New EDC articles, Sep. 4 – 10, 2019 – HEEDS

New EDC articles, Sep. 4 – 10, 2019

Post author:HEEDS
Post published:September 10, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy/Screening, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Regulations/Policy/Screening

The IARC Monographs: Updated procedures for modern and transparent evidence synthesis in cancer hazard identification.

Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches.

Understanding lead in water and avoidance strategies: a United States perspective for informed decision-making.

Public health and evidence-informed policy-making: The case of a commonly used herbicide. [Commentary on Roundup]

Screening

A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity.

Soluble Guanylyl Cyclase Alpha1 Subunit: A New Marker for Estrogenicity of Endocrine Disruptor Compounds.

Reviews

Effects of pollution on freshwater aquatic organisms.

The interplay between thyroid hormones and the placenta: a comprehensive review. [includes EDCs]

BPA

Understanding the molecular mechanisms of bisphenol A action in spermatozoa.

PFAS

Research progress on the removal of hazardous perfluorochemicals: A review.

Pesticides

Organophosphorus pesticides can influence the development of obesity and type 2 diabetes with concomitant metabolic changes.

Paraquat and Parkinson’s disease: a systematic review and meta-analysis of observational studies.

Chlorpyrifos induces metabolic disruption by altering levels of reproductive hormones.

Metals

Cellular pathologies and genotoxic effects arising secondary to heavy metal exposure: A review.

Toxicity of cadmium in musculoskeletal diseases.

Review of Cadmium Pollution in Bangladesh.

Air Pollution

Ambient air pollution and pregnancy outcomes: A comprehensive review and identification of environmental public health challenges.

Air Pollution, Multiple Sclerosis and its Relevance to Mexico City.

Human Health Studies

Phthalates

The analysis of endocrine disruptors in patients with central precocious puberty. [various phthalates]

Persistent Organic Pollutants

Risk of breast cancer and adipose tissue concentrations of polychlorinated biphenyls and organochlorine pesticides: a hospital-based case-control study in Chinese women.

Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth: The ACCEPT study.

Pesticides

Organophosphate pesticides exposure in pregnant women and maternal and cord blood thyroid hormone concentrations.

A cluster-randomized crossover trial of organic diet impact on biomarkers of exposure to pesticides and biomarkers of oxidative stress/inflammation in primary school children.

Residential Proximity to Agricultural Fields and Neurological and Mental Health Outcomes in Rural Adults in Matlab, Bangladesh.

The relationship between environmental factors and different Parkinson’s disease subtypes in Greece: Data analysis of the Hellenic Biobank of Parkinson’s disease. [pesticides]

Arsenic/Metals

Patterns of ovarian cancer and uterine cancer mortality and incidence in the contiguous USA. [arsenic]

Serum concentrations of heavy metals in women with endometrial polyps.

Air Pollution

Association between ambient air pollution exposure and infants small for gestational age in Huangshi, China: a cross-sectional study.

Investigating potential associations between O3 exposure and lipid profiles: A longitudinal study of older adults in Beijing.

Ambient air pollution exposure and obesity-related traits in Korean adults.

Health impact assessment of PM2.5 from a planned coal-fired power plant in Taiwan.

Miscellaneous

Early-Life Environmental Exposures and Blood Pressure in Children. [a slew of chemicals, plus other environmental factors]

Laboratory Studies

BPA/Phenols

Effects of co-administered melatonin, fructose and bisphenol A (BPA) on rat epididymis and sperm characteristics.

Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol.

Effects of bisphenol A exposure on DNA integrity and protamination of mouse spermatozoa.

Phthalates

Di (2-ethylhexyl) phthalate targets the thioredoxin system and the oxidative branch of the pentose phosphate pathway in liver of Balb/c mice.

Effects of α-ethinyl estradiol (EE2) and diethylhexyl phthalate (DEHP) on growth performance, antioxidant status and immune response of juvenile yellow catfish Pelteobagrus fulvidraco.

Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.

Parabens

Oxidative stress in testes of rats exposed to n-butylparaben.

Persistent Organic Pollutants

Tissue distribution and characterization of feline cytochrome P450 genes related to polychlorinated biphenyl exposure.

Estrogen-related receptor γ is a novel target for Lower-Chlorinated Polychlorinated Biphenyls and their hydroxylated and sulfated metabolites.

Endocrine-disrupting chemicals alter the neuromolecular phenotype in F2 generation adult male rats. [PCBs and vinclozolin]

Embryonic Exposure to 2,2′,3,5′,6-pentachlorobiphenyl (PCB-95) Causes Developmental Malformations in Zebrafish.

A mixture of persistent organic pollutants relevant for human exposure inhibits the transactivation activity of the aryl hydrocarbon receptor in vitro.

Perfluoroalkyl Substances

Derivation of a chronic reference dose for perfluorohexane sulfonate (PFHxS) for reproductive toxicity in mice.

Pesticides

Shrinking body size and physiology contribute to geographic variation and the higher toxicity of pesticides in a warming world.

Effects of Paraoxon Exposure on Expression of Apoptosis-Related Genes, Neuronal Survival, and Astrocyte Activation in Rat Prefrontal Cortex.

Effects of the Neonicotinoid Insecticide Clothianidin on Southern Leopard Frog (Rana sphenocephala) Tadpole Behavior.

Magnesium supplementation ameliorates toxic effects of 2,4-dichlorophenoxyacetic acid in rat model.

Effects of dietary exposure to chlorpyrifos on immune cell populations and inflammatory responses in mice with dextran sulfate sodium-induced colitis.

