EDC Science Weekly, Mar. 3 – 9, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Methods/Tools/Screening

Utilization of a NIST SRM: a case study for per- and polyfluoroalkyl substances in NIST SRM 1957 organic contaminants in non-fortified human serum.

Expanded high-throughput screening and chemotype-enrichment analysis of the phase II: e1k ToxCast library for human sodium-iodide symporter (NIS) inhibition.

Next generation risk assessment of human exposure to anti-androgens using newly defined comparator compound values.

Creating a human-induced pluripotent stem cell-based NKX2.5 reporter gene assay for developmental toxicity testing.

Human iPSC-Derived 2D and 3D Platforms for Rapidly Assessing Developmental, Functional, and Terminal Toxicities in Neural Cells.

Commentaries/Conference Summaries

Metabolically healthy obese vs. Metabolic syndrome – The crosslink between nutritional exposure to bisphenols and physical exercise.

The role of validation in establishing the scientific credibility of predictive toxicology approaches intended for regulatory application.

Reviews

Numerous EDCs

Breast and prostate glands affected by environmental substances (Review).

The effects of endocrine disruptors on the male germline: an intergenerational health risk.

Neurotoxicity in Marine Invertebrates: An Update.

Organic contaminants in Ganga basin: from the Green Revolution to the emerging concerns of modern India.

Heavy Metals and Pesticides Toxicity in Agricultural Soil and Plants: Ecological Risks and Human Health Implications.

Mixtures

Impact of endocrine-disrupting chemicals on steroidogenesis and consequences on testicular function.

Hallmarks of environmental insults.

BPA/Phenols

A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence.

Phthalates

Association between prenatal phthalate exposure and gestational metabolic syndrome parameters: a systematic review of epidemiological studies.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Ecotoxicology of persistent organic pollutants in birds.

Environmental characteristics and formations of polybrominated dibenzo-p-dioxins and dibenzofurans.

Perfluoroalkyl Substances

Endocrine Disruptor Potential of Short- and Long-Chain Perfluoroalkyl Substances (PFASs)-A Synthesis of Current Knowledge with Proposal of Molecular Mechanism.

Per- and polyfluoroalkyl substances and their alternatives in paper food packaging.

Flame Retardants

40 Years of Research on Polybrominated Diphenyl Ethers (PBDEs)-A Historical Overview and Newest Data of a Promising Anticancer Drug

Pesticides

Signs of carcinogenicity induced by parathion, malathion, and estrogen in human breast epithelial cells (Review).

Newer characters, same story: neonicotinoid insecticides disrupt food webs through direct and indirect effects.

Toxicity and detoxification of monocrotophos from ecosystem using different approaches: A review.

Review on Sublethal Effects of Environmental Contaminants in Honey Bees (Apis mellifera), Knowledge Gaps and Future Perspectives.

Assessment of Glyphosate Impact on the Agrofood Ecosystem.

Potentially Toxic Elements

The association between maternal cadmium exposure and small for gestational age: a systematic review and meta-analysis.

Low-level metal contamination and chelation in cardiovascular disease – a ripe area for toxicology research.

Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review

Microplastics/Nanomaterials

Impact of Microplastics and Nanoplastics on Human Health.

Effect of microplastics in water and aquatic systems.

A One Health perspective of the impacts of microplastics on animal, human and environmental health.

Does microplastic really represent a threat? A review of the atmospheric contamination sources and potential impacts.

Microplastics in the Marine Environment: Sources, Fates, Impacts and Microbial Degradation.

Organic Contaminants and Interactions with Micro- and Nano-Plastics in the Aqueous Environment: Review of Analytical Methods.

Nanoparticles in the Food Industry and Their Impact on Human Gut Microbiome and Diseases.

Microplastic fibers – Underestimated threat to aquatic organisms?

Air Pollution

Air pollution exposure-the (in)visible risk factor for respiratory diseases.

Environmental Determinants of Coronavirus Disease 2019 (COVID-19).

Exposure to Atmospheric Particulate Matter-Bound Polycyclic Aromatic Hydrocarbons and Their Health Effects: A Review.

