EDC Science Weekly, June 19-25, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

NOTE: There will be no newsletter next week due to the Gordon Conference on EDCs. Hope to see you there!

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

June 25 webinar: Reporting on Toxics & Health: Lessons from covering “forever chemicals” [CHE]

June 29 hybrid conference: Workshop on Advancing PFAS and Cancer Research [National Cancer Institute]

July 8-10: U.S. Developmental Origins of Health and Disease (DOHaD) annual meeting (Raleigh NC); Trainee day July 8.

July 9-10 hybrid conference: Trans‑NIH Workshop on Micro[nano]plastic Measurement for Population Studies [National Cancer Institute]

July 15: Environmental Law Institute Summer School Session 5: Toxic Chemical Regulation

Regulations/Policy

EU Omnibus proposal increases pesticide risks.

FDA roadmap to reducing animal testing: a regulatory and scientific paradigm shift in nonclinical safety assessment.

Making the FDA Great Again

NGRA in Cosmetic Safety: Moving From the Frameworks and Case Studies to Wide Adoption

Microplastics matter: practical implications of the EU REACH restriction for the pharmaceutical industry.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

A NAMs-based framework for screening the endocrine-disrupting potential of plastic additives using cross-species molecular docking and Caenorhabditis elegans.

Liver organoids for chemical risk assessment: biological fidelity, standardization, and context-of-use frameworks.

Explainable Bidirectional Long Short-Term Memory Networks Learn Chemistry from SMILES for Predicting Toxicity of Androgen and Estrogen Receptor Chemicals.

Read-Across for Toxicological Data Gap Filling: State-of-the-Art, Challenges and Future Needs

Effect-Based Photoelectrochemical Screening of Estrogenic Activity in Wastewater via Cell-Free ERα-ERE Assembly.

A framework for chemical hazard assessments under “Safe and Sustainable by Design” using multiple in silico tools

Commentaries

When Health Costs No Longer Count — Air Pollution and EPA Rulemaking

Are Thyroid Hormone-Mediated Mechanisms an Overlooked Pathway in Male Reproductive Toxicity?

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Evolutionary and epigenetic drivers of the global trajectory of sperm count decline: an integrative framework for male reproductive health.

Multifaceted mechanisms by which environmental endocrine-disrupting chemicals promote cancer progression: crosstalk among carcinogenesis, immunity, and metabolic reprogramming: narrative mini-review.

Environmental endocrine disruptors in cardio-oncology: emerging modifiers of cardiovascular vulnerability in patients with cancer.

Environmental Exposure-Induced Epigenetic Modifications and Adverse Pregnancy Outcomes: A Systematic Review.

The Hepato-Exposome Axis: How Endocrine Disruptors Hijack Liver Receptors to Drive MASLD.

Phthalates

Anogenital distance as a cross‑species biomarker of fetal androgen action: origins, translation, and implications for reproductive toxicology.

PFAS

Molecular Mechanisms of PFAS-induced Neurotoxicity: Dysregulation of PPARs and VDR as a New Therapeutic Frontier.

Pesticides

Toxicological impacts of neonicotinoid insecticides in zebrafish: a review of individual and mixture toxicity.

Pesticide contamination in infant formula: a systematic review.

Metals/Metalloids

Effect of cadmium exposure on ovarian abnormalities.

Microplastics/Nanomaterials

Neuroactive steroids as targets of micro- and nano-plastics: Putative impact on brain function and disease.

Mitochondria at the crossroad: Mechanisms of nanoplastic-induced neurotoxicity and brain accumulation.

The Plastisphere: not a unique biofilm but a unifying concept for the interdisciplinary plastic biofilm research community.

The Impact of microplastics and nanoplastics on human health: a growing concern.

Air Pollution

Sex differences in the association between air pollution and obesity: a systematic review and meta-analysis.

Human Health Studies

Numerous Chemicals/Mixtures

Geospatial correlation of industrial plastics emissions with bladder and kidney cancer burden in Ohio.

The Metabolomic Characterization of Healthy Individuals Exposed to Complex Pollutants: Exploring the Relationships between Metabolites, Pollutants, and Subclinical Biomarkers.

Joint Associations of Prenatal Per- and Polyfluoroalkyl Substances and Metal Mixtures with Adiposity in Childhood and Adolescence.

Phthalates/Parabens

Co-exposure to phthalates and their alternatives in early pregnancy and the subsequent risk of pregnancy complications: A nested case-control study.

Urinary phthalate metabolite concentrations and oxidative stress biomarkers in pre and perimenopausal women from the Midlife Women’s Health Study.

Paraben and Phthalate Exposure in Adolescents With Attention-Deficit/Hyperactivity Disorder: A Case-Control Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations between serum persistent organic pollutants and polycystic ovary syndrome risk: a case-control study with mediation analysis.

