EDC Science Weekly, May 28 – June 3, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed two weeks ago. I’ll send these out intermittently as I catch up after vacation.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

An Environmental Health Behavior Change Tool for Pregnant Women and Parents.
Efficacy of an e-Learning Module on Endocrine Disruptors for Family Medicine Residents
Exploratory Study on Plasticiser Intake During Intermittent Fasting
Reduction in Circulating Microplastics in Humans Following Gastrointestinal Sequestration by Chitosan

Science summaries and highlights

Events

June 17 webinar: Plastics, Chemicals & Reproductive Health: Implications for a changing Arctic [CHE Alaska]

June 25 webinar: Reporting on Toxics & Health: Lessons from covering “forever chemicals” [CHE]

June 28 – July 3: New and emerging threats, approaches, and mitigation strategies for environmental endocrine disruptors [Gordon Research Conference] and accompanying Gordon Research Seminar June 27 – 28, Harnessing interdisciplinary evidence for endocrine disruption.

July 8-10: U.S. Developmental Origins of Health and Disease (DOHaD) annual meeting (Raleigh NC); Trainee day July 8.

Regulations/Policy

The PFAS roadmap-Navigating a path together to improved management.

Europe’s roadmap finally arrives: Long on rigor, short on a clock.

Global plastics treaty must be built on a foundation of monitoring.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

Sex-Associated Variables – A Framework for Neurotoxicology.

Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays.

Relevance and challenges of exposome studies for environmental health research.

Artificial Intelligence-Augmented Mixture Toxicology: Reframing Unresolved Risk at Camp Lejeune.

An integrated computational framework for hazard identification of emerging contaminants: a case study of 6PPD.

Commentaries

The IADR Policy and Position Statements on Safety of Dental Amalgam.

The Role of ES&T in Advancing Environmental Toxicology and Chemical Risk Assessment: Past, Present, and Future.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The Impact of Endocrine Disruptor Exposure During Pregnancy on Bacterial Complications and Viral Infections: A Narrative Review

Emerging Environmental Contaminants Targeting Cardiovascular Ion Channels: Exposure Effects, Underlying Mechanisms, and Implications for Cardiovascular Health Risks.

Mixture Effects of Metals, PCBs, Dioxins, and Furans on Liver Function.

A meta-analysis based on epidemiological studies to identify the key environmental pollutants inducing gestational diabetes mellitus.

Prenatal and postnatal exposure to endocrine-disrupting chemicals: Implications for extremely preterm infants, narrative review.

Environmental estrogens and animal reproductive health: mechanisms, biomarkers, and intervention approaches.

Environmental exposures and atopic dermatitis: an umbrella review of systematic reviews and meta-analyses.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations Between Neurological Diseases and Dioxin Exposure Originating from Agent Orange in Vietnam: A Narrative Review.

PFAS

Do Perfluorinated Chemicals Enhance the Toxicity of Other Contaminants in Aquatic Organisms? A Review.

Toxicological Effects and Health Impacts of Per- and Polyfluoroalkyl Substances (PFAS) in Humans.

Perfluoroalkyl and Polyfluoroalkyl Substances Exposure and Liver Disease: A Review.

PFAS exposure and reproductive dysfunction: implications for outcomes in assisted reproductive technologies.

Exposure to per- and polyfluoroalkyl substances and risk of reproductive system cancers: A systematic review and meta-analysis.

Pesticides

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies.

Protective Strategies Against Glyphosate and Glyphosate-Based Herbicide Toxicity: Mechanisms, Experimental Evidence, and Translational Limitations

Metals/Metalloids

In-Utero Exposure to Electronic Waste Heavy Metals and Adverse Pregnancy and Neonatal Outcomes: A Systematic Review

Trace Elements in the Pancreas: From Physiological Homeostasis to the Pathogenesis of Diabetes, Pancreatitis, and Cancer-A Review

Microplastics/Nanomaterials

Plastics in the Perioperative Period: Deleterious Health Effects on Patients and Providers.

