New EDC articles, June 26 – July 2, 2019 – HEEDS

New EDC articles, June 26 – July 2, 2019

Post author:HEEDS
Post published:July 2, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Reviews

Early-life exposure to endocrine-disrupting chemicals and pubertal development in girls.

Public Health Burden of E-waste in Africa.

BPA/Phenols/Phthalates

Bisphenol A co-exposure effects: a key factor in understanding BPA’s complex mechanism and health outcomes.

Bisphenols in the pathology of reproduction.

Use of the Adverse Outcome Pathway (AOP) framework to evaluate species concordance and human relevance of Dibutyl Phthalate (DBP)-induced male reproductive toxicity.

Persistent Organic Pollutants

The socio-economic impact timeline in Serbia for persistent organic pollutants (POPs).

Effects of prenatal PCB exposure. [editorial]

Flame Retardants

A review of organophosphorus flame retardants (OPFRs): occurrence, bioaccumulation, toxicity, and organism exposure.

Metals

Braving the Element: Pancreatic β-Cell Dysfunction and Adaptation in Response to Arsenic Exposure.

Measurements and Distribution of Atmospheric Particulate-Bound Mercury: A Review.

Fluoride contamination, health problems and remediation methods in Asian groundwater: A comprehensive review.

Mercury Contamination from Dental Amalgam.

Pesticides

Pyrethroid exposure and neurotoxicity: a mechanistic approach.

Systematic Literature Review of the Take-Home Route of Pesticide Exposure via Biomonitoring and Environmental Monitoring.

Animal models in the neurotoxicology of 2,4-D.

Pharmaceuticals

Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy.

Air Pollution

Associations between long-term exposure to ambient air pollution and risk of type 2 diabetes mellitus: A systematic review and meta-analysis.

Human Health Studies

BPA/Phenols

Bisphenol A and cognitive function in school-age boys: Is BPA predominantly related to behavior?

Parabens/Triclosan

Association between urinary triclosan with bone mass density and osteoporosis in the US adult women, 2005-2010.

The sex-specific association between maternal paraben exposure and size at birth.

Perfluoroalkyl Substances

First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy.

Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid β-Oxidation Disorder, and Kidney Injury in a Manufactory in China.

Maternal plasma concentrations of perfluoroalkyl and polyfluoroalkyl substances during pregnancy and anogenital distance in male infants.

Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women.

High exposure to perfluorinated compounds in drinking water and thyroid disease. A cohort study from Ronneby, Sweden.

Flame Retardants

Fetal exposure to polybrominated diphenyl ethers and the risk of hypospadias: focus on the congeners involved.

Pesticides

Environmental pyrethroid exposure and thyroid hormones of pregnant women in Shandong, China.

Glyphosate use and associations with non-Hodgkin lymphoma major histological sub-types: findings from the North American Pooled Project.

Pesticide Exposure Modifies DNA Methylation of Coding Region of WRAP53α, an Antisense Sequence of p53, in a Mexican Population.

Relationship between internal and external factors and the activity of PON1.

Biochemical and genotoxic effects in women exposed to pesticides in Southern Ecuador.

LC-ESI/MS/MS analysis of neonicotinoids in urine of very low birth weight infants at birth.

Arsenic/Metals

Chronic Methylmercury Exposure Induces Production of Prostaglandins: Evidence From A Population Study and A Rat Dosing Experiment. [human and lab]

A Birth Cohort Study about the Genetic Modification of Prenatal Methylmercury Association with Child Cognitive Development.

Cadmium Exposure and Risk of Breast Cancer by Histological and Tumor Receptor Subtype in White Caucasian Women: A Hospital-Based Case-Control Study.

Early lead exposure and childhood adiposity in Mexico city.

Pharmaceuticals

Prenatal Diethylstilbestrol Exposure and Risk of Depression in Women and Men.

Miscellaneous

Invited Commentary: Interaction Between Diet and Chemical Exposures comment on:

Exposure to Traffic-Related Air Pollution, Supplemental Folate Intake, and Live Birth Among Women Undergoing Assisted Reproduction.

Human exposure to trichloroethylene is associated with increased variability of blood DNA methylation that is enriched in genes and pathways related to autoimmune disease and cancer.

Laboratory Studies

BPA/Phenols

Expression of serine proteases in neutrophils from women and men: Regulation by endocrine disruptor bisphenol A.

