EDC Science Weekly, June 9 – 15, 2022

Post author:HEEDS
Post published:June 15, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Strengthening Australia’s Chemical Regulation.

The Burden of Microplastics Pollution and Contending Policies and Regulations.

Arbuscular mycorrhizal fungi and the need for a meaningful regulatory plant protection product testing strategy.

National characterization of pesticide runoff and erosion potential to put USEPA standard ecological scenarios in context for pyrethroids.

A Critical Review of the Application of Polymer of Low Concern Regulatory Criteria to Fluoropolymers II: Fluoroplastics and Fluoroelastomers.

Future perspectives for advancing regulatory science of nanotechnology-enabled health products.

Methods/Tools/Screening

Towards replacement of animal tests with in vitro Assays:A gene expression biomarker predicts in vitro and in vivo estrogen receptor activity.

Development of a Liquid Chromatography-Mass Spectrometry-Based In Vitro Assay to Assess Changes in Steroid Hormones Due to Exposure to Per- and Polyfluoroalkyl Substances.

Bovine In Vitro Oocyte Maturation and Embryo Production Used as a Model for Testing Endocrine Disrupting Chemicals Eliciting Female Reproductive Toxicity With Diethylstilbestrol as a Showcase Compound.

Liver organ-on-chip models for toxicity studies and risk assessment.

Critical features identification for chemical chronic toxicity based on mechanistic forecast models.

Using Live Imaging and Fluorescence Ubiquitinated Cell Cycle Indicator Embryonic Stem Cells to Distinguish G1 Cell Cycle Delays for General Stressors like Perfluoro-Octanoic Acid and Hyperosmotic Sorbitol or G2 Cell Cycle Delay for Mutagenic Stressors like Benzo(a)pyrene.

Comparison of the lower limit of benchmark dose confidence interval with no-observed-adverse-effect level by applying four different software for tumorigenicity testing of pesticides in Japan.

Humane acute testing with tadpoles for risk assessment of chemicals: Avoidance instead of lethality.

Blueprint for the ideal microplastic effect study: Critical issues of current experimental approaches and envisioning a path forward.

Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin.

Position paper on management of personal data in environment and health research in Europe.

Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants

Contributions and perspectives of Indigenous Peoples to the study of mercury in the Arctic.

Toward a digital analysis of environmental impacts on rodent mammary gland density during critical developmental windows.

Uncertainty estimation strategies for quantitative non-targeted analysis.

Neuronal differentiation pathways and compound-induced developmental neurotoxicity in the human neural progenitor cell test (hNPT) revealed by RNA-seq.

Tools

Development of a Flame Retardant and an Organohalogen Flame Retardant Chemical Inventory.

A System for Standardizing and Combining U.S. Environmental Protection Agency Emissions and Waste Inventory Data.

CAS Common Chemistry in 2021: Expanding Access to Trusted Chemical Information for the Scientific Community.

Commentaries

Reply to the opinion paper “The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard assessment” by Scholz et al.

Reviews

Numerous Chemicals/Mixtures

Early-life chemical exposome and gut microbiome development: African research perspectives within a global environmental health context.

Pollutants: a candidate as a new risk factor for osteoarthritis-results from a systematic literature review.

Strategies for Protecting Mitochondria From Metals and Chemicals.

BPA/Phenols

Role of Nrf2 in bisphenol effects: a review study.

Food and beverage can coatings: A review on chemical analysis, migration, and risk assessment.

Phthalates

Phthalate exposures and placental health in animal models and humans: a systematic review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure sources of polychlorinated biphenyls (PCBs) and health risk assessment: a systematic review in Iran.

Perfluoroalkyl Substances

Immunomodulation and exposure to per- and polyfluoroalkyl substances: an overview of the current evidence from animal and human studies.

Sonolysis of per- and poly fluoroalkyl substances (PFAS): A meta-analysis.

Pesticides

Glyphosate and neurological outcomes: A systematic literature review of animal studies.

How advanced are we on the consequences of oral exposure to food contaminants on the occurrence of chronic non communicable diseases?

Microplastics/Nanomaterials

Ecotoxic effects of microplastics and contaminated microplastics – Emerging evidence and perspective.

Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment.

Microplastic profusion in food and drinking water: are microplastics becoming a macroproblem?

