EDC Science Weekly, May 3-9, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: UK chemical regulation post-Brexit; the last paper by Ron Hites: A tale of four cities: PCBs in America; flame retardants in cars influenced by use in seat foam and temperature; PFAS blood-brain barrier transmission in humans.

More science highlights

Events

May 10 early-bird registration deadline for Skills for Health and Research Professionals (SHARP) Training summer sessions (Columbia University Mailman School of Public Health)

May 20 symposium: Brain and environment [Univ of Rochester/in Washington DC]

May 21 seminar: Silent Spring 2.0: Adverse impacts of neonicotinoid pesticides on human and wildlife health [CACHET and EHS/HEEDS. Virtual and in-person in Chicago. See the ChicAgo Center for Health and EnvironmentT (CACHET) website for additional seminars.]

May 20-21 Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Public Forum, plus a May 22 training session on NTP’s Integrated Chemical Environment.

May 29: Webinaire dédié au rassemblement de la communauté française sur les perturbateurs endocriniens [in French]

June 10-11 workshop: Complementary and integrative interventions to prevent and mitigate the effects of endocrine-disrupting chemicals [NCCIH]

June 10-12: National PFAS Conference in Ann Arbor, MI

June 18 webinar: Research needs for protecting human health and the environment – an EU agencies’ perspective [ECHA]

June 23-28: Gordon Research Conference on EDCs in Tuscany, Italy

Aug. 5-8: DOHaD summer course in Portland, OR [OHSU Center for Developmental Health]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

More events

Regulations/Policy

REACHing for divergence?-UK chemical regulation post-Brexit.

Assessing the impact of authorisation process as a regulatory tool in the European REACH regulation: A study on improving occupational safety for applying companies.

Safe and sustainable fish and seafood system and per- and poly-fluorinated substances occurrence: the role of PFAS toxicity in the assessment.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Probabilistic Reference and 10% Effect Concentrations for Characterizing Inhalation Non-cancer and Developmental/Reproductive Effects for 2,160 Substances.

Accessible methods and tools to estimate chemical exposure in humans to support risk assessment: a systematic scoping review.

Development of an Automated Morphometric Approach to Assess Vascular Outcomes following Exposure to Environmental Chemicals in Zebrafish.

Quantitative Read-Across Structure-Activity Relationship (q-RASAR): A novel approach to estimate the subchronic oral safety (NOAEL) of diverse organic chemicals in rats.

Recognizing High-Priority Disinfection Byproducts Based on Experimental and Predicted Endocrine Disrupting Data: Virtual Screening and in vitro Study.

Concept of a six-fold multiplex planar bioassay to distinguish endocrine agonist, antagonist, cytotoxic and false-positive responses.

Thresholds of adversity for endocrine disrupting substances: a conceptual case study.

The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors.

A Portable and Reusable Database Infrastructure for Mass Spectrometry, and Its Associated Toolkit (The DIMSpec Project).

Zooplankton-Based Adverse Outcome Pathways: A Tool for Assessing Endocrine Disrupting Compounds in Aquatic Environments.

Toward Nano- and Microplastic Sensors: Identification of Nano- and Microplastic Particles via Artificial Intelligence Combined with a Plasmonic Probe Functionalized with an Estrogen Receptor.

Commentaries

The Last Paper by Ron Hites. A Tale of Four Cities: Polychlorinated Biphenyls in America.

Are Cyclic Volatile Methylsiloxanes POPs? For Rigorous Science in Regulatory Decision Making.

Is the volume of pesticides consumed in agriculture a good indicator of environmental concerns?

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Cytosolic sulfotransferases in endocrine disruption.

Comprehensive review of emerging contaminants: Detection technologies, environmental impact, and management strategies.

Parabens/Triclosan/Antimicrobials

Critical review on the environmental behaviors and toxicity of triclosan and its removal technologies.

PFAS

Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps.

PFAS in Nigeria: Identifying data gaps that hinder assessments of ecotoxicological and human health impacts.

Pesticides

Pesticide exposure and increased breast cancer risk in women population studies.

The toxicity and health risk of chlorothalonil to non-target animals and humans: A systematic review.

Metals/Metalloids

Association between arsenic exposure and melanoma: a meta-analysis.

Microplastics/Nanomaterials

Microplastics in the environment: analytical chemistry methods, sorption materials, risks and sustainable solutions.

Effects of micro/nanoplastics on oxidative damage and serum biochemical parameters in rats and mice: a meta-analysis.

Freshwater plastisphere: a review on biodiversity, risks, and biodegradation potential with implications for the aquatic ecosystem health.

