EDC Science Weekly, Jan. 26 – Feb. 1, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

TL;DR Highlights: US chemical biomonitoring exposure trends; EDCs and autism; Comparing long-term DDT and sperm in Greenland and South Africa; EPA/ORD’s efforts on cumulative impacts.

More science highlights

Events

Webinar February 13: Science for Prevention: Identifying breast carcinogens [EDC Strategies Partnership]

CME course Feb. 13: How Environmental Health Research Guides Clinical Care: PFAS, Obesity, and Bone Health [The Pediatric Environmental Health Center at Boston Children’s Hospital and the New England Region Pediatric Environmental Health Specialty Unit]

Webinar Feb. 20: How NY is Holding Pepsi Accountable for Its Plastic Pollution – & Your State Can, Too [Beyond Plastics]

Webinar Feb. 20: Prioritizing Five Chemicals for Risk Evaluation Under TSCA [EPA]

Webinar Feb. 21: Informational webinar on the Reach the Decision Makers program [UCSF EaRTH Center. Applications due Mar. 11]

Webinar Feb. 22: Tattoo Inks, Cancer and Other Chronic Diseases: Gaps in research and regulation [in Spanish and English, via CHE]

Conference Mar. 11-14: 10th Copenhagen Workshop on Endocrine Disruptors – COW2024. Abstracts are due Feb. 1.

Meeting March 22: HEEDS EDC- North Carolina annual meeting [free and open to anyone]

Gordon Research Conference on EDCs June 23-28, Tuscany Italy.

More events

Regulations/Policy

Changes in the European Union definition for endocrine disruptors: how many molecules remain a cause for concern? The example of crop protection products used in agriculture in France in the six last decades.

News:

ECHA launches new chemicals database

EPA accepting public comments on TSCA Science Advisory Committee on Chemicals and Scientific Integrity Policy

More EDC policy and regulations open for comment

Methods/Tools/Screening

PFAS ghosts: how to identify, evaluate, and exorcise new and existing analytical interference

A plausibility database summarizing the level of evidence regarding the hazards induced by the exposome on children health.

Screening of the Antagonistic Activity of Potential Bisphenol A Alternatives toward the Androgen Receptor Using Machine Learning and Molecular Dynamics Simulation.

The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics.

Grouping approaches based on structure alone are insufficient to conclude about toxicological properties-the example of monoamine-based chelates.

Artificial Intelligence and Machine Learning Methods to Evaluate Cardiotoxicity following the Adverse Outcome Pathway Frameworks.

Establishing performance metrics for quantitative non-targeted analysis: a demonstration using per- and polyfluoroalkyl substances.

Developing a Novel Read-Across Concept for Ecotoxicological Risk Assessment of Phosphate Chemicals: A Case Study.

The methodology of quantitative risk assessment studies.

The First Steps on AOPs’ Concepts, Development, and Applications in Teratology.

Three-Dimensional Cell Culture of Epididymal Basal Cells and Organoids: A Novel Tool for Toxicology.

MolToxPred: small molecule toxicity prediction using machine learning approach.

Microcarrier-based fluorescent yeast estrogen screen assay for fast determination of endocrine disrupting compounds.

More tools, reports, and resources

Commentaries

Challenges and opportunities for research supporting cumulative impact assessments at the United States environmental protection agency’s office of research and development.

Endocrine-Disrupting Chemicals in Children.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Linking Environmental Chemicals to Neuroinflammation and Autism Spectrum Disorder: Mechanisms and Implications for Prevention.

Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD).

A systematic review of contaminants in donor human milk. [PFAS, metals, etc.]

Ferroptosis Induced by Pollutants: An Emerging Mechanism in Environmental Toxicology.

PFAS

PFAS: exploration of neurotoxicity and environmental impact.

A comprehensive review on PFAS including survey results from the EFLM Member Societies.