Data describing effects of perinatal exposure to bisphenol S on a peripubertal estrogen challenge in intact female CD-1 mice.

Influence of nonylphenol exposure on basic growth, development, and thyroid tissue structure in F1 male rats.

Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells.

Perinatal Bisphenol A (BPA) Exposure Alters Brain Oxytocin Receptor (OTR) Expression in a Sex- and Region- Specific Manner: a CLARITY-BPA Consortium Follow-up Study.

Data demonstrating distinct embryonic developmental defects induced by bisphenol a alternatives.

Phthalates

In vitro exposure to the next-generation plasticizer diisononyl cyclohexane-1,2-dicarboxylate (DINCH): cytotoxicity and genotoxicity assessment in human cells. [a phthalate alternative]

Tissue-specific changes in Srebf1 and Srebf2 expression and DNA methylation with perinatal phthalate exposure.

Di (2-ethyl hexyl) phthalate (DEHP)-induced spleen toxicity in quail (Coturnix japonica) via disturbing Nrf2-mediated defense response.

Early life exposure to di(2-ethylhexyl)phthalate causes age-related declines associated with insulin/IGF-1-like signaling pathway and SKN-1 in Caenorhabditis elegans.

Plasticizer Interaction With the Heart and commentary, Shocking Aspects of Nonconductive Plastics.

Triclosan

Maternal exposure to triclosan causes fetal development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring.

Persistent Organic Pollutants

Dietary Aroclor 1254-Induced Toxicity on Antioxidant Capacity, Immunity and Energy Metabolism in Chinese Mitten Crab Eriocheir sinensis: Amelioration by Vitamin A.

Morphological Changes in the Thymus of Newborn Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during the Prenatal Period.

DDT exposure induces cell cycle arrest and apoptosis of skin fibroblasts from Indo-Pacific humpback dolphin via mitochondria dysfunction.

Perfluoroalkyl Substances

Comparative in Vitro and in Vivo Evaluation of the Estrogenic Effect of Hexafluoropropylene Oxide Homologues. [PFOA substitutes]

Accumulation, Biotransformation, and Endocrine Disruption Effects of Fluorotelomer Surfactant Mixtures on Zebrafish. [PFOS substitutes]

Exploring Toxicity of Perfluorinated Compounds Through Complex Network and Pathway Modeling. [pathways linked to obesity, hepatocellular carcinoma and diabetes]

PFOS mediates immunomodulation in an avian cell line that can be mitigated via a virus infection.

Flame Retardants

Gestational and Lactational Exposure to an Environmentally-relevant Mixture of Brominated Flame Retardants Down-regulates Junctional Proteins, Thyroid Hormone Receptor α1 Expression and the Proliferation-Apoptosis Balance in Mammary Glands Post Puberty.

Optimization of experimental conditions and measurement of oxygen consumption rate (OCR) in zebrafish embryos exposed to organophosphate flame retardants (OPFRs).

Pesticides

Developmental Exposure to the Endocrine Disruptor Tolylfluanid Induces Sex-Specific Later-Life Metabolic Dysfunction.

How glyphosate and its associated acidity affect early development in zebrafish (Danio rerio).

Plasma Protein and Lipoprotein Binding of cis- and trans-Permethrin and Deltamethrin in Adult Humans and Rats.

Cardiotoxicity of forchlorfenuron (CPPU) in zebrafish (Danio rerio) and H9c2 cardiomyocytes.

Arsenic/Metals

Gene networks and toxicity/detoxification pathways in juvenile largemouth bass (Micropterus salmoides) liver induced by acute lead stress.

Exploring the kidney hazard of exposure to mercuric chloride in mice:Disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis.

Behavioral toxicity of tannery effluent in zebrafish (Danio rerio) used as model system.

Bone mineral health is sensitively related to environmental cadmium exposure- experimental and human data.

Chronic exposure to arsenic and high fat diet induces sex-dependent pathogenic effects on the kidney.

Analysis of the dynamic aberrant landscape of DNA methylation and gene expression during arsenic-induced cell transformation.

Effects of preconception and in utero inorganic arsenic exposure on the metabolic phenotype of genetically diverse Collaborative Cross mice.

One year exposure to Cd- and Pb-contaminated soil causes metal accumulation and alteration of global DNA methylation in rats.

