New EDC articles, week of July 10 – 16, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

Satirical contribution: Non-linear endocrine no-dose effects-towards a new paradigm in toxicology, with the introduction of the new section in the journal Arch Toxicol, Satirical contributions in toxicology… please note that they are accepting additional satirical submissions…

Regulations/Policy

A Most Reckless Proposal — A Plan to Continue Asbestos Use in the United States [Perspective article in NEJM]

Regulators must work on indoor air pollution. [Editorial in The Lancet]

Bisphenol Exposure, Hazard and Regulation.

Reviews

Environmental exposures and cancer: using the precautionary principle.

A critical review of synthetic chemicals in surface waters of the US, the EU and China.

Environmental inhibitors of the expression of cytochrome P450 17A1 in mammals.

1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needs.

BPA/Phenols/Phthalates

CLARITY-BPA Program in Rats: Is It Translatable to Humans?

[also, NTP Research Report on the CLARITY-BPA Core Study: A Perinatal and Chronic Extended-Dose-Range Study of Bisphenol A in Rats [Internet], from 2018, was just added to PubMed]

The adverse health effects of bisphenol A and related toxicity mechanisms.

Persistent Organic Pollutants

PFAS health effects database: Protocol for a systematic evidence map.

Pentachlorophenol and Some Related Compounds. [IARC]

Metals

Mercury in aquatic fauna contamination: A systematic review on its dynamics and potential health risks.

Pesticides

Genetic polymorphisms as determinants of pesticide toxicity: Recent advances.

Risk of obstructive pulmonary diseases and occupational exposure to pesticides: a systematic review and meta-analysis.

Microplastics

Particulate plastics as a vector for toxic trace-element uptake by aquatic and terrestrial organisms and human health risk.

Screening/New Approaches

Deep learning driven QSAR model for environmental toxicology: Effects of endocrine disrupting chemicals on human health.

Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity.

Development of outcome-specific criteria for study evaluation in systematic reviews of epidemiology studies.

Human Health Studies

BPA/Phenols/Phthalates

Unhealthy Levels of Phthalates and Bisphenol A in Mexican Pregnant Women with Gestational Diabetes and Its Association to Altered Expression of miRNAs Involved with Metabolic Disease.

Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates.

Exposure to bisphenol A and diabetes risk in Mexican women.

Inverse associations of bisphenol A and phthalate metabolites with serum bilirubin levels in Korean population.

Parabens/Triclosan/Antimicrobials

Exposure to breast-milk triclosan and parabens and eczema phenotypes at 12-months: a nested case-control study.

Persistent Organic Pollutants

Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960’s. [DDT, PFAS, PCBs]

Sex and poverty modify associations between maternal peripartum concentrations of DDT/E and pyrethroid metabolites and thyroid hormone levels in neonates participating in the VHEMBE study, South Africa.

Perfluoroalkyl Substances

Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Incident Diabetes and Microvascular Disease.

Prenatal exposure to per- and polyfluoroalkyl substances and infant growth and adiposity: the Healthy Start Study.

Perfluoroalkyls/polyfluoroalkyl substances and dental caries experience in children, ages 3-11 years, National Health and Nutrition Examination Survey, 2013-2014

Perfluorooctanoate and changes in anthropometric parameters with age in young girls in the Greater Cincinnati and San Francisco Bay Area.

Arsenic/Metals

Salivary N1-Methyl-2-Pyridone-5-Carboxamide, a Biomarker for Uranium Uptake, in Kuwaiti Children Exhibiting Exceptional Weight Gain.

Urinary trace metals, maternal circulating angiogenic biomarkers, and preeclampsia: a single-contaminant and mixture-based approach.

A study protocol to determine the association between lifetime lead exposure and violent criminal behaviour in young males in conflict with the law.

Biomarkers of metal toxicity in embryos in the general population.

Toxicological effects in children exposed to lead: A cross-sectional study at the Colombian Caribbean coast.

Pharmaceuticals

Oral Contraceptive Use and Genital Anomalies in Sons. A Danish Cohort Study.

Air Pollution

Evaluation of maternal exposure to PM2.5 and its components on maternal and neonatal thyroid function and birth weight: a cohort study.

Cancer and mortality in relation to traffic-related air pollution among coronary patients: Using an ensemble of exposure estimates to identify high-risk individuals.

Exposure to ambient air pollution and the incidence of lung cancer and breast cancer in the Ontario Population Health and Environment Cohort (ONPHEC).

Associations between ambient air pollution and pregnancy rate in women who underwent in vitro fertilization in Shenyang, China.

