EDC Science Weekly, July 1-7, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

A flow scheme for cumulative assessment of pesticides for adverse liver effects.

Flawed analysis of an intentional human dosing study and its impact on chlorpyrifos risk assessments.

Methods/Tools/Screening

Methodological Issues in Population-Based Studies of Multigenerational Associations. [includes EDCs]

Model averaging methods for the evaluation of dose-response model uncertainty when assessing the suitability of studies for estimating risk. [uses a case study of arsenic and cancer]

The impact of comet assay data normalization in human biomonitoring studies outcomes.

Commentaries/Conference Summaries

COVID-19 pandemic and the reduction in ST-elevation myocardial infarction admissions. [what can explain the recent reduction in heart attacks? lower air pollution? lower stress? Letter in BMJ’s Postgrad Med J.]

Ocean data need a sea change to help navigate the warming world. [Comment in Nature]

Environmental Pollution and Lung Cancer: The Carcinogenic Power of the Air We Breathe. [editorial]

Reviews

Numerous EDCs

Unwitting Accomplices: Endocrine Disruptors Confounding Clinical Care. [” the role of healthcare in exposing individuals to EDCs is grossly underappreciated”]

What is new in the exposome?

Regulation of Thyroid Disrupting Chemicals to Protect the Developing Brain.

Updates on molecular and environmental determinants of luteal progesterone production.

Sublethal effects of contaminants on marine habitat-forming species: a review and meta-analysis.

From bench to bedside: biosensing strategies to evaluate endocrine disrupting compounds based on epigenetic events and their potential use in medicine.

Flame Retardants

Emerging environmental pollutants hydroxylated polybrominated diphenyl ethers: From analytical methods to toxicology research.

Pesticides

Agrochemicals and obesity.

Effects of agricultural pesticides on the reproductive system of aquatic wildlife species, with crocodilians as sentinel species.

MicroRNAs alteration as early biomarkers for cancer and neurodegenerative diseases: New challenges in pesticides exposure.

Pesticide prioritization approaches and limitations in environmental monitoring studies: From Europe to Latin America and the Caribbean.

Treatment technologies and degradation pathways of glyphosate: A critical review.

Review and Analysis of the Potential for Glyphosate to Interact with the Estrogen, Androgen, and Thyroid Pathways. [by Bayer]

Potentially Toxic Elements

Gut microbiota: A target for heavy metal toxicity and a probiotic protective strategy.

Microplastics/Nanomaterials

Incidence of microplastics in personal care products: An appreciable part of plastic pollution.

Neutrophils as Main Players of Immune Response Towards Nondegradable Nanoparticles.

Current trends in the production of biodegradable bioplastics: The case of polyhydroxyalkanoates.

Microplastic pollution research methodologies, abundance, characteristics and risk assessments for aquatic biota in China.

Air Pollution

Environmental and Endogenous Acids Can Trigger Allergic-Type Airway Reactions.

Exposure, assessment and health hazards of particulate matter in metal additive manufacturing: A review.

Exposure to indoor air pollution across socio-economic groups in high-income countries: A scoping review of the literature and a modelling methodology.

Miscellaneous

Essential Oils and Health. [includes a discussion of essential oils as EDCs]

Human Health Studies

Numerous Chemicals/Mixtures

Environment-Wide Association Study of CKD.

Where you live can impact your cancer risk: a look at multiple myeloma in New York City.

Phthalates

Do Plasticizers within the Indoor Environment Increase Airway Allergen Responsiveness? [commentary on Dibutyl Phthalate Augments Allergen-induced Lung Function Decline and Alters Human Airway Immunology: A Randomized Crossover Study, previously sent]

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dioxin-like compound exposures and DNA methylation in the Anniston Community Health Survey Phase II.

Impact of environmental exposure to persistent organic pollutants on lung cancer risk.

Perfluoroalkyl Substances

Pregnancy per- and polyfluoroalkyl substance concentrations and postpartum health in Project Viva, a prospective cohort.

Prenatal Exposures to Perfluoroalkyl Acids and Associations with Markers of Adiposity and Plasma Lipids in Infancy: An Odense Child Cohort Study.

Blood levels of perfluoroalkyl substances (PFASs), elements and their associations with metabolic syndrome (MetS) in Chinese male adults mediated by metabolic-related risk factors.

