EDC Science Weekly, May 26 – June 1, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Today, June 1, 5:30pm Eastern The Training Committee of ICEDA will broadcast live the first episode of their “DisruPtED” podcast [Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA)]

Webinar June 15: Exposure to Per- and Polyfluoroalkyl Substances and Markers of Liver Injury (EDC Strategies Partnership)

Regulations/Policy

Failure to Launch: The Endocrine Disruptor Screening Program at the U.S. Environmental Protection Agency

Cereal and Juice, Lead and Arsenic, Our Children at Risk: A Call for the FDA to Re-Evaluate the Allowable Limits of Lead and Arsenic That Children May Ingest

IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making.

Risk Assessment of Food Contact Materials II.

Methods/Tools/Screening

Assessment of endocrine disruptive properties of PFOS: EFSA/ECHA guidance case study utilising AOP networks and alternative methods.

MRA Toolbox v. 1.0: a web-based toolbox for predicting mixture toxicity of chemical substances in chemical products.

Semiparametric distributed lag quantile regression for modeling time-dependent exposure mixtures.

An improved in vitro model simulating the feto-maternal interface to study developmental effects of potentially toxic compounds: The example of titanium dioxide nanoparticles.

Pesticide Informatics Platform (PIP): An International Platform for Pesticide Discovery, Residue, and Risk Evaluation.

Quantitative chemical risk assessment for mixtures: Application to alkylphenol mixtures and phthalate mixtures in tap and bottled water.

Trophoblast Organoids: A New Tool for Studying Placental Development.

Commentaries

Invited Perspective: Eliminating Toxics to Prevent Disease: Asbestos Leads the Way.

Behavioral Impairment in Aquatic Organisms Exposed to Neurotoxic Pollutants.

Reviews

Numerous Chemicals/Mixtures

Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System.

Obesogens in Foods.

Chemical food safety hazards in circular food systems: a review.

Oxidative Stress and Toxicity in Reproductive Biology and Medicine: Historical Perspectives and Future Horizons in Male Fertility.

Phthalates

Effects of Phthalate Mixtures on Ovarian Folliculogenesis and Steroidogenesis.

Maternal phthalate exposure during pregnancy and male reproductive disorders: a systematic review and metaanalysis.

Perfluoroalkyl Substances

Historical and current usage of per- and polyfluoroalkyl substances (PFAS): A literature review.

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms.

Flame Retardants

Sources, behaviors, transformations, and environmental risks of organophosphate esters in the coastal environment: A review.

Pesticides

Pesticide Exposure and Risk of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Potentially Toxic Elements

The concentration and health risk of potentially toxic elements (PTEs) in the breast milk of mothers: a systematic review and meta-analysis.

Arsenic Exposure through Dietary Intake and Associated Health Hazards in the Middle East.

Microplastics/Nanomaterials

Nanoplastics: Status and Knowledge Gaps in the Finalization of Environmental Risk Assessments.

Microplastics in environment: global concern, challenges, and controlling measures.

Air Pollution

Association of DNA methylation in circulating CD4⁺T cells with short-term PM_2.5 pollution waves: A quasi-experimental study of healthy young adults.

Miscellaneous

Toxicological Effects of Technical Xylene Mixtures on the Female Reproductive System: A Systematic Review.

Human Health Studies

BPA/Phenols

Association between dietary exposure to bisphenols and body mass index in Spanish schoolchildren.

Phthalates

Relationships among phthalate exposure, oxidative stress, and insulin resistance in young military soldiers: A cumulative risk assessment and mediation approach.

Parabens/Triclosan/Antimicrobials

Urinary paraben derivatives in pregnant women at three trimesters: Variability, predictors, and association with oxidative stress biomarkers.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Perinatal Dioxin Exposure and Attention Deficit Hyperactivity Disorder (ADHD) Symptoms in Children Living in a Dioxin Contamination Hotspot in Vietnam.

An Interactive Online App for Predicting Diabetes via Machine Learning from Environment-Polluting Chemical Exposure Data.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances (PFAS) exposure in women seeking in vitro fertilization-embryo transfer treatment (IVF-ET) in China: Blood-follicular transfer and associations with IVF-ET outcomes.

Flame Retardants

Associations between prenatal exposure to polybrominated diphenyl ethers and physical growth in a seven year cohort study.

Pesticides

Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort.

Prenatal organophosphorus pesticide exposure and executive function in preschool-aged children in the Norwegian Mother, Father and Child Cohort Study (MoBa).

Urinary 3-phenoxybenzoic acid (3-PBA) levels and changes in hematological parameters in Korean adult population: A Korean National Environmental Health Survey (KoNEHS) 2012-2014 analysis.