Association between prenatal perfluorinated compounds exposure and risk of pregnancy complications: A meta-analysis.

Pesticides

Biodegradation of chlorpyrifos pollution from contaminated environment – A review on operating variables and mechanism.

Updated peer review of the pesticide risk assessment of the active substance pydiflumetofen. [EFSA]

Metals/Metalloids

Elucidating the link between thyroid cancer and mercury exposure: a review and meta-analysis.

A critical review on the ecotoxicity of heavy metal on multispecies in global context: A bibliometric analysis.

Mechanism and impact of heavy metal-aluminum (Al) toxicity on male reproduction: Therapeutic approaches with some phytochemicals.

Cadmium exposure and cardiovascular disease risk: A systematic review and dose-response meta-analysis.

Assessment of human exposure to cadmium and its nephrotoxicity in the Chinese population.

Microplastics/Nanomaterials

Research advances on the toxicity of biodegradable plastics derived micro/nanoplastics in the environment: A review.

Connecting the Dots: Livestock Animals as Missing Links in the Chain of Microplastic Contamination and Human Health.

Under-researched and under-reported new findings in microplastic field.

Miscellaneous

Contaminants of emerging concern: Occurrence, analytical techniques, and removal with electrochemical advanced oxidation processes with special emphasis in Latin America.

Review: Fish bile, a highly versatile biomarker for different environmental pollutants.

Human Health Studies

Numerous Chemicals/Mixtures

EDC mixtures during pregnancy and body fat at 7 years of age in a Swedish cohort, the SELMA study.

Parental occupations at birth and risk of adult testicular germ cell tumors in offspring: a French nationwide case-control study.

BPA/Phthalates

Maternal Exposure to Endocrine-Disrupting Chemicals: Analysis of Their Impact on Infant Gut Microbiota Composition. [BPA and phthalates]

Relationship between phthalates exposure, risk of decreased ovarian reserve, and oxidative stress levels.

The association between prenatal bisphenol F exposure and infant neurodevelopment: The mediating role of placental estradiol.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The Association between Long-Term DDT or DDE Exposures and an Altered Sperm Epigenome-a Cross-Sectional Study of Greenlandic Inuit and South African VhaVenda Men. and related Invited Perspective: Is DDT’s Imprint Here to Stay?

Polychlorinated Biphenyls and Semen Quality in Healthy Young Men Living in a Contaminated Area.

PFAS

Associations of legacy perfluoroalkyl and polyfluoroalkyl substances, alternatives, and isomers with gestational diabetes mellitus and glucose homeostasis among women conceiving through assisted reproduction in Shanghai, China.

Prenatal exposure to poly- and perfluoroalkyl substances and postpartum depression in women with twin pregnancies.

Epidemic-specific association of maternal exposure to per- and polyfluoroalkyl substances (PFAS) and their components with maternal glucose metabolism: A cross-sectional analysis in a birth cohort from Hong Kong.

Maternal and Paternal Preconception Serum Concentrations of Per and Polyfluoroalkyl Substances in Relation to Birth Outcomes.

Occurrence of COVID-19 and serum per– and polyfluoroalkyl substances: A case-control study among workers with a wide range of exposures.

Pesticides

Prenatal current-use pesticide exposure and children’s neurodevelopment at one year of age in the Infants’ Environmental Health (ISA) birth cohort, Costa Rica.

Association of prenatal chlorpyrifos exposure with sexually dimorphic differences in anogenital distance among Thai farmworker children.

Pesticide use patterns and their association with cytokine levels in Mexican flower workers.

Metals/Metalloids

Heavy Metals and Trajectories of Anti-Müllerian Hormone During the Menopausal Transition.

Analysis of Relationships between Metabolic Changes and Selected Nutrient Intake in Women Environmentally Exposed to Arsenic.

Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017-2018.

Placental cellular composition and umbilical cord tissue metal(loid) concentrations: A descriptive molecular epidemiology study leveraging DNA methylation.

