EDC Science Weekly, May 27 – June 2, 2020 – HEEDS

EDC Science Weekly, May 27 – June 2, 2020

Post author:HEEDS
Post published:June 2, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

Methods/Tools/Screening

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner.

Estrogenic activity of food contact materials-evaluation of 20 chemicals using a yeast estrogen screen on HPTLC or 96-well plates.

Systematic Analysis of Environmental Chemicals That Dysregulate Critical Period Plasticity-Related Gene Expression Reveals Common Pathways That Mimic Immune Response to Pathogen.

Application of Biomarker Tools using Bivalve Models Towards the Development of Adverse Outcome Pathways (AOPs) for Contaminants of Emerging Concern.

A generic PBTK model implemented in the MCRA platform: Predictive performance and uses in risk assessment of chemicals.

AOP4EUpest: Mapping of pesticides in Adverse Outcome Pathways using a text mining tool.

Discriminant models on mitochondrial toxicity improved by consensus modeling and resolving imbalance in training.

Integrating QSAR models predicting acute contact toxicity and mode of action profiling in honey bees (A. mellifera): Data curation using open source databases, performance testing and validation.

MixONat, a software for the dereplication of mixtures based on 13C NMR spectroscopy.

Reviews

Commentaries/Conference Summaries

Estimating Environmental Hazard and Risks from Exposure to Per- and Polyfluoroalkyl Substances (PFAS): Outcome of a SETAC Focused Topic Meeting.

Climate Change and Cancer

Leaving no one behind – understanding environmental inequality in Europe.

The Threat of Antibiotics and Heavy Metal Pollution to Human Health and Potential Solutions. [intro to a special issue in Biomed Res Int]

BPA/Phenols/Phthalates

Bisphenols and Oxidative Stress Biomarkers-Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers.

Plastics derived endocrine-disrupting compounds and their effects on early development.

Perfluoroalkyl Substances

Distribution and effects of branched versus linear isomers of PFOA, PFOS, and PFHxS: A review of recent literature.

Perfluoroalkyl substances cause Leydig cell dysfunction as endocrine disruptors.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary.

Flame Retardants

Exposure pathways, levels and toxicity of polybrominated diphenyl ethers in humans: A review.

Organotins

Autophagy in trimethyltin-induced neurodegeneration.

Pesticides

Pesticides used in Europe and autism spectrum disorder risk: can novel exposure hypotheses be formulated beyond organophosphates, organochlorines, pyrethroids and carbamates? – A systematic review.

Pesticide-Virus Interactions in Honey Bees: Challenges and Opportunities for Understanding Drivers of Bee Declines.

Potentially Toxic Elements

E-waste lead exposure and children’s health in China.

Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water.

The Effects of Cadmium Toxicity.

Microplastics

A review of microplastics pollution in the soil and terrestrial ecosystems: A global and Bangladesh perspective.

Interactions between microplastics and organic compounds in aquatic environments: A mini review.

Invertebrate responses to microplastic ingestion: Reviewing the role of the antioxidant system.

Synthetic microfibers: Pollution toxicity and remediation.

Air Pollution

Ambient air pollution and homocysteine: Current epidemiological evidence and a call for further research.

Effects of Home Particulate Air Filtration on Blood Pressure: A Systematic Review.

Mixtures

Adverse health effects for populations living near waste incinerators with special attention to hazardous waste incinerators. A review of the scientific literature.

Miscellaneous

A Scoping Review of Capacity-Building Efforts to Address Environmental Justice Concerns.

Environmental transformation of n-TiO2 in the aquatic systems and their ecotoxicity in bivalve mollusks: A systematic review.

Perspectives from the Society for Pediatric Research: contaminants of water and children’s health: Can we do better? [lead, perchlorate, arsenic, nitrates]

Human Health Studies

Phthalates/Phenols

Prenatal phthalate exposure, oxidative stress-related genetic vulnerability and early life neurodevelopment: a birth cohort study.

Thyroxine-binding globulin, peripheral deiodinase activity, and thyroid autoantibody status in association of phthalates and phenolic compounds with thyroid hormones in adult population.

Association of phthalates with nasal patency and small airway dysfunction in first-grade elementary schoolchildren.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prediagnostic serum polychlorinated biphenyl concentrations and primary liver cancer: A case-control study nested within two prospective cohorts.

Perfluoroalkyl Substances

Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns.

Associations of per- and polyfluoroalkyl substances (PFAS) with glucose tolerance during pregnancy in Project Viva.

Perfluoroalkyl substances exposure and hearing impairment in US adults.