PFAS

Metabolome-wide association study identifies metabolites associated with human exposure to perfluoroalkyl substances.

Association between exposure to perfluoroalkyl ether sulfonate F-53B and cervical cancer risk and its mechanisms of cervical toxicity in Chinese women.

Association between PFAS exposure and bilirubin metabolism: A metabolome-wide analysis in children.

Association between perfluoroalkyl and polyfluoroalkyl substances and response to the COVID-19 vaccine in a paediatric prospective observational cohort in Arizona.

Association between PFAS exposure and attention processing in adolescent boys: a pilot study.

Flame Retardants

High-resolution metabolomics of maternal polybrominated diphenyl ethers (PBDE) exposure and preterm birth in the Atlanta African American Maternal-Child Cohort.

Pesticides

Artificial intelligence improves risk stratification for breast cancer recurrence and mortality in women exposed to pesticides: a call for reassessment of stratification criteria.

Maternal agrochemical exposure during pregnancy and risk of orofacial clefts: a case-control study in eight low- and middle-income countries.

Parental occupational exposure to pesticides at birth and risk of adult testicular germ cell tumours in offspring: a French nationwide case-control study.

Prevalence of metabolic syndrome among family farmers in southern Brazil chronically exposed to pesticides.

Metals/Metalloids

Impact of low levels of arsenic in drinking water with incident urologic cancers in Washington state.

Long-term groundwater arsenic exposure is associated with altered arsenic methylation capacity and gut microbiota composition in a rural Chinese population.

Urinary arsenic speciation, methylation capacity, and growth outcomes in longitudinal mother-child pairs across pregnancy to preschool age: A single prenatal spot measurement poorly predicts children’s arsenic profiles and growth.

Longitudinal Blood Pressure Changes in Relation to Urinary Toxic/Essential Metals and Metal Mixtures.

Air Pollution

Long-term exposure to ambient air pollution and incidence of type 2 diabetes in an industrial contaminated area in Central Italy.

Prenatal exposure to prescribed smoke PM_2.5 and low birth weight in Georgia, USA.

Pharmaceuticals/Personal Care Products

Maternal paracetamol use during pregnancy and child IQ at age 7: A prospective cohort study.

Laboratory Studies

Bisphenols

Analysis of molecular targets and mechanisms of Bisphenol F (BPF)-induced non-alcoholic fatty liver disease (NAFLD) based on network toxicology and molecular dynamics.

Maternal Thyroid Disruption: A Probable Key Mechanism of Bisphenol S Induced Testis Development Alteration.

A mechanistic study of bisphenol a exposure on asthma through integrating clinical research, network toxicology, machine learning, and multi-omics.

Chronic bisphenol A exposure impairs cognitive function in male mice associated with NLRP3 inflammasome-driven pyroptosis and gut microbiota dysbiosis along the microbiota-gut-brain axis.

YY1/HIF-1α/NDUFA4L2 signaling axis mediates bisphenol A-induced mitochondrial dysfunction and apoptosis in human ovarian granulosa cells.

Multi-Omics Analyses Reveal BPA Accelerates Glioma Progression via Cell Cycle Dysregulation.

Pregnancy and lactation exposure to bisphenol S induces ferroptosis via disrupted hepatic lipid metabolism in offspring mice.

Prenatal BPA exposure perturbs RNA-binding protein-mediated splicing regulation and synaptogenesis in the developing cerebellum in a sex-dependent manner.

Phthalates

Association of the Endosomal TLR4 Pathway with Dorsolateral Prostatic Remodeling Induced by Perinatal Phthalate Mixture Exposure in Rats.

Neonatal exposure to di-(2-ethylhexyl) phthalate (DEHP) through breastfeeding leads to dysfunction endocrine-metabolic outcomes in male rats at adulthood.

Elucidating the toxicity of the plasticizer DPhP: Evidence of neurotoxicity and developmental impairment from in vitro to in vivo models.

MEHP exposure damages the basement membrane by suppressing the expression of its constituent proteins in peritubular myoid cells of the rat testis.

Dibutyl phthalate affects glycerolipid metabolism and causes maternal impacts on the cladoceran Daphnia magna.

Astaxanthin ameliorates cardiac damage induced by prepubertal di(2-ethylhexyl) phthalate exposure via inhibition of PPAR-α-mediated excessive autophagy.

In vitro evaluation of apheresis platelet and plasma products collected and stored in non-DEHP disposable sets.

PFAS

Multi-omics analysis of PFOA-induced sperm DNA damage in mice identifies candidate genes and mendelian randomization reveals their human genetic associations.

Multi-omics investigation of per- and polyfluoroalkyl substances in lung adenocarcinoma: comprehensive network toxicology, machine learning and molecular docking experiments.

