EDC Science Weekly, Aug. 26 – Sept. 1, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, New Book, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Sept 22 webinar: Multi- and transgenerational outcomes of an exposure to a mixture of EDCs on puberty and maternal behavior in the female rat

For more upcoming events, see the August edition of HEEDS News and feel free to subscribe!

New Book on EDCs

Advances in Pharmacology Book on Endocrine Disrupting Chemicals, edited by Laura Vandenberg and Judith Turgeon

Regulations/Policy

Scientific support for preparing an EU position for the 52nd Session of the Codex Committee on Pesticide Residues (CCPR).

Upholding the EU’s Commitment to ‘Animal Testing as a Last Resort’ Under REACH Requires a Paradigm Shift in How We Assess Chemical Safety to Close the Gap Between Regulatory Testing and Modern Safety Science.

Methods/Tools/Screening

Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery.

Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors.

Commentaries/Conference Summaries

Documenting Environmental Contamination in Vulnerable Populations.

Bisphenol A and cancer: a prelude to challenging epidemiology. [letter]

Recent Progress and Research Trends in Microplastic Pollution and the Potential Health Risks. [intro to a special issue on microplastics in BECT]

From Florence to fossil fuels: Nursing has always been about environmental health.

Reviews

Numerous EDCs

Endocrine disruptors: Challenges and future directions in epidemiologic research.

Endocrine-disrupting chemicals.

The U.S. national biomonitoring network – Enhancing capability and capacity to assess human chemical exposures.

E-Waste in Africa: A Serious Threat to the Health of Children.

Environmental Exposure to Endocrine Disrupting Chemicals Influences Genomic Imprinting, Growth, and Metabolism

Endocrine-Disrupting Chemicals and Disorders of Penile Development in Humans.

Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms.

Systematic review of reptile reproductive toxicology to inform future research directions on endangered or threatened species, such as sea turtles

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs).

Environment and food safety: a novel integrative review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Experimental Evidence of 2,3,7,8-Tetrachlordibenzo-p-Dioxin (TCDD) Transgenerational Effects on Reproductive Health.

Perfluoroalkyl Substances

Understanding the Impact of Perfluorinated Compounds on Cardiovascular Diseases and Their Risk Factors: A Meta-Analysis Study.

Per/polyfluoroalkyl substances production, applications and environmental impacts.

Flame Retardants

A review of the success and challenges in characterizing human dermal exposure to flame retardants.

Pesticides

A systematic review and meta-analysis of the impacts of glyphosate on the reproductive hormones.

Effect of paraquat on cytotoxicity involved in oxidative stress and inflammatory reaction: A review of mechanisms and ecological implications.

Indirect Effect of Pesticides on Insects and Other Arthropods.

Pesticides pollution and risk assessment of river Ganga: A review.

Potentially Toxic Elements

Melatonin: a pleiotropic hormone as a novel potent therapeutic candidate in arsenic toxicity.

Heavy Metals in the Environment and Thyroid Cancer

Exposure to Environmental Arsenic and Emerging Risk of Alzheimer’s Disease: Perspective Mechanisms, Management Strategy, and Future Directions.

Microplastics

Science-society-policy interface for microplastic and nanoplastic: Environmental and biomedical aspects.

Plastic Impacts in Argentina: a Critical Research Review Contributing to the Global Knowledge.

Environmental behaviors of microplastics in aquatic systems: A systematic review on degradation, adsorption, toxicity and biofilm under aging conditions.

Chemical Analysis of Microplastics and Nanoplastics: Challenges, Advanced Methods, and Perspectives.

Miscellaneous

Testis Toxicants: Lesson from Traditional Chinese Medicine (TCM).

Human Health Studies

Numerous Chemicals

Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco.

Identifying active xenobiotics in humans by use of a suspect screening technique coupled with lipidomic analysis.

BPA/Phenols

Bisphenol A, S, and F exposure, ESR1/2, CAT, and eNOS genetic polymorphisms, and the risk of hypertension.

Phthalates

Urinary phthalate metabolites mixture, serum cytokines and renal function in children: A panel study.

Relationships between di-(2-ethylhexyl) phthalate exposure and lipid metabolism in adolescents: Human data and experimental rat model analyses

Phthalates exposure is associated with non-alcoholic fatty liver disease among US adults.

Parabens/Triclosan/Antimicrobials

Association of triclosan and triclocarban in urine with obesity risk in Chinese school children.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

DNA methylation in the adipose tissue and whole blood of Agent Orange-exposed Operation Ranch Hand veterans: a pilot study.

Perfluoroalkyl Substances

Early pregnancy loss: DoPer- and polyfluoroalkyl substances matter?

Childhood exposure to per- and polyfluoroalkyl substances (PFAS) and neurobehavioral domains in children at age 8 years.

Pesticides

The pesticide health risk index – An application to the world’s countries.

Cancer incidence in agricultural workers: Findings from an international consortium of agricultural cohort studies (AGRICOH).

Relationship between Respiratory Morbidity and Environmental Exposure to Organochlorine Pesticides in Armenia.

