Key Publications on EDCs

Key Publications and Reviews on Endocrine Disrupting Chemicals (EDCs)

Minireview: Endocrine Disruptors: Past Lessons and Future Directions.
Schug TT, Johnson AF, Birnbaum LS, et al.
Mol Endocrinol. 2016 Aug;30(8):833-47. doi: 10.1210/me.2016-1096. Review.
PMID:27477640

A Proposed Framework for the Systematic Review and Integrated Assessment (SYRINA) of Endocrine Disrupting Chemicals.
Vandenberg LN, Ågerstrand M, Beronius A, et al.
Environ Health. 2016 Jul 14;15(1):74. doi: 10.1186/s12940-016-0156-6. Review.
PMID:27412149

Peer-Reviewed and Unbiased Research, Rather than ‘Sound Science’, Should Be Used To Evaluate Endocrine-Disrupting Chemicals.
Trasande L, Vandenberg LN, Bourguignon JP, et al.
J Epidemiol Community Health. 2016
Nov;70(11):1051-1056. doi: 10.1136/jech-2016-207841. Epub 2016 Jul 13. Review.
PMID:27417427

Estimating Burden and Disease Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union.
Trasande L, Zoeller RT, Hass U, et al.
J Clin Endocrinol Metab. 2015 Apr;100(4):1245-55. doi: 10.1210/jc.2014-4324. Epub 2015 Mar 5.
PMID:25742516

Regulatory Decisions on Endocrine Disrupting Chemicals Should Be Based on the Principles of Endocrinology.
Vandenberg LN, Colborn T, Hayes TB, et al.
Reprod Toxicol. 2013 Jul;38:1-15. doi: 10.1016/j.reprotox.2013.02.002. Epub 2013 Feb 11. Review.
PMID:23411111

Designing Endocrine Disruption Out of the Next Generation of Chemicals.
Schug TT, Abagyan R, et al.
Green Chem. 2013 Jan;15(1):181-198.
PMID:25110461

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses.
Vandenberg LN, Colborn T, Hayes TB, et al.
Endocr Rev. 2012 Jun;33(3):378-455. doi: 10.1210/er.2011-1050.
Epub 2012 Mar 14. Review.
PMID:22419778

Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement
Solecki R, Kortenkamp A, Bergman Å, et al.
Arch Toxicol. 2017 Feb;91(2):1001-1006. doi: 10.1007/s00204-016-1866-9.
PMID:27714423

Scientific Society Statements on EDCs and Health

EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals
Gore AC, Chappell VA, Fenton SE, et al.
Endocrine Reviews 2015 Dec;36(6):E1-E150. doi: 10.1210/er.2015-1010.
PMID:26544531
Also see:
EDC-2 Executive Summary
The first Endocrine Society Scientific Statement on EDCs (2009)

The International Federation of Gynecology and Obstetrics Opinion on Reproductive Health Impacts of Exposure to Toxic Environmental Chemicals
Di Renzo GC, Conry JA, Blake J, et al.
Int J Gynaecol Obstet. 2015 Dec;131(3):219-25. doi: 10.1016/j.ijgo.2015.09.002.
PMID:26433469

The American College of Obstetricians and Gynecologists: Committee Opinion on Exposure to Toxic Environmental Agents
2013; Reaffirmed 2018

The United Nations: Scientific Knowledge of Endocrine Disrupting Chemicals
Three reports on EDCs, on identifying EDCs, the environmental effects of EDCs, and global regulatory frameworks.

EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.