Miscellaneous

Estimating outcome-exposure associations when exposure biomarker detection limits vary across batches. [EDCs and preterm birth]

Laboratory Studies

BPA/Phenols

Transcriptome analysis revealed Bisphenol A and Nonylphenol affect reproduction.

Impact of gestational low protein diet and postnatal bisphenol A exposure on chemically induced mammary carcinogenesis in female offspring rats

Learning and behavior in hatchling Trachemys scripta exposed to bisphenol-a during embryonic development.

Effects of bisphenol S, a major substitute of bisphenol A, on neurobehavioral responses and cerebral monocarboxylate transporters expression in mice.

Comparative study of environmental pollutants bisphenol A and bisphenol S on sexual differentiation of anteroventral periventricular nucleus and spermatogenesis.

Phthalates

Lactobacillus plantarum TW1-1 Alleviates Diethylhexylphthalate-Induced Testicular Damage in Mice by Modulating Gut Microbiota and Decreasing Inflammation.

Encircling granulosa cells protects against di-(2-ethylhexyl)phthalate-induced apoptosis in rat oocytes cultured in vitro.

Parabens/Triclosan/Antimicrobials

Effects of triclosan on early development of Solea senegalensis: from biochemical to individual level.

Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators.

Persistent Organic Pollutants

Effects of Aryl Hydrocarbon Receptor Deficiency on PCB-77-Induced Impairment of Glucose Homeostasis during Weight Loss in Male and Female Obese Mice.

Perfluoroalkyl Substances

Acute exposure to environmentally relevant concentrations of Chinese PFOS alternative F-53B induces oxidative stress in early developing zebrafish.

Pesticides

The fungicide azoxystrobin perturbs the gut microbiota community and enriches antibiotic resistance genes in Enchytraeus crypticus.

Ameliorative Effect of Beta vulgaris Root Extract on Chlorpyrifos-Induced Oxidative Stress, Inflammation and Liver Injury in Rats.

Toxicity effects of captan on different life stages of zebrafish (Danio rerio).

Toxicological evaluation of carcinogenicity of the pyrethroid imiprothrin in rats and mice.

Combined in vitro fertilization and culture (IVF/IVC) in mouse for reprotoxicity assessment of xenobiotic exposure.

A weight of evidence approach to investigate potential common mechanisms in pesticide groups to support cumulative risk assessment: A case study with dinitroaniline pesticides.

Sub-chronic exposure to a neonicotinoid does not affect susceptibility of larval leopard frogs to infection by trematode parasites, via either depressed cercarial performance or host immunity.

Evaluating the role of fish as surrogates for amphibians in pesticide ecological risk assessment.

Glyphosate-based herbicides at low doses affect canonical pathways in estrogen positive and negative breast cancer cell lines.

Immunomodulatory effect of mancozeb, chlorothalonil, and thiophanate methyl pesticides on macrophage cells.

Effects of bifenthrin on sex differentiation in Japanese Medaka (Oryzias latipes).

Effects of two juvenile hormone analogue insecticides, fenoxycarb and methoprene, on Neocaridina davidi.

Linking cholinesterase inhibition with behavioural changes in the sea snail Gibbula umbilicalis: Effects of the organophosphate pesticide chlorpyrifos.

Endosulfan toxicity in Nile tilapia (Oreochromis niloticus) and the use of lycopene as an ameliorative agent.

Paraquat induced impaired reproductive function and modulation of retinal and extra-retinal photoreceptors in Japanese quail (Coturnix coturnix japonica).

Arsenic/Metals

Amelioration of Cd-Induced Oxidative Stress, MT Gene Expression, and Immune Damage by Vitamin C in Grass Carp Kidney Cells.

Bioaccessibility analysis of toxic metals in consumed rice through an in vitro human digestion model – Comparison of calculated human health risk from raw, cooked and digested rice.

Impacts of acute toxicity of arsenic (III) alone and with high temperature on stress biomarkers, immunological status and cellular metabolism in fish.

Myo-inositol in the protection from cadmium-induced toxicity in mice kidney: An emerging nutraceutical challenge.

Organotins

Tributyltin exposure disturbs hepatic glucose metabolism in male mice.

Microplastics/Nanoparticles

High-throughput COPAS assay for screening of developmental and reproductive toxicity of nanoparticles using the nematode Caenorhabditis elegans.

Mixtures

Linking chemical exposure to lipid homeostasis: A municipal waste water treatment plant influent is obesogenic for zebrafish larvae.