Environmental Micro(nano)plastic Exposure and Associated Human Health Risks: A Comprehensive Review.

Toxic Substances in Plastics, Micro- and Nanoplastics: Utilizing ATSDR’s Plastics-Related Toxicological Profile Tool and Mixtures Framework for Human Health Risk Assessment.

Neurotoxic Effects of Nanoplastics: Current Evidence and Mechanistic Insights.

Microplastics in Female Reproductive and Pregnancy Organs: A Systematic Review

Micro- and nanoplastics in the human genitourinary system: oncological impact – a systematic review.

Micro and Nanoplastics and Obstetric Outcomes in Humans and Animals: A Systematic Review.

A Bibliometric Review and Knowledge Mapping of Microplastics and Nanoplastics in Cardiovascular Research.

Microplastics Release From Clear Aligners: A Scoping Review of Current Evidence, Health Implications, and Policy Directions.

Umbrella Review on Micro and Nanoplastics: Mapping the Scientific Landscape.

Miscellaneous

Polycyclic Aromatic Hydrocarbons Through the One Health Lens: Integrating Human, Animal, and Environmental Health Perspectives.

Environmental occurrence, exposure, toxicity, and transformation of benzothiazoles: A review.

Weight-of-evidence assessment of the endocrine-disrupting properties of propylene oxide. [industry article]

Human Health Studies

Numerous Chemicals/Mixtures

Chemical Exposure and Hepatic Steatosis: How Environmental Factors Impact Liver Health.

Associations of co-exposure to organophosphate flame retardants and pesticides with maternal thyroid function in early pregnancy: Findings from the Shanghai Birth Cohort.

Urinary concentration levels and health risk assessment of phthalates, parabens, benzophenone-3, bisphenols and triclosan in the adult population of Kinshasa: a cross-sectional study in Democratic Republic of Congo (DRC).

Bisphenols

Perinatal Exposure Profiles to Bisphenols and Their Associations With Thyroid Hormones Changes.

Urinary Bisphenol A Analogues and Metabolically Unhealthy Obesity in School-Age Children.

Associations between food contaminants exposure and pubertal development at 10 and 13 years old.

Phthalates

Exploratory Study on Plasticiser Intake During Intermittent Fasting: Effects on Weight, Glycaemic Control and Vitamin D Levels in Type 2 Diabetes.

From risk factors to molecular targets: clinical associations and molecular docking insights into phthalate-associated diabetic retinopathy.

Parabens/Triclosan/Antimicrobials

Exposure to Endocrine Disruptors and Stress Hormones Across Pregnancy Trimesters: Links with Maternal Telomere Length.

PFAS

Longitudinal trends of per- and polyfluoroalkyl substances in Chinese children from birth to 7 years of age.

Per- and polyfluoroalkyl substances are associated with gestational diabetes and perturb hepatic metabolic regulatory networks: Convergent epidemiological, computational, and experimental evidence.

Association between PFAS and renal function indicators in cord blood of newborns: modifying effects of newborn sex and maternal factors.

Associations of serum per- and polyfluoroalkyl substances (PFAS) mixture with the risk of chronic diseases: evidence from single‑ , multi-pollutant, and machine learning models.

Flame Retardants

The association between exposure to flame retardants and cognitive function in the elderly: Unveiling potential intervention strategies.

Dietary intake of polybrominated diphenyl ethers (PBDEs) and the risk of obesity in the French E3N cohort.

Pesticides

Prenatal Exposure to Neonicotinoid Insecticides and Neurological and Cognitive Development in Preschool Children: Evidence from a Birth Cohort in Guangxi, China.

Occupational pesticide exposure, hematological parameters, and cholinesterase and paraoxonase-1 activities among avocado farmworkers in Michoacán, Mexico.

Endocrine-disrupting pesticides and breast cancer incidence in the United States: an ecological analysis.

Urine glyphosate levels and kidney function outcomes in a cohort study of workers in El Salvador and Nicaragua.