Toxic metals and essential trace elements in placenta and their relation to placental function.

Associations of heavy metal mixtures with blood pressure among U.S. adults in NHANES 2017-2018 by four statistical models.

Environmental exposure to lead and cadmium are associated with triglyceride glucose index.

Association between blood metals mixture and chronic kidney disease in adults: NHANES 2013-2016.

Air Pollution

Prenatal Exposure to Air Pollution and Respiratory Distress in Term Newborns: Results from the MIREC Prospective Pregnancy Cohort. and related Invited Perspective: Prenatal PM2.5 Exposure Associated with Adverse Birth Outcomes Requiring Medical Interventions.

Urinary metabolite biomarkers of pregnancy complications associated with maternal exposure to particulate matter.

Long-Term Exposure to AIR Pollution and COVID-19 Mortality and Morbidity in DENmark: Who Is Most Susceptible? (AIRCODEN).

Miscellaneous

Benzo[a]pyrene exposure affects colorectal cancer susceptibility by regulating ERβ-mediated LINC02977 transcription.

Laboratory Studies

Numerous Chemicals/Mixtures

Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms.

BPA/Phenols

Nonspecific immune, histology and accumulation of marine worm, Urechis unicinctus in response to bisphenol A (BPA).

Liver and ovarian toxicities boosted by bisphenol and gamma radiation in female albino rats.

Comparison of the Effect of BPA and Related Bisphenols on Membrane Integrity, Mitochondrial Activity, and Steroidogenesis of H295R Cells In Vitro.

Genetic and Epigenetic Profiles of Polycystic Ovarian Syndrome and In Vitro Bisphenol Exposure in a Human Granulosa Cell Model.

Restoring Impaired Neurogenesis and Alleviating Oxidative Stress by Cyanidin against Bisphenol A-induced Neurotoxicity: In Vivo and In Vitro Evidence.

Induction of Phosphorylated Tau Accumulation and Memory Impairment by Bisphenol A and the Protective Effects of Carnosic Acid in In Vitro and In Vivo.

Self-Assembled Fe^III-TAML-Based Magnetic Nanostructures for Rapid and Sustainable Destruction of Bisphenol A.

Downregulation of the Expression of Steroidogenic Acute Regulatory Protein and Aromatase in Steroidogenic KGN Human Granulosa Cells after Exposure to Bisphenol A.

Gestational Exposure to Bisphenol A Causes DNA Hypomethylation and the Upregulation of Progesterone Receptor Expression in the Uterus in Adult Female Offspring Rats.

Acute Exposure to Bisphenol S Decreases In Vitro Right Atrial Contractility in Rats.

Effects of Nonylphenol on the Secretion of Catecholamines and Adrenocortical Hormones from Short-Term Incubated Rat Adrenal Glands.

Identification of non-volatile non-intentionally added substances from polyester food contact coatings and genotoxicity assessment of polyester coating’s migrates.

Phthalates

Rapid Assessment of Di(2-ethylhexyl) Phthalate Migration from Consumer PVC Products.

Ca²⁺ homeostasis imbalance induced by Pparg: A key factor in di (2-ethylhexyl) phthalate (DEHP)-induced cardiac dysfunction in zebrafish larvae.

Dibutyl phthalate adsorbed on multi-walled carbon nanotubes can aggravate liver injury in mice via the Jak2/STAT3 pathway.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

DDT exposure induces tremor-like behavior and neurotoxicity in developmental stages of embryonic zebrafish.

High-Throughput GPCRome Screen of Pollutants Reveals the Activity of Polychlorinated Biphenyls at Melatonin and Sphingosine-1-phosphate Receptors.

Exosomes released by environmental pollutant-stimulated Keratinocytes/PBMCs can trigger psoriatic inflammation in recipient cells via the AhR signaling pathway. [dioxin and B[a]P]

PFAS

Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development.

Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish.

Integrated evidence of transcriptional, metabolic, and intestinal microbiota changes in Ruditapes philippinarum due to perfluorooctanoic acid-induced immunotoxicity.

Mixture Effects of Per- and Polyfluoroalkyl Substances on Embryonic and Larval Sheepshead Minnows (Cyprinodon variegatus).

Transplacental transport of per- and polyfluoroalkyl substances (PFAS): Mechanism exploration via BeWo cell monolayer model.

Evidence on the genotoxic and ecotoxic effects of PFOA, PFOS and their mixture on human lymphocytes and bacteria.

Flame Retardants

Tri-ortho-cresyl phosphate induces hepatic steatosis by mTOR activation and ER stress induction.

Unravelling bioaccumulation, depletion and metabolism of organophosphate triesters in laying hens: Insight of in vivo biotransformation assisted by diester metabolites.

Cresyl Diphenyl Phosphate exposure induces reproductive functional defects in men and male mice.

Organotins

Assessment of toxicity, genotoxicity and oxidative stress in Fejervarya limnocharis exposed to tributyltin.

Developmental defects in cognition, metabolic and cardiac function following maternal exposures to low environmental levels of selective serotonin re-uptake inhibitors and tributyltin in Daphnia magna.

Pesticides

Antioxidant Vitamins Attenuate Glyphosate-Induced Development of Type-2 Diabetes Through the Activation of Glycogen Synthase Kinase-3 β and Forkhead Box Protein O-1 in the Liver of Adult Male Rats.

Nonalcoholic Fatty Liver Disease Development in Male Mice upon Exposure to Flubendiamide.

Curcumin alleviates atrazine-induced cardiotoxicity by inhibiting endoplasmic reticulum stress-mediated apoptosis in mice through ATF6/Chop/Bcl-2 signaling pathway.

Cypermethrin induces Sertoli cell apoptosis through endoplasmic reticulum-mitochondrial coupling involving IP3R1-GRP75-VDAC1.

Developmental exposure to hormone-mimicking insect growth disruptors alters expression of endocrine-related genes in worker honey bee (Hymenoptera: Apidae) brains and hypopharyngeal glands.

Metals/Metalloids

Transgenerational inheritance of methylmercury and vitamin A-induced toxicological effects in a Wistar rats environmental-based model.

Cadmium Exposure Induces Apoptosis and Necrosis of Thyroid Cells via the Regulation of miR-494-3p/PTEN Axis.

Molecular mechanisms of cadmium-induced cytotoxicity in human ovarian granulosa cells identified using integrated omics.

Differentially expressed long non-coding RNAs and mRNAs of cadmium exposure on learning disability of offspring rats.

Microplastics/Nanomaterials

Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis.

Investigation of the adsorption behavior and adsorption mechanism of pollutants onto electron beam-aged microplastics.

Polystyrene microplastics photo-aged under simulated sunlight influences gonadal development in the Pacific oyster.

Polyethylene microplastics induced gut microbiota dysbiosis leading to liver injury via the TLR2/NF-κB/NLRP3 pathway in mice.

DDT and titanium dioxide nanoparticle coexposure induced neurobehavioral deficits in zebrafish.

Effects of polystyrene nanoplastics and PCB-44 exposure on growth and physiological biochemistry of Chlorella vulgaris.

Co-exposure with cadmium elevates the toxicity of microplastics: Trojan horse effect from the perspective of intestinal barrier.

Chronic exposure to polytetrafluoroethylene microplastics caused sex-specific effects in the model insect, Drosophila melanogaster (Diptera: Drosophilidae).

Chronic exposure to low concentrations of microplastics causing gut tissue damage but non-significant changes in the microbiota of marine medaka larvae (Oryzias melastigma).

Microplastic-induced NAFLD: Hepatoprotective effects of nanosized selenium.