Micro- and nanoplastics in agricultural soils: Assessing impacts and navigating mitigation.

Exploring developmental toxicity of microplastics and nanoplastics (MNPS): Insights from investigations using zebrafish embryos.

A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review.

Toxicological review of micro- and nano-plastics in aquatic environments: Risks to ecosystems, food web dynamics and human health.

Pharmaceuticals/Personal Care Products

Exposure to UV-B filter octylmethoxycinnamate and human health effects: focus on endocrine disruptor actions.

Miscellaneous

Current global status of male reproductive health.

How to deal with xenobiotic compounds through environment friendly approach?

Human Health Studies

BPA/Phenols

Maternal concentrations of environmental phenols during early pregnancy and behavioral problems in children aged 4 years from the Shanghai Birth Cohort.

Phthalates

Urinary concentrations of phthalate metabolites in relation to preeclampsia and other hypertensive disorders of pregnancy in the environmental influences on child health outcomes (ECHO) program.

Cohort profile: the Environmental Reproductive and Glucose Outcomes (ERGO) Study (Boston, Massachusetts, USA) – a prospective pregnancy cohort study of the impacts of environmental exposures on parental cardiometabolic health.

PFAS

Per- and polyfluoroalkyl substances (PFAS) exposure in plasma and their blood-brain barrier transmission efficiency-A pilot study.

Prenatal exposure to per- and polyfluoroalkyl substances, fetal thyroid function, and intelligence quotient at 7 years of age: Findings from the Sheyang Mini Birth Cohort Study.

Associations between per- and polyfluoroalkyl chemicals and abdominal aortic calcification in middle-aged and older adults.

Flame Retardants

Associations between organophosphate esters and bone mineral density in adults in the United States: 2011-2018 NHANES.

Pesticides

Glyphosate presence in human sperm: First report and positive correlation with oxidative stress in an infertile French population.

Genetic variation and pesticide exposure influence blood DNA methylation signatures in females with early-stage Parkinson’s disease.

Environmental pesticide exposure and Alzheimer’s disease in southern Spain: A cross-sectional study.

Sex and adrenal hormones in association with insecticide biomarkers among adolescents living in ecuadorian agricultural communities.

Biomonitoring urinary pesticide metabolites in preschool children by supported liquid extraction and ultra-high performance liquid chromatography-tandem mass spectrometry and their association with oxidative stress.

County-Level Atrazine Use and Gastroschisis.

Exposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury.

Metals/Metalloids

Metal mixture exposures and serum lipid levels in childhood: the Rhea mother-child cohort in Greece.

Associations of Perinatal Metal and Metalloid Exposures with Early Child Behavioral Development Over Time in the New Hampshire Birth Cohort Study.

Association between urinary arsenic species and vitamin D deficiency: a cross-sectional study in Chinese pregnant women.

Modification Effects of Homologous Recombination Repair Gene Polymorphisms on the Associations Between Urinary Metals and Breast Cancer Risk.

Air Pollution

Positive association between blood ethylene oxide levels and metabolic syndrome: NHANES 2013-2020.

Insulin resistance and its relationship with long-term exposure to ozone: Data based on a national population cohort.

Laboratory Studies

Numerous Chemicals/Mixtures

Developmental and Biochemical Markers of the Impact of Pollutant Mixtures Under the Effect of Global Climate Change.

BPA/Phenols

Obesity aggravates neuroinflammatory and neurodegenerative effects of bisphenol A in female rats.

Genome-wide transcriptome analysis reveals that bisphenol A activates immune responses in skeletal muscle.

Bisphenol A and its structural analogues exhibit differential potential to induce mitochondrial dysfunction and apoptosis in human granulosa cells.

Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer’s-like neuropathology by restoring canonical Wnt signaling.

A combined in vitro-in silico method for assessing the androgenic activities of bisphenol A and its analogues.

Impact of bisphenol A and analogues eluted from resin-based dental materials on cellular and molecular processes: An insight on underlying toxicity mechanisms.

Bisphenol a (BPA) aggravate the adverse effect on physiological and biochemical response in freshwater mussel potomida littoralis.

Prenatal exposure to low-dose bisphenol A disrupts hippocampal DNA methylation and demethylation in male rat offspring.

Phthalates

Phthalate ester (PAEs) accumulation in wheat tissues and dynamic changes of rhizosphere microorganisms in the field with plastic-film residue

Parabens/Triclosan/Antimicrobials

Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4.

