EDC Science Weekly, Nov. 10-16, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: 491 chemicals found in recycled plastic; conflicts of interest in science panel; pets are the new canaries

More science highlights

Events

Webinar Nov. 16 (starting soon!): PFAS and Testicular Cancer: A Study of U.S. Air Force Servicemen [EDC Strategies Partnership]

Webinar Nov. 28: Chemical Recycling: A Dangerous Deception [Beyond Plastics and IPEN]

Webinar Nov. 29: Shades of Pink: Breast Cancer, Pinkwashing, and the Importance of Prevention [CHE-Alaska Partnership]

Webinar Nov. 29: Development and Application of NAMs Workflows and Tools [EPA, PETA, Institute for In Vitro Sciences, California Department of Pesticide Regulation]

Webinar Dec. 12: Neuroendocrine disruptors and brain development: Lessons from PCBs [EDC Strategies Partnership]

Conference Jan 22-24, 2024: USA Exposome Symposium: Children’s Health, Environmental Justice, and the Exposome in Nashville TN; posters due Dec. 1 [Mount Sinai Institute for Climate Change, Environmental Health, and Exposomics; Meharry Medical College Institute for Health Disparities, Equity, and the Exposome]

More events

Regulations/Policy

Conflicts of Interest in the Assessment of Chemicals, Waste, and Pollution.

The inadequacy of current pesticide regulations for protecting brain health: the case of glyphosate and Parkinson’s disease.

More EDC policy and regulations open for comment

Methods/Tools/Screening

The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls

Interpretable machine learning for the identification of estrogen receptor agonists, antagonists, and binders.

Comprehensive profiling and semi-quantification of exogenous chemicals in human urine using HRMS-based strategies.

A dataset of organic pollutants identified and quantified in recycled polyethylene pellets.

Coproducing health research with Indigenous peoples.

Optimization for the analysis of 42 per- and polyfluorinated substances in human plasma: A high-throughput method for epidemiological studies.

The plastic health map: A systematic evidence map of human health studies on plastic-associated chemicals.

Deep eutectic solvents for the determination of endocrine disrupting chemicals.

Scannotation: A Suspect Screening Tool for the Rapid Pre-Annotation of the Human LC-HRMS-Based Chemical Exposome.

EISA-EXPOSOME: One Highly Sensitive and Autonomous Exposomic Platform with Enhanced in-Source Fragmentation/Annotation.

Assessing human internal exposure to chemicals at different physical activity levels: A physiologically based kinetic (PBK) model incorporating metabolic equivalent of task (MET).

Dataset on aquatic ecotoxicity predictions of 2697 chemicals, using three quantitative structure-activity relationship platforms.

More tools, reports, and resources

Commentaries

Redefining exposure science to advance research supporting cumulative impacts, environmental justice, and decision-making.

Adverse Effects of Micro- and Nanoplastics on Humans and the Environment.

Editorial trend: adverse outcome pathway (AOP) and computational strategy – towards new perspectives in ecotoxicology.

From Canaries to Cats: Domestic Animals as Sentinels for Human Exposure Effects.

Reviews

Numerous Chemicals/Mixtures

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The Role of Endocrine Disrupting Chemicals in Gestation and Pregnancy Outcomes.

Endocrine Disruptors and Thyroid Health.

Environmental factors and stroke: Risk and prevention.

Impacts of climate change on the fate of contaminants through extreme weather events.

PFAS

The Association of Hypertension with Perfluoroalkyl and Polyfluoroalkyl Substances.

Pesticides

Adult Organophosphate and Carbamate Insecticide Exposure and Sperm Concentration: A Systematic Review and Meta-Analysis of the Epidemiological Evidence. [see related Invited Perspective: Risk of Bias Assessments, Target Trials, and the Strengths of Environmental Epidemiology.]

Reproductive and developmental toxicity of plant growth regulators in humans and animals.

Pesticide Mediated Silent Neurotoxicity and Its Unmasking: An Update on Recent Progress.

Pyrethroids toxicity in vertebrates and invertebrates and amelioration by bioactive compounds: A review.

Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis.