Microplastics affect mosquito from aquatic to terrestrial lifestyles and are transferred to mammals through mosquito bites.

Hepatotoxic of polystyrene microplastics in aged mice: Focus on the role of gastrointestinal transformation and AMPK/FoxO pathway.

Miscellaneous

A low dose of benzo(a)pyrene during prepuberty in male rats generated immediate oxidative stress in the testes and compromised steroidogenic enzymes/proteins.

Regulation of Benzo[a]pyrene-Induced Hepatic Lipid Accumulation through CYP1B1-Induced mTOR-Mediated Lipophagy.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data.

Phthalates

Tracing of Di-Ethylhexyl Phthalate in the Tequila Production Process.

Relationship between the use of plastics in refrigerator food storage and urine phthalate metabolites: the Korean National Environmental Health Survey (KoNEHS) cycle 3.

Dust phase and window film phase phthalates in dormitories: profile characteristics, source screening, and estimated gas-phase concentration and dermal exposure comparison.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dietary exposure levels to polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and non-ortho-polychlorinated biphenyls in US meat, poultry and siluriform fish from 2018 to 2019.

PFAS

Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood.

Spatial distribution characteristics of perfluoroalkyl substances in bulk and grain size fractionated sediments in Shenzhen Bay.

Simulating behavior of perfluorooctane sulfonate (PFOS) in the mainstream of a river system with sluice regulations.

Field study on endogenous perfluoroalkyl acid release and their spatiotemporal distribution processes induced by inland navigation.

Per- and poly-fluoroalkyl substances removal in multi-barrier advanced water purification system for indirect potable reuse.

Quantification of long-chain, short-chain, and ultrashort-chain liquid chromatography-amenable PFASs in water: Evaluation of approaches and tradeoffs for AFFF-impacted water.

Evaluation of commercial nanofiltration and reverse osmosis membrane filtration to remove per-and polyfluoroalkyl substances (PFAS): Effects of transmembrane pressures and water matrices.

Flame Retardants

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food.

Exploring the residential exposome: Determination of hazardous flame retardants in air filter dust from HVAC systems.

Novel method for rapid monitoring of OPFRs by LLE and GC-MS as a tool for assessing biodegradation: validation and applicability.

Pesticides

Multiple lines of evidence point to pesticides as stressors affecting invertebrate communities in small streams in five United States regions.

Low-background interference detection of glyphosate, glufosinate, and AMPA in foods using UPLC-MS/MS without derivatization.

Metals/Metalloids

Particulate Pb emission factors from wildland fires in the United States.

Large mercury release from the Greenland Ice Sheet invalidated.

Microplastics/Nanomaterials/Plastics

MicroRaman spectroscopy detects the presence of microplastics in human urine and kidney tissue.

Natural aging and adsorption/desorption behaviors of polyethylene mulch films: Roles of film types and exposure patterns.

Effect of aging on the release of di-(2-ethylhexyl) phthalate from biodegradable and petroleum-based microplastics into soil.

Tracking the micro- and nanoplastics in the terrestrial-freshwater food webs. Bivalves as sentinel species.

Air Pollution

Air pollution benefits from reduced on-road activity due to COVID-19 in the United States.

Miscellaneous

The occurrence, sources, and health risks of substituted polycyclic aromatic hydrocarbons (SPAHs) cannot be ignored.

High-Resolution Mass Spectrometry Screening of Quaternary Ammonium Compounds (QACs) in Dust from Homes and Various Microenvironments in South China.

Levels, distribution, sources and human exposure pathways of alkylphenol and alkylphenol ethoxylates in indoor dust in Turkiye.

PAH residues and toxicity levels two years after an extensive oil spill on the northeast Brazilian coast.

Evaluation of Appropriate Conditions for Efficient Simultaneous Determination of US EPA and EU Priority Polycyclic Aromatic Hydrocarbons in Various Food Categories and Assessment of Their Consumption Risk.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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