Per- and poly-fluoroalkyl substances and bone mineral density: Results from the Bayesian weighted quantile sum regression.

Pesticides

Association between Prenatal Exposure to Household Pesticides and Neonatal Weight and Length Growth in the Japan Environment and Children’s Study.

Herbicide, fumigant, and fungicide use and breast cancer risk among farmers’ wives.

Potentially Toxic Elements

Locus-Specific Differential DNA Methylation and Urinary Arsenic: An Epigenome-Wide Association Study in Blood among Adults with Low-to-Moderate Arsenic Exposure.

Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass.

Urinary Metal Levels after Repeated Edetate Disodium Infusions: Preliminary Findings.

CSF neurotoxic metals/metalloids levels in amyotrophic lateral sclerosis patients: comparison between bulbar and spinal onset.

Air Pollution

Age-Period-Cohort Analysis of Type 2 Diabetes Mortality Attributable to Particulate Matter Pollution in China and the U.S.

Ambient air pollution exposure association with diabetes prevalence and glycosylated hemoglobin (HbA1c) levels in China. Cross-sectional analysis from the WHO study of AGEing and adult health wave 1.

Household Fuel Use and the Risk of Gastrointestinal Cancers: The Golestan Cohort Study.

Long-term exposure to fine particulate matter and development of chronic obstructive pulmonary disease in the elderly.

Chronic Effects of High Fine Particulate Matter Exposure on Lung Cancer in China.

Annual changes in the prevalence of asthma may be related to air pollution in Fukuoka: 29 years of observation.

Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation.

Attributable risks associated with hospital outpatient visits for mental disorders due to air pollution: A multi-city study in China.

Fine particulate matter constituents and cause-specific mortality in China: A nationwide modelling study.

Concentrations and mortality due to short- and long-term exposure to PM2.5 in a megacity of Iran (2014-2019).

The linkage between particulate matter properties and lung function in schoolchildren: A panel study in southern China.

Acute differences in blood lipids and inflammatory biomarkers following controlled exposures to cookstove air pollution in the STOVES study.

Laboratory Studies

BPA/Phenols

Down-regulation of gap junctional intercellular communication and connexin 43 expression by bisphenol A in human granulosa cells.

Zinc deficient diet increases the toxicity of bisphenol A in rat testis.

The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus.

Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPARγ.

Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood.

Transcriptome analysis of testis reveals the effects of developmental exposure to bisphenol a or 17α-ethinylestradiol in medaka (Oryzias latipes).

Involvement of NMDAR/PSD-95/nNOS-NO-cGMP pathway in embryonic exposure to BPA induced learning and memory dysfunction of rats.

Interactions of bisphenol diglycidyl ethers with estrogen receptors α: fluorescence polarization, reporter gene, and molecular modeling investigations.

Bisphenol S exposure alters behavioral parameters in adult zebrafish and offspring.

Human phase I in vitro liver metabolism of two bisphenolic diglycidyl ethers BADGE and BFDGE.

Leachability of endocrine disrupting chemicals (EDCs) in municipal sewage sludge: Effects of EDCs interaction with dissolved organic matter.

Phthalates

Effect of mitochondrial quality control on the lycopene antagonizing DEHP-induced mitophagy in spermatogenic cells.

Influence of in utero di-n-hexyl phthalate and di-cyclohexyl phthalate exposure on the endocrine glands and T3, T4, and TSH hormone levels of male and female rats: Postnatal outcomes.

Di-(2-ethylhexyl) phthalate induced developmental abnormalities of the ovary in quail (Coturnix japonica) via disruption of the hypothalamic-pituitary-ovarian axis.

Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice.

Rosmarinic acid alleviates di-2-ethylhexyl phthalate (DEHP) -induced thyroid dysfunction via multiple inflammasomes activation.

Microplastics release phthalate esters and cause aggravated adverse effects in the mouse gut.

Di-n-butyl phthalate exposure induced abnormal autophagy in renal tubular cells via hedgehog signaling in newborn rats.

Effects of DEHP on the ecdysteroid pathway, sexual behavior and offspring of the moth Spodoptera littoralis.

Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver.