Air Pollution Health Risk Assessment (AP-HRA), Principles and Applications

Air pollution and pregnancy outcomes based on exposure evaluation using a land use regression model: A systematic review

Pharmaceuticals/Personal Care Products

Antidepressants’ effects on testosterone and estrogens: what do we know?

Occurrence, sources and fate of pharmaceuticals and personal care products and artificial sweeteners in groundwater.

A systematic review of antibiotics and antibiotic resistance genes in estuarine and coastal environments.

Miscellaneous

Understanding the Link Between Allergy and Neurodevelopmental Disorders: A Current Review of Factors and Mechanisms.

The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens.

Narrative review of citizen science in environmental epidemiology: Setting the stage for co-created research projects in environmental epidemiology.

Perinatal and Early-Life Nutrition, Epigenetics, and Allergy.

Immunological Responses of Marine Bivalves to Contaminant Exposure: Contribution of the -Omics Approach.

Human Health Studies

Numerous Chemicals

Organophosphate Flame Retardants, Highly Fluorinated Chemicals, and Biomarkers of Placental Development and Disease during Mid-Gestation.

Prenatal Exposure to Mixtures of Phthalates, Parabens, and Other Phenols and Obesity in Five-Year-Olds in the CHAMACOS Cohort.

Comparison of the Effect on Fetal Growth of a Mixture of Atrazine and Nitrates in Drinking Water and of Active Tobacco Exposure during Pregnancy.

BPA

Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men.

Phthalates

Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses.

Association between Phthalate Exposure and Frailty among Community-Dwelling Older Adults: A Repeated Panel Data Study

Association between Urinary Phthalate Metabolite Concentration and Atopic Dermatitis in Korean Adolescents Participating in the Third Korean National Environmental Health Survey, 2015-2017

Associations of Prenatal Exposure to Phthalates with Measures of Cognition in 4.5-Month-Old Infants

Trimester-specific and sex-specific effects of prenatal exposure to di(2-ethylhexyl) phthalate on fetal growth, birth size, and early-childhood growth: A longitudinal prospective cohort study.

Inverse association of certain seminal phthalate metabolites with semen quality may be mediated by androgen synthesis: A cross-sectional study from the South China.

Parabens/Triclosan/Antimicrobials

Effect of triclosan on the pathogenesis of allergic diseases among children.

The sex-specific association between maternal urinary paraben levels and offspring size at birth.

Pesticides

Chronic Exposure to Organophosphates Pesticides and Risk of Metabolic Disorder in Cohort from Pakistan and Cameroon.

Organophosphate pesticide exposure and atopic disease in NHANES 2005-2006.

Evaluation of Gonadal Alterations in a Population Environmentally Exposed to a Mixture of Endocrine Active Pesticides.

Potentially Toxic Elements

Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, México.

Assessment of Urinary Lead (Pb) and Essential Trace Elements in Autism Spectrum Disorder: a Case-Control Study Among Preschool Children in Malaysia.

Vitamin D is associated with blood lead exposure through bone turnover in type 2 diabetes patients.

Relationship between heavy metal exposure and type 2 diabetes: a large-scale retrospective cohort study using occupational health examinations.

Associations among Heavy Metals and Proteinuria and Chronic Kidney Disease

Air Pollution

Exposure to PM_2.5 and Obesity Prevalence in the Greater Mexico City Area.

Maternal exposure to O₃ and NO₂ may increase the risk of newborn congenital hypothyroidism: a national data-based analysis in China.

Foetal 25-hydroxyvitamin D moderates the association of prenatal air pollution exposure with foetal glucolipid metabolism disorder and systemic inflammatory responses.

Effects of acute ambient pollution exposure on preterm prelabor rupture of membranes: A time-series analysis in Shanghai, China.

Ambient air pollutant exposure and in vitro fertilization treatment outcomes in Zhengzhou, China.

Long-term exposure to fine particulate matter and osteoporotic fracture: A case-control study in Taiwan.

Particulate Matter and Cardiovascular Risk in Adults with Chronic Obstructive Pulmonary Disease.

Short and long term exposure to air pollution increases the risk of ischemic heart disease.

Impact of short- and long-term exposure to air pollution on blood pressure: A two-decade population-based study in Tehran.