A study on assessing the toxic effects of ethyl paraben on rohu (Labeo rohita) using different biomarkers; hemato-biochemical assays, histology, oxidant and antioxidant activity and genotoxicity.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro.

Hydroxylated polychlorinated biphenyls may affect the thyroid hormone-induced brain development during metamorphosis of Xenopus laevis by disturbing the expression of matrix metalloproteinases.

p,p’-DDT induces apoptosis in human endometrial stromal cells via the PI3K/AKT pathway and oxidative stress.‘

Developmental toxicity and mechanism of polychlorinated biphenyls 126 and nano-polystyrene combined exposure to zebrafish larvae.

PFAS

Sub-acute exposure of male guppies (Poecilia reticulata) to environmentally relevant concentrations of PFOA and GenX induces significant changes in the testis transcriptome and reproductive traits.

Gradual effects of gradient concentrations of perfluorooctane sulfonate on the antioxidant ability and gut microbiota of red claw crayfish (Cherax quadricarinatus).

Does salinity mediate the toxicity of perfluorooctanesulfonic acid (PFOS) in an estuarine fish?

Interfacial effects of perfluorooctanoic acid and its alternative hexafluoropropylene oxide dimer acid with polystyrene nanoplastics on oxidative stress, histopathology and gut microbiota in Crassostrea hongkongensis oysters.

Flame Retardants

Mechanistic Insights into 1,2-bis(2,4,6-tribromophenoxy)ethane-Induced Male Reproductive Toxicity in Zebrafish.

Cuproptosis is involved in decabromodiphenyl ether-induced ovarian dysfunction and the protective effect of melatonin.

Developmental toxicity and potential mechanisms exposed to polystyrene microplastics and polybrominated diphenyl ethers during early life stages of fat greenling (Hexagrammos otakii).

Exposure to resorcinol bis (diphenyl phosphate) induces colonization of alien microorganisms with potential impacts on the gut microbiota and metabolic disruption in male zebrafish.

Pesticides

Neonicotinoids differentially modulate nicotinic acetylcholine receptors in immature and antral follicles in the mouse ovary

LRRK2 kinase inhibition protects against Parkinson’s disease-associated environmental toxicants. [rotenone, paraquat, TCE, PERC]

Methanolic Extract of Ricinus Communis ameliorated cardiovascular dysfunction in dichlorvos-exposed rats.

Pesticide-Induced Alterations in Locomotor Activity, Anxiety, and Depression-like Behavior Are Mediated through Oxidative Stress-Related Autophagy: A Persistent Developmental Study in Mice.

Combined effects of three insecticides with different modes of action on biochemical responses of the solitary bee Osmia bicornis.

Metals/Metalloids

Subacute cadmium exposure changes different metabolic functions, leading to type 1 and 2 diabetes mellitus features in female rats.

Chronic lead poisoning-induced budgerigar liver damage, gut microbiota dysbiosis, and metabolic disorder.

Tissue-, region-, and gene-specific induction of microsomal epoxide hydrolase expression and activity in the mouse intestine by arsenic in drinking water.

Plastics/Microplastics/Nanomaterials

Ecotoxicity assessment of additives in commercial biodegradable plastic products: Implications for sustainability and environmental risk.

Effects of micro- and nano-plastics on growth, antioxidant system, DMS, and DMSP production in Emiliania huxleyi.

Interactions between intestinal microbiota and metabolites in zebrafish larvae exposed to polystyrene nanoplastics: Implications for intestinal health and glycolipid metabolism.

Acceleration a Yeast-based Biodegradation Process of Polyethylene Terephthalate Microplastics by Tween 20: Efficiency, By-Product Analysis, and Metabolic Pathway Prediction.

Combined exposure of polystyrene microplastics and benzo[a]pyrene in rat: Study of the oxidative stress effects in the liver.

Down to Size: Exploring the Influence of Plastic Particle Dimensions on Physiological and Nervous Responses in Early-Stage Zebrafish.

Unravelling the microplastic menace: different polymers additively increase bee vulnerability.

Micro-and nano-plastics induce kidney damage and suppression of innate immune function in zebrafish (Danio rerio) larvae.

Nanoplastic contamination: Impact on zebrafish liver metabolism and implications for aquatic environmental health.

Selective bioaccumulation of polystyrene nanoplastics in fetal rat brain and damage to myelin development.

The Role of Gut Microbiota in Mediating Increased Toxicity of Nano-sized Polystyrene Compared to Micro-sized Polystyrene in Mice.