Potentially Toxic Elements

Applying Machine Learning to Arsenic Species and Metallomics Profiles of Toenails to Evaluate Associations of Environmental Arsenic with Incident Cancer Cases.

Mercury in the brain (tumor tissues) and in markers (hair and blood) of exposure in Western Amazonia patients.

Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study.

Association between prenatal cadmium exposure and child development: The Japan Environment and Children’s study.

Air Pollution

Combined toxicity of air pollutants related to e-waste on inflammatory cytokines linked with neurotransmitters and pediatric behavioral problems.

Pharmaceuticals/Personal Care Products

Antibiotic exposure and risk of overweight/obesity in school children: A multicenter, case-control study from China.

Miscellaneous

Environmental Health Needs Among Latinas in Cleaning Occupations: A Mixed Methods Approach.

Laboratory Studies

Numerous Chemicals/Mixtures

Enhanced Toxicity of Bisphenols Together with UV Filters in Water: Identification of Synergy and Antagonism in Three-Component Mixtures.

Toxic Exposure to Endocrine Disruptors Worsens Parkinson’s Disease Progression through NRF2/HO-1 Alteration.

The toxic effects of combined exposure of chlorpyrifos and p, p’-DDE to zebrafish (Danio rerio) and tissue bioaccumulation.

Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results.

Chemical Mixtures in Household Environments: In Silico Predictions and In Vitro Testing of Potential Joint Action on PPARγ in Human Liver Cells.

In Vivo Estimation of the Biological Effects of Endocrine Disruptors in Rabbits after Combined and Long-Term Exposure: Study Protocol.

Acute and Chronic Toxicity of Binary Mixtures of Bisphenol A and Heavy Metals.

Application of cross-validation strategies to avoid overestimation of performance of 2D-QSAR models for the prediction of aquatic toxicity of chemical mixtures.

Synergistic Activity of Ketoconazole and Miconazole with Prochloraz in Inducing Oxidative Stress, GSH Depletion, Mitochondrial Dysfunction, and Apoptosis in Mouse Sertoli TM4 Cells

BPA/Phenols

Bisphenol-A Mediated Impaired DRP1-GFER Axis and Cognition Restored by PGC-1α Upregulation Through Nicotinamide in the Rat Brain Hippocampus.

Bisphenol F Impaired Zebrafish Cognitive Ability through Inducing Neural Cell Heterogeneous Responses.

Bisphenol A aggravates renal apoptosis and necroptosis in selenium-deficient chickens via oxidative stress and PI3K/AKT pathway.

Repercussions of Bisphenol A on the Physiology of Human Osteoblasts.

Impact of Environmentally Relevant Concentrations of Bisphenol A (BPA) on the Gene Expression Profile in an In Vitro Model of the Normal Human Ovary.

Endocrine Disruptor Bisphenol a Affects the Neurochemical Profile of Nerve Fibers in the Aortic Arch Wall in the Domestic Pig.

Bisphenol A Coupled with a High-Fat Diet Promotes Hepatosteatosis through Reactive-Oxygen-Species-Induced CD36 Overexpression.

Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation.

Investigation of long-term bisphenol A exposure on rainbow trout (Oncorhynchus mykiss): Hematological parameters, biochemical indicator, antioxidant activity, and histopathological examination.

Cytotoxicity, redox and immune status in African catfish, Clarias gariepinus (Burchell, 1822) exposed to bisphenol A (BPA) and its analogues.

Last piece in the puzzle of bisphenols BPA, BPS and BPF metabolism: Kinetics of the in vitro sulfation reaction.

[Effect of electroacupuncture on mood and estrogen receptor α expression in mice with polycystic ovary syndrome induced by bisphenol A exposure]. [Chinese]

Phthalates

Insights into the Endocrine Disrupting Activity of Emerging Non-Phthalate Alternate Plasticizers against Thyroid Hormone Receptor: A Structural Perspective.

Parabens/Triclosan/Antimicrobials

Triclosan-induced neuroinflammation develops caspase-independent and TNF-α signaling pathway associated necroptosis in Neuro-2a cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Transcriptome sequencing of 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)-treated human preadipocytes demonstrates progressive changes in pathways associated with inflammation and diabetes.

Mechanisms of Suppression of Epinephrine Production in Rats by Low-Dose Developmental Exposure to DDT.

Comparative Toxicotranscriptomics of Single Cell RNA-Seq and Conventional RNA-Seq in TCDD-Exposed Testicular Tissue.

Perfluoroalkyl Substances

Perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) modify in vitro mitogen- and antigen-induced human peripheral blood mononuclear cell (PBMC) responses.