Miscellaneous

Benzo[a]pyrene-Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity

The Monetary Benefits of Reducing Emissions of Dioxin-like Compounds-Century Poisons-Over Half a Century: Evaluation of the Benefit per Ton Method

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal Exposure to Emerging Plasticizers and Synthetic Antioxidants and Their Potency to Cross Human Placenta.

Combined exposures to bisphenols, polychlorinated dioxins, paracetamol, and phthalates as drivers of deteriorating semen quality.

A preliminary study on the relationship between environmental endocrine disruptors and precocious puberty in girls.

Effects of chemical mixtures on liver function biomarkers in the Korean adult population: thresholds and molecular mechanisms for non-alcoholic fatty liver disease involved.

Citizens’ Perception and Concerns on Chemical Exposures and Human Biomonitoring-Results from a Harmonized Qualitative Study in Seven European Countries

Four-year population exposure study: Implications for the effectiveness of e-waste control and biomarkers of e-waste pollution.

BPA/Phenols

Maternal urinary concentrations of bisphenol a during pregnancy are associated with global Dna methylation in cord blood of newborns in the “Nela” birth cohort.

Combined effects of bisphenol A and diabetes genetic risk score on incident type 2 diabetes: A nested case-control study.

Association of serum bisphenol AF concentration with depressive symptoms in adolescents: A nested case-control study in China.

Pregnancy exposure to phenols and anthropometric measures in gestation and at birth.

Phthalates

Association between phthalate metabolites in human amniotic fluid and offspring birth size: a sub-study of the PERSIAN birth cohort.

Urinary concentration of endocrine-disrupting phthalates and breast cancer risk in Indian women: A case-control study with a focus on mutations in phthalate-responsive genes.

Investigating associations between urinary phthalate metabolite concentrations and chronic diarrhea: findings from the National Health and Nutrition Examination Survey, 2005-2010.

Parabens/Triclosan/Antimicrobials

Paraben exposures and their interactions with ESR1/2 genetic polymorphisms on hypertension.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal Environmental Exposure to Persistent Organic Pollutants and Indices of Overweight and Cardiovascular Risk in Dutch Adolescents

Serum concentrations of persistent organic pollutants mixture during pregnancy and anogenital distance in 8-year-old children from the INMA-Asturias cohort.

Chiral signatures of polychlorinated biphenyls in serum from e-waste workers and their correlation with hydroxylated metabolites.

Perfluoroalkyl Substances

Early-pregnancy plasma per- and polyfluoroalkyl substance (PFAS) concentrations and hypertensive disorders of pregnancy in the Project Viva cohort.

Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women’s Health Across the Nation.

Association of polyfluoroalkyl substances and allergy in U.S. adolescents: Results from NHANES 2005-2006.

Exposure to per- and polyfluoroalkyl substances as a risk factor for gestational diabetes mellitus through interference with glucose homeostasis.

Pesticides

The Role of CYP2B6*6 Gene Polymorphisms in 3,5,6-Trichloro-2-pyridinol Levels as a Biomarker of Chlorpyrifos Toxicity Among Indonesian Farmers.

Alterations in reproductive hormone levels among farm women and their children occupationally exposed to organophosphate pesticides.

Urinary 2,4-dichlorophenoxyacetic acid in Chinese pregnant women at three trimesters: Variability, exposure characteristics, and association with oxidative stress biomarkers.

Use of permethrin and other pyrethroids and mortality in the Agricultural Health Study.

Acute Kidney Failure among Brazilian Agricultural Workers: A Death-Certificate Case-Control Study.

Insights of OPs and PYR cytotoxic potential Invitro and genotoxic impact on PON1 genetic variant among exposed workers in Pakistan.

Association between Polymorphisms in Telomere-Associated Protein Genes and the Cholinesterase Activity of Omethoate-Exposed Workers.

Potentially Toxic Elements

Effects of heavy metals on cardiovascular diseases in pre and post-menopausal women: from big data to molecular mechanism involved.

Individual and mixed metal maternal blood concentrations in relation to birth size: An analysis of the Japan Environment and Children’s Study (JECS).

Pre and postnatal exposure to mercury and sexual development in 9-year-old children in Spain: The role of brain-derived neurotrophic factor.

