New EDC articles, May 8 – 14, 2019 – HEEDS

New EDC articles, May 8 – 14, 2019

Post author:HEEDS
Post published:May 14, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.

Reviews

The Endocrine Society in Endocrine Disruptor Research and Policy.

The epigenetic impacts of endocrine disruptors on female reproduction across generations

Development Priority

The burden of cancer attributable to modifiable risk factors in Canada: Methods overview. [EDCs, aside from air pollution, are not listed as main risk factors]

BPA/Phthalates/Phenols

Achieving CLARITY on Bisphenol A (BPA), Brain and Behavior.

Fetal growth in environmental epidemiology: mechanisms, limitations, and a review of associations with biomarkers of non-persistent chemical exposures during pregnancy.

PFAS

Interspecies differences in perfluoroalkyl substances (PFAS) toxicokinetics and application to health-based criteria.

Arsenic/Metals

Review of arsenic toxicity, speciation and polyadenylation of canonical histones. [arsenic and cancer]

Environmental risk factors for liver cancer and nonalcoholic fatty liver disease.

Human Health Studies

BPA/Phenols/Phthalates/Parabens

The Associations between Immunological Reactivity to the Haptenation of Unconjugated Bisphenol A to Albumin and Protein Disulfide Isomerase with Alpha-Synuclein Antibodies. [re Parkinson’s]

A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort.

Study of possible association between endometriosis and phthalate and bisphenol A by biomarkers analysis.

Persistent Organic Pollutants

Perinatal dioxin exposure and neurodevelopment of 2-year-old Vietnamese children in the most contaminated area from Agent Orange in Vietnam.

Association of serum levels of p,p’- Dichlorodiphenyldichloroethylene (DDE) with type 2 diabetes in African American and Caucasian adult men from agricultural (Delta) and non-agricultural (non-Delta) regions of Mississippi.

Perfluoroalkyl Substances

Perfluoroalkyl acids serum concentrations and their relationship to biomarkers of renal failure: Serum and urine albumin, creatinine, and albumin creatinine ratios across the spectrum of glomerular function among US adults.

Pesticides

Occupational Pesticide Exposure and Symptoms of Attention Deficit Hyperactivity Disorder in Adolescent Pesticide Applicators in Egypt.

Results of buccal micronucleus cytome assay in pesticide-exposed and non-exposed group.

Arsenic/Metals

Inorganic arsenic exposure and neuropsychological development of children of 4-5 years of age living in Spain.

Thyroid hormones and neurobehavioral functions among adolescents chronically exposed to groundwater with geogenic arsenic in Bangladesh.

The association between plasma selenium and chronic kidney disease related to lead, cadmium and arsenic exposure in a Taiwanese population.

Evaluation of the association between urinary cadmium levels below threshold limits and the risk of diabetes mellitus: a dose-response meta-analysis.

Concentrations of trace elements and KRAS mutations in pancreatic ductal adenocarcinoma.

Association of Arsenic Exposure With Cardiac Geometry and Left Ventricular Function in Young Adults. also see: Arsenic: A Metal That Might Break Your Heart. [editorial]

UV Filters

Urinary concentrations of benzophenone-3 and reproductive outcomes among women undergoing infertility treatment with assisted reproductive technologies.

Mixtures

Two-step approach for assessing the health effects of environmental chemical mixtures: application to simulated datasets and real data from the Navajo Birth Cohort Study.

Air Pollution

Association between Early Life Exposure to Air Pollution and Working Memory and Attention.

Laboratory Studies

BPA/Phenols

BPA activates EGFR and ERK1/2 through PPARγ to increase expression of steroidogenic acute regulatory protein in human cumulus granulosa cells.

Neuroprotective effects of Withania somnifera in BPA induced-cognitive dysfunction and oxidative stress in mice.

Dose exposure of Bisphenol- A on female Wistar rats fertility.

Accumulation and toxicological effects of nonylphenol in tomato (Solanum lycopersicum L) plants.

Phthalates

Using a high-resolution mass spectrometry-based metabolomics strategy for comprehensively screening and identifying biomarkers of phthalate exposure: Method development and application.

Di-(2-ethylhexyl) phthalate (DEHP)-induced hepatotoxicity in quail (Coturnix japonica) via suppression of the heat shock response.

Persistent Organic Pollutants

Lactational exposure to dioxin-like polychlorinated biphenyl 169 and nondioxin-like polychlorinated biphenyl 155: Effects on rat femur growth, biomechanics and mineral composition.

Hexachloronaphthalene as a hemostasis disturbing factor in female Wistar rats – A pilot study.

Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A. [PCBs and organotins]

Induction of maxillary and mandibular squamous epithelial cell proliferation in mink (Neovison vison) by β-naphthoflavone. [re TCDD/dioxin]

Role of epigenetic regulation of Igf2 and H19 in 2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD)-induced ovarian toxicity in offspring rats.

Perfluoroalkyl Substances

Can sustained exposure to PFAS trigger a genotoxic response? A comprehensive genotoxicity assessment in mice after subacute oral administration of PFOA and PFBA.

Bacterial community in a freshwater pond responding to the presence of perfluorooctanoic acid (PFOA).

Sex-specific endocrine-disrupting effects of three halogenated chemicals in Japanese medaka. [PFASs and Tris]

Maternal exposure to perfluorooctanoic acid (PFOA) causes liver toxicity through PPAR-α pathway and lowered histone acetylation in female offspring mice.

Flame Retardants

A comparison of the thyroid disruption induced by decabrominated diphenyl ethers (BDE-209) and decabromodiphenyl ethane (DBDPE) in rats.

Sub-lethal doses of polybrominated diphenyl ethers affect some biomarkers involved in energy balance and cell cycle, via oxidative stress in the marine fish cell line SAF-1.

Thyroid disruption properties of three indoor dust chemicals tested in Silurana tropicalis tadpoles. [Tris/TDCiPP, TBBPA, propylparaben]

Pesticides

Transgenerational sperm DNA methylation epimutation developmental origins following ancestral vinclozolin exposure.

Chronic exposure to environmental levels of cis-bifenthrin: Enantioselectivity and reproductive effects on zebrafish (Danio rerio).

Chlorpyrifos-induced reproductive toxicity in rats could be partly relieved under high-fat diet.

Cytotoxic and genotoxic effects of epoxiconazole on F98 glioma cells.

Comparative study of esterase activities in different tissues of marine fish species Trachurus trachurus, Merluccius merluccius and Trisopterus luscus.

Evaluating sub-lethal stress from Roundup® exposure in Artemia franciscana using 1H NMR and GC-MS.

Stereoselective endocrine-disrupting effects of the chiral triazole fungicide prothioconazole and its chiral metabolite.

Long-term dynamics of honey bee colonies following exposure to chemical stress.

Mitochondrial and lysosomal dysfunction induced by the novel metal-insecticide [Mg(hesp)2(phen)] in the zebrafish (Danio rerio) hepatocyte cell line (ZF-L).

The biological activities of prothioconazole enantiomers and their toxicity assessment on aquatic organisms.

Acute Rat and Mouse Oral Toxicity Determination of Anticholinesterase Inhibitor Carbamate Pesticides: A QSTR Approach.

Glyphosate and Glyphosate-based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behavior and microbiome.

Comparison of metabolomic responses of earthworms to sub-lethal imidacloprid exposure in contact and soil tests.

Protective effects of kefir against deltamethrin-induced hepatotoxicity in rats.

Flutolanil affects circadian rhythm in zebrafish (Danio rerio) by disrupting the positive regulators.

Fungicides at environmentally relevant concentrations can promote the proliferation of toxic bloom-forming cyanobacteria by inhibiting natural fungal parasite epidemics.

Arsenic/Metals

Distinctive fingerprints of genotoxicity induced by As, Cr, Cd, and Ni in a freshwater fish.

Immune response, MT and HSP70 gene expression, and bioaccumulation induced by lead exposure of the marine crab, Charybdis japonica.

Mercury Leads to Features of Polycystic Ovary Syndrome in Rats.

Biochemical evidence on the potential role of methyl mercury in hepatic glucose metabolism through inflammatory signaling and free radical pathways.

Pharmaceuticals

Medroxyprogesterone acetate affects sex differentiation and spermatogenesis in zebrafish.

Alterations to the vision-associated transcriptome of zebrafish (Danio rerio) following developmental norethindrone exposure.

Microbiota alter metabolism and mediate neurodevelopmental toxicity of 17β-estradiol.

Microplastics

Exposure to microplastics lowers arsenic accumulation and alters gut bacterial communities of earthworm Metaphire californica.

Screening/Models

Evaluation of a panel of in vitro methods for assessing thyroid receptor β and transthyretin transporter disrupting activities.

Identification of oxidative stress and estrogenic activity induced by polarity fractions of effluent organic matter.

The Xenopus tropicalis Model for Studies of Developmental and Reproductive Toxicity.

Ex Vivo Fetal Whole Ovarian Culture Model: An Essential Tool for Studies in Reproductive Toxicology and Pharmacology.

Miscellaneous

Modulation of endocrine nuclear receptor activities by polyaromatic compounds present in fractionated extracts of diesel exhaust particles.

Oxidative stress mediates renal endothelial cell damage in trichloroethylene-sensitized mice.

