EDC Science Weekly, Mar. 15-21, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: PFAS in Food Packaging; organic food intervention and inflammation in children; brake and tire wear-related particulate matter and autism; EDCs in childhood and ADHD.

More science highlights

Events

Mar. 25: U.S. Research Community stakeholder call on the future plastic pollution instrument [U.S. Dept. of State; not open to media]

Mar. 26 webinar: EDC Free Asia: Regulatory policies and frameworks addressing environmental and human exposure to EDCs [IPEN]

Mar. 28 webinar: Chemical exposures and children’s mental health [CHE-Alaska]

Apr. 3 webinar: A Global Plastics Treaty That Protects Endocrine Health [Endocrine Society EDC Special Interest Group]

Apr. 4 symposium: Environmental exposures and kidney health [Duke Integrated Toxicology and Environmental Health Program]

Apr. 5: NIEHS Biomedical Career Symposium [EPA campus in Research Triangle Park, NC]

Apr. 18 webinar: Chemicals in plastics: Human health costs [EDC Strategies Partnership]

May 7 webinar: Endocrine disruptors and hormone levels during pregnancy [HEEDS Young EDC Scientists Showcase]

June 10-12: National PFAS Conference in Ann Arbor MI

June 23-28: Gordon Research Conference on EDCs June, in Tuscany Italy

More events

Regulations/Policy

The “forever” per- and polyfluoroalkyl substances (PFAS): A critical accounting of global research on a major threat under changing regulations.

Review of the standards of proof (of safety) for FDA regulated consumer products and how the generally recognized as safe criteria could be applied to cosmetics

Upgrading water treatment trains to comply with the DBPs standards introduced by the Directive (EU) 2020/2184

The health and welfare effects of environmental governance: Evidence from China.

More EDC policy and regulations open for comment

Methods/Tools/Screening

An Update on Pediatric Environmental Health Specialty Units: Activities and Impacts, 2015-2019.

Systematic Approaches for the Encoding of Chemical Groups: A Case Study.

Modeling mixtures interactions in environmental toxicology

Phase-out planning for animal experimentation.

Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing.

Intuitive toxicology in the 21st century-Bridging the perspectives of the public and risk assessors in Europe.

Improving consistency in estimating future health burdens from environmental risk factors: Case study for ambient air pollution.

Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors. [see related Invited Perspective: Uneven Progress Addressing Population Variability in Human Health Risk Assessment.]

WHO Toxic Equivalency Factors (TEFs) for dioxin like compounds, including studies supporting novel methodology for derivation of TEFs. [Intro to a special issue in Regulatory Toxicology and Pharmacology] Includes articles:

Commentaries

PFAS raise their ugly head in malaria control: Diverging views on risk substitution.

Reverse EU’s growing greenlash.

Selectively addressing total risk avoidance for certain chemicals while overlooking others: The case of per-and-poly-fluoroalkyls.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Deteriorating Semen Quality: The Role of the Environment.

BPA/Phenols

Associations of bisphenol A exposure with metabolic syndrome and its components: A systematic review and meta-analysis.

Phthalates

The mitochondrial link: Phthalate exposure and cardiovascular disease.

PFAS

Per- and Polyfluoroalkyl Substances in Food Packaging: Migration, Toxicity, and Management Strategies.

A data-driven analysis to discover research hotspots and trends of technologies for PFAS removal.

Insights into PFAS environmental fate through computational chemistry: A review.

Cutting-edge technologies and relevant reaction mechanism difference in treatment of long- and short-chain per- and polyfluoroalkyl substances: A review.

Influence of soil composition and environmental factors on the adsorption of per- and polyfluoroalkyl substances: A review.

Metals/Metalloids

Autism spectrum disorder: Cadmium and mercury concentrations in different biological samples, a systematic literature review and meta-analysis of human studies.

Microplastics/Nanomaterials

Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases.

Toxicological Research on Nano and Microplastics in Environmental Pollution: Current Advances and Future Directions.

Genotoxic and neurotoxic potential of intracellular nanoplastics: A review.

A Meta-analysis of Potential Biomarkers Associated with Microplastic Ingestion in Marine Fish.

Microplastics and nanoplastics: Source, behavior, remediation, and multi-level environmental impact.

Miscellaneous

The key characteristics of cardiotoxicity for the pervasive pollutant phenanthrene.