Association of Blood Heavy Metal Levels and Renal Function in Korean Adults

Urinary metals as influencing factors of coronary heart disease among a population in Guangzhou, China.

Evaluation of low to moderate arsenic exposure, metabolism and skin lesions in a Turkish rural population exposed through drinking water.

Role of renal function in the association of drinking water fluoride and plasma fluoride among adolescents in the United States: NHANES, 2013-2016.

Air Pollution

Maternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods.

Long-term exposure to ambient air pollution and serum liver enzymes in older adults: a population-based longitudinal study.

Associations of pregnancy complications with ambient air pollution in China.

Vascular benefits of vitamin C supplementation against fine particulate air pollution in healthy adults: A double-blind randomised crossover trial.

PM_2.5 air pollution exposure and nonalcoholic fatty liver disease in the Nationwide Inpatient Sample.

Miscellaneous

Association of blood trihalomethane concentrations with lung function in U.S. adolescents: a nationally representative cross-sectional study.

Environmental polycyclic aromatic hydrocarbon exposure in relation to metabolic syndrome in US adults.

Exposure to polycyclic aromatic hydrocarbons and the associations with oxidative stress in waste incineration plant workers from South China.

Laboratory Studies

Numerous Chemicals/Mixtures

Activation of the xenobiotic metabolism and oxidative stress response by mixtures of organic pollutants extracted with in-tissue passive sampling from liver, kidney, brain and blubber of marine mammals.

BPA/Phenols

Effects of bisphenol A and estradiol in adult rat testis after prepubertal and pubertal exposure.

Hematotoxicity of co-administration of bisphenol A and acetaminophen in rats and its amelioration by melatonin.

Bisphenol S Alters the Steroidome in the Preovulatory Follicle, Oviduct Fluid and Plasma in Ewes With Contrasted Metabolic Status.

Gestational exposure to bisphenol A induces region-specific changes in brain metabolomic fingerprints in sheep.

Long-term exposure to bisphenol A and its analogues alters the behavior of marine medaka (Oryzias melastigma) and causes hepatic injury.

Phthalates

The inhibition of CFTR in the descended testis of SD rats with unilateral cryptorchidism induced by di-(2-ethylhexyl) phthalate (DEHP).

Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.

Effects of dibutyl phthalate and di (2-ethylhexyl) phthalate on hepatic structure and function of adult male mice.

Parabens/Triclosan/Antimicrobials

Characterization of triclosan-induced hepatotoxicity and triclocarban-triggered enterotoxicity in mice by multiple omics screening

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Gut microbiota dysbiosis induced by polychlorinated biphenyl 126 contributes to increased brain proinflammatory cytokines: Landscapes from the gut-brain axis and fecal microbiota transplantation.

Nrf2a dependent and independent effects of early life exposure to 3,3′-dichlorobiphenyl (PCB-11) in zebrafish (Danio rerio).

Perfluoroalkyl Substances

Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model.

Bioavailability of inhaled or ingested PFOA adsorbed to house dust.

Flame Retardants

Use of enzymatic biomarkers of Labeo rohita to study the effect of polybrominated diphenyl ether (BDE- 209) via dietary exposure in laboratory conditions.

Tri-n-butyl phosphate delays tissue repair by dysregulating neutrophil function in zebrafish.

Long-Term Exposure to Decabromodiphenyl Ether Promotes the Proliferation and Tumourigenesis of Papillary Thyroid Carcinoma by Inhibiting TRß.

Organotins

Environmentally relevant dose of the endocrine disruptor tributyltin disturbs redox balance in female thyroid gland.

Neuroprotective effects of ex vivo-expanded regulatory T cells on trimethyltin-induced neurodegeneration in mice.

Pesticides

Developmental, toxicological effects and recovery patterns in Xenopus laevis after exposure to penconazole-based fungicide during the metamorphosis process.

Reproductive toxicity by exposure to low concentrations of pesticides in Caenorhabditis elegans.

Effect of a mixture of pyrethroids at doses similar to human exposure through food in the Indian context.

Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring.

Chronic dietary exposure to a glyphosate-based herbicide results in reversible increase early embryo mortality in chicken.