Wildlife/Environment/Exposure Studies

BPA/Phenols/Parabens

Once Resin Composites and Dental Sealants Release Bisphenol-A, How Might This Affect Our Clinical Management?-A Systematic Review.

Urinary bisphenol A (BPA) concentrations and exposure predictors among pregnant women in the Laizhou Wan Birth Cohort (LWBC), China.

Variations, determinants, and co-exposure patterns of personal care product chemicals among Chinese pregnant women: a longitudinal study.

Occurrence, distribution, bioaccumulation, and ecological risk of bisphenol analogues, parabens and their metabolites in the Pearl River Estuary, South China.

Phthalates

Variations of phthalate exposure and metabolism over three trimesters.

Contribution of phthalates and phthalate monoesters from drinking water to daily intakes for the general population.

Effect of biochars on the bioavailability of cadmium and di-(2-ethylhexyl) phthalate to Brassica chinensis L. in contaminated soils.

Distribution of five SVOCs in a model room: effect of vacuuming and air cleaning measures.

Persistent Organic Pollutants

Modulation of microbial growth and enzymatic activities in the marine environment due to exposure to organic contaminants of emerging concern and hydrocarbons. [PFASs, flame retardants, PAHs, etc.]

Semi-volatile organic compounds in tap water from Hangzhou, China: Influence of pipe material and implication for human exposure. [various POPs and phthalates]

Air-water PCB fluxes from southwestern Lake Michigan revisited.

Perfluoroalkyl Substances

Assessing exposure to legacy and emerging per- and polyfluoroalkyl substances via hair – The first nationwide survey in India.

Dietary exposure of Chinese adults to perfluoroalkyl acids (PFAAs) via animal-origin foods – Chinese Total Diet Study (2005-2007, 2011-2013).

Perfluoroalkyl substances (PFASs) in the marine environment: Spatial distribution and temporal profile shifts in shellfish from French coasts.

Seasonal Variation of Water Quality in Unregulated Domestic Wells.

Flame Retardants

Organophosphate esters (OPEs) in Chinese foodstuffs: Dietary intake estimation via a market basket method, and suspect screening using high-resolution mass spectrometry.

Polybrominated diphenyl ethers (PBDEs) in chicken eggs and cow milk around municipal dumpsites in Abuja, Nigeria.

Pesticides

Optimization and validation of kinetic spectrophotometric method for quantitative determination of pesticide atrazine and its application in infant formulae and cereal based baby food.

Estimating the cumulative human exposures to pyrethroids by combined multi-route PBPK models: Application to the French population.

Agricultural and domestic pesticides in house dust from different agricultural areas in France.

Are independent agricultural advisors more oriented towards recommending reduced pesticide use than supplier-affiliated advisors?

Residues of pesticides and some metabolites in dissolved and particulate phase in surface stream water of Cachapoal River basin, central Chile.

Historical evidence of glyphosate exposure from a US agricultural cohort.

Arsenic/Metals

Examining toxic trace element exposure in American alligators.

Natural antidotes and management of metal toxicity.

Arsenic concentrations after drinking water well installation: Time-varying effects on arsenic mobilization.

Predicting groundwater arsenic contamination: Regions at risk in highest populated state of India.

Origin, distribution, and geochemistry of arsenic in the Altiplano-Puna plateau of Argentina, Bolivia, Chile, and Perú.

Determination of heavy metals (lead, cadmium, arsenic, and mercury) in authorized and unauthorized cosmetics.

Parasites and Metals in Walleye (Sander vitreus) and Northern Pike (Esox lucius) from Boreal Montreal Lake (Saskatchewan, Canada): Assessment of Human Health Risks.

Metal concentrations in electronic cigarette aerosol: Effect of open-system and closed-system devices and power settings.

Metals in soils from a typical rapidly developing county, Southern China: levels, distribution, and source apportionment.

Trace metals in green sea turtles (Chelonia mydas) inhabiting two southern California coastal estuaries.

Microplastics

Municipal solid waste (MSW) landfill: A source of microplastics? -Evidence of microplastics in landfill leachate.

Microplastic in wild populations of the omnivorous crab Carcinus aestuarii: A review and a regional-scale test of extraction methods, including microfibres.

Developing Predictive Models for Carrying Ability of Micro-Plastics towards Organic Pollutants.

Occurrence and Ecological Impacts of Microplastics in Soil Systems: A Review.

Microplastic ingestion in deep-sea fish from the South China Sea.

Miscellaneous

Air Emissions from Natural Gas Facilities in New York State.

Natural attenuation mechanism and health risk assessment of 1,1,2-trichloroethane in contaminated groundwater.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.