EDC Science Weekly, Dec. 16 – 22, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Note: Happy Holidays everyone! I won’t be sending this out next week due to vacation. It will be back sometime in early January whenever I catch up! Thanks for reading!

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

For events, see the December issue of HEEDS News (and sign up to receive it to your inbox in the top left)

Regulations/Policy

Bisphenol A: EFSA draft opinion proposes lowering the tolerable daily intake [not a scientific study but newsworthy; you can make comments here]

Children’s Rights, Environmental Justice, and Environmental Health Policy in the United States. [this review is part of a special issue in J Pediatr Health Care; see introductory editorial here: Planetary Health, Environmental Justice, and Child Health, a guest editorial here: Turning Crisis Into Opportunity, and more articles in various sections below.]

Methods/Tools/Screening

How to investigate human health effects related to exposure to mixtures of per- and polyfluoroalkyl substances: A systematic review of statistical methods.

Prediction of the endocrine-disrupting ability of 49 per- and polyfluoroalkyl substances: In silico and epidemiological evidence.

An In vitro dimerization assay for the adverse outcome pathway approach in risk assessment of human estrogen receptor α-mediated endocrine-disrupting chemicals.

Uncovering global-scale risks from commercial chemicals in air. [case study using flame retardants but applicable to others]

Benchmark dose modelling in regulatory ecotoxicology, a potential tool in pest management.

Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated with Chemical Alterations of in Vitro Neural Network Formation.

A synergism of in silico and statistical approaches to discover new potential endocrine disruptor mycotoxins.

Commentaries/Conference Summaries

Invited Perspective: Moving from Characterizing to Addressing Racial/Ethnic Disparities in Air Pollution Exposure. [re Disparities in Air Pollution Exposure in the United States by Race/Ethnicity and Income, 1990-2010.]

Relevant and Realistic Assessments of Microplastics and Nanoplastics in the Environment. [special issue in Environ Toxicol Chem.]

How much pesticide residue is in your diet? It depends on what you eat-and how it’s grown.

A Measure of Strength: Developmental PFAS Exposures and Bone Mineral Content in Adolescence. [science selection in EHP]

Reviews

Numerous Chemicals/Mixtures

Environmental factors in declining human fertility.

Pediatric Chemical Exposure: Opportunities for Prevention.

New insights on the effects of endocrine-disrupting chemicals on children.

Which Micropollutants in Water Environments Deserve More Attention Globally?

Perfluoroalkyl Substances

Association between per- and polyfluoroalkyl substances and risk of gestational diabetes mellitus.

A review on per- and polyfluorinated alkyl substances (PFASs) in microplastic and food-contact materials.

The transplacental transfer efficiency of per- and polyfluoroalkyl substances (PFAS): a first meta-analysis.

Pesticides

Chronic Effects of Imidacloprid on Honey Bee Worker Development-Molecular Pathway Perspectives.

Potentially Toxic Elements

Toxic heavy metal concentrations in multiple sclerosis patients: A systematic review and meta-analysis.

Microplastics

Untoward effects of micro- and nanoplastics: An expert review of their biological impact and epigenetic effects.

Towards a framework for environmental fate and exposure assessment of polymers.

Air Pollution

Easy Breathing: A Review of the Impact of Air Quality on Pediatric Health Outcomes.

Evidence of susceptibility to autism risks associated with early life ambient air pollution: A systematic review.

Epidemiologic evidence of exposure to polycyclic aromatic hydrocarbons and breast cancer: A systematic review and meta-analysis.

Pharmaceuticals/Personal Care Products

Algae bioprocess to deal with cosmetic chemical pollutants in natural ecosystems: A comprehensive review.

Miscellaneous

Contaminants of emerging concern (CECs) in aquaculture effluent: Insight into breeding and rearing activities, alarming impacts, regulations, performance of wastewater treatment unit and future approaches.

Trends in mitigation of industrial waste: Global health hazards, environmental implications and waste derived economy for environmental sustainability.

Potential Use of Microbial Enzymes for the Conversion of Plastic Waste Into Value-Added Products: A Viable Solution.

Cardioprotective and nephroprotective effects of Quercetin against different toxic agents.

Human Health Studies

Numerous Chemicals/Mixtures

ALS risk factors: Industrial airborne chemical releases.

BPA/Phenols

Urinary bisphenol concentrations and its association with metabolic disorders in the US and Korean populations.

Phthalates

Association between urinary phthalate metabolites and dyslipidemia in children: Results from a Chinese cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Environmental contaminants and the disproportionate prevalence of type-2 diabetes mellitus among Indigenous Cree women in James Bay Quebec, Canada.

