New EDC articles, Sep. 18 – 24, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy/Screening, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

Communicating Arsenic’s Risks [from the Dartmouth Superfund Research Program, re the Arsenic and You website and more]

Regulations/Policy/Screening

Competitive Biotransformation among Phenolic Xenobiotic Mixtures: Underestimated Risks for Toxicity Assessment. [i.e., other chemicals can affect BPA metabolism]

Reducing the need for animal testing while increasing efficiency in a pesticide regulatory setting: Lessons from the EPA Office of Pesticide Programs’ Hazard and Science Policy Council.

Incorporating new approach methodologies in toxicity testing and exposure assessment for tiered risk assessment using the RISK21 approach: Case studies on food contact chemicals.

Moving beyond honeybee-centric pesticide risk assessments to protect all pollinators. [commentary]

Hazardous waste characterization implications of updating the toxicity characteristic list.

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization.

Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization.

Reviews

Occupational Exposures Among Hair and Nail Salon Workers: a Scoping Review.

Environmental risk factors of primary brain tumors: A review.

Biosensors for epigenetic biomarkers detection: A review.

EASL Clinical Practice Guideline: Occupational liver diseases.

Organic Micropollutants in Groundwater of India – A Review.

BPA/Phenols/Phthalates

Occurrence, fate and risk assessment of BPA and its substituents in wastewater treatment plant: A review.

Pesticides

A Systematic Review on Organophosphate Pesticide and Type II Diabetes Mellitus.

The association between pesticide use and cutaneous melanoma: a systematic review and meta-analysis.

The Human Health Benefits from GM Crops.

Metals

Mercury and Atherosclerosis: Cell Biology, Pathophysiology, and Epidemiological Studies.

The impact of metalloestrogens on the physiology of male reproductive health as a current problem of the XXI century.

Air Pollution

Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?

Nanomaterials

Engineered nanomaterials: From their properties and applications, to their toxicity towards marine bivalves in a changing environment.

The nanoGRAVUR framework to group (nano)materials for their occupational, consumer, environmental risks based on a harmonized set of material properties, applied to 34 case studies.

Human Health Studies

BPA/Phenols

Urinary Bisphenols and Obesity Prevalence Among U.S. Children and Adolescents.

Bisphenol A analogs in patients with chronic kidney disease and dialysis therapy.

In utero bisphenol A exposure is linked with sex specific changes in the transcriptome and methylome of human amniocytes.

Phthalates

Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule.

Persistent Organic Pollutants

Cancer incidence in an Austrian alpine valley 1983-2012 : A descriptive study.

Perfluoroalkyl Substances

The association between perfluoroalkyl substances and lipids in cord blood.

A mortality study on male subjects exposed to polyfluoroalkyl acids with high internal dose of perfluorooctanoic acid.

Pesticides

Occupational exposure to pesticides and multiple myeloma in the AGRICAN cohort.

Chronic exposure to organophosphate pesticides as an important challenge in promoting reproductive health: A comparative study.

Arsenic/Metals

Blood metal levels and early childhood anthropometric measures in a cohort of Canadian children.

Oxidative Stress Indices as Markers of Lead and Cadmium Exposure Toxicity in Auto Technicians in Ibadan, Nigeria.

Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort.

Using disability-adjusted life years to estimate the cancer risks of low-level arsenic in drinking water.

A study of relationship between blood mercury concentration and hypertension in residents living in old mine fields and related factors.

Air Pollution

Air pollution-associated changes in biomarkers of diabetes risk.

Association of residential air pollution, noise, and greenspace with initial ischemic stroke severity.

Effects of prenatal exposure to particulate matter air pollution on corpus callosum and behavioral problems in children.

Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China.

Estimating the causal effect of annual PM2.5 exposure on mortality rates in the Northeastern and mid-Atlantic states.

Maternal exposure to outdoor air pollution and congenital limb deficiencies in the National Birth Defects Prevention Study.

Miscellaneous

Occupational exposures and male breast cancer: A nested case-control study in the Nordic countries.

Laboratory Studies

BPA/Phenols

Prenatal exposure to bisphenol A, E and S induces transgenerational effects on male reproductive functions in mice.

The effects of acute BPA exposure on skeletal muscle mitochondrial function and glucose metabolism.

Low Dose Bisphenol-A Regulates Inflammatory Cytokines through GPR30 in Mammary Adipose Cells.

BPA Replacement Chemical Concern: New Evidence from a Mouse Model of Endometriosis. [EHP Science Selection on Use of a Mouse Model of Experimentally Induced Endometriosis to Evaluate and Compare the Effects of Bisphenol A and Bisphenol AF Exposure, previously on this list]

Phthalates

Taxifolin ameliorates DEHP-induced cardiomyocyte hypertrophy via attenuating mitochondrial dysfunction and glycometabolism disorder in chicken.