Human Health Studies

Numerous Chemicals/Mixtures

Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study.

Association between exposure to chemical mixtures and epigenetic ageing biomarkers: Modifying effects of thyroid hormones and physical activity.

BPA/Phenols

Does Bisphenol-A play a role in the development of neural tube defects?

Phthalates

Prenatal phthalate exposure and sex steroid hormones in newborns: Taiwan Maternal and Infant Cohort Study.

Association between biomarkers of phthalate exposure and serum folate concentrations in U.S. children: a population-based cross-sectional study of the NHANES from 2011 to 2016.

Association of phthalate exposure with type 2 diabetes and the mediating effect of oxidative stress: A case-control and computational toxicology study.

Exposure to di-2-ethylhexyl phthalate and breast neoplasm incidence: A cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study.

Inverse association between plasma chlordecone concentrations and progression of alcoholic liver fibrosis: the role of liver metabolism.

PFAS

Association between per- and polyfluoroalkyl substances exposure and prevalence of chronic obstructive pulmonary disease: The mediating role of serum albumin.

Prenatal exposure to poly/perfluoroalkyl substances and risk for congenital heart disease in offspring.

No increased rates of COVID-19 breakthrough infections in Altötting, a Bavarian district with a history of environmental PFOA contamination-results from a retrospective observational study.

Pesticides

An anti-inflammatory response of an organic food intervention by reducing pesticide exposures in children of Cyprus: A cluster-randomized crossover trial.

Association of urinary chlorpyrifos, paraquat, and cyproconazole levels with the severity of fatty liver based on MRI.

Associations of pyrethroid exposure with bone mineral density and osteopenia in adults.

Metals/Metalloids

Federal Housing Assistance and Blood Lead Levels in a Nationally Representative US Sample Age 6 and Older: NHANES, 1999-2018.

Microplastics/Nanomaterials

Microplastics in human urine: Characterisation using μFTIR and sampling challenges using healthy donors and endometriosis participants.

Air Pollution

Associations between brake and tire wear-related PM_2.5 metal components, particulate oxidative stress potential, and autism spectrum disorder in Southern California.

Prenatal Household Air Pollution Exposure and Childhood Blood Pressure in Rural Ghana. [see related Invited Perspective: Longitudinal Follow-up of a Household Air Pollution Trial in a Birth Cohort Yields an Impactful Finding.]

Risk of dementia due to Co-exposure to air pollution and neighborhood disadvantage.

Unveiling causal connections: Long-term particulate matter exposure and type 2 diabetes mellitus mortality in Southern China.

Laboratory Studies

Numerous Chemicals/Mixtures

Mechanistic interplay of dual environmental stressors: Bisphenol-A and cadmium-induced ovarian follicular damage and hepatocyte dysfunction in vivo.

BPA/Phenols

Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression.

Combination treatment of zinc and selenium intervention ameliorated BPA-exposed germ cell damage in SD rats: elucidation of molecular mechanisms.

Toxic effects of environmental concentration Bisphenol AF exposure on the survival, growth and reproduction of adult male Oryzias curvinotus.

Phthalates

Dibutyl phthalate (DBP) promotes Epithelial-Mesenchymal Transition (EMT) to aggravate liver fibrosis into cirrhosis and portal hypertension (PHT) via ROS/TGF-β1/Snail-1 signalling pathway in adult rats.

Di-(2-ethylhexyl) phthalate exposure induces premature testicular senescence by disrupting mitochondrial respiratory chain through STAT5B-mitoSTAT3 in Leydig cell.

Parabens/Triclosan/Antimicrobials

Endocrine disrupting effects of parabens in zebrafish (Danio rerio): New insights from transcriptomics, metabolomics, and molecular dynamics simulation.

Estrogenic disruption effects and formation mechanisms of transformation products during photolysis of preservative parabens.

Reproductive endocrine disruption effect and mechanism in male zebrafish after life cycle exposure to environmental relevant triclosan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of organochlorine pesticides on human and rat 17β-hydroxysteroid dehydrogenase 1 activity: structure-activity relationship and in silico docking analysis.

PFAS

Perfluorooctane sulfonate (PFOS) and its selected analogs induce various cell death types in peripheral blood mononuclear cells.