Flame Retardants

Association of exposure to organophosphate esters with increased blood pressure in children and adolescents.

Pesticides

Association between residential proximity to agricultural crops and adaptive behaviors in children with autism spectrum disorder from the French ELENA cohort.

Pesticides Use and Impaired Lung Function Among Male Agricultural Farmers in Rural Sindh, Pakistan.

Potentially Toxic Elements

Prenatal lead exposure, telomere length in cord blood, and DNA methylation age in the PROGRESS prenatal cohort.

Heavy metals exposure is associated with early liver dysfunction among rural residents aged 40-75 years in southwest China.

Blood lead level in Chinese adults with and without coronary artery disease.

The Association Between Cadmium Exposure and Osteoporosis: A Longitudinal Study and Predictive Model in a Chinese Female Population.

High Cadmium Levels in Individuals with Depressive Mood: Results from the 2008-2013 Korean National Health and Nutrition Survey.

Heavy metal toxicity and mortality-association between density of heavy metal bands and cause specific hospital admissions and mortality: population based cohort study.

Alcohol Consumption Moderated the Association Between Levels of High Blood Lead or Total Urinary Arsenic and Bone Loss.

Air Pollution

Pre- and postnatal exposure to multiple ambient air pollutants and child behavioral problems at five years of age.

Composition of fine particulate matter and risk of preterm birth: A nationwide birth cohort study in 336 Chinese cities.

Exposure to air pollutants during pregnancy and after birth increases the risk of neonatal hyperbilirubinemia.

Miscellaneous

[Trend of change in sperm concentration in Chinese fertile males from 1984 to 2019]. [in Chinese; it declined]

Laboratory Studies

Numerous Chemicals/Mixtures

Long-term in vitro exposure of human granulosa cells to the mixture of endocrine disrupting chemicals found in human follicular fluid disrupts steroidogenesis.

Quantum Chemical Calculation and Evaluation of Partition Coefficients for Classical and Emerging Environmentally Relevant Organic Compounds.

BPA/Phenols

Crystal structure of endocrine-disrupting chemical bisphenol A and estrogen-related receptor γ.

A Comparative Study of Effects of 28-Day Exposure of Bisphenol A and Bisphenol S on Body Weight Changes, Organ Histology, and Relative Organ Weight.

Bisphenol A induces pyroptotic cell death via ROS/NLRP3/Caspase-1 pathway in osteocytes MLO-Y4.

Naringenin protects swine testis cells from bisphenol A-induced apoptosis via Keap1/Nrf2 signaling pathway.

Comparative toxicities of BPA, BPS, BPF, and TMBPF in the nematode Caenorhabditis elegans and mammalian fibroblast cells.

Computational risk assessment framework for the hazard analysis of bisphenols and quinone metabolites.

Effects of an environmental endocrine disruptor, para-nonylphenol on the cell growth of Euglena gracilis: association with the cellular oxidative stress.

Phthalates

Molecular mechanisms of developmental toxicity induced by BBP in zebraﬁsh embryos.

Parabens/Triclosan/Antimicrobials

Assessment of Thyroid Endocrine Disruption Effects of Parabens Using In Vivo, In Vitro, and In Silico Approaches.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Proteomic Analysis of Subchronic Furan Exposure in the Liver of Male Fischer F344 Rats.

Sex and Genotype Modulate the Dendritic Effects of Developmental Exposure to a Human-Relevant Polychlorinated Biphenyls Mixture in the Juvenile Mouse.

Glutamatergic transmission associated with locomotion-related neurotoxicity to lindane over generations in Caenorhabditis elegans.

Flame Retardants

Decabromodiphenyl Ethane Mainly Affected the Muscle Contraction and Reproductive Endocrine System in Female Adult Zebrafish.

Tris(1,3-dichloro-2-propyl) phosphate reduces longevity through a specific microRNA-mediated DAF-16/FoxO in an unconventional insulin/insulin-like growth factor‑1 signaling pathway.

Developmental and Hepatic Gene Expression Changes in Chicken Embryos Exposed to p-tert-butylphenyl Diphenyl Phosphate and Isopropylphenyl Phosphate via Egg Injection.

Biological responses of Eisenia fetida towards the exposure and metabolism of tris (2-butoxyethyl) phosphate.

The phytotoxicity of exposure to two polybrominated diphenyl ethers (BDE47 and BDE209) on photosynthesis and the response of the hormone signaling and ROS scavenging system in tobacco leaves.

