New EDC articles, May 1 – 7, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

Express yourself: Individuals with bold personalities exhibit increased behavioral sensitivity to dynamic herbicide exposure. [crayfish and atrazine]

Regulations/Policy

Integration of epidemiological findings with mechanistic evidence in regulatory pesticide risk assessment: EFSA experiences.

Reviews

Heightened susceptibility: a review of how pregnancy and chemical exposures influence maternal health

Sex and Gender Analysis of Toxicity and Epidemiology Data on Environmental Chemicals in the Three Major Toxicology Databases.

Prevention of Cardiovascular Diseases in Children and Adolescents.

Estrogenic compounds as exogenous modulators of physiological functions in molluscs: Signaling pathways and biological responses.

Improving environmental risk assessments of chemicals: Steps towards evidence-based ecotoxicology. [industry-sponsored]

Pesticides

Effects of prenatal and postnatal exposure to organophosphate pesticides on child neurodevelopment in different age groups: a systematic review.

Chronic Interstitial Nephritis in Agricultural Communities (CINAC) in Sri Lanka.

Chronic Kidney Disease of Unknown Etiology: Hotspots in India and Other Asian Countries.

Environmental and Occupational Exposures in Kidney Disease.

Metals

A critical prospective analysis of the potential toxicity of trace element regulation limits in soils worldwide: Are they protective concerning health risk assessment? – A review.

Human Health Studies

BPA/Phthalates

Exposure to phthalates and bisphenol A is associated with higher risk of cardiometabolic impairment in normal weight children.

Persistent Organic Pollutants

An Increased Level of Aryl Hydrocarbon Receptor in Patients with Pancreatic Cancer.

Perfluoroalkyl Substances

Exposure to Environmental Pollutants and Their Association with Biomarkers of Aging: A Multipollutant Approach. [PFASs, metals, organohalogens]

Pesticides

Parental Occupational Exposure to Pesticides, Animals, and Organic Dust and Risk of Childhood Leukemia and Central Nervous System Tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C).

Raising awareness of the health effects of environmental exposures. [Letter on Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study, previously sent]

Arsenic/Metals

Arsenic exposure and serum antibody concentrations to diphtheria and tetanus toxoid in children at age 5: A prospective birth cohort in Bangladesh.

Assessment of arsenic exposure by drinking well water and associated carcinogenic risk in peri-urban areas of Vehari, Pakistan.

Benzene

No correlation between blood benzene levels and luteinizing hormone plasma values in outdoor workers.

Miscellaneous

Effects of Low-level Occupational Exposure to Ammonia on Hematological Parameters and Kidney Function.

Association of Maternal Neurodevelopmental Risk Alleles With Early-Life Exposures.

Laboratory Studies

BPA/Phenols

The effects of fluorene-9-bisphenol on female zebrafish (Danio rerio) reproductive and exploratory behaviors.

A comparative evaluation of the immunotoxicity and immunomodulatory effects on macrophages exposed to aromatic trihalogenated DBPs.

Bisphenol A and 17α-ethinylestradiol-induced transgenerational differences in expression of osmoregulatory genes in the gill of medaka (Oryzias latipes).

Toxicity of three emerging contaminants to non-target marine organisms.

Bisphenol AF promotes estrogen receptor-positive breast cancer cell proliferation through amphiregulin-mediated crosstalk with receptor tyrosine kinase signaling.

Bisphenol A Activates Calcium Influx in Immortalized GnRH Neurons.

Minor structural modifications of bisphenol A strongly affect physiological responses of HepG2 cells.

Reprotoxicity of 4-nonylphenol to Biomphalaria alexandrina snails at certain temperatures.

Phthalates

Isolation and molecular characterization of spermatogonia from male Sprague-Dawley rats exposed in utero and postnatally to dibutyl phthalate or acrylamide.

Mono(2-ethylhexyl) phthalate (MEHP) induces transcriptomic alterations in oocytes and their derived blastocysts.

Persistent Organic Pollutants

Uptake and accumulation of pentachloronitrobenzene in pak choi and the human health risk.

Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice.

Perfluoroalkyl Substances

Maternal exposure causes mitochondrial dysfunction in brain, liver, and heart of mouse fetus: An explanation for perfluorooctanoic acid induced abortion and developmental toxicity.

Effect of prenatal PFOS exposure on liver cell function in neonatal mice.

Thyroid endocrine disruption effects of perfluoroalkyl phosphinic acids on zebrafish at early development.

Flame Retardants

Maternal BDE-209 exposure during lactation causes testicular and epididymal toxicity through increased oxidative stress in peripubertal mice offspring.

Pesticides

The Effect of Diazinon on Cell Proliferation and Apoptosis in Testicular Tissue of Rats and The Protective Effect of Vitamin E.

Acute exposure to chlorpyrifos and glyphosate induces changes in hemolymph biochemical parameters in the crayfish, Astacus leptodactylus (Eschscholtz, 1823).