Arsenic/Metals

The effects of long-term exposure to low doses of cadmium on the health of the next generation of mice.

The effect of diosmin against liver damage caused by cadmium in rats.

Piceatannol inhibits oxidative stress through modification of Nrf2-signaling pathway in testes and attenuates spermatogenesis and steroidogenesis in rats exposed to cadmium during adulthood.

Proteomic characterization of arsenic and cadmium exposure in bladder cells.

Pharmaceuticals

In Utero Dexamethasone Exposure Exacerbates Hepatic Steatosis in Rats That Consume Fructose During Adulthood.

Effects of long term antiprogestine mifepristone (RU486) exposure on sexually dimorphic lncRNA expression and gonadal masculinization in Nile tilapia (Oreochromis niloticus).

Microplastics

Microplastics modify the toxicity of glyphosate on Daphnia magna.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Phthalate Metabolites, Hydroxy-Polycyclic Aromatic Hydrocarbons, and Bisphenol Analogues in Bovine Urine Collected from China, India, and the United States.

Phthalates

Determinants and characterization of exposure to phthalates, DEHTP and DINCH among pregnant women in the PROTECT birth cohort in Puerto Rico.

German Environmental Specimen Bank: 24-hour urine samples from 1999 to 2017 reveal rapid increase in exposure to the para-phthalate plasticizer di(2-ethylhexyl) terephthalate (DEHTP).

Phthalate esters in biota, air and water in an agricultural area of western China, with emphasis on bioaccumulation and human exposure.

Triclosan

Occurrence and removal of triclosan in Canadian wastewater systems.

Persistent Organic Pollutants

Biomonitoring of populations in Western New York at risk for exposure to Great Lakes contaminants. [PCBs, flame retardants, PFAS, metals, etc.]

Endocrine disrupting compounds in sediment from KimNguu river, Northern area of Vietnam: a comprehensive assessment of seasonal variation, accumulation pattern and ecological risk. [PCBs, PAHs, PBDEs]

Organochlorine contaminant concentrations in blubber of young Steller sea lion (Eumetopias jubatus) are influenced by region, age, sex, and lipid stores.

Occurrence and Human Health Risk of Dichlorodiphenyltrichloroethane (DDT) and Hexachlorocyclohexane (HCH) Pesticide Residues in Commonly Consumed Vegetables in Southwestern Nigeria.

Residues of legacy organochlorine pesticides and DDT metabolites in highly consumed fish from the polluted Guanabara Bay, Brazil: distribution and assessment of human health risk.

Perfluoroalkyl Substances

Assessing the contribution of atmospheric transport and tourism activities to the occurrence of perfluoroalkyl acids (PFAAs) in an Alpine Nature Reserve.

An investigation into per- and polyfluoroalkyl substances (PFAS) in nineteen Australian wastewater treatment plants (WWTPs).

Occurrence and transport behaviors of perfluoroalkyl acids in drinking water distribution systems.

Morphological evidence of neurotoxic effects in chicken embryos after exposure to perfluorooctanoic acid (PFOA) and inorganic cadmium.

Ultra-short-chain perfluoroalkyl acids including trifluoromethane sulfonic acid (TFMS) in water connected to known and suspected point sources in Sweden.

Per- and polyfluoroalkyl substances – Challenges associated with a family of ubiquitous emergent contaminants.

Flame Retardants

Large-scale distribution of organophosphate esters (flame retardants and plasticizers) in soil from residential area across China: Implications for current level.

Atmospheric deposition and air-soil exchange of polybrominated diphenyl ethers (PBDEs) in a background site in Central China.

Concentrations and loadings of organophosphate and replacement brominated flame retardants in house dust from the home study during the PBDE phase-out.

Pesticides

Evaluation of the atmospheric contamination level for the use of herbicide glyphosate in the northeast region of Brazil.

Arsenic/Metals

Mercury Pollution in the Arctic from Wildfires: Source Attribution for the 2000s.

Metal accumulation capacity in indigenous Alaska vegetation growing on military training lands.

Risk assessment of methylmercury in pregnant women and newborns in the island of Madeira (Portugal) using exposure biomarkers and food-frequency questionnaires.

Probabilistic Human Health Risk Assessment of Heavy Metal Intake via Vegetable Consumption around Pb/Zn Smelters in Southwest China.

Capability for arsenic mobilization in groundwater is distributed across broad phylogenetic lineages.

Ecological and health risk assessment of exposure to atmospheric heavy metals.

Pharmaceuticals

Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China.

Prioritizing environmental risks of pharmaceuticals and personal care products in reclaimed water on urban green space in Beijing.

Analytical methodologies for the determination of pharmaceuticals and personal care products (PPCPs) in sewage sludge: A critical review.

Microplastics

Accurate quantification and transport estimation of suspended atmospheric microplastics in megacities: Implications for human health.

Can biotechnology strategies effectively manage environmental (micro)plastics?

How to get rid of ingested microplastic fibers? A straightforward approach of the Atlantic ditch shrimp Palaemon varians.

Miscellaneous

Oil dispersant Corexit 9500 is weakly estrogenic, but does not skew the sex ratio in Alligator mississippiensis.

Health Risk Assessment of Groundwater Contaminated by Oil Pollutants Based on Numerical Modeling.

Basin-scale monitoring and risk assessment of emerging contaminants in South American Atlantic coastal lagoons.

The relationship between air pollutants and healthcare expenditure: empirical evidence from South Korea.

Polycyclic aromatic hydrocarbons in infant formulae, follow-on formulae, and baby foods in Iran: An assessment of risk.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.