Metals/Metalloids

Exposure to metal mixtures and adverse pregnancy and birth outcomes: A systematic review.

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure.

Arsenic pollution cycle, toxicity and sustainable remediation technologies: A comprehensive review and bibliometric analysis.

Association between maternal exposure to arsenic by drinking water during pregnancy and risk of preterm birth: a systematic review and meta-analysis.

A Comprehensive Review on Molecular Mechanism Involved in Arsenic Trioxide Mediated Cerebral Neurodegenerative and Infectious Diseases.

Microplastics/Nanomaterials

Are Microplastics a Macro Issue? A Review on the Sources of Contamination, Analytical Challenges and Impact on Human Health of Microplastics in Food.

Biodegradation of microplastics: Advancement in the strategic approaches towards prevention of its accumulation and harmful effects.

A bibliometric analysis of global research hotspots and progress on microplastics in soil‒plant systems.

Air Pollution

Effect of Air Pollution Particulate Matter on Ischemic and Hemorrhagic Stroke: A Scoping Review.

Pharmaceuticals/Personal Care Products

Systematic evidence mapping informs a class-based approach to assessing personal care products and pubertal timing.

Human Health Studies

Numerous Chemicals/Mixtures

Exposure to a Mixture of Endocrine-Disrupting Chemicals and Metabolic Outcomes in Belgian Adolescents.

Sex-specific association of exposure to a mixture of phenols, parabens, and phthalates with thyroid hormone and antibody levels in US adolescents and adults.

Neighborhood Environmental Burden and Cardiovascular Health in the US.

BPA/Phenols

Effects of prenatal single and mixed bisphenol exposure on bone mineral density in preschool children: A population-based prospective cohort study.

An Examination of the Relationship Between Exposure to Bisphenol A and Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Combined effects of organochlorine pesticides on type 2 diabetes mellitus: Insights from endocrine disrupting effects of hormones.

PFAS

Prenatal Exposure to PFAS, Associations with Preterm Birth and Modification by Maternal Estrogen Levels: The Maoming Birth Study.

Pesticides

Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients.

Analysis of mitochondrial DNA copy number variation in Brazilian farmers occupationally exposed to pesticides.

Metals/Metalloids

Associations of multiple plasma metals with osteoporosis: findings from the Dongfeng-Tongji cohort.

The Association among Urinary Lead and Cadmium, Serum Adiponectin, and Serum Apoptotic Microparticles in a Young Taiwanese Population.

Air Pollution

Associations of Exposure to Air Pollution during the Male Programming Window and Mini-Puberty with Anogenital Distance and Penile Width at Birth and at 1 Year of Age in the Multicenter U.S. TIDES Cohort.

Associations between exposure to air pollution and sex hormones during the menopausal transition.

Ultrafine particulate matter exposure during second year of life, but not before, associated with increased risk of autism spectrum disorder in BKMR mixtures model of multiple air pollutants.

Long-term exposure to air pollution and incidence of mental disorders. A large longitudinal cohort study of adults within an urban area.

Trends in global ambient fine particulate matter pollution and diabetes mortality rates attributable to it in the 1990-2019: 30 years systematic analysis of global burden of disease.

Contrasting Health Outcomes following a Severe Smoke Episode and Ambient Air Pollution in Early Life: Findings from an Australian Data Linkage Cohort Study of Hospital Utilization.

Laboratory Studies

BPA/Phenols

Bisphenol A and its analogue bisphenol S exposure reduce estradiol synthesis via the ROS-mediated PERK/ATF4 signaling pathway.

Teratogenic and neuro-behavioural toxic effects of bisphenol A (BPA) and B (BPB) on Xenopus laevis development

Bisphenol F and Bisphenol S exposure during development reduce neuronal ganglia integrity and change behavioral profile of Drosophila melanogaster larvae.

A missing jigsaw within the hygiene hypothesis: Low-dose bisphenol A exposure attenuates lipopolysaccharide-induced asthma protection.

Non-monotonic effects of Bisphenol A Dimethacrylate on male mouse reproductive system and fertility leads to impaired conceptive performance.

Phthalates

Diethyl phthalate, a plasticizer, induces adipocyte inflammation and apoptosis in mice after long-term dietary administration.

