New EDC articles: June 5 – 11, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

A Novel Approach to Chemical Mixture Risk Assessment-Linking Data from Population-Based Epidemiology and Experimental Animal Tests.

Regulations/Policy

The Case of Juliana v. U.S. – Children and the Health Burdens of Climate Change. [editorial in NEJM]

The USA lags behind other agricultural nations in banning harmful pesticides.

And a bunch of food for thought this month in the Amer J Public Health:

The Environmental Protection Agency Toxic Substances Control Act Systematic Review Method May Curtail Science Used to Inform Policies, With Profound Implications for Public Health.

Fighting Independent Risk Assessment of Talc and Glyphosate: Whose Benefit Is It Anyway?

Expert Review Under Attack: Glyphosate, Talc, and Cancer.

“Nondetected”: The Politics of Measurement of Asbestos in Talc, 1971-1976.

Reliance, Not Responsibility: Relations Between Science and Industry.

Science and Industry: Let’s Agree on Goals and Shared Wins.

Reviews

The Role of Environmental Exposures and the Epigenome in Health and Disease.

Baby Steps Forward: Recommendations for Better Understanding Environmental Chemicals in Breast Milk and Infant Formula. [EHP science selection]

Qualitative and quantitative use of micropollutants as source and process indicators. A review.

Environmental Factors and the Risk of Brain Tumours in Young People: A Systematic Review.

Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future.

BPA

Determination of Endocrine Disruption Potential of Bisphenol A Alternatives in Food Contact Materials Using In Vitro Assays: State of the Art and Future Challenges.

Persistent Organic Pollutants

Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism.

Can contamination of the environment by dioxins cause craniofacial defects?

Pharmaceuticals

Environmental Transformation of Pharmaceutical Formulations: A Scientific Review.

Metals

The relative impact of toxic heavy metals (THMs) (arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview.

Air Pollution

Household air pollution from domestic combustion of solid fuels and health.

Health effects of air pollution: what we need to know and to do in the next decade.

Nanoplastics

Recent advances in toxicological research of nanoplastics in the environment: A review.

Human Health Studies

BPA and Phthalates

Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents.

Prenatal bisphenol A and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels.

Phthalate Exposure From Prescription Medications and Breast Cancer Risk. [editorial re Phthalate Exposure and Breast Cancer Incidence: A Danish Nationwide Cohort Study, previously sent]

Triclosan

Triclosan and Female Reproductive Health: A Preconceptional Cohort Study.

Persistent Organic Pollutants

Polybrominated Biphenyl Exposure and Menstrual Cycle Function.

Perfluoroalkyl Substances

Cord blood Per- and polyfluoroalkyl substances, placental steroidogenic enzyme, and cord blood reproductive hormone.

Flame Retardants

PBDE serum concentration and preschool maturity of children from Slovakia.

Pesticides

Hearing Loss in Agricultural Workers Exposed to Pesticides and Noise.

Caregiving and infants’ neurodevelopment in rural Costa Rica: Results from the Infants’ Environmental Health Study (ISA).

Arsenic/Metals

Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study.

Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children’s Study (JECS).

The Association Between Mercury Exposure and Atopic Dermatitis in Early Childhood: A Mothers and Children’s Environmental Health Study.

Air Pollution

Effect of ambient air pollution on premature SGA in Changzhou city, 2013-2016: a retrospective study.

Air pollution and semen parameters in men seeking fertility treatment for the first time.

Evaluation of PM1, PM2.5, and PM10 exposure and the resultant health risk of preschool children and their caregivers.

Accountability Assessment of Health Improvements in the United States Associated with Reduced Coal Emissions Between 2005 and 2012.

Miscellaneous

Association between occupational exposure to trichloroethylene and serum levels of microRNAs: a cross-sectional molecular epidemiology study in China.

Laboratory Studies

BPA/Phenols

Bisphenol S-induced chronic inflammatory stress in liver via peroxisome proliferator-activated receptor γ using fish in vivo and in vitro models.

Bisphenols (A, S, and F) affect the basic hormonal activity determined for pharmaceuticals – Study of Saccharomyces cerevisiae.

Inhibition of Type 1 Iodothyronine Deiodinase by Bisphenol A.

In vitro study to evaluate the cytotoxicity of BPA analogues based on their oxidative and genotoxic potential using human peripheral blood cells.

Phthalates

Genetic resistance to DEHP-induced transgenerational endocrine disruption.

Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPARγ/PTEN/AKT pathway in differentiated human embryonic stem cells.

Icariin protects mouse Leydig cell testosterone synthesis from the adverse effects of di(2-ethylhexyl) phthalate.

Perfluoroalkyl Substances

In vitro and in silico modeling of perfluoroalkyl substances mixture toxicity in an amphibian fibroblast cell line.

Exposure of Juncus effusus to seven perfluoroalkyl acids: Uptake, accumulation and phytotoxicity.

Flame Retardants

Perigestational low-dose BDE-47 exposure alters maternal serum metabolome and results in sex-specific weight gain in adult offspring.

Using a Multi-Stage hESC Model to Characterize BDE-47 Toxicity during Neurogenesis.

Pesticides

Fish behavior: A promising model for aquatic toxicology research.

Maternal exposure to fipronil results in sulfone metabolite enrichment and transgenerational toxicity in zebrafish offspring: Indication for an overlooked risk in maternal transfer?

Neonicotinoids and ectoparasitic mites synergistically impact honeybees.

A two-year monitoring of pesticide hazard in-hive: High honey bee mortality rates during insecticide poisoning episodes in apiaries located near agricultural settings.

Pesticide exposure affects flight dynamics and reduces flight endurance in bumblebees.

Early impairment of epigenetic pattern in neurodegeneration: Additional mechanisms behind pyrethroid toxicity.

In vitro enantioselective study of the toxicokinetic effects of chiral fungicide tebuconazole in human liver microsomes.

Fungicides chlorothanolin, azoxystrobin and folpet induce transcriptional alterations in genes encoding enzymes involved in oxidative phosphorylation and metabolism in honey bees (Apis mellifera) at sublethal concentrations.

Amelioration of fenitrothion induced oxidative DNA damage and inactivation of caspase-3 in the brain and spleen tissues of male rats by N-acetylcysteine.

Acetamiprid, a neonicotinoid insecticide, induced cytotoxicity and genotoxicity in PC12 cells.

Triiodothyronine reduces toxic effects of diazinon in Persian sturgeon (Acipenser persicus) embryos.

Arsenic/Metals

Non-monotonic dose-response effects of arsenic on glucose metabolism.

Mechanistic assessment of cadmium toxicity in association with the functions of estrogen receptors in the Langerhans islets.

Effects of sub-chronic, low-dose cadmium exposure on kidney damage and potential mechanisms.

Assessing interactions between environmental factors and aquatic toxicity: Influences of dissolved CO2 and light on Cd toxicity in the aquatic macrophyte Potamogeton crispus.

Arsenic-induced metabolic shift triggered by the loss of miR-199a-5p through Sp1-dependent DNA methylation.

Modulation of the gut microbiota by a galactooligosaccharide protects against heavy metal lead accumulation in mice.

Miscellaneous

Comparing the disrupting effects of short-, medium- and long-chain chlorinated Paraffins on cell viability and metabolism.

Aflatoxin B1 impairs leydig cells through inhibiting AMPK/mTOR-mediated autophagy flux pathway.

PM2.5 affects establishment of immune tolerance in newborn mice by reducing PD-L1 expression.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Exposure assessment of bisphenols in Chinese women during pregnancy: a longitudinal study.

Phthalates

Characterizing Airborne Phthalate Concentrations and Dynamics in a Normally Occupied Residence.

Phthalates and organophosphorus insecticide residues in shrimp determined by liquid/gas chromatography-Tandem mass spectrometry and a health risk assessment.

Persistent Organic Pollutants

Spatial and temporal distribution of p,p’-DDE (1‑dichloro‑2,2‑bis (p‑chlorophenyl) ethylene) blood levels across the globe. A systematic review and meta-analysis.

Source Apportionment of Polychlorinated Biphenyls in Atmospheric Deposition in the Seattle, WA, USA Area Measured with Method 1668.

Organochlorine pesticides in marine ecosystems of the Far Eastern Seas of Russia (2000-2017).

Occurrence and risk evaluation of organochlorine contaminants in surface water along the course of Swartkops and Sundays River Estuaries, Eastern Cape Province, South Africa.

Polychlorinated biphenyls are still alarming persistent organic pollutants in marine-origin animal feed (fishmeal).

Distributions and seasonal variations of organochlorine pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers in surface sediment from coastal areas of central Vietnam.

