EDC Science Weekly, Apr. 7 – 13, 2023

Post author:HEEDS
Post published:April 13, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Highlights: Regulating mixtures; assessing the risk of phthalates as a group; maternal bisphenols and neonatal TSH levels; water disinfectants leach chemicals from plastic pipes.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Today, April 13: Long-term Health Effects of Childhood Glyphosate Exposure (EDC Strategies Partnership)

Note that comments on the NIEHS Strategic Plan are due April 20!

Regulations/Policy

Cumulative Risk Evaluation of Phthalates Under TSCA.

Evaluating Chemical Mixtures in Epidemiological Studies to Inform Regulatory Decisions and related Invited Perspective: Mixtures-Are They Worth the Risk (Assessment)?

US regulations to curb alleged cancer causes are ineffectual and compromised by scientific, constitutional and ethical violations.

Safety assessment of the process Steinbeis PolyVert, based on the Vacunite (EREMA Basic and Polymetrix SSP V-LeaN) technology, used to recycle post-consumer PET into food contact materials.

What potential does the EU Single-Use Plastics Directive have for reducing plastic pollution at coastlines and riversides? An evaluation based on citizen science data.

Methods/Tools/Screening

A dynamic inventory database for assessing age-, gender-, and route-specific chronic internal exposure to chemicals in support of human exposome research.

Application of Effect-Based Methods to Water Quality Monitoring: Answering Frequently Asked Questions by Water Quality Managers, Regulators, and Policy Makers.

PBPK modeling as an alternative method of extrapolation interspecies that reduce the use of animals: a systematic review.

Making in silico predictive models for toxicology FAIR.

Data-Driven Quantitative Structure-Activity Relationship Modeling for Human Carcinogenicity by Chronic Oral Exposure.

Application and progress of machine learning in pesticide hazard and risk assessment.

Establishment of a human induced pluripotent stem cell derived alveolar organoid for toxicity assessment.

Deciphering the origin of total estrogenic activity of complex mixtures.

Application of cell painting for chemical hazard evaluation in support of screening-level chemical assessments.

Commentaries

Chemical mixtures and multiple stressors – Same but different?

Three ways to solve the plastics pollution crisis. [News item in Nature]

Plastic waste found chemically bonded to rocks in China. [News item in Nature]

Hazardous train spills prompt calls for tougher safety rules. [News item in The Lancet]

Reviews

Numerous Chemicals/Mixtures

Endocrine disrupting compounds in the baby’s world – A harmful environment to the health of babies.

The role of environmental pollutants in body composition: Systematic review and meta-analysis.

Endocrine disrupting chemicals: A promoter of non-alcoholic fatty liver disease.

Phthalates

Environmental health risks induced by interaction between Phthalic Acid Esters (PAEs) and biological macromolecule: A review.

Metals/Metalloids

Metal exposure and risk of Parkinson’s disease: a systematic review and meta-analysis.

An Insight into the Salutary Prospect of the Probiotic Microorganisms for the Remediation of Mercury Toxicity.

What’s in your water? A well-known risk for arsenic toxicity.

Higher rates of autism and attention deficit/hyperactivity disorder in American children: Are food quality issues impacting epigenetic inheritance?

Microplastics/Nanomaterials/Plastics

Recent advances towards micro(nano)plastics research in wetland ecosystems: A systematic review on sources, removal, and ecological impacts.

Recent development of end-of-life strategies for plastic in industry and academia: bridging their gap for future deployment.

Air Pollution

Air Pollution and Arrhythmias.

Connections Between Air Pollution, Climate Change & Cardiovascular Health.

Human Health Studies

Numerous Chemicals/Mixtures

Metals and per- and polyfluoroalkyl substances mixtures and birth outcomes in the New Hampshire birth cohort study: Beyond single-class mixture approaches.

Exposure to phenols, chlorophenol pesticides, phthalate and PAHs and mortality risk: A prospective study based on 6 rounds of NHANES.

BPA/Phenols

Trimester-specific associations of maternal exposure to bisphenols with neonatal thyroid stimulating hormone levels: A birth cohort study.

Urinary bisphenol A and S are associated with diminished ovarian reserve in women from an infertility clinic in Northern China.

Perfluoroalkyl Substances

Prenatal exposure to perfluoroalkyl substances and child intelligence quotient: Evidence from the Shanghai birth cohort.

Flame Retardants

Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study.

Exposures to Organophosphate Esters and Respiratory Morbidity among School-Aged Children with Asthma.

Pesticides

Health implications of pesticides application among cocoa farmers in Idanre local government area, Southwest Nigeria.

Can Sulfonylureas for Agricultural Use Cause Diabetes? A Report of Three Cases.

Metals/Metalloids

Association of urinary exposure to multiple metal(loid)s with kidney function from a national cross-sectional study.

A machine learning-based diagnosis modelling of type 2 diabetes mellitus with environmental metal exposure.

Maternal exposure to metal components of PM2.5 and low birth weight in New Mexico, USA.