Mono-(2-ethylhexyl) phthalate (MEHP) reversibly disrupts the blood-testis barrier (BTB) in pubertal rats.

Urinary extracellular vesicles prevent di-(2-ethylhexyl) phthalate-induced hypospadias by facilitating epithelial-mesenchymal transition via PFN2 delivery.

Combined exposure to multiwalled carbon nanotubes and dibutyl phthalates aggravated airway inflammation in rats.

Mitigating effect of ferulic acid on di-(2-ethylhexyl) phthalate-induced neurocognitive dysfunction in male rats with a comprehensive in silico survey.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Environmental Toxicant Exposure Paralyzes Human Placental Macrophage Responses to Microbial Threat. [dioxin]

Resveratrol Attenuates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Induction of Myeloid-Derived Suppressor Cells (MDSC) and Their Functions.

PFAS

Evaluation of Neural Regulation and Microglial Responses to Brain Injury in Larval Zebrafish Exposed to Perfluorooctane Sulfonate. [see related Invited Perspective: PFAS Effects on Brain Development-Are Microglia the Missing Link?]

Differential Developmental Neurotoxicity and Tissue Uptake of the Per- and Polyfluoroalkyl Substance Alternatives, GenX and PFBS.

A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior.

Toxicities of Legacy and Current-Use PFAS in an Anuran: Do Larval Exposures Influence Responses to a Terrestrial Pathogen Challenge?

Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling.

Sodium p-perfluorous nonenoxybenzene sulfonate induces ROS-mediated necroptosis by directly targeting catalase in HepG2 cells.

Environment relevant exposure of perfluorooctanoic acid accelerates the growth of hepatocellular carcinoma cells through mammalian target of rapamycin (mTOR) signal pathway.

Flame Retardants

Toxicological Mechanisms and Potencies of Organophosphate Esters in KGN Human Ovarian Granulosa Cells as Revealed by High-throughput Transcriptomics.

Evidence for Adverse Effects on Liver Development and Regeneration in Zebrafish by Decabromodiphenyl Ethane.

The brominated flame retardant tetrabromobisphenol A-bis(2,3-dibromo-2-methylpropyl ether) as well as hexabromocyclododecane lead to lipid disorders in mice.

The bioaccumulation and biotransformation of tetrabromobisphenol A bis (allyl ether) in common carp (Cyprinus carpio).

Environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) induce hepatotoxicity in zebrafish (Danio rerio): a whole life-cycle assessment.

Study on the Biomolecular Competitive Mechanism of Polybrominated Diphenyl Ethers and Their Derivatives on Thyroid Hormones.

Pesticides

The role of fenugreek seed extract in alleviating pancreatic toxic effects and altering glucose homeostasis induced by acetamiprid via modulation of oxidative stress, apoptosis, and autophagy.

Locomotion behavior testing as a complementary tool in Collembola avoidance assays with neurotoxic insecticides.

Bifenthrin induces cell death in bovine mammary epithelial cells via ROS generation, calcium ion homeostasis disruption, and MAPK signaling cascade alteration.

Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazine.

‘Inert’ co-formulants of a fungicide mediate acute effects on honey bee learning performance.

Diuron-induced fetal Leydig cell dysfunction in in vitro organ cultured fetal testes.

Latent pesticide effects and their mechanisms.

Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment.

Metals/Metalloids

Cadmium exposure exacerbates kidney damage by inhibiting autophagy in diabetic rats.

Pancreatic Antioxidative Defense and Heat Shock Proteins Prevent Islet of Langerhans Cell Death After Chronic Oral Exposure to Cadmium LOAEL Dose.

Arsenic induces metabolome remodeling in mature human adipocytes.

Mechanisms underlying the combination effect of arsenite and high-fat diet on aggravating liver injury in mice.

Chronic arsenite exposure induced skeletal muscle atrophy by disrupting angiotensin II-melatonin axis in rats.

Microplastics/Nanomaterials

Combined exposure to polyvinyl chloride and polystyrene microplastics induces liver injury and perturbs gut microbial and serum metabolic homeostasis in mice.