The impact of long- and short-term exposure to different ambient air pollutants on cognitive function in China.

Association of long-term exposure to PM_2.5 with blood lipids in the Chinese population: Findings from a longitudinal quasi-experiment.

Associations between air pollutant exposure and renal function: A prospective study of older adults without chronic kidney disease.

Wildfire smoke impacts respiratory health more than fine particles from other sources: observational evidence from Southern California.

Fine particulate matter exposure and perturbation of serum metabolome: A longitudinal study in Baoding, China.

Prenatal exposure to air pollutants and childhood atopic dermatitis and allergic rhinitis adopting machine learning approaches: 14-year follow-up birth cohort study.

Metabolomic Changes after Subacute Exposure to Polycyclic Aromatic Hydrocarbons: A Natural Experiment among Healthy Travelers from Los Angeles to Beijing.

Long-term PM_2.5 exposure before diagnosis is associated with worse outcome in breast cancer.

Do air pollutants as well as meteorological factors impact Corona Virus Disease 2019 (COVID-19)? Evidence from China based on the geographical perspective.

Air pollutants and SARS-CoV-2 in 33 European countries.

Miscellaneous

Cohort Profile: The Ewha Birth and Growth Study.

Laboratory Studies

BPA/Phenols

Breast cancer proliferation and deterioration-associated metabolic heterogeneity changes induced by exposure of bisphenol S, a widespread replacement of bisphenol A.

Bisphenol A Exposure Disrupts Enamel Formation via EZH2-Mediated H3K27me3.

Evaluation of the oestrogenic potential of oestrone and bisphenol-A on the reproduction of Astyanax bimaculatus males after subacute exposure.

Gamma aminobutyric acid signaling disturbances and altered astrocytic morphology associated with Bisphenol A induced cognitive impairments in rat offspring.

Bisphenol AF elevates procoagulant platelets by inducing necroptosis via RIPK1-inflammasome axis.

Influence of experimental parameters on in vitro human skin permeation of Bisphenol A.

Long-term exposure to low doses of bisphenol S has hypoglycaemic effect in adult male mice by promoting insulin sensitivity and repressing gluconeogenesis.

Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus against the bisphenol A-induced motor and cognitive impairments in a postnatal rat model of schizophrenia.

Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome.

Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-α pathways.

Chronic exposure of bisphenol S (BPS) affect hypothalamic-pituitary-testicular activities in adult male rats: possible in estrogenic mode of action.

In vitro screening of 21 BPA replacement alternatives: Compared to BPA, the majority are more cytotoxic and dysregulate more genes in avian hepatocytes.

Phthalates

Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis.

Di-(2-ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice.

The Effect of Di (2-Ethylhexyl) Phthalate on Hair Trace Mineral Levels in Rats.

Parabens/Triclosan/Antimicrobials

Ecotoxicogenomic analysis of zebrafish embryos exposed to triclosan and mixture triclosan and methyl triclosan using suppression subtractive hybridization and next-generation sequencing.

Effects of triclosan exposure on the energy budget of Ruditapes philippinarum and R. decussatus under climate change scenarios.

Evaluation of Triclosan Effects on Cultured Swine Luteal Cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of neonatal exposure to methoxychlor on corpus luteum in gilts: A transcriptomic analysis.

PCB and TCDD derived embryonic cardiac defects result from a novel AhR pathway.

Effect of Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Polychlorinated Biphenyls (PCBs) on Mitochondrial DNA (mtDNA) Copy Number in Rats.

Aggressiveness and Metastatic Potential of Breast Cancer Cells Co-Cultured with Preadipocytes and Exposed to an Environmental Pollutant Dioxin: An in Vitro and in Vivo Zebrafish Study.

Transcriptomic response patterns of hornyhead turbot (Pleuronichthys verticalis) dosed with polychlorinated biphenyls and polybrominated diphenyl ethers.

TCDD induced lipid accumulation by impairment of autophagic flux in THP-1 macrophages.

Perfluoroalkyl Substances

Perfluoroalkyl Acid Binding with Peroxisome Proliferator-Activated Receptors α, γ, and δ, and Fatty Acid Binding Proteins by Equilibrium Dialysis with a Comparison of Methods.