Metals/Metalloids

Associations between urinary arsenic and vitamin D deficiency: a cross-sectional analysis of NHANES 2011-2018.

Microplastics/Nanomaterials

Reduction in Circulating Microplastics in Humans Following Gastrointestinal Sequestration by Chitosan: A Pilot Controlled Study.

Air Pollution

Prenatal exposure to ambient air pollution and the risk of type 1 diabetes in the offspring: a nationwide Danish study.

Childhood Outdoor Air Pollution Exposure Across Multiple Microenvironments and Metabolic Syndrome: A HELIX Cohort Analysis.

Inhibitory control mediates the association between perinatal PM2.5 exposure and childhood obesity in children in the PROGRESS cohort, Mexico City.

Laboratory Studies

Numerous Chemicals/Mixtures

Immunomodulatory effects of Bisphenol A, perfluorooctanoic acid, and tris(1,3-dichloro-2-propyl) phosphate on THP-1-derived macrophages.

Bisphenols

A network toxicology and molecular docking study predicting putative molecular targets and pathways linking bisphenol a exposure to diffuse large B-cell lymphoma.

Elucidating the molecular mechanisms linking bisphenol A to breast cancer: an integrated study of bioinformatics, machine learning, and molecular docking.

Protective Effects of Myrtus communis Essential Oil Against Bisphenol A-Induced Sperm Dysfunction: Insights from Lipidomic, Amino Acid Profiling, Oxidative Stress and Molecular Docking

Bisphenol BPAF and BPC are agonists for estrogen receptor ERα but antagonists for N-terminal domain-lacking ERα.

Transcriptomic analysis of mouse testes with disordered spermatogenesis induced by high-dose BPA exposure during puberty.

Hesperidin Mitigates Bisphenol-A Induced Oxidative Stress, Endocrine Disruption and Testicular Damage in Adult Male Wistar Rats.

Phthalates

Effects of phthalate metabolite mixture exposure on mouse oocyte development.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCBs exposure and renal injury: comprehensive assessment strategy based upon TRAEC strategy

PFAS

Assessment of the obesogenic properties of PFAS using an in vitro-based testing strategy.

Perfluorooctanesulfonic acid contributes to primary open-angle glaucoma in a FABP4-Dependent manner: a novel mechanism for environmental risk of glaucoma.

Multi-Omics Integrated Analysis Reveals Correlative Signatures of Short-Chain PFAS Mixtures on Mouse Midbrain Dopaminergic Neurons Involving the TM/5-HT Pathway

Transcriptome and Behavioral Assessment in Larval Zebrafish (Danio rerio) Following Exposure to Perfluorononanoic Acid (PFNA)

Hereditary PCOS and the environmental toxicant F-53B converge on lipid metabolic reprogramming to impair fetal brain development.

PFAS exposure modulates mitochondrial susceptibility in steatotic hepatocytes.

Perfluorooctanoic acid (PFOA) induces lipid accumulation, oxidative stress, and reduced neurogenesis in primary human neuronal progenitor cells.

Flame Retardants

Early-life triphenyl phosphate (TPhP) exposure impairs the zebrafish dopaminergic system and elevates parkinsonian-like neurotoxicity risk.

Effects and underlying mechanisms of tetrabromobisphenol A on glucose and lipid metabolism in goldfish.

Environmentally relevant concentrations of tris(2-chloroethyl) phosphate disrupt zebrafish hypothalamus-pituitary-gonad-liver axis and transgenerational reproduction.

Tris(1,3-dichloro-2-propyl) phosphate induces hepatic injury and lipid metabolic disturbance associated with ferroptosis: evidence from mice and human liver organoids.

Triphenyl phosphate promotes lipid accumulation in human mesenchymal stem cells through metabolic stress pathways.

TBBPA-Induced Insulin Reduction in Two Generations of Marine Medaka (Oryzias melastigma) with Calcium Signaling as a Key Event.