Pesticides

Association between pyrethroid pesticide exposure and hearing loss in adolescents.

Health status among greenhouse workers exposed to different levels of pesticides: A genetic matching analysis.

Potentially Toxic Elements

Effect of low- and high-level groundwater arsenic on peripheral blood and lung function of exposed rural women.

Low level prenatal exposure to a mixture of Sr, Se and Mn and neurocognitive development of 2-year-old children.

Non-linear association of serum molybdenum and linear association of serum zinc with nonalcoholic fatty liver disease: Multiple-exposure and Mendelian randomization approach.

Potentially toxic metals and the risk to children’s health in a coal mining city: An investigation of soil and dust levels, bioaccessibility and blood lead levels.

Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome.

Air Pollution

Ambient particle radioactivity and gestational diabetes: A cohort study of more than 1 million pregnant women in Massachusetts, USA.

Assessment of Maternal Glycemia and Newborn Size Among Pregnant Women Who Use Wood Stoves in Northern New England.

An Itali an Network of Population-Based Birth Cohorts to Evaluate Social and Environmental Risk Factors on Pregnancy Outcomes: The LEAP Study.

Prenatal exposure to ambient air multi-pollutants significantly impairs intrauterine fetal development trajectory.

Correlation between environmental pollution indicators and COVID-19 pandemic: A brief study in Californian context.

Children’s microvascular traits and ambient air pollution exposure during pregnancy and early childhood: prospective evidence to elucidate the developmental origin of particle-induced disease.

Cancer mortality risk, fine particulate air pollution, and smoking in a large, representative cohort of US adults.

Fine-Scale Modeling of Individual Exposures to Ambient PM2.5, EC, NOx, CO for the Coronary Artery Disease and Environmental Exposure (CADEE) Study.

Prenatal particulate air pollution and newborn telomere length: Effect modification by maternal antioxidant intakes and infant sex.

Fine particulate matter exposure and renal function: A population-based study among pregnant women in China.

Association of internal exposure to polycyclic aromatic hydrocarbons with inflammation and oxidative stress in prediabetic and healthy individuals.

Ambient fine particulate matter pollution and years of life lost from cardiovascular diseases in 48 large Chinese cities: Association, effect modification, and additional life gain.

Mixtures

A spatial analysis of childhood cancer and industrial air pollution in a metropolitan area of Colombia.

Miscellaneous

Possible Effects of Perchlorate Contamination of Drinking Water on Thyroid Health.

Laboratory Studies

BPA/Phenols

Transcriptome analysis of the effect of bisphenol A exposure on the growth, photosynthetic activity and risk of microcystin-LR release by Microcystis aeruginosa.

Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice.

Oncogenic Potential of Bisphenol A and Common Environmental Contaminants in Human Mammary Epithelial Cells.

Estrogenic hazards of short chain phthalates and bisphenols found in cosmetic products.

Phthalates

DNA methylation of JAK3/STAT5/PPARγ regulated the changes of lipid levels induced by di (2-ethylhexyl) phthalate and high-fat diet in adolescent rats.

Long-Term Exposure to Low-Dose Di-(2-ethylhexyl) Phthalate Impairs Cholesterol Metabolism in Hepatic Stellate Cells and Exacerbates Liver Librosis.

Parabens/Triclosan/Antimicrobials

Butylparaben Is Toxic to Porcine Oocyte Maturation and Subsequent Embryonic Development Following In Vitro Fertilization.

In utero and lactational exposure to triclocarban: Age-associated changes in reproductive parameters of male rat offspring.

Parabens inhibit hNaV 1.2 channels.

Perfluoroalkyl Substances

Dietary administration of probiotic Lactobacillus rhamnosus modulates the neurological toxicities of perfluorobutanesulfonate in zebrafish.

Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish.

Parental exposure to perfluorobutane sulfonate disturbs the transfer of maternal transcripts and offspring embryonic development in zebrafish.

8:8 Perfluoroalkyl phosphinic acid affects neurobehavioral development, thyroid disruption, and DNA methylation in developing zebrafish.

In Vivo Generation of PFOA, PFOS, and Other Compounds from Cationic and Zwitterionic Per- and Polyfluoroalkyl Substances in a Terrestrial Invertebrate (Lumbricus terrestris).

Flame Retardants

Effects of triphenyl phosphate on ciliate protozoa Tetrahymena thermophila following acute exposure and sub-chronic exposure.

Insight into the transplacental transport mechanism of methoxylated polybrominated diphenyl ethers using a BeWo cell monolayer model.