Organotins

Solid-state ¹H NMR-based metabolomics assessment of tributylin effects in zebrafish bone.

Pesticides

Glyphosate damages blood-testis barrier via NOX1-triggered oxidative stress in rats: Long-term exposure as a potential risk for male reproductive health.

Assessment of acetylcholinesterase, catalase, and glutathione S-transferase as biomarkers for imidacloprid exposure in penaeid shrimp.

Comparison of Species Sensitivity Distributions for Sediment-associated Nonionic Organic Chemicals Through Equilibrium Partitioning Theory and Spiked-sediment Toxicity Tests with Invertebrates.

Evaluation of human relevance of Nicofluprole-induced rat thyroid disruption.

Potentially Toxic Elements

Arsenic exposure via drinking water during pregnancy and lactation induces autism-like behaviors in male offspring mice.

Co-exposure of sodium arsenite and uranyl acetate differentially alters gene expression in CD3/CD28 activated CD4+ T-cells.

Microplastics/Nanomaterials

Transcriptomic analysis and transgenerational effects of ZnO nanoparticles on Daphnia magna: Endocrine-disrupting potential and energy metabolism.

Speciation and release risk of heavy metals bonded on simulated naturally-aged microplastics prepared from artificially broken macroplastics.

Polystyrene Nanoplastics Inhibit the Transformation of Tetrabromobisphenol A by the Bacterium Rhodococcus jostii.

Embryotoxicity of polystyrene microplastics in zebrafish Danio rerio.

Synergistic effect of ZnO NPs and imidacloprid on liver injury in male ICR mice: Increase the bioavailability of IMI by targeting the gut microbiota.

Microplastics and bisphenol A hamper gonadal development of whiteleg shrimp (Litopenaeus vannamei) by interfering with metabolism and disrupting hormone regulation.

Dual role of titanium dioxide nanoparticles in the accumulation of inorganic and methyl mercury by crustacean Daphnia magna through waterborne and dietary exposure.

Pharmaceuticals/Personal Care Products

Mixture toxicity of six pharmaceuticals towards Aliivibrio fischeri, Daphnia magna, and Lemna minor.

Miscellaneous

Carcinogenic Risk of 2,6-Di-tert-Butylphenol and Its Quinone Metabolite 2,6-DTBQ Through Their Interruption of RARβ: In Vivo, In Vitro, and In Silico Investigations.

Thyroid disruption and growth inhibition of zebrafish embryos/larvae by phenanthrene treatment at environmentally relevant concentrations.

Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Concentrations of bisphenols, benzophenone-type ultraviolet filters, triclosan, and triclocarban in the paired urine and blood samples from young adults: Partitioning between urine and blood

Circulating exosome level of indigenous fish may be a novel biomarker for the integrated ecotoxicity effect of water environment.

Occurrence and risk assessment of organophosphate esters and bisphenols in San Francisco Bay, California, USA.

BPA/Phenols

Knowledge, attitude and practice on exposure to Bisphenol A among dental surgeons in Southern India.

Phthalates

The effect of heavy rainfall on the exposure risks of sedimentary phthalate esters to aquatic organisms.

The reaction laws and toxicity effects of phthalate acid esters (PAEs) ozonation degradation on the troposphere.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Concentrations and Toxic Implications of Dioxin-Like PCBs in Soil Samples from Electrical Power Stations in Lagos, Nigeria.

Perfluoroalkyl Substances

Comparison of untargeted and targeted perfluoroalkyl acids measured in adolescent girls.

Occurrence and infant exposure assessment of per and polyfluoroalkyl substances in breast milk from South Africa.

Development and validation of an LC-MS/MS method for the quantitation of 30 legacy and emerging per- and polyfluoroalkyl substances (PFASs) in human plasma, including HFPO-DA, DONA, and cC6O4.

Investigation of perfluoroalkyl substances in proglacial rivers and permafrost seep in a high Arctic watershed.

Sea Spray Aerosol (SSA) as a Source of Perfluoroalkyl Acids (PFAAs) to the Atmosphere: Field Evidence from Long-Term Air Monitoring.

Assessing exposures to per- and polyfluoroalkyl substances in two populations of Great Lakes Basin fish consumers in Western New York State.

Physiologically based pharmacokinetic (PBPK) modeling of perfluorohexane sulfonate (PFHxS) in humans.

Selectivity of Per- and Polyfluoroalkyl Substance Sensors and Sorbents in Water.