Prenatal arsenic exposure, arsenic metabolism and neurocognitive development of 2-year-old children in low-arsenic areas.

A cross-sectional study of the association between heavy metals and pan-cancers associated with sex hormones in NHANES 1999-2018.

Cadmium exposure and the risk of prostate cancer among Nigerian men: Effect modification by zinc status.

Air Pollution

Air pollution, genetic factors and the risk of osteoporosis: A prospective study in the UK biobank.

Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder.

Long-term exposure to air pollution and COVID-19 severity: A cohort study in Greater Manchester, United Kingdom.

Air pollution, genetic factors and the risk of osteoporosis: A prospective study in the UK biobank.

Association between annual exposure to air pollution and systolic blood pressure among adolescents in Montréal, Canada.

Miscellaneous

Long-term effect of styrene and ethylbenzene exposure on fasting plasma glucose: A gene-environment interaction study.

Laboratory Studies

Numerous Chemicals/Mixtures

In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity.

BPA/Phenols

Maternal BPAF exposure impaired synaptic development and caused behavior abnormality in offspring.

Environmental estrogen exposures alter molecular signaling in immune cells that promote the development of childhood asthma. [BPA and BPS]

Glutamine Supplementation Attenuates Bisphenol A-Induced Testicular Toxicity in Rats.

Phthalates

Chronic exposure to a mixture of phthalates shifts the white and brown adipose tissue phenotype in female mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Establishment of killer whale (Orcinus orca) primary fibroblast cell cultures and their transcriptomic responses to pollutant exposure.

Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance.

Differences in Age-Related Changes in the Thymus in Rats Developmentally Exposed to Endocrine Disrupter Dichlorodiphenyltrichloroethane.

Perfluoroalkyl Substances

Lipidomic Profiling of PFOA-Exposed Mouse Liver by Multi-Modal Mass Spectrometry Analysis.

Transcriptional investigation of the toxic mechanisms of perfluorooctane sulfonate in rats based on an RNA-Seq approach.

Multiple toxicity evaluations of perfluorooctane sulfonate on intact planarian Dugesia japonica.

Flame Retardants

Amniogenesis in Human Amniotic Sac Embryoids after Exposures to Organophosphate Flame Retardants.

Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition.

First insight into the sex-dependent accumulation, tissue distribution and potential toxicities of 2-ethylhexyl diphenyl phosphate and its metabolites in adult zebrafish.

Prediction of Thermogravimetric Data in Bromine Captured from Brominated Flame Retardants (BFRs) in e-Waste Treatment Using Machine Learning Approaches.

Pesticides

Thyroid-Disrupting Effects of Exposure to Fipronil and Its Metabolites from Drinking Water Based on Human Thyroid Follicular Epithelial Nthy-ori 3-1 Cell Lines.

Triazole pesticides exposure impaired steroidogenesis associated to an increase in AHR and CAR expression in testis and altered sperm parameters in chicken.

The neonicotinoid thiacloprid leads to multiple defects during early embryogenesis of the South African clawed frog (Xenopuslaevis).

Effects of the pesticide deltamethrin on high fat diet-induced obesity and insulin resistance in male mice.

Developmental exposure to the pesticide malathion enhances expression of Prdm12, a regulator of nociceptor development, in Xenopus laevis.

Metabolomics and mass spectrometry imaging reveal the chronic toxicity of indoxacarb to adult zebrafish (Danio rerio) livers.

Xylopia aethiopica suppresses markers of oxidative stress, inflammation, and cell death in the brain of Wistar rats exposed to glyphosate.

In silico assessment of risks associated with pesticides exposure during pregnancy.

Metals/Metalloids

Mineral, trace element, and toxic metal concentration in hair from dogs with idiopathic epilepsy compared to healthy controls.

Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats.

Effects of antimony exposure on DNA damage and genome-wide variation in zebrafish (Danio rerio) liver.

Dietary intake of household cadmium-contaminated rice caused genome-wide DNA methylation changes on gene/hubs related to metabolic disorders and cancers.

A Pair of Cadmium-exposed Zebrafish Affect Social Behavior of the Un-exposed Majority.

Black Tea Extract, via Modulation of TGF-β Pathway, Prevents Inorganic Arsenic-induced Development of Squamous Cell Carcinoma of the Skin in Swiss Albino Mice.

Microplastics/Nanomaterials

Oral feeding of nanoplastics affects brain function of mice by inducing macrophage IL-1 signal in the intestine.

Polyvinyl chloride microplastics induce changes in gene expression and organ histology along the HPG axis in Cyprinus carpio var. larvae.

Adsorption of highly toxic chlorophenylacetonitriles on typical microplastics in aqueous solutions: Kinetics, isotherm, impact factors and mechanism.

Assessment of Nonalcoholic Fatty Liver Disease Symptoms and Gut-Liver Axis Status in Zebrafish after Exposure to Polystyrene Microplastics and Oxytetracycline, Alone and in Combination.