Predictive Analysis Using Chemical-Gene Interaction Networks Consistent with Observed Endocrine Activity and Mutagenicity of U.S. Streams.

Chemical and bioassay assessment of waters related to hydraulic fracturing at a tight gas production site.

Transcriptional effects in the estuarine guppy Poecilia vivipara exposed to sanitary sewage in laboratory and in situ.

Pharmaceuticals

Ancestral fluoxetine exposure sensitizes zebrafish to venlafaxine-induced reductions in cortisol and spawning.

Physical, histological, endocrinological and steroidogenical evaluation of male cats postnatally exposed to sexual steroids.

Fetal androgen signaling defects affect β-cell mass and function, leading to glucose intolerance in high-fat diet-fed male rats

Rapid prolactin induction in adult male rats after treatment with diethylstilbestrol.

Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption in rats.

Multiple Chemicals

Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach. [Pharmaceuticals and personal care products (PPCPs)]

Miscellaneous

Estrogen receptor-mediated transcriptional activities of spent coffee grounds and spent coffee grounds compost, and their phenolic acid constituents.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Linking probabilistic exposure and pharmacokinetic modeling to assess the cumulative risk from the bisphenols BPA, BPS, BPF, and BPAF for Europeans.

Quantification of eight bisphenol analogues in blood and urine samples of workers in a hazardous waste incinerator.

A pilot study: Bisphenol-A and Bisphenol-A glucuronide levels in mother and child pairs in a South African population.

Phthalates

Urinary concentrations and distribution profiles of 21 phthalate metabolites in pet cats and dogs.

Human exposure to phthalates from house dust in Bangkok, Thailand.

Bioavailability of phthalate and DINCH® plasticizers, after oral administration of dust to piglets.

Parabens/Triclosan/Antimicrobials

Urinary parabens in adults from South China: Implications for human exposure and health risks.

Persistent Organic Pollutants

Predictors of plasma polychlorinated biphenyl concentrations among reproductive-aged black women.

Dynamics of PCB exposure in the past 50 years and recent high concentrations in human breast milk: Analysis of influencing factors using a physiologically based pharmacokinetic model.

Snow Amplification of Persistent Organic Pollutants at Coastal Antarctica.

First polychlorinated biphenyls (PCBs) monitoring in seawater, surface sediments and marine fish communities of the Persian Gulf: Distribution, levels, congener profile and health risk assessment.

Flame Retardants

Organophosphorus flame retardants and persistent, bioaccumulative, and toxic contaminants in Arctic seawaters: On-board passive sampling coupled with target and non-target analysis.

Inference of Organophosphate Ester Emission History from Marine Sediment Cores Impacted by Wastewater Effluents.

Brominated and organophosphorus flame retardants in South African indoor dust and cat hair.

Pesticides

An educational intervention on the risk perception of pesticides exposure and organophosphate metabolites urinary concentrations in rural school children in Maule Region, Chile.

Exposure to neonicotinoid insecticides in the U.S. general population: Data from the 2015-2016 national health and nutrition examination survey.

Pesticide and trace element residues in honey and beeswax combs from Israel in association with human risk assessment and honey adulteration.

Arsenic/Metals

Pervasive Arctic lead pollution suggests substantial growth in medieval silver production modulated by plague, climate, and conflict

Fish consumption for cardiovascular health: benefits from long-chain omega-3 fatty acids versus potential harms due to mercury.

Corn (Zea mays L.): A low methylmercury staple cereal source and an important biospheric sink of atmospheric mercury, and health risk assessment.

Soil elemental concentrations, geoaccumulation index, non-carcinogenic and carcinogenic risks in functional areas of an informal e-waste recycling area in Accra, Ghana.

Metals in biological tissues of the population living near a hazardous waste incinerator in Catalonia, Spain: Two decades of follow-up.

Market Basket Survey of Arsenic Species in the Top Ten Most Consumed Seafoods in the United States.

Mixtures/Multiple Chemicals

Which type of pollutants need to be controlled with priority in wastewater treatment plants: Traditional or emerging pollutants?

First nationwide investigation and environmental risk assessment of 72 pharmaceuticals and personal care products from Sri Lankan surface waterways.

Microplastics

Solutions and Integrated Strategies for the Control and Mitigation of Plastic and Microplastic Pollution.

Microplastic contamination of table salts from Taiwan, including a global review.

Micropollutants in treated wastewater.

Clinical pathology of plastic ingestion in marine birds and relationships with blood chemistry.

Miscellaneous

An urban stormwater runoff mortality syndrome in juvenile coho salmon.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.