Promoting differentiation and lipid metabolism are the primary effects for DINP exposure on 3T3-L1 preadipocytes.

Parabens/Triclosan/Antimicrobials

Triclosan affects Ca2+ regulatory module and musculature development in skeletal myocyte during early life stage of zebrafish (Danio rerio).

Persistent Organic Pollutants

Epigenetic transgenerational inheritance of testis pathology and Sertoli cell epimutations: generational origins of male infertility. [DDT and vinclozolin]

The organochlorine pesticides pentachlorophenol and dichlorodiphenyltrichloroethane increase secretion and production of interleukin 6 by human immune cells.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts control of cell proliferation and apoptosis in a human model of adult liver progenitors.

Perfluoroalkyl Substances

Parental exposure to perfluorobutanesulfonate impairs offspring development through inheritance of paternal methylome.

Per- and polyfluoroalkyl substances (PFASs) modify lung surfactant function and pro-inflammatory responses in human bronchial epithelial cells.

Flame Retardants

Sex-Specific Behavioral Effects Following Developmental Exposure to Tetrabromobisphenol A (TBBPA) in Wistar Rats.

Environmentally relevant doses of tetrabromobisphenol A (TBBPA) cause immunotoxicity in murine macrophages.

Pesticides

Effect of a beta-cypermethrin and emamectin benzoate pesticide mixture on reproductive toxicity in male mice in a greenhouse environment.

Validation and kinetic of enzymatic method for the detection of organophosphate insecticides based on cholinesterase inhibition.

Clethodim exposure induced development toxicity and behaviour alteration in early stages of zebrafish life.

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes.

Chlorpyrifos-induced dysfunction of lipid metabolism is not restored by supplementation of polyunsaturated fatty acids EPA and ARA in Atlantic salmon liver cells.

Melatonin protects against defects induced by malathion during porcine oocyte maturation.

Chloramphenicol Mitigates Oxidative Stress by Inhibiting Translation of Mitochondrial Complex I in Dopaminergic Neurons of Toxin-Induced Parkinson’s Disease Model.

Immunotoxicity and transcriptome analysis of zebrafish embryos in response to glufosinate-ammonium exposure.

Characterization of boscalid-induced oxidative stress and neurodevelopmental toxicity in zebrafish embryos.

Immunotoxicity and transcriptome analysis of zebrafish embryos in response to glufosinate-ammonium exposure.

Roundup® induced AMPK/mTOR mediated autophagy in human A549 cells.

Arsenic/Metals

Late-life Cardiac Injury in Rats following Early Life Exposure to Lead: Reversal Effect of Nutrient Metal Mixture.

Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats.

Myelin Disturbances Produced by Sub-Toxic Concentration of Heavy Metals: The Role of Oligodendrocyte Dysfunction.

Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood.

Protective role of vitamin E against cadmium induced oxidative stress into the rat liver.

Bioaccumulation, cellular and molecular effects in adult zebrafish after exposure to cadmium sulphide nanoparticles and to ionic cadmium.

Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress.

Mixtures

C. elegans as a promising alternative model for environmental chemical mixture effect assessment – a comparative study.

Metabolic Impairments Caused by a “Chemical Cocktail” of DDE and Selenium in Mice Using Direct Infusion Triple Quadrupole Time-of-Flight and Gas Chromatography-Mass Spectrometry.

A mixture of routinely encountered xenobiotics induces both redox adaptations and perturbations in blood and tissues of rats after a long-term low-dose exposure regimen: The time and dose issue.

Impact of co-exposure to titanium dioxide nanoparticles and Pb on zebrafish embryos.

Interactions between decabromodiphenyl ether and lead in soil-plant system.

Androgens augment pulmonary responses to ozone in mice.

Miscellaneous

Leucaena leucocephala extract has estrogenic and antiestrogenic actions on female rat reproduction.

Antidepressants in Surface Waters: Fluoxetine Influences Mosquitofish Anxiety-Related Behavior at Environmentally Relevant Levels.

Cell-based assays that predict in vivo neurotoxicity of urban ambient nano-sized particulate matter.

PAHs increase the production of extracellular vesicles both in vitro in endothelial cells and in vivo in urines from rats.

Underlying mechanisms of reproductive toxicity caused by multigenerational exposure of 2, bromo-4, 6-dinitroaniline (BDNA) to Zebrafish (Danio rerio) at environmental relevant levels.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Modelling BPA effects on three-spined stickleback population dynamics in mesocosms to improve the understanding of population effects.