Distribution of perfluorooctane sulfonate in mice and its effect on liver lipidomic.

Interaction between probiotic additive and perfluorobutanesulfonate pollutant on offspring growth and health after parental exposure using zebrafish.

Perfluorotridecanoic acid inhibits fetal Leydig cell differentiation after in utero exposure in rats via increasing oxidative stress and autophagy.

Perfluorooctane Sulfonate Promotes Doxycycline-induced Liver Tumor Progression in Male Kras^v12 Transgenic Zebrafish.

Flame Retardants

Triphenyl phosphate disturbs the lipidome and induces endoplasmic reticulum stress and apoptosis in JEG-3 cells.

Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.

Pesticides

The Differential Effects of Salinity Level on Chlorpyrifos and Imidacloprid Toxicity to an Estuarine Amphipod.

Stereoisomeric selectivity in the endocrine-disrupting potential of cypermethrin using in vitro, in vivo, and in silico assays.

Structural Aspects of Potential Endocrine-Disrupting Activity of Stereoisomers for a Common Pesticide Permethrin against Androgen Receptor.

Comparative toxicity of multiple exposure routes of pyraclostrobin in adult zebrafish (Danio rerio).

Potentially Toxic Elements

The Role of miRNAs in Regulating the effect of Prenatal Cadmium Exposure on Ovarian Granulosa Cells in a Transgenerational Manner in Female Rats.

Environmental cadmium exposure during pregnancy causes diabetes-like phenotypes in mouse offspring: Association with oxidative stress in the fetal liver.

Arsenic or/and antimony induced mitophagy and apoptosis associated with metabolic abnormalities and oxidative stress in the liver of mice.

Paternal Exposure to Non-essential Heavy Metal Affects Embryo Cleavage and Implantation in Intracytoplasmic Sperm Injection (ICSI) Cycles: Evidence for a Paradoxical Effect.

Microplastics

Polystyrene Nanoplastics Can Alter the Toxicological Effects of Simvastatin on Danio rerio.

Adaptation of life-history traits and trade-offs in marine medaka (Oryzias melastigma) after whole life-cycle exposure to polystyrene microplastics.

Stress Response of Mouse Embryonic Fibroblasts Exposed to Polystyrene Nanoplastics.

Size-dependent effects of microplastic on uptake, immune system, related gene expression and histopathology of goldfish (Carassius auratus).

Air Pollution

Dynamic recovery after acute single fine particulate matter exposure in male mice: Effect on lipid deregulation and cardiovascular alterations.

Integrated RNA Sequencing Reveals Epigenetic Impacts of Diesel Particulate Matter Exposure in Human Cerebral Organoids.

Metabolic and Lipid Alterations in Mice Brain Cortex after PM_2.5 Exposure.

Fine particulate matter (PM_2.5) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance.

Pharmaceuticals/Personal Care Products

Could the musk compound tonalide affect physiological functions and act as an endocrine disruptor in rainbow trout?

DNA methylation and expression of estrogen receptor alpha in fathead minnows exposed to 17α-ethynylestradiol.

Norethindrone causes cellular and hepatic injury in zebrafish by compromising the metabolic processes associated with antioxidant defence: Insights from metabolomics.

Early exposure to paracetamol reduces level of testicular testosterone and changes gonadal expression of genes relevant for steroidogenesis in rats offspring.

Enhanced Disrupting Effect of Benzophenone-1 Chlorination Byproducts to the Androgen Receptor: Cell-Based Assays and Gaussian Accelerated Molecular Dynamics Simulations.

Effect of ibuprofen in vivo and in vitro on the sperm quality of the striped catfish Pseudoplatystoma magdaleniatum.

Mixtures

Joint toxicity of imidacloprid and azoxystrobin to Chironomus dilutus at organism, cell, and gene levels.

Thyroid Disrupting Chemicals in mixture Perturb Thymocyte Differentiation in Xenopus laevis tadpoles.

Miscellaneous

Xylene delays the development of Leydig cells in pubertal rats by inducing reactive oxidative species.

Prenatal exposure to hexavalent chromium disrupts testicular steroidogenic pathway in peripubertal F₁ rats.