Chronic exposure to di-n-butyl phthalate causes reproductive toxicity in zebrafish.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Developmental origins of transgenerational sperm histone retention following ancestral exposures. [DDT and the fungicide vinclozolin]

Immunotoxicological effects of dioxin-like polychlorinated biphenyls extracted from Zhanjiang Bay sediments in zebrafish.

Perfluoroalkyl Substances

Perfluorooctane sulfonic acid, a persistent organic pollutant, inhibits iodide accumulation by thyroid follicular cells in vitro.

Flame Retardants

Structural studies on the endocrine-disrupting role of polybrominated diphenyl ethers (PBDEs) in thyroid diseases.

Uptake, accumulation and biomarkers of PM2.5-associated organophosphate flame retardants in C57BL/6 mice after chronic exposure at real environmental concentrations.

Hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish following sub-chronic exposure to BDE-47 and BDE-153.

Organotins

Combined and independent effects of hypoxia and tributyltin on mRNA expression and physiology of the Eastern oyster (Crassostrea virginica).

Pesticides

Chlorpyrifos-induced toxicity has no gender selectivity in the early fetal brain.

Comparing the effect of triadimefon and its metabolite on male and female Xenopus laevis: Obstructed growth and gonad morphology.

Acute exposure to the fungicide penconazole affects some biochemical parameters in the crayfish (Astacus leptodactylus Eschscholtz, 1823).

Bioaccumulation and toxic effects of penconazole in earthworms (Eisenia fetida) following soil exposure.

The effects of a short-term exposure to propiconazole in zebrafish (Danio rerio) embryos.

Parkinsonian neurotoxicants impair the anti-inflammatory response induced by IL4 in glial cells: involvement of the CD200-CD200R1 ligand-receptor pair. [rotenone]

Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish.

Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions.

Flubendiamide, the first phthalic acid diamide insecticide, impairs neuronal calcium signalling in the honey bee’s antennae.

The effects of field-realistic doses of imidacloprid on Melipona quadrifasciata (Apidae: Meliponini) workers.

Gut bacteria of the silkworm Bombyx mori facilitate host resistance against the toxic effects of organophosphate insecticides.

Effects of Roundup and its main component, glyphosate, upon mammalian sperm function and survival.

In-vitro effect of diazoxon, a metabolite of diazinon, on proliferation, signal transduction, and death induction in mononuclear cells of Nile tilapia fish (Oreochromis niloticus).

Potentially Toxic Elements

Histone demethylase JHDM2A regulates H3K9 dimethylation in response to arsenic-induced DNA damage and repair in normal human liver cells.

Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat.

Metal-induced neurotoxicity in a RAGE-expressing C. elegans model.

Microplastics

Microplastic ingestion induces behavioral disorders in mice: A preliminary study on the trophic transfer effects via tadpoles and fish.

The response of Synechococcus sp. PCC 7002 to micro-/nano polyethylene particles – Investigation of a key anthropogenic stressor.

Platform to study intracellular polystyrene nanoplastic pollution and clinical outcomes.

Toxicity and trophic transfer of polyethylene microplastics from Poecilia reticulata to Danio rerio.

Mixtures

Multifactorial Analysis of Environmental Metabolomic Data in Ecotoxicology: Wild Marine Mussel Exposed to WWTP Effluent as a Case Study.

Mixture effects of oxygenated PAHs and benzo[a]pyrene on cardiovascular development and function in zebrafish embryos.

Synergistic effect of fenpropathrin and paclobutrazol on early life stages of zebrafish (Danio rerio).

Miscellaneous

Duration-dependent effects induced by titanium dioxide nanoparticles on pancreas of adult male albino rats (histological and biochemical study).

Parental transgenerational epigenetic inheritance related to dietary crude oil exposure in Danio rerio.

Expression dynamics of genes in the hypothalamic-pituitary-thyroid (HPT) cascade and their responses to 3,3′,5-triiodo-l-thyronine (T3) highlights potential vulnerability to thyroid-disrupting chemicals in zebrafish (Danio rerio) embryo-larvae.

Assessment of reproductive and developmental effects of graphene oxide on Japanese medaka (Oryzias latipes). [evaluated graphene oxide as an EDC]

Toxicological assessment of seven unregulated drinking water Disinfection By-products (DBPs) using the zebrafish embryo bioassay.

Exposure/Environment Studies

BPA/Phenols

Evaluation of bisphenol A levels in Nigerian thermal receipts and estimation of daily dermal exposure.