Pharmaceuticals/Personal Care Products

Computational study on the endocrine-disrupting metabolic activation of Benzophenone-3 catalyzed by Cytochrome P450 1A1: A QM/MM Approach.

Enhanced hepatotoxicity in zebrafish due to co-exposure of microplastics and sulfamethoxazole: Insights into ROS-mediated MAPK signaling pathway regulation.

Subchronic co-exposure of polystyrene nanoplastics and 3-BHA significantly aggravated the reproductive toxicity of ovaries and uterus in female mice.

Miscellaneous

Acute toxicity testing of 6PPD-quinone on the estuarine-dependent sport fish, Sciaenops ocellatus.

Environmental BaP/BPDE suppressed trophoblast cell invasion/migration and induced miscarriage by down-regulating lnc-HZ01/MEST/VIM axis.

Reproductive and endocrine-disrupting toxicity of Pyrogallol in catfish (Clarias gariepinus).

Microcystin-LR Induces Estrogenic Effects at Environmentally Relevant Concentration in Black-Spotted Pond Frogs (Pelophylax nigromaculatus): In Situ, In Vivo, In Vitro, and In Silico Investigations.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Cumulative Exposures to Environmental and Socioeconomic Risk Factors in Milwaukee County, Wisconsin.

BPA/Phenols

Environmental phenol exposures in 6- to 12-week-old infants: the Infant Feeding and Early Development (IFED) Study.

Phthalates

Phthalate alternatives and their monoesters in indoor dust from several regions, China and implications for human exposure.

Parabens/Triclosan/Antimicrobials

Monitoring human exposure to four parabens and triclosan: comparing silicone wristbands with spot urine samples as predictors of internal dose.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Presence of polycyclic aromatic hydrocarbons and persistent organochlorine pollutants in human Milk: Evaluating their levels, association with Total antioxidant capacity, and risk assessment.

Organochlorine pesticide contamination of soils and dust from an urban environment in the Niger Delta of Nigeria.

Tissue-Specific Distribution and Maternal Transfer of Persistent Organic Halogenated Pollutants in Frogs.

Monitoring of environmental persistent organic pollutants in hair samples of cats and dogs.

PFAS

Human biomonitoring follow-up study on PFOA contamination and investigation of possible influencing factors on PFOA exposure in a German population originally exposed to emissions from a fluoropolymer production plant.

Towards process-based modelling and parameterisation of bioaccumulation in humans across PFAS congeners.

Can on-site leachate treatment facilities effectively address the issue of perfluoroalkyl acids (PFAAs) in leachate?

Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment.

Total and Class-Specific Determination of Fluorinated Compounds in Consumer and Food Packaging Samples Using Fluorine-19 Solid-State Nuclear Magnetic Resonance Spectroscopy.

Flame Retardants

Flame Retardant Exposure in Vehicles Is Influenced by Use in Seat Foam and Temperature.

Biomarkers of Organophosphate and Polybrominated Diphenyl Ether (PBDE) Flame Retardants of American Workers and Associations with Inhalation and Dermal Exposures.

Pollution characteristics and risk assessment of organophosphate esters (OPEs) in typical industrial parks in Southwest China.

Pesticides

Determinants of urinary dialkyl phosphate metabolites in midlife women: the Study of Women’s Health Across the Nation Multi-Pollutant Study (SWAN-MPS).

Optimization of QuEChERS method for determination of pesticide residues in vegetables and health risk assessment.

Risk analysis for groundwater intakes based on the example of neonicotinoids.

Effects of common co-occurring pesticides (a neonicotinoid and fungicide) on honey bee colony health in a semi-field study.

Metals/Metalloids

Sources and human health risks associated with potentially toxic elements (PTEs) in urban dust: A global perspective.

Plastics/Microplastics/Nanomaterials

Ecotoxicological Assessment of Microplastics and Cellulose Particles in the Galápagos Islands and Galápagos Penguin Food Web.

Evidence of plastics contamination and sewage-derived residues in a Brazilian Hope Spot for conservation of marine biodiversity – Cagarras Islands and surrounding waters.

Mapping Plastic and Plastic Additive Cycles in Coastal Countries: A Norwegian Case Study.

Aerosolization of Micro- and Nanoplastics via Sea Spray: Investigating the Role of Polymer Type, Size, and Concentration, and Potential Implications for Human Exposure.

The application of PTR-MS and non-targeted analysis to characterize VOCs emitted from a plastic recycling facility fire.

Nanoplastics Detected in Commercial Sea Salt.

Source traceability of microplastics in road dust using organic/inorganic plastic additives as chemical indicators.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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