The toxicokinetics and risk assessment of pyrethroids pesticide in tilapia (Oreochromis mossambicus) upon short-term water exposure.

Exposure to the novel insecticide flupyradifurone impairs bumblebee feeding motivation, learning, and memory retention.

Potentially Toxic Elements

Nrf2/Keap1 pathway in countering arsenic-induced oxidative stress in mice after chronic exposure at environmentally-relevant concentrations.

Moderate exercise relieves fluoride-induced liver and kidney inflammatory responses through the IKKβ/NFκB pathway.

Microplastics/Nanomaterials

Polystyrene nanoparticles aggravate the adverse effects of di-(2-ethylhexyl) phthalate on different segments of intestine in mice.

In Vivo Toxicity and Pharmacokinetics of Polytetrafluoroethylene Microplastics in ICR Mice.

Negative impacts of chronic dietary exposure to polyethylene microplastics on growth, gut microbiota, liver metabolism and gene expressions in genetically improved farmed tilapia (Oreochromis niloticus).

Pharmaceuticals/Personal Care Products

Testicular cancer in mice: interplay between stem cells and endocrine insults. [DES]

Evaluation of the potential role of diethylstilbestrol on the induction of endometriosis in a rat model – An alternative approach.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Occurrence of legacy and replacement plasticizers, bisphenols, and flame retardants in potable water in Montreal and South Africa.

Old World Vultures Reflect Effects of Environmental Pollutants Through Human Encroachment.

Phthalates

Personal care product use and lifestyle affect phthalate and DINCH metabolite levels in teenagers and young adults.

Occurrence and health risk assessment of phthalate esters in tobacco and soils in tobacco-producing areas of Guizhou province, southwest China.

Occurrence of Phthalate Acid Esters (PAEs) in Protected Agriculture Soils and Implications for Human Health Exposure.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Occurrence of persistent organic pollutants (POPs) in the atmosphere of South Korea: A review.

Perfluoroalkyl Substances

Field-Based Distribution and Bioaccumulation Factors for Cyclic and Aliphatic Per- and Polyfluoroalkyl Substances (PFASs) in an Urban Sedentary Waterbird Population.

A food web bioaccumulation model for the accumulation of per- and polyfluoroalkyl substances (PFAS) in fish: how important is renal elimination?

Global distributions of per- and polyfluoroalkyl substances in the environment.

Simplifying Nontargeted Analysis of PFAS in Complex Food Matrices.

A pilot study on extractable organofluorine and per- and polyfluoroalkyl substances (PFAS) in water from drinking water treatment plants around Taihu Lake, China: what is missed by target PFAS analysis?

Flame Retardants

Nine alkyl organophosphate triesters newly identified in house dust.

Pesticides

Exposure to Airborne Pesticides and Its Residue in Blood Serum of Paddy Farmers in Malaysia.

Widespread pesticide contamination of drinking water and impact on cancer risk in Brazil.

Opposing global change drivers counterbalance trends in breeding North American monarch butterflies.

[A pesticide in Franco’s regime: communicating toxic risks in Spain, 1945-1975]. [in Spanish]

Potentially Toxic Elements

Correlation between maternal and fetal umbilical cord blood lead concentrations in Libya.

How Do Different Physical Stressors’ Affect the Mercury Release from Dental Amalgam Fillings and Microleakage? A Systematic Review.

Estimation of blood lead levels in the French population using two complementary approaches: Esteban (2014-2016) as part of the human biomonitoring program and the national surveillance system for childhood lead poisoning (2015-2018).

Using carbon, nitrogen, and mercury isotope values to distinguish mercury sources to Alaskan lake trout.

Microplastics/Nanomaterials

Freeze-thaw alternations accelerate plasticizers release and pose a risk for exposed organisms.

Microplastics sully Antarctic snow – and science might be to blame.

Microplastic pollution at Qilianyu, the largest green sea turtle nesting grounds in the northern South China Sea.

Air Pollution

Inhalation bioaccessibility of multi-class organic pollutants associated to atmospheric PM_2.5: Correlation with PM_2.5 properties and health risk assessment.

Pharmaceuticals/Personal Care Products

Occurrence and temporal trends of industrial antioxidants and UV absorbents in the endangered St. Lawrence Estuary beluga whale (Delphinapterus leucas).

Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.