Evaluating the mode of action of perfluorooctanoic acid-induced liver tumors in male Sprague-Dawley rats using a toxicogenomic approach.

Environmental impact of PFAS: Filling data gaps using theoretical quantum chemistry and QSPR modeling.

A structural basis for the activation of peroxisome proliferator-activated receptor gamma (PPARγ) by perfluorooctanoic acid (PFOA).

Flame Retardants

The role of Sertoli cells-secreted factors in different stages of germ cells development in mice exposed to BDE-209.

Pesticides

Exposure to the environmental pollutant chlorpyrifos induces hepatic toxicity through activation of the JAK/STAT and MAPK pathways.

Effect of chlorpyrifos-exposure on the expression levels of CYP genes in Daphnia magna and examination of a possibility that an up-regulated clan 3 CYP, CYP360A8, reacts with pesticides.

Chronic low-dose deltamethrin exposure induces colon injury and aggravates DSS-induced colitis via promoting cellular senescence.

Multifaceted Effects of Subchronic Exposure to Chlorfenapyr in Mice: Implications from Serum Metabolomics, Hepatic Oxidative Stress, and Intestinal Homeostasis.

In vitro and in vivo investigation of a thyroid hormone system-specific interaction with triazoles.

Epoxiconazole altered hepatic metabolism in adult zebrafish based on transcriptomic analysis.

Late gestational exposure to fenvalerate impacts ovarian reserve in neonatal mice via YTHDF2-mediated P-body assembly.

Microplastics/Nanomaterials

Exposure to polystyrene microplastics and perfluorooctane sulfonate disrupt the homeostasis of intact planarians and the growth of regenerating planarians.

Oxidized/unmodified-polyethylene microplastics neurotoxicity in mice: Perspective from microbiota-gut-brain axis.

Neurotoxic effects of polystyrene nanoplastics on memory and microglial activation: Insights from in vivo and in vitro studies.

Photoaged polystyrene nanoplastics exposure results in reproductive toxicity due to oxidative damage in Caenorhabditis elegans.

Miscellaneous

Toxic effects and comparison of common amino antioxidants (AAOs) in the environment on zebrafish: A comprehensive analysis based on cells, embryos, and adult fish.

Exposure/Environment Studies

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Occurrence, distribution and annual emissions of chlorinated paraffins in hazardous byproducts from municipal solid waste incineration plants in South China.

Diffusion of organochlorine (OCPs) and cypermethrin pesticides from rohu (Labeo rohita) internal organs to edible tissues during ice storage: a threat to human health.

Centurial deposition records of polychlorinated biphenyls and organochlorine pesticides in sediment cores from a plateau deep-water lake of China: Significance of anthropogenic impacts, transformation signals and ecological risks revealed by full congener analysis.

PFAS

Predictors of Serum Per- and Polyfluoroalkyl Substances Concentrations among U.S. Couples Attending a Fertility Clinic.

Per- and Polyfluoroalkyl Substance Exposure Risks in US Carceral Facilities, 2022.

Per- and Polyfluoroalkyl Substances in Water (2008-2022) and Fish (2015-2022) in The Netherlands: Spatiotemporal Trends, Fingerprints, Mass Discharges, Sources, and Bioaccumulation Factors.

Metabolic disruptions and impaired reproductive fitness in wild-caught freshwater turtles (Emydura macquarii macquarii) exposed to elevated per- and polyfluoroalkyl substances (PFAS).

Partitioning of PFAS to serum, tissues, eggs, and hatchlings of an Australian freshwater turtle.

Sediment-seawater partitioning, bioaccumulation, and biomagnification of perfluorobutane sulfonamide in marine environment.

Trend of PFAS concentrations and prediction of potential risks in Taihu Lake of China by AQUATOX.

Conflicted and Relevant: Systematic Processing of Information on PFAS Contamination.

Pesticides

Assessing pesticide residues occurrence and risks in water systems: A Pan-European and Argentina perspective.

Metals/Metalloids

Estimated Childhood Lead Exposure From Drinking Water in Chicago.

Microplastics/Nanomaterials

Effects of biodegradable microplastics on arsenic migration and transformation in paddy soils: a comparative analysis with conventional microplastics.

Miscellaneous

First Evidence of the Bioaccumulation and Trophic Transfer of Tire Additives and Their Transformation Products in an Estuarine Food Web.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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