Toxicity of tris(2-chloroethyl) phosphate in Daphnia magna after lifetime exposure: Changes in growth, reproduction, survival and gene transcription.

Organotins

Transcriptomic effects of tributyltin (TBT) in zebrafish eleutheroembryos. A functional benchmark dose analysis.

Pesticides

The use of non-targeted metabolomics to assess the toxicity of bifenthrin to juvenile Chinook salmon (Oncorhynchus tshawytscha).

Pyriproxyfen induced impairment of reproductive endocrine homeostasis and gonadal histopathology in zebrafish (Danio rerio) by altered expression of hypothalamus-pituitary-gonadal (HPG) axis genes.

Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio).

Reliability of behavioral test with fish: How neurotransmitters may exert neuromodulatory effects and alter the biological responses to neuroactive agents.

Exposure to low doses of malathion during juvenile and peripubertal periods impairs testicular and sperm parameters in rats: Role of oxidative stress and testosterone.

Potentially Toxic Elements

Single cell analysis of the gene expression effects of developmental lead (Pb) exposure on the mouse hippocampus.

Chronic arsenic exposure lowered sperm motility via impairing ultra-microstructure and key proteins expressions of sperm acrosome and flagellum formation during spermiogenesis in male mice.

Toxicological assessment of arsenic-containing phosphatidylcholines in HepG2 cells.

Curcumin alleviates arsenic-induced toxicity in PC12 cells via modulating autophagy/apoptosis.

Response Patterns of Biomarkers as Tools to Identify Toxic Effects of Cadmium and Lead on Bufo gargarizans Embryo.

MiADMSA ameliorate arsenic induced urinary bladder carcinogenesis in vivo and in vitro.

Determination of arsenicals in mouse tissues after simulated exposure to arsenic from rice for sixteen weeks and the effects on histopathological features.

Arsenic induced alteration in Mrp-1 like activity leads to zebrafish hepatocyte apoptosis: the cellular GSH connection.

Ecotoxicity of trace elements to chicken GALLUS gallus domesticus exposed to a gradient of polymetallic-polluted sites.

Microplastics

Immunotoxicity of polystyrene nanoplastics in different hemocyte subpopulations of Mytilus galloprovincialis.

Regulation of response to nanopolystyrene by intestinal microRNA mir-35 in nematode Caenorhabditis elegans.

Microplastics but not natural particles induce multigenerational effects in Daphnia magna.

Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models.

Exposure to microplastics impairs digestive performance, stimulates immune response and induces microbiota dysbiosis in the gut of juvenile guppy (Poecilia reticulata).

Ingestion and effects of polystyrene nanoparticles in the silkworm Bombyx mori.

Air Pollution

Effects of PM2.5 exposure in utero on heart injury, histone acetylation and GATA4 expression in offspring mice.

Systemic Exposure to Air Pollution Induces Oxidative Stress and Inflammation in Mouse Brain, Contributing to Neurodegeneration Onset.

Pharmaceuticals

Occurrences of benzalkonium chloride in streams near a pharmaceutical manufacturing complex in Korea and associated ecological risk.

Mixtures

Microplastics aggravate the adverse effects of BDE-47 on physiological and defense performance in mussels.

Synergistic and antagonistic interactions among organic and metallic components of the ambient particulate matter (PM) for the cytotoxicity measured by Chinese hamster ovary cells.

Calcium signaling as a possible mechanism behind increased locomotor response in zebrafish larvae exposed to a human relevant persistent organic pollutant mixture or PFOS.

Changes in thyroid hormone levels and related gene expressions in embryo-larval zebrafish exposed to binary combinations of bifenthrin and acetochlor.

Evidence-based assessment on environmental mixture using a concentration-dependent transcriptomics approach.

Numerous Chemicals

Identifying adipogenic chemicals: Disparate effects in 3 T3-L1, OP9 and primary mesenchymal multipotent cell models.

Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function.

Miscellaneous

Environmentally relevant concentrations of geosmin affect the development, oxidative stress, apoptosis and endocrine disruption of embryo-larval zebrafish.

Exposure/Environment Studies

BPA/Phenols

Nationwide distribution and potential risk of bisphenol analogues in Indian waters.

Thermal degradation of bisphenol A and bisphenol S in water and fish (cod and basa) fillets.

Occurrence and distribution of hormones and bisphenol A in Laguna Lake, Philippines.

Phthalates

Risk assessment of unintentional phthalates contaminants in cosmetics.