Gestational Arsenic Trioxide Exposure Acts as a Developing Neuroendocrine-Disruptor by Downregulating Nrf2/PPARγ and Upregulating Caspase-3/NF-ĸB/Cox2/BAX/iNOS/ROS.

Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae.

Organotins

Tributyltin Affects Retinoid X Receptor-Mediated Lipid Metabolism in the Marine Rotifer Brachionus koreanus.

Pharmaceuticals

Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner – From molecular mechanisms to environmental concerns.

Microplastics/Nanoplastics

Effects of microplastics on the innate immunity and intestinal microflora of juvenile Eriocheir sinensis.

Nanoplastics Decrease the Toxicity of a Complex PAH Mixture but Impair Mitochondrial Energy Production in Developing Zebrafish.

Mixtures

Assessment of mixture toxicity of (tri)azoles and their hepatotoxic effects in vitro by means of omics technologies.

Skeletal Muscle Lipidomics as a New Tool to Determine Altered Lipid Homeostasis in Fish Exposed to Urban and Industrial Wastewaters.

Miscellaneous

Identifying Compounds with Genotoxicity Potential Using Tox21 High-Throughput Screening Assays.

Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene.

Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells.

Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring.

Chronic exposure to environmental concentrations of phenanthrene impairs zebrafish reproduction.

Wildlife/Environment/Exposure Studies

Persistent Organic Pollutants

Transplacental transfer of organochlorine pesticides: Concentration ratio and chiral properties.

The correlation study between fatty acids and organochlorine pesticides or δ15N values in fish tissues from Dongting Lake, China.

Comparability of long-term temporal trends of POPs from co-located active and passive air monitoring networks in Europe.

Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Umbilical Cord Serum from Pregnant Women Living Near a Chemical Plant in Tianjin, China.

Spatiotemporal variations of organochlorine pesticides in an apex predator: Influence of government regulations and farming practices.

Biomonitoring of mercury and persistent organic pollutants in Michigan urban anglers and association with fish consumption.

Perfluoroalkyl Substances

Bioaccumulation and biomagnification of perfluoroalkyl acids and precursors in East Greenland polar bears and their ringed seal prey.

Environmental risks associated with contaminants of legacy and emerging concern at European aquaculture areas.

Prediction of maternal and foetal exposures to perfluoroalkyl compounds in a Spanish birth cohort using toxicokinetic modelling.

Per- and Polyfluoroalkyl Substances in Commercially Available Biosolid-Based Products: The Effect of Treatment Processes.

Flame Retardants

Assessment of selected chlorinated and brominated flame retardants in human plasma samples among co-residing family members.

Mass balance study of brominated flame retardants in female captive peregrine falcons.

Contamination of polybrominated diphenyl ethers (PBDEs) in watershed sediments and plants adjacent to e-waste sites.

Spatial distribution and hazard of halogenated flame retardants and polychlorinated biphenyls to common kingfisher (Alcedo atthis) from a region of South China affected by electronic waste recycling.

Pesticides

Analysis and occurrence of organophosphate esters in meats and fish consumed in the USA.

Production-related contaminants (pesticides, antibiotics and hormones) in organic and conventionally produced milk samples sold in the USA.

Parallel declines in abundance of insects and insectivorous birds in Denmark over 22 years.

Arsenic/Metals

Predictors of toxic metal exposures among US women of reproductive age.

Mercury Exposure in Mother-Children Pairs in A Seafood Eating Population: Body Burden and Related Factors.

Environmental Risk of Metal Contamination in Sediments of Tropical Reservoirs.

Concentrations of cadmium, lead, and mercury in blood among US cigarettes, cigars, electronic cigarettes, and dual cigarette-e-cigarette users.

Mapping human health risk by geostatistical method: a case study of mercury in drinking groundwater resource of the central ganga alluvial plain, northern India.

Heavy Metals in California Women Living in a Gold Mining-Impacted Community.

Miscellaneous

A screening questionnaire for occupational and hobby exposures during pregnancy.

Results Communication in Breast Milk Biomonitoring Studies: A Scoping Review and Stakeholder Consultation.

The Amazon River: A Major Source of Organic Plastic Additives to the Tropical North Atlantic? [bisphenols, PFASs, organophosphate esters]

Shorter than short-chain: Very short-chain chlorinated paraffins (vSCCPs) found in wildlife from the Yangtze River Delta.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.