Genetic Polymorphisms of Pesticide-Metabolizing Enzymes and Transporters in Agricultural Workers and Thyroid Hormone Levels.

Pesticide Spraying and Reduced Cholinesterase Activity among Hill Tribe Farmers in Thailand.

Autoimmune dysautonomia secondary to chronic organophosphate exposure.

Potentially Toxic Elements

Heavy metals controlling cardiovascular diseases risk factors in myocardial infarction patients in critically environmentally heavy metal-polluted steel industrial town Mandi-Gobindgarh (India).

Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia.

Association between placental toxic metal exposure and NICU Network Neurobehavioral Scales (NNNS) profiles in the Rhode Island Child Health Study (RICHS).

Environmental exposure to lead, mercury, and cadmium is not associated with abnormal kidney function in Korean adolescents.

Nephrotoxic Metal Mixtures and Preadolescent Kidney Function

Genetic Polymorphism of Delta Aminolevulinic Acid Dehydratase (ALAD) Gene and Symptoms of Chronic Mercury Exposure in Munduruku Indigenous Children within the Brazilian Amazon.

Concentrations of Lead, Mercury, Arsenic, Cadmium, Manganese, and Aluminum in the Blood of Pakistani Children with and without Autism Spectrum Disorder and Their Associated Factors.

Selenium Status, Its Interaction with Selected Essential and Toxic Elements, and a Possible Sex-Dependent Response In Utero, in a South African Birth Cohort.

Observational Study of the Association between Air Cadmium Exposure and Prostate Cancer Aggressiveness at Diagnosis among a Nationwide Retrospective Cohort of 230,540 Patients in the United States.

Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer

Air Pollution

Air pollution and the pandemic: Long-term PM_2.5 exposure and disease severity in COVID-19 patients.

Long-term exposure to fine particulate matter air pollution: An ecological study of its effect on COVID-19 cases and fatality in Germany.

Pharmaceuticals/Personal Care Products

Multigenerational endometriosis : consequence of fetal exposure to diethylstilbestrol?

Laboratory Studies

Numerous Chemicals/Mixtures

Differences in marine megafauna in vitro sensitivity highlights the need for species-specific chemical risk assessments. [Cr, Cd, Hg, DDE, PFNA]

Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures.

Neonatal exposure to BPA, BDE-99, and PCB produces persistent changes in hepatic transcriptome associated with gut dysbiosis in adult mouse livers.

Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome-An Examination Using Triclosan and Perfluorohexane Sulfonate.

Exposure to a mixture of 23 chemicals associated with unconventional oil and gas operations alters immune response to challenge in adult mice.

Impact of Estrogen Withdrawal and Replacement in Female Mice along the Intestinal Tract. Comparison of E2 Replacement with the Effect of a Mixture of Low Dose Pollutants.

BPA/Phenols

Environmental level bisphenol A accelerates alterations of the reno-cardiac axis by the MAPK cascades in male diabetic rats: An analysis based on transcriptomic profiling and bioinformatics.

Bisphenol A exposure during the embryonic period: Insights into dopamine relationship and behavioral disorders in Drosophila melanogaster.

Astaxanthin Inhibits Autophagic Cell Death Induced by Bisphenol A in Human Dermal Fibroblasts

Therapeutic effects of astragaloside IV and Astragalus spinosus saponins against bisphenol A-induced neurotoxicity and DNA damage in rats.

Bisphenol S promotes fat storage in multiple generations of Caenorhabditis elegans in a daf-16/nhr-49 dependent manner.

Effects of chronic exposure to nonylphenol at environmental concentration on thyroid function and thyroid hyperplasia disease in male rats.

Phthalates

Enhancement of placental inflammation by Dibutyl Phthalate.

Combined effect of co-exposure to di (2-ethylhexyl) phthalates and 50-Hz magnetic-fields on promoting human amniotic cells proliferation.

Effects of bis(2-butoxyethyl) phthalate exposure in utero on the development of fetal Leydig cells in rats.

The impact of di-isononyl phthalate exposure on specialized epithelial cells in the colon.

A study of possible substitutes for the endocrine disruptor DEHP in two hormone receptors.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Intrauterine exposure to 2,3′,4,4′,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in F1 male mice.

Chronic DDE Exposure Modifies Mitochondrial Respiration during Differentiation of Human Adipose-Derived Mesenchymal Stem Cells into Mature Adipocytes

Cutaneous Effects of In Utero and Lactational Exposure of C57BL/6J Mice to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Perfluoroalkyl Substances

Potency ranking of per- and polyfluoroalkyl substances using high-throughput transcriptomic analysis of human liver spheroids.

Pre-Fertilization Exposure of Rainbow Trout Eggs to PFAS to Simulate Accumulation During Oogenesis.

First Evidence of In Vitro Effects of C6O4-A Substitute of PFOA-On Haemocytes of the Clam Ruditapes philippinarum.

Determination of Perflourooctanoic Acid Toxicity in a Human Hepatocarcinoma Cell Line.

The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure.