Bioaccumulation potential of bisphenols and benzophenone UV filters: A multiresidue approach in raptor tissues.

Fate of bisphenol S (BPS) and characterization of non-extractable residues in soil: Insights into persistence of BPS.

Exploratory study on the presence of bisphenol A and bis(2-ethylhexyl) phthalate in the Santa Catarina River in Monterrey, N.L., Mexico.

Phthalates

Determination of Selected Phthalates in Some Commercial Cosmetic Products By HPLC-UV.

Non-occupational exposure to phthalates in Finland.

Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Brown bullhead at the St. Lawrence River (Cornwall) Area of Concern: health and endocrine status in the context of tissue concentrations of PCBs and mercury.

Bioaccumulation of organochlorine pesticides in the Western Sandpiper (Calidris mauri) during the wintering season in Sinaloa, Mexico.

Perfluoroalkyl Substances

A robust matrix effect-free method for simultaneous determination of legacy and emerging per- and polyfluoroalkyl substances (PFASs) in crop and soil matrices.

Perfluoroalkyl substances in the Lingang hybrid constructed wetland, Tianjin, China: occurrence, distribution characteristics, and ecological risks.

Non-target and suspect screening of per- and polyfluoroalkyl substances in Chinese municipal wastewater treatment plants.

Flame Retardants

Occurrence and spatial distribution of organophosphorus flame retardants and plasticizers in the Bohai, Yellow and East China seas.

Polybrominated diphenyl ethers in soils from Tianjin, North China: distribution, health risk, and temporal trends.

Bioaccumulation and trophic transfer of organophosphate esters in tropical marine food web, South China Sea.

Pesticides

Pesticide lifecycle management in agriculture and public health: Where are the gaps?

Combined impact of pesticides and other environmental stressors on animal diversity in irrigation ponds.

Beyond neonicotinoids – Wild pollinators are exposed to a range of pesticides while foraging in agroecosystems.

Organophosphorus Pesticide Multi-residues in Commercialized Asian Rice.

The first report of selected herbicides and fungicides in water and fish from a highly utilized and polluted freshwater urban impoundment.

High prevalence of the neonicotinoid clothianidin in liver and plasma samples collected from gamebirds during autumn sowing.

Potentially Toxic Elements

Policy adjustment impacts Cd, Cu, Ni, Pb and Zn contamination in soils around e-waste area: Concentrations, sources and health risks.

Evaluation of some heavy metals and physicochemical properties of public refuse dumpsites in Nsukka metropolis, Nigeria.

Toxicity of particles emitted by fireworks.

Integrated environmental evaluation of heavy metals and metalloids bioaccumulation in invertebrates and seaweeds from different marine coastal areas of sardinia, mediterranean sea.

Lead source and bioaccessibility in windowsill dusts within a Pb smelting-affected area.

Seasonal and ontogenic variations of metal content in the European pilchard (Sardina pilchardus) in northwestern African waters.

Persistent thallium contamination in river sediments, source apportionment and environmental implications.

Risk of Mercury exposure during childhood: a review of Sri Lankan situation.

Comparative study of toxic heavy metal residues and other properties of honey from different environmental production systems.

Microplastics

Composition, spatial distribution and sources of plastic litter on the East China Sea floor.

Air Pollution

Mobilizing for Community Benefits to Assess Health and Promote Environmental Justice near the Gordie Howe International Bridge.

Indoor Climate and Air Quality in a Neonatal Intensive Care Unit.

Translational data analytics in exposure science and environmental health: a citizen science approach with high school students.

Air pollution in Ontario, Canada during the COVID-19 State of Emergency.

Pharmaceuticals/Personal Care Products

Monitoring pharmaceuticals and personal care products in water and fish from the Gulf of Urabá, Colombia.

Quantitation and localization of beta-blockers and SSRIs accumulation in fathead minnows by complementary mass spectrometry analyses.

Mixtures

Environmental contamination alters the intestinal microbial community of the livebearer killifish Phalloceros caudimaculatus.

Miscellaneous

Endocrine disruptors and pregnancy: Knowledge, attitudes and practice of perinatal health professionals. A French multicentre survey.

Prioritisation of emerging contaminants in the northern Antarctic Peninsula based on their environmental risk. [numerous chemicals]

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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