Disruption of giant unilamellar vesicles mimicking cell membranes induced by the pesticides glyphosate and picloram.

A Neurodevelopmental Model of Combined Pyrethroid and Chronic Stress Exposure.

Toxicological Effects of Traumatic Acid and Selected Herbicides on Human Breast Cancer Cells: In Vitro Cytotoxicity Assessment of Analyzed Compounds.

Arsenic/Metals

Chronic arsenic exposure induces oxidative stress and perturbs serum lysolipids and fecal unsaturated fatty acid metabolism.

Enrichment of genes associated with squamous differentiation in cancer initiating cells isolated from urothelial cells transformed by the environmental toxicant arsenite.

Taurine Protects Against Arsenic Trioxide-Induced Insulin Resistance via ROS-Autophagy Pathway in Skeletal Muscle.

Quantitative proteomic study of arsenic treated mouse liver sinusoidal endothelial cells using a reverse super-SILAC method.

Transient Receptor Potential Melastatin 4 Contributes to Early-Stage Endothelial Injury Induced by Arsenic Trioxide.

Organotins

Effects of Tributyltin (TBT) on Rat Bone and Mineral Metabolism.

NLRP3 inflammasome activation is involved in trimethyltin-induced neuroinflammation.

Miscellaneous

Long-term exposure to the non-steroidal anti-inflammatory drug (NSAID) naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations.

Gestational Exposure to Low Dose Zearalenone Disrupting Offspring Spermatogenesis Might Be through Epigenetic Modifications. [a mycotoxin]

Two-generation exposure to 2-ethylhexyl 4-methoxycinnamate (EHMC) in Japanese medaka (Oryzias latipes) and its reproduction and endocrine related effects. [a UV filter]

Wildlife/Environment/Exposure Studies

BPA/Phenols

Assessing the presence of endocrine disruptors and markers of anthropogenic activity in a water supply system in northeastern Brazil. [phthalates, phenols, pharmaceuticals, etc.]

Naturally occurring bisphenol F in plants used in traditional medicine.

Phthalates

The extent and predictors of phthalate exposure among couples undergoing in vitro fertilization treatment.

Persistent Organic Pollutants

Study on the pollution characteristics and emission factors of PCDD/Fs from disperse dye production in China.

Occurrence of persistent organic pollutants in air at different sites in the province of Córdoba, Argentina.

Persistent organic pollutants in lakes of Broknes peninsula at Larsemann Hills area, East Antarctica.

Perfluoroalkyl Substances

Use of Aqueous Film-Forming Foams and Knowledge of Perfluorinated Compounds among Florida Firefighters.

Flame Retardants

Halogenated flame retardants and organophosphate esters in the air of electronic waste recycling facilities: Evidence of high concentrations and multiple exposures.

Pesticides

Environmental and economic impacts of better cotton: a panel data analysis.

Knowledge and Practices of Safe Use of Pesticides among a Group of Farmers in Northern Iran.

Knowledge and Perception of Farmers Regarding Pesticide Usage in a Rural Farming Village, Southern India.

Assessing the accuracy of citizen scientist reported measurements for agrichemical contaminants.

Glyphosate in yam from Ghana.

National assessment of spatiotemporal loss in agricultural pesticides and related potential exposure risks to water quality in China.

Local adaptation of the MHC class IIβ gene in populations of wood frogs (Lithobates sylvaticus) correlates with proximity to agriculture.

Biomonitoring of pesticides, pharmaceuticals and illicit drugs in a freshwater invertebrate to estimate toxic or effect pressure.

Arsenic/Metals

High arsenic contamination and presence of other trace metals in drinking water of Kushtia district, Bangladesh.

An integrated study of health, environmental and socioeconomic indicators in a mining-impacted community exposed to metal enrichment.

Distribution and health risk assessment of arsenic and selected heavy metals in Groundwater of Chandigarh, India.

Geographical variation in arsenic, cadmium, and lead of soils and rice in the major rice producing regions of China.

Status assessment and probabilistic health risk modeling of metals accumulation in agriculture soils across China: A synthesis.

Lead and Arsenic in Shed Deciduous Teeth of Children Living Near a Lead-Acid Battery Smelter.

Arsenic in Argentina: Occurrence, human health, legislation and determination.

Using an apex predator for large-scale monitoring of trace element contamination: Associations with environmental, anthropogenic and dietary proxies.

Organotins

Levels of tin and organotin compounds in human urine samples from Iowa, United States.

Microplastics

Microplastic contamination and pollutant levels in mussels and cockles collected along the channel coasts.

The contribution of washing processes of synthetic clothes to microplastic pollution.

Microplastic freshwater contamination: an issue advanced by science with public engagement.

Miscellaneous

Health status of the lizard Podarcis siculus (Rafinesque-Schmaltz, 1810) subject to different anthropogenic pressures. [metals, pesticides, nonylphenol, etc.]

Use of high-throughput screening results to prioritize chemicals for potential adverse biological effects within a West Virginia watershed.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.