2006: EDCs linked to diabetes and obesity

2006 Animal and human studies link EDCs to type 2 diabetes

Lee, D. H., Lee, I. K., Song, K., Steffes, M., Toscano, W., Baker, B. A., & Jacobs, D. R., Jr (2006). A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002Diabetes care29(7), 1638–1644.

 

Alonso-Magdalena P, Morimoto S, Ripoll C, Fuentes E and Nadal A. The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and Induces Insulin Resistance. Environmental Health Perspectives 2006 Jan;114(1):106-12. 

Term “obesogen” coined

Grün F, Blumberg B. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology. 2006 Jun;147(6 Suppl):S50-5.

 

BPA linked to cancer

Ho, S. M., Tang, W. Y., Belmonte de Frausto, J., & Prins, G. S. (2006). Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer research66(11), 5624–5632.

Chapel Hill BPA expert panel consensus statement meeting

vom Saal FS, Akingbemi BT, Belcher SM, Birnbaum LS, Crain DA, Eriksen M, Farabollini F, Guillette LJ Jr, Hauser R, Heindel JJ, Ho SM, Hunt PA, Iguchi T, Jobling S, Kanno J, Keri RA, Knudsen KE, Laufer H, LeBlanc GA, Marcus M, McLachlan JA, Myers JP, Nadal A, Newbold RR, Olea N, Prins GS, Richter CA, Rubin BS, Sonnenschein C, Soto AM, Talsness CE, Vandenbergh JG, Vandenberg LN, Walser-Kuntz DR, Watson CS, Welshons WV, Wetherill Y, Zoeller RT. Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol. 2007 Aug-Sep;24(2):131-8.