Molecular mechanism by which perfluorooctane sulfonate regulates the initiation and progression of prostate cancer via the ENTPD5-adenine axis.

Freshwater snails avoid perfluorooctanesulfonic acid (PFOS) but only at concentrations well above U. S. Environmental Protection Agency safe water standards.

Field-derived PFAS mixtures impair biological functions across organisational levels in a terrestrial invertebrate.

Exposure to Per- and Polyfluoroalkyl Substances (PFAS) Causes Dental Developmental Anomalies: Underrecognized Risk of Fluoride Bioaccumulation.

Effects of HFPO-DA (GenX) Exposure on Placental Glycolysis and Metabolic Microenvironment in Pregnant Rats.

Perfluorooctanoic acid induces mitochondrial dysfunction-driven apoptosis and PINK1/Parkin-mediated mitophagy in testicular cells.

Perfluorooctanoic Acid Exposure Disrupts Gut Microbiota and Aggravates Experimental Colitis.

Differential effects of legacy and new-generation perfluoro-alkyl substances on in vitro differentiation and immunoglobulins production by B cells.

Flame Retardants

Brominated Flame Retardants: UQCRC1 and NR3C2 as Potential Targets in IBD and CRC.

Integrated network toxicology and transcriptomics reveal NF-κB signaling as a key mediator of TDCPP-induced inflammatory responses in human microglia.

Multi-omics analysis reveals mitochondrial dysfunction-driven oxidative stress pathways in Caenorhabditis elegans exposed to 2,2-bis(chloromethyl) trimethylene bis[bis(2-chloroethyl) phosphate] (V6).

Pesticides

Impacts of long-term glyphosate and/or 2,4-D exposures on the thyroid of mice fed a western diet.

Niosomal l-carnitine and quercetin improve sperm quality and testicular function in atrazine-induced reproductive toxicity in rats.

Metals/Metalloids

Arsenic induced deubiquitination modification of PLCE1 in a de-SUMO-dependent manner to affect malignant behavior in bladder epithelial cells.

Microplastics/Nanomaterials

Developmental effects of intrauterine and lactational exposure to nanoplastics and phthalates on rat testis.

Polystyrene nanoplastics induce size-associated oxidative-inflammatory stress, hepatic insulin-signaling impairment and metabolic disturbances in normal and diabetic mice.

Combined developmental toxicity and endocrine disruption of diisobutyl phthalate and polyethylene microplastics in Zebrafish.

Polystyrene Microplastics Activate Noncanonical TGF‑β Signaling and Metabolomic Reprogramming to Promote Epithelial-Mesenchymal Transition and Fibrosis in the Kidney.

Polystyrene microplastics trigger intestinal inflammation through CXCL11-mediated T-cell recruitment.

Mechanisms of Polystyrene Microplastics in Multipathway Disruption of the Blood-Testis Barrier.

Miscellaneous

6-PPD quinone reduces lifespan by activating a feedback loop between cholesterol transformation related signal and insulin signaling in Caenorhabditis elegans.

4-Nonylphenol mediated tumor progression and immune modulation through CDK2: Computational and experimental validation.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Determinants of Exposures to Preconception Plasma Perfluoroalkyl Substances and Periconceptional Urinary Phthalate and Pesticide Metabolites in a Singaporean Longitudinal Preconception Cohort.

Organic phosphorus flame retardants and bisphenols in municipal wastewater, runoff and drinking water in a sub-arctic city.

Multiclass endocrine-disrupting chemicals in China WWTPs: occurrence, removal efficiencies, and ecological implications based on chemical and biodegradable evidence.

Phthalates

Contribution of non-dietary indoor exposure pathways to total phthalate intake of 324 children in Tianjin, China.

Phthalate burdens of North Atlantic and South Pacific Humpback Whales (Megaptera novaeangliae), and their species-specific mitochondrial effect.

PFAS

Elevated per- and polyfluoroalkyl substances (PFASs) in tap water and serum in a community near an abandoned paper mill.

Decades-long distribution of per- and polyfluoroalkyl substances (PFASs) in global surface waters: Spatiotemporal variability and future trends.

Trophic magnification and distribution of PFAS in an aqueous film forming foam-affected aquatic food web.

Flame Retardants

A family-based risk assessment of PBDE exposure using a multi-pathway approach: Integrating diet, dust, air and serum measurements.

Polybrominated Diphenyl Ethers (PBDEs) contamination across environmental compartments in Europe.

Microplastics/Nanomaterials

Beyond Source Restrictions: Combined Mitigation Strategies Substantially Reduce Emissions and Exposure of Intentionally Added Microplastics in the UK.

Air Pollution

A Comparative Analysis of Wildland Fire Smoke PM_2.5 Exposure Estimates Across California From 2008 to 2018.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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