Parabens/Triclosan/Antimicrobials

Hair care products used by women of African descent: review of ingredients.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Toxicogenomic Assessment of Complex Chemical Signatures in Double-Crested Cormorant Embryos from Variably Contaminated Great Lakes Sites. [PCBs and PBDEs]

Brown bullhead at the St. Lawrence River (Cornwall) Area of Concern: health and endocrine status in the context of tissue concentrations of PCBs and mercury.

Legacy persistent organic pollutants (POPs) in archive samples of wild Bluefin tuna from the Mediterranean Sea.

Occurrence of Halogenated Pollutants in Domestic and Occupational Indoor Dust. [PCBs, PFASs, flame retardants, etc.]

Estimated PCDD/F TEQ and total TEQ concentrations in the serum of 7-10 year old Finnish children.

Perfluoroalkyl Substances

Identifying risk factors for levels of per- and polyfluoroalkyl substances (PFAS) in the placenta in a high-risk pregnancy cohort in North Carolina.

Prevalence of per- and polyfluoroalkyl substances (PFASs) in drinking and source water from two Asian countries.

Long-term investigation on the removal of perfluoroalkyl substances in a full-scale drinking water treatment plant in the Veneto Region, Italy.

PFAS in Food Packaging: A Hot, Greasy Exposure.

The Effects of Soil Organic Carbon Content on Plant Uptake of Soil PFAAs and its Potential Regulatory Implications.

Multi-year atmospheric concentrations of per- and polyfluoroalkyl substances (PFASs) at a background site in central Europe.

Per- and polyfluoroalkyl substances (PFASs) in blood of captive Siberian tigers in China: Occurrence and associations with biochemical parameters.

Flame Retardants

Organic contaminants formed during fire extinguishing using different firefighting methods assessed by nontarget analysis.

Fate and migration of polybrominated diphenyl ethers in a workshop for waste printed circuit board de-soldering.

The influence of an upgrade on the reduction of organophosphate flame retardants in a wastewater treatment plant.

Occurrence and air-soil exchange of organophosphate flame retardants in the air and soil of Dalian, China.

Polybrominated Diphenyl Ether and Organophosphate Flame Retardants in Canadian Fire Station Dust.

Contamination Level, Distribution Characteristics, and Ecotoxicity of Tetrabromobisphenol A in Water and Sediment from Weihe River Basin, China.

Pesticides

Inclusion of seasonal variation in river system microbial communities and phototroph activity increases environmental relevance of laboratory chemical persistence tests.

Presence and Health Risks of Obsolete and Emerging Pesticides in Paddy Rice and Soil from Thailand and China.

Review of pesticide residue analysis in fruits and vegetables. Pre-treatment, extraction and detection techniques.

Potentially Toxic Elements

Association between genetic variations in GSH-related and MT genes and low-dose methylmercury exposure in children and women of childbearing age: a pilot study.

Children exposure to inorganic and organic arsenic metabolites: A cohort study in Northeast Italy.

Mercury Exposure Assessment in Mother-Infant Pairs from Continental and Coastal Croatia.

Compound health risk assessment of cumulative heavy metal exposure: a case study of a village near a battery factory in Henan Province, China.

Exposure to total and methylmercury among pregnant women in Suriname: sources and public health implications.

A population-based mercury exposure assessment near an artisanal and small-scale gold mining site in the Peruvian Amazon.

Impacts of the Samarco tailing dam collapse on metals and arsenic concentration in freshwater fish muscle from Doce River, southeastern Brazil.

Is arsenic responsible for the toxicity of the hyperaccumulating mushroom Sarcosphaera coronaria?

Mercury and arsenic in processed fins from nine of the most traded shark species in the Hong Kong and China dried seafood markets: The potential health risks of shark fin soup.

Hydrogeochemical investigation of arsenic in drinking water of schools and age dependent risk assessment in Vehari District, Punjab Pakistan: a multivariate analysis.

Microplastics

Microplastics from consumer plastic food containers: Are we consuming it?

Micro- and nano-plastics in edible fruit and vegetables. The first diet risks assessment for the general population.

Storm events as key moments of microplastic contamination in aquatic ecosystems.

Microplastic pollution in surface water from east coastal areas of Guangdong, South China and preliminary study on microplastics biomonitoring using two marine fish.

Air Pollution

Carcinogenic organic content of particulate matter at urban locations with different pollution sources.

Increased ozone levels during the COVID-19 lockdown: Analysis for the city of Rio de Janeiro, Brazil.

Miscellaneous

Improved comprehensive ecological risk assessment method and sensitivity analysis of polycyclic aromatic hydrocarbons (PAHs).

Evaluating the potential role of bioactive chemicals on the distribution of invasive Asian carp upstream and downstream from river mile 278 in the Illinois waterway.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.