Tissue distribution of organic contaminants in stranded pregnant sperm whale (Physeter microcephalus) from the Huizhou coast of the South China Sea.

Occurrence and bioaccumulation of persistent toxic substances in sediments and biota from intertidal zone of Abu Ali Island, Arabian Gulf.

Perfluoroalkyl Substances

Levels, accumulation patterns and retrospective trends of perfluoroalkyl acids (PFAAs) in terrestrial ecosystems over the last three decades.

Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of U.S. Women.

Occurrence and human exposure assessment of perfluorinated substances in house dust from three European countries.

Investigation of the spatial variability of poly- and perfluoroalkyl substance trophic magnification in selected riverine ecosystems.

Emerging per- and polyfluoroalkyl substances (PFASs) in surface water and sediment of the North and Baltic Seas.

Occurrences, levels and risk assessment studies of emerging pollutants (pharmaceuticals, perfluoroalkyl and endocrine disrupting compounds) in fish samples from Kalk Bay harbour, South Africa.

Flame Retardants

The influence of temperature on the emissions of organophosphate ester flame retardants from polyisocyanurate foam: Measurement and modeling (supporting information).

Pesticides

Pesticide residues in ready-to-eat leafy vegetables from markets of Santiago, Chile, and consumer’s risk.

Arsenic/Metals

Carbon and mercury export from the Arctic rivers and response to permafrost degradation.

Replacing fish meal with insect meal in the diet of Atlantic salmon (Salmo salar) does not impact the amount of contaminants in the feed and it lowers accumulation of arsenic in the fillet.

Dietary exposure assessment of aluminium and cadmium from cocoa in relation to cocoa origin.

Mercury, Lead and Cadmium Concentrations in Talpa occidentalis and in Their Digeneans of the Genus Ityogonimus.

Distribution and availability of heavy metals in soils near electroplating factories.

Bioaccessibility and radioisotopes of lead in soils around a fertilizer industry in Lebanon.

Cadmium stress effects indicating marine pollution in different species of sea urchin employed as environmental bioindicators.

Exposure to metals and arsenic from yellow and red tuna consumption.

Historical patterns in mercury exposure for North American songbirds.

Assessment of heavy metal pollution from anthropogenic activities and remediation strategies: A review.

A quantitative analysis of chronic exposure of selected heavy metals in a model diet in a CKD hotspot in Sri Lanka.

Pollution and Health Risk Assessments of Potentially Toxic Elements in Soil and Sediment Samples in a Petrochemical Industry and Surrounding Area.

Analysis of oxidative stress and cellular aggregation in the coelomocytes of earthworms collected from metal contaminated sites of industrial and agricultural soils of West Bengal, India.

Heavy metal accumulation in surface sediments of the Ganga River (India): speciation, fractionation, toxicity, and risk assessment.

Levels of Cadmium in Human Mandibular Bone.

Polycyclic aromatic hydrocarbons and potentially toxic elements in seafood from the Persian Gulf: presence, trophic transfer, and chronic intake risk assessment.

Arsenic contamination in Kolkata metropolitan city: perspective of transportation of agricultural products from arsenic-endemic areas.

Lead release to potable water during the Flint, Michigan water crisis as revealed by routine biosolids monitoring data.

Prediction and risk assessment of five heavy metals in maize and peanut: A case study of Guangxi, China.

Metal Contamination Hotspots at Unregulated Firearm Target Shooting Sites in the Everglades.

Using lead isotopes and potentially toxic elements to trace pollutant sources in the northern region of Guanabara Bay, southeastern Brazil.

Contamination and ecological risk assessment of heavy metals pollution from the Shalateen coastal sediments, Red Sea, Egypt.

Microplastics

Microplastic abundance in atmospheric deposition within the Metropolitan area of Hamburg, Germany.

Are gold nanoparticles and microplastics mixtures more toxic to the marine microalgae Tetraselmis chuii than the substances individually?

Study on the capability and characteristics of heavy metals enriched on microplastics in marine environment.

Ingestion of microplastics by fish and other prey organisms of cetaceans, exemplified for two large baleen whale species.

Input of plastic debris in an urban tropical river system.

Miscellaneous

Analyzing a broader spectrum of endocrine active organic contaminants in sewage sludge with high resolution LC-QTOF-MS suspect screening and QSAR toxicity prediction.

Quantifying personal exposure to air pollution from smartphone-based location data.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.