and Chemical Characterization of Plastic Additives and Small Microplastics (<100 μm) in Highway Road Dust.

Atmospheric deposition is an important pathway for inputting microplastics: Insight into the spatiotemporal distribution and deposition flux in a mega city.

Microplastic in fishes: the first report from a Himalayan River – Alaknanda.

Analysis of microplastics in ships ballast water and its ecological risk assessment studies from the Persian Gulf.

Pharmaceuticals/Personal Care Products

A 4-year study of bovine reproductive hormones that are induced by pharmaceuticals and appear as steroid estrogenic pollutants in the resulting slurry, using in vitro and instrumental analytical methods.

Simultaneous determination of steroid hormones and pharmaceuticals in killer whale (Orcinus orca) faecal samples by liquid chromatography tandem mass spectrometry.

Increasing exposure to the UV filters octocrylene and 2-ethylhexyl salicylate in Germany from 1996 to 2020: Human biomonitoring in 24-h urine samples of the German Environmental Specimen Bank (ESB).

Miscellaneous

Detection and Quantification of Acrylamide in Second Trimester Amniotic Fluid Using a Novel LC-MS/MS Technique to Determine Whether High Acrylamide Content during Pregnancy Is Associated with Fetal Growth.

Investigation of 6PPD-Quinone in Rubberized Asphalt Concrete Mixtures.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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