Nephrotoxicity of perfluorooctane sulfonate (PFOS)-effect on transcription and epigenetic factors

Flame Retardants

Individual and Combined Effects of Paternal Deprivation and Developmental Exposure to Firemaster 550 on Socio-Emotional Behavior in Prairie Voles.

Transcriptomic profiling and differential analysis revealed the neurodevelopmental toxicity and mechanisms of zebrafish (Danio rerio) larvae in response to tetrabromobisphenol A bis(2-hydroxyethyl) ether (TBBPA-DHEE) exposure.

Thyroid-disrupting effects caused by exposure to alternative flame retardants from groundwater contamination in rural central China.

Organotins

Tributyltin chloride exposure to post-ejaculatory sperm reduces motility, mitochondrial function and subsequent embryo development.

Pesticides

Low level of mancozeb exposure affects ovary in mice.

Does Glyphosate Affect the Human Microbiota?

Lifelong Exposure to a Low-Dose of the Glyphosate-Based Herbicide RoundUp^® Causes Intestinal Damage, Gut Dysbiosis, and Behavioral Changes in Mice.

Anxiety and Gene Expression Enhancement in Mice Exposed to Glyphosate-Based Herbicide.

Enantioselective bioaccumulation, oxidative stress, and thyroid disruption assessment of cis-metconazole enantiomers in zebrafish (Danio rerio).

Potentially Toxic Elements

Exposure to Cadmium Alters the Population of Glial Cell Types and Disrupts the Regulatory Mechanisms of the HPG Axis in Prepubertal Female Rats.

Microplastics/Nanomaterials

Intergenerational and biological effects of roxithromycin and polystyrene microplastics to Daphnia magna.

Cytotoxicity of nanomixture: Combined action of silver and plastic nanoparticles on immortalized human lymphocytes.

Air Pollution

Prenatal exposure to a mixture of PAHs causes the dysfunction of islet cells in adult male mice: Association with type 1 diabetes mellitus.

Filtered air intervention modulates hypothalamic-pituitary-thyroid/gonadal axes by attenuating inflammatory responses in adult rats after fine particulate matter (PM2.5) exposure.

Ambient fine particulate matter exposure disrupts placental autophagy and fetal development in gestational mice.

Pharmaceuticals/Personal Care Products

Waterborne exposure to avobenzone and octinoxate induces thyroid endocrine disruption in wild-type and thrαa^-/- zebrafish larvae.

Effects of dietary 2-(2H-benzotriazol-2-yl)-4-methylphenol (UV-P) exposure on Japanese medaka (Oryzias latipes) in a short-term reproduction assay.

Miscellaneous

1-Nitropyrene disrupts testosterone biogenesis via AKAP1 degradation promoted mitochondrial fission in mouse Leydig cell.

Short-Term Exposure Effects of the Environmental Endocrine Disruptor Benzo(a)Pyrene on Thyroid Axis Function in Zebrafish.

UV-B Filter Octylmethoxycinnamate Is a Modulator of the Serotonin and Histamine Receptors in Human Umbilical Arteries

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Chemical Mixtures in the EU Population: Composition and Potential Risks.

Occurrence, exposure and risk assessment of semi-volatile organic compounds in Chinese homes.

Proportional contributions to organic chemical mixture effects in groundwater and surface water.

BPA/Phenols

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe.

Phthalates

Cumulative risk assessment of dietary exposure to phthalates in pregnant women in Beijing, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Applying the Global Monitoring Plan and analysis of POPs results in atmospheric air in Mexico (2017-2018).

Perfluoroalkyl Substances

Environmental Fate of Cl-PFPECAs: Predicting the Formation of PFAS Transformation Products in New Jersey Soils.

Application of soil amendments for reducing PFAS leachability and bioavailability.

Flame Retardants

Risk Assessment of Dietary Exposure to Organophosphorus Flame Retardants in Children by Using HBM-Data.

Pesticides

Harmonized Quality Assurance/Quality Control Provisions for Nontargeted Measurement of Urinary Pesticide Biomarkers in the HBM4EU Multisite SPECIMEn Study.

Microplastics/Nanomaterials

Polymers of micro(nano) plastic in household tap water of the Barcelona Metropolitan Area.

High abundance of microplastics in groundwater in Jiaodong Peninsula, China.

Pharmaceuticals/Personal Care Products

Bioaccumulation and bioamplification of pharmaceuticals and endocrine disruptors in aquatic insects.

Long-Term Calculation of Predicted Environmental Concentrations to Assess the Risk of Anticancer Drugs in Environmental Waters.

Environmental Occurrence and Predicted Pharmacological Risk to Freshwater Fish of over 200 Neuroactive Pharmaceuticals in Widespread Use.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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