Prenatal polycyclic aromatic hydrocarbons, altered ERα pathway-related methylation and expression, and mammary epithelial cell proliferation in offspring and grandoffspring adult mice.

Exposure/Environment Studies

BPA/Phenols

Sorption and leaching behaviors between aged MPs and BPA in water: The role of BPA binding modes within plastic matrix.

Differences of bisphenol analogue concentrations in indoor dust between rural and urban areas.

Phthalates

Maternal Food and Beverage Consumption Behaviors and Discrepant Phthalate Exposure by Race.

Persistent contamination of polycyclic aromatic hydrocarbons (PAHs) and phthalates linked to the shift of microbial function in urban river sediments.

Concentrations and endocrine disruptive potential of phthalates in marine mammals from the Norwegian Arctic.

Exposure to Phthalate and Organophosphate Esters via Indoor Dust and PM10 Is a Cause of Concern for the Exposed Saudi Population.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticide residues in Uganda’s honey as a bioindicator of environmental contamination and reproductive health implications to consumers.

Pentachlorophenol and nine other chlorophenols in urine of children and adolescents in Germany – human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V).

Persistent organic pollution in Antarctic marine biota: Level, transport and risk assessment.

Recording and response of persistent toxic substances (PTSs) in urban lake sediments to anthropogenic activities.

Persistent organic and inorganic pollutants in the effluents from the textile dyeing industries: Ecotoxicology Appraisal via a battery of Biotests.

Perfluoroalkyl Substances

Risks posed by per- and polyfluoroalkyl substances (PFAS) on the African continent, with an emphasis on aquatic ecosystems.

Ultrashort-chain perfluoroalkyl substance trifluoroacetate (TFA) in beer and tea – An unintended aqueous extraction.

Flame Retardants

Spatiotemporal characteristics and pollution level of brominated flame retardants in bivalves from Fujian southern coastal areas.

Temporal trends of novel brominated flame retardants in mollusks from the Chinese Bohai Sea (2011-2018).

Pesticides

Pesticide usage practices as sources of occupational exposure and health impacts on horticultural farmers in Meru County, Kenya.

Sensitivity of turtles to anticoagulant rodenticides: Risk assessment for green sea turtles (Chelonia mydas) in the Ogasawara Islands and comparison of warfarin sensitivity among turtle species.

Pyrethroid exposure among children residing in green versus non-green multi-family, low-income housing.

Agrochemical pesticide production, trade, and hazard: Narrowing the information gap in Colombia.

Optimization of a rice cooking method using response surface methodology with desirability function approach to minimize pesticide concentration.

Potentially Toxic Elements

Levels of Mercury, Methylmercury and Selenium in Fish: Insights into Children Food Safety.

Global patterns of accumulation and partitioning of metals in halophytic saltmarsh taxa: A phylogenetic comparative approach.

Ecological and Health Risks Assessment of Potentially Toxic Metals and Metalloids Contaminants: A Case Study of Agricultural Soils in Qatar.

Microplastics

A fish tale: a century of museum specimens reveal increasing microplastic concentrations in freshwater fish.

The dynamics of microplastics and associated contaminants: Data-driven Lagrangian and Eulerian modelling approaches in the Mediterranean Sea.

Air Pollution

Examining the status of improved air quality in world cities due to COVID-19 led temporary reduction in anthropogenic emissions.

Pharmaceuticals/Personal Care Products

Aquatic Insects Transfer Pharmaceuticals and Endocrine Disruptors from Aquatic to Terrestrial Ecosystems.

A chemical prioritization process: Applications to contaminants of emerging concern in freshwater ecosystems (Phase I).

Modeling the fate and human health impacts of pharmaceuticals and personal care products in reclaimed wastewater irrigation for agriculture.

Miscellaneous

Assessment of emerging polar organic pollutants linked to contaminant pathways within an urban estuary using non-targeted analysis.

[Occupational exposures, diet and storing: Recommendations to reduce environmental pollutants in breastfeeding]. [in Spanish]

Screening priority indicator pollutants in full-scale wastewater treatment plants by non-target analysis.

Unusual male size vs sperm count relationships in a coastal marine amphipod indicate reproductive impairment by unknown toxicants.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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