Polyacrylonitrile microfibers pose a significant threat to the early-stage survival of zebrafish.

Non-negligible vector effect of micro(nano)plastics on tris(1,3-dichloro-2-propyl) phosphate in zebrafish quantified by toxicokinetic model.

Microplastics induced inflammation in the spleen of developmental Japanese quail (Coturnix japonica) via ROS-mediated p38 MAPK and TNF signaling pathway activation

Microplastics aggravate the bioaccumulation and corresponding food safety risk of antibiotics in edible bivalves by constraining detoxification-related processes.

Pharmaceuticals/Personal Care Products

Prenatal exposure to acetaminophen at different doses, courses and time causes testicular dysplasia in offspring mice and its mechanism.

Androgens exacerbate hepatic triglyceride accumulation in rats with polycystic ovary syndrome by downregulating MTTP expression. [flutamide]

Miscellaneous

Biological Responses of Pacific Herring Embryos to Crude Oil Are Quantifiable at Exposure Levels Below Conventional Limits of Quantitation for PAHs in Water and Tissues.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

A dataset of organic pollutants identified and quantified in recycled polyethylene pellets.

Plastic protective nets: A significant but neglected “reservoir” for priority chemicals as revealed by composition analysis.

Phthalates

HBM4EU e-waste study: Occupational exposure of electronic waste workers to phthalates and DINCH in Europe.

Status of phthalate esters pollution in facility agriculture across China: Spatial distribution, risk assessment, and remediation measures.

Emerging and legacy plasticisers in coastal and estuarine environments: A review.

Parabens/Triclosan/Antimicrobials

Parabens and their metabolite in a marine benthic-dominated food web from the Beibu gulf, South China Sea: Occurrence, trophic transfer and health risk assessment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Occurrence and diffusive air-seawater exchanges of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in Fildes Bay, King George Island, Antarctica.

PFAS

Trends in Serum Per- and Polyfluoroalkyl Substance (PFAS) Concentrations in Teenagers and Adults, 1999-2018 NHANES.

HBM4EU chromates study – PFAS exposure in electroplaters and bystanders.

Per- and poly-fluoroalkyl substances in commercial organic eggs via fishmeal in feed.

The perfluoroalkyl substances influenced the distribution of bacterial communities and their functions from source water to tap water.

Dispersion and stratification of per-and polyfluoroalkyl substances (PFAS) in surface and deep-water profiles: A case study of the Biscayne Bay area.

Hepatic concentrations of per- and polyfluoroalkyl substances (PFAS) in dolphins from south-east Australia: Highest reported globally.

Draft genome sequence of perfluorinated acids C₇-C₉ degrading bacterium Pseudomonas mosselii 5(3), isolated from soil contaminated with pesticides.

Flame Retardants

Exposure levels and determinants of placental polybrominated diphenyl ethers in Chinese pregnant women.

Organotins

Occurrence of organotin compounds in food: increasing challenge of phenyltin compounds.

Factors affecting the accumulation of organotins by wild fish: A case study in the Three Gorges Reservoir, China.

Pesticides

Higher serum concentrations of PFAS among pesticide exposed female greenhouse workers.

Characterization of Environmental Levels of Pesticide Residues in Household Air and Dust Samples near a Bioenergy Plant Using Treated Seed as Feedstock.

Metals/Metalloids

Metal levels in waste pickers in Brasilia, Brazil: hair and nail as exposure matrices.

Microplastics/Nanomaterials

Microplastics in marine mussels, biological effects and human risk of intake: A case study in a multi-stressor environment.

A characterization and an exposure risk assessment of microplastics in settled house floor dust in Istanbul, Turkey.

Identification and quantification of nanoplastics (20-1000 nm) in a drinking water treatment plant using AFM-IR and Pyr-GC/MS.

Fate and potential risks of microplastic fibers and fragments in water and wastewater treatment processes.

Characterising microplastics in indoor air: Insights from Raman imaging analysis of air filter samples.

Air Pollution

Firefighters’ personal exposure to gaseous PAHs during controlled forest fires: A case study with estimation of respiratory health risks and in vitro toxicity.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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