Flame Retardants

Accelerated oxidation of the emerging brominated flame retardant tetrabromobisphenol S by unactivated peroxymonosulfate: The role of bromine catalysis and formation of disinfection byproducts.

Thyroid disruption and oxidative stress in American kestrels following embryonic exposure to the alternative flame retardants, EHTBB and TBPH.

Organotins

Transgenerational metabolomic fingerprints in mice ancestrally exposed to the obesogen TBT.

Tributyltin(IV) Butyrate: A Novel Epigenetic Modifier with ER Stress- and Apoptosis-Inducing Properties in Colon Cancer Cells.

Pesticides

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue.

Bioaccumulation, metabolism and endocrine-reproductive effects of metolachlor and its S-enantiomer in adult zebrafish (Danio rerio).

Benoxacor caused developmental and cardiac toxicity in zebrafish larvae.

Developmental toxicity of 3-phenoxybenzoic acid (3-PBA) and endosulfan sulfate derived from insecticidal active ingredients: Abnormal heart formation by 3-PBA in zebrafish embryos.

Atrazine Promoted Epithelial Ovarian Cancer Cells Proliferation and Metastasis by Inducing Low Dose Reactive Oxygen Species (ROS).

Improved mitochondrial function corrects immunodeficiency and impaired respiration in neonicotinoid exposed bumblebees.

Environmentally Relevant Mixture of Pesticides Affect Mobility and DNA Integrity of Early Life Stages of Rainbow Trout (Oncorhynchus mykiss).

Effects of 2,4-dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy-related proteins as well as the protective effect of Lycium barbarum polysaccharide in neonatal rats.

Potentially Toxic Elements

Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic.

Defining drinking water metal contaminant mixture risk by coupling zebrafish behavioral analysis with citizen science.

Microplastics

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell.

Effects of secondary polyethylene microplastic exposure on crucian (Carassius carassius) growth, liver damage, and gut microbiome composition.

Air Pollution

Cerebral cortex and blood transcriptome changes in mouse neonates prenatally exposed to air pollution particulate matter.

Miscellaneous

Benzo[a]pyrene impairs the migratory pattern of human gonadotropin-releasing-hormone-secreting neuroblasts.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

HBM4EU combines and harmonises human biomonitoring data across the EU, building on existing capacity – The HBM4EU survey.

BPA/Phenols

Estimation of lactating mothers’ daily intakes of bisphenol A using breast milk

Phthalates

Pre- and early post-natal exposure to phthalates and DINCH in a new type of mother-child cohort relying on within-subject pools of repeated urine samples.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Concentrations of polychlorinated biphenyl in indoor environment of public bars and its health implications.

Perfluoroalkyl Substances

Analysis of per- and poly-fluoroalkyl substances (PFAS) in processed foods from FDA’s Total Diet Study.

Small-Footprint, Field-Deployable LC/MS System for On-Site Analysis of Per- and Polyfluoroalkyl Substances in Soil.

Rapid Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Harbour Porpoise Liver Tissue by HybridSPE^®-UPLC^®-MS/MS.

Levels and trends of perfluoroalkyl acids (PFAAs) in water (2013-2020) and fish from selected riverine basins in Spain.

Flame Retardants

Risk Characterization and Benefit-Risk Assessment of Brominated Flame Retardant in Commercially Exploited Freshwater Fishes and Crayfish of Lake Trasimeno, Italy.

Assessment of Exposure of Korean Firefighters to Polybrominated Diphenyl Ethers and Polycyclic Aromatic Hydrocarbons via Their Measurement in Serum and Polycyclic Aromatic Hydrocarbon Metabolites in Urine.

Pesticides

Fungicide and insecticide exposure adversely impacts bumblebees and pollination services under semi-field conditions.

Association between Pesticides in House Dust and Residential Proximity to Farmland in a Rural Region of Taiwan.

Potentially Toxic Elements

Lead concentrations and isotope ratios in blood, breastmilk and feces: contribution of both lactation and soil/dust exposure to infants in a lead mining area, Kabwe, Zambia.

Children with amalgam dental restorations have significantly elevated blood and urine mercury levels.

Lead, cadmium, mercury, and chromium in urine and blood of children and adolescents in Germany – Human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V).

Enhanced Susceptibility of Methylmercury Bioaccumulation into Seston of the Laurentian Great Lakes.

Tissue distribution and health risk of trace elements in East Asian finless porpoises.

A Health Risk Assessment of Lead and Other Metals in Pharmaceutical Herbal Products and Dietary Supplements Containing Ginkgo biloba in the Mexico City Metropolitan Area.

Pharmaceuticals/Personal Care Products

Levels of urinary metabolites of benzene compounds, trichloroethylene, and polycyclic aromatic hydrocarbons and their correlations with socioeconomic, demographic, dietary factors among pregnant women in six cities of China.

Miscellaneous

Estimating the release of chemical substances from consumer products, textiles and pharmaceuticals to wastewater.

Recognition and Selectivity Analysis Monitoring of Multicomponent Steroid Estrogen Mixtures in Complex Systems Using a Group-Targeting Environmental Sensor.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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