Mass Balance of Perfluoroalkyl Acids, Including Trifluoroacetic Acid, in a Freshwater Lake.

Effects of long-term perfluorooctane sulfonate (PFOS) exposure on activated sludge performance, composition, and its microbial community.

Resistance of Perfluorooctanoic Acid to Degradation by the Microbially-Driven Fenton Reaction.

Dependency of the photocatalytic and photochemical decomposition of per- and polyfluoroalkyl substances (PFAS) on their chain lengths, functional groups, and structural properties.

Occurrence and removal of poly/perfluoroalkyl substances (PFAS) in municipal and industrial wastewater treatment plants.

Comparing the Leaching Behavior of Per- and Polyfluoroalkyl Substances from Contaminated Soils Using Static and Column Leaching Tests.

Flame Retardants

Exploring source footprint of Organophosphate esters in the Bohai Sea, China: Insight from temporal and spatial variabilities in the atmosphere from June 2014 to May 2019.

Pesticides

Quantitative assessment of multiple pesticides in silicone wristbands of children/guardian pairs living in agricultural areas in South Africa.

Correction: Pesticide exposure among Bolivian farmers: associations between worker protection and exposure biomarkers.

Acute toxicity and metabolism of pesticides in birds.

Ecotoxicological QSTR and QSTTR Modeling for the Prediction of Acute Oral Toxicity of Pesticides against Multiple Avian Species.

Environmental fate of glyphosate used on Swedish railways – Results from environmental monitoring conducted between 2007-2010 and 2015-2019.

Behavior and fate of fungicide chlorothalonil in urban landscape soils and associated environmental concern.

Direct pesticide exposure of insects in nature conservation areas in Germany.

Potentially Toxic Elements

The role of dietary factors on blood lead concentration in children and adolescents – Results from the nationally representative German Environmental Survey 2014-2017 (GerES V).

Arsenic and toxic metals in meat and fish consumed in Niger delta, Nigeria: Employing the margin of exposure approach in human health risk assessment.

A County-Level Program for the Evaluation of the Potential for Take-Home Lead Exposures Among Children in Michigan.

Relating mercury occurrence in soil gases at establishments hosting children to historical mercury-using activities in Paris, France.

Validation of blood arsenic and manganese assessment from archived clotted erythrocyte fraction in an urban cohort of mother-child dyads.

Feather heavy metal contamination in various species of waterbirds from Asia: a review.

Metal(loid) pollution, not urbanisation nor parasites predicts low body condition in a wetland bioindicator snake.

Cement and oil refining industries as the predominant sources of trace metal pollution in the Red Sea: A systematic study of element concentrations in the Red Sea zooplankton.

Ecotoxicological risk ranking of 19 metals in the lower Yangtze River of China based on their threats to aquatic wildlife.

Heavy metal pollution of soils and risk assessment in Houston, Texas following Hurricane Harvey.

Anthropogenic and Climatic Drivers of Long-Term Changes of Mercury and Feeding Ecology in Arctic Beluga (Delphinapterus leucas) Populations.

Experimental evidence for recovery of mercury-contaminated fish populations.

Toxic arsenic in marketed aquatic products from coastal cities in China: Occurrence, human dietary exposure risk, and coexposure risk with mercury and selenium.

Lead and other elements-based pollution in soil, crops and water near a lead-acid battery recycling factory in Bangladesh.

Metal transfer and related human health risk assessment through milk from cattle grazing at an industrial discharge area.

Ecological risk assessment of trace elements accumulated in stormwater ponds within industrial areas.

Microplastics

Detection and characterization of small-sized microplastics (≥ 5 µm) in milk products.

Quantification of microplastics in sediments from Narragansett Bay, Rhode Island USA using a novel isolation and extraction method.

Microplastics removal and characteristics of constructed wetlands WWTPs in rural area of Changsha, China: A different situation from urban WWTPs.

Microplastics in the high-altitude Himalayas: Assessment of microplastic contamination in freshwater lake sediments, Northwest Himalaya (India).

Occurrence of microplastics in the gastrointestinal tract of benthic by-catches from an eastern Mediterranean deep-sea environment.

Pharmaceuticals/Personal Care Products

Concentration profiles of a typical ultraviolet filter benzophenone-3 and its derivatives in municipal sewage sludge in China: Risk assessment in sludge-amended soil.

Miscellaneous

Environmental Risk Assessment for Relevant Ingredients in Adhesives and Sealants in Commonplace Industrial Uses.

Globalization-Driven Industry Relocation Significantly Reduces Arctic PAH Contamination.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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