Occurrence of bisphenol-A and its brominated derivatives in tributary and estuary of Xiaoqing River adjacent to Bohai Sea, China.

Phthalates

Determinants of exposure levels, metabolism, and health risks of phthalates among pregnant women in Wuhan, China.

Emission characteristics of diethylhexyl phthalate (DEHP) from building materials determined using a passive flux sampler and micro-chamber.

Persistent Organic Pollutants

Distribution of Organochlorine Pesticide and Polychlorinated Biphenyl Residues in Lake Sediment Cores from the Plitvice Lakes National Park (Croatia).

Multiyear levels of PCDD/Fs, dl-PCBs and PAHs in background air in central Europe and implications for deposition.

A preliminary ecological and human health risk assessment for organic contaminants in composted municipal solid waste generated in New South Wales, Australia.

Impact of environmental pollution on PCDD/F and PCB bioaccumulation in game animals.

Health risks and source identification of dietary exposure to indicator polychlorinated biphenyls (PCBs) in Lanzhou, China.

Endocrine Disrupting Compounds (EDCs) in Surface Waters of the KimNguu River, Vietnam. [PCBs, PBDEs, phthalates]

PCBs in Older Buildings: Measuring PCB Levels in Caulk and Window Glazing Materials in Older Buildings.

Persistent organic pollutants are still present in surface marine sediments from the Seto Inland Sea, Japan.

Perfluoroalkyl Substances

Level and determinants of serum perfluoroalkyl acids (PFAAs) in a population in Klang Valley, Malaysia.

Evaluation of perfluoroalkyl substances in field-cultivated vegetables.

Influence of soil physicochemical properties on the depth profiles of perfluoroalkylated acids (PFAAs) in soil along a distance gradient from a fluorochemical plant and associations with soil microbial parameters.

Flame Retardants

Organophosphorus Flame Retardants and Plasticizers in Breast Milk from the United States.

Seasonal trends of legacy and alternative flame retardants in river water in a boreal catchment.

Pesticides

Changes in Indoor Insecticide Residue Levels after Adopting an Integrated Pest Management Program to Control German Cockroach Infestations in an Apartment Building.

Monitoring the complex occurrence of pesticides in the Llobregat basin, natural and drinking waters in Barcelona metropolitan area (Catalonia, NE Spain) by a validated multi-residue online analytical method.

Ecological Risk Assessment (ERA) of pesticides from freshwater ecosystems in the Pampas region of Argentina: Legacy and current use chemicals contribution.

Arsenic/Metals

A preliminary assessment of mercury in the feathers of migratory songbirds breeding in the North American subarctic.

Heavy metals (Cr, Pb, Cd, Ni) in aerosols emitted from electronic cigarettes sold in Malaysia.

Toxic heavy metal (Pb and Cd) content in tobacco cigarette brands in Selangor state, Peninsular Malaysia.

Comprehensive study on metal contents and their ecological risks in beach sediments of KwaZulu-Natal province, South Africa.

The spatial distribution of total mercury in sediments in the Yatsushiro Sea, Japan.

Spatial variations and periodic changes in heavy metals in surface water and sediments of the Three Gorges Reservoir, China.

Risk assessment for and microbial community changes in Farmland soil contaminated with heavy metals and metalloids.

Exposure to metals and semivolatile organic compounds in Australian fire stations.

Contribution of fluorite mining waste to mercury contamination in coastal systems.

Body feather mercury and arsenic concentrations in five species of seabirds from the Falkland Islands.

Spatial variability of arsenic in Indo-Gangetic basin of Varanasi and its cancer risk assessment.

Critical review of mercury contamination in Sri Lankan fish and aquatic products.

Microplastics

Riverine Microplastic Pollution in the Pearl River Delta, China: Are Modeled Estimates Accurate?

As(III) adsorption onto different-sized polystyrene microplastic particles and its mechanism.

Offshore surface waters of Antarctica are free of microplastics, as revealed by a circum-Antarctic study.

Does mechanical stress cause microplastic release from plastic water bottles?

Distribution characteristics of microplastics in Zhubi Reef from South China Sea.

Microplastics in the surface water of small-scale estuaries in Shanghai.

Sea-surface microplastic concentrations along the coastal shelf of KwaZulu-Natal, South Africa.

Miscellaneous

Antibiotics and antidepressants occurrence in surface waters and sediments collected in the north of Portugal.

Suspect screening of plastic-related chemicals in northern pike (Esox lucius) from the St. Lawrence River, Canada.

Nasal lavages as a tool for monitoring exposure to organic pollutants.

Occurrence and distribution of clinical and veterinary antibiotics in the faeces of a Chinese population.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.