Unveiling the residual plastics and produced toxicity during biodegradation of polyethylene (PE), polystyrene (PS), and polyvinyl chloride (PVC) microplastics by mealworms (Larvae of Tenebrio molitor).

Co-exposure of iron oxide nanoparticles with glyphosate herbicides in Poecilia reticulata: Fish liver damages is reversible during iron accumulation and elimination period.

Interactive effects of polystyrene nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonates on the histomorphology, oxidative stress and gut microbiota in Hainan Medaka (Oryzias curvinotus).

Combined toxic effects of nanoplastics and norfloxacin on mussel: Leveraging biochemical parameters and gut microbiota.

Adsorption behavior of triclosan on microplastics and their combined acute toxicity to D. magna.

Pinostrobin alleviates testicular and spermatological damage induced by polystyrene microplastics in adult albino rats.

Single and combined effects of cadmium, microplastics, and their mixture on whole-body serotonin and feeding behaviour following chronic exposure and subsequent recovery in the freshwater leech, Nephelopsis obscura.

Air Pollution

Multi-omics reveals hypertrophy of adipose tissue and lipid metabolism disorder via mitochondria in young mice under real-ambient exposure to air pollution.

Pharmaceuticals/Personal Care Products

Biological-Activity-Based Prioritization of Antidepressants in Wastewater in England and Japan.

Antineoplastic drugs in environmentally relevant concentrations cause endocrine disruption and testicular dysfunction in experimental conditions.

Miscellaneous

The disinfectant residues promote the leaching of water contaminants from plastic pipe particles.

Development, testing, parameterisation, and calibration of a human PBK model for the plasticiser, di (2-ethylhexyl) adipate (DEHA) using in silico, in vitro and human biomonitoring data.

Glutaminase 1 isoform up-regulation associated with lipid metabolism disorder induced by methyl tertiary-butyl ether in male rats.

Chemical characteristics, leaching, and stability of the ubiquitous tire rubber-derived toxicant 6PPD-quinone.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Impacts of hydraulic fracturing wastewater from oil and gas industries on drinking water: Quantification of 69 disinfection by-products and calculated toxicity.

Novel Google Maps and Google Earth application for chemical industry disaster risk assessment during complex emergencies in Eastern Ukraine.

Phthalates

Characteristics and health risks of population exposure to phthalates via the use of face towels.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Widespread presence of chlorinated paraffins in consumer products.

PCDD/Fs in indoor environments of residential communities around a municipal solid waste incineration plant in East China: Occurrence, sources, and cancer risks.

Perfluoroalkyl Substances

Perfluorinated Compounds (PFCs) in River Waters of Central Italy: Monthly Variation and Ecological Risk Assessment (ERA).

Transport behavior difference and transport model of long- and short-chain per- and polyfluoroalkyl substances in underground environmental media: A review.

Trophic behaviors of PFOA and its alternatives perfluoroalkyl ether carboxylic acids (PFECAs) in a coastal food web.

Ecological characteristics impact PFAS concentrations in a U.S. North Atlantic food web.

Flame Retardants

Screening of organophosphate esters in different indoor environments: Distribution, diffusion, and risk assessment.

Occurrence and risk of human exposure to organophosphate flame retardants in indoor air and dust in Hanoi, Vietnam.

Descriptive analysis of organophosphate ester metabolites in a pan-Canadian pregnancy cohort.

Dietary exposure and risk assessment of polybrominated diphenyl ethers in the Republic of Korea: A nationwide study.

A critical review on sources and environmental behavior of organophosphorus flame retardants in the soil: Current knowledge and future perspectives.

Pesticides

Pesticide use in banana plantations in Costa Rica – A review of environmental and human exposure, effects and potential risks.

Metals/Metalloids

Comparison of toxic heavy metals in the breast milk of diabetic and non-diabetic postpartum mothers in Yenagoa, Nigeria.

Deterioration of the quality of packaged potable water (bottled water) exposed to sunlight for a prolonged period: An implication for public health.

A heavy burden: Metal exposure across the land-ocean continuum in an adaptable carnivore.

Microplastics/Nanomaterials

Contamination and removal efficiency of microplastics and synthetic fibres in a conventional drinking water treatment plant in Geneva, Switzerland.

Continents of plastics: An estimate of the stock of microplastics in agricultural soils.

Spatio-temporal variation of soil microplastics as emerging pollutant after long-term application of plastic mulching and organic compost in apple orchards.

Macro- and microplastics as complex threats to coral reef ecosystems.

Microplastics impair seabird gut microbiomes.

Air Pollution

PM-bound polycyclic aromatic compounds (PACs) in two large-scale petrochemical bases in South China: Spatial variations, sources, and risk assessment.

Pharmaceuticals/Personal Care Products

A time trend of urinary 4-methylbenzylidene camphor metabolites in young adults from Germany.

Miscellaneous

Occurrence and distribution of PAHs in stranded dolphin tissues from the Northwestern Mediterranean.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.