Pesticides

Insulin resistance induced by pesticides is overcome by pancreatic islet adaptation in a mouse model of Parkinson’s disease.

Maternal exposure to the thyroperoxidase-inhibiting pesticide amitrole induces hypothyroidism and developmental neurotoxicity in the rat brain.

Thirteen-week toxicity study in rats exposed to acetamiprid, glyphosate, tebuconazole and their mixture from prenatal life.

Effects of Glyphosate and Roundup® Herbicides on Cardiac and H9c2 Cells’ Mitochondrial Respiration and Oxidative Stress

Paternal fenvalerate exposure causes autism-like behavior partly by altering epigenetic reprogramming of the imprinted gene IGF2 in fetal brain and paternal sperm.

Sex-Specific sRNA Signatures in Rat Liver Reveal Divergent Alterations Following Perinatal Exposure to Glyphosate and Its Mixture with 2,4-D and Dicamba

Integrative network toxicology and multi-omics analyses reveal divergent molecular programs underlying pyrethroid-induced ovarian dysfunction.

Green Coffee Extract Mitigates Fipronil-Induced Endocrine Disruption, Metabolic Disturbances and Oxidative Stress in Male Albino Rats.

Metals/Metalloids

Real-Life Metal Cocktail Induced Pancreatic Alterations in Rats: Influence of Sex and Exposure Duration

Network toxicology and bioinformatics reveal potential molecular links between cadmium exposure and pancreatic cancer.

Do metals in tampons pose a health risk? A toxicological risk assessment study.

Chronic Arsenic Exposure Induced Reproductive Toxicity by Promoting Ferroptosis and the Protective Effects of Xylo-Oligosaccharides.

Microplastics/Nanomaterials

Exposure to Polystyrene Microplastics Disrupts Blood Cell Homeostasis and Metabolic Profiles in Pregnant Mice and Offspring: The Role of Oxidative Stress and Inflammation.

Effects of microplastic release from 3D-printed orthodontic aligners: a histological and immunological bioassay approach.

Early-Life Exposure to Phthalates and Nanoplastics Alters Gut Microbiota and Intestinal Morphophysiology in Rat Dams and Male Offspring.

Long-term exposure to polystyrene microplastics exacerbates seizure symptoms via lipid metabolic disruption and ferroptosis: insights from multi-omics analyses.

Miscellaneous

6PPDQ Exposure Exacerbates Seizure-Induced Neuronal Damage via the TP53/Nrf2 Axis: An Integrated Strategy Combining Network Toxicology and Experimental Validation.

Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21.

Anxiety-like behavior and social stress in adult zebrafish induced by 6PPD: insights from single-cell RNA sequencing.

Perinatal exposure to nonylphenol reprograms hepatic clock machinery and energy metabolism in rat offspring.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Teachable Moments: Development of an Environmental Health Behavior Change Tool for Pregnant Women and Parents.

Efficacy of an e-Learning Module on Endocrine Disruptors for Family Medicine Residents: Matched Before-And-After Cohort Study.

Bisphenols

Beyond Steady-State: An Integrated Framework Unveils BPAP as the Highest-Risk Bisphenol in a Dynamic River System.

PFAS

Comprehensive Per- and Polyfluorinated Substances Profiling in Beverages: Simultaneous Quantification of Ultrashort-Chain to Long-Chain Compounds in Ready-to-Drink Teas and Fruit Juices.

PFASs in China’s soils: Temporal declines in legacy compounds mask rising threats from substitutes

Flame Retardants

Vehicle Cabins as Hotspots of Brominated Flame Retardants: Legacy-Replacement Profiles, Sources, and Human Exposure in a Hot-Climate Environment.

Pesticides

Exposure to currently used pesticides in Belgian children: Urinary biomonitoring and risk assessment of frequently detected chlorpyrifos and pyrethroid metabolites.

Metals/Metalloids

National-scale prediction of arsenic, fluoride and its co-occurrence in groundwater of Mexico: Implications for drinking-water.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!