A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this holiday season.
Contents: Interesting Research of the Week, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.
Interesting Research of the Week
Reproductive and Hormone-Related Outcomes in Women whose Mothers were Exposed in utero to Diethylstilbestrol (DES): A Report from the US National Cancer Institute DES Third Generation Study.
Regulations/Policy/Screening
Flaws in design, execution and interpretation limit CLARITY-BPA’s value for risk assessments of bisphenol A.
Advancing the zebrafish embryo test for endocrine disruptor screening using micro-injection: ethinyl estradiol as a case study.
High-throughput screening and Environmental Risk Assessment: State of the science and emerging applications.
Workflow for defining reference chemicals for assessing performance of in vitro assays.
Selection of nonlinear interactions by a forward stepwise algorithm: Application to identifying environmental chemical mixtures affecting health outcomes.
An ecotoxicological view on neurotoxicity assessment.
Reviews
A Review on Gut Remediation of Selected Environmental Contaminants: Possible Roles of Probiotics and Gut Microbiota.
Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology.
The role of endocrine disruptors in ocular surface diseases.
Environmental contaminants and preeclampsia: a systematic literature review.
Pharmacologic and Environmental Endocrine Disruptors in the Pathogenesis of Hypospadias: a Review.
Effects of environmental contaminants on fertility and reproductive health.
Endocrine disruptor compounds in environment: As a danger for children health.
Impact of changes in human reproduction on the incidence of endocrine-related diseases.
BPA/Phthalates/Parabens
Bisphenol A: A notorious player in the mosaic of autoimmunity.
Hazards of diisobutyl phthalate (DIBP) exposure: A systematic review of animal toxicology studies.
Association between diethylhexyl phthalate exposure and thyroid function: A meta-analysis.
Parabens: Contact (Non)Allergen of the Year.Paraben Toxicology: An Overview.
Persistent Organic Pollutants
TCDD Toxicity Mediated by Epigenetic Mechanisms.
Arsenic/Metals
Arsenic Exposure and Effects in Humans: A Mini-Review in Brazil.
A systematic review of global legal regulations on the permissible level of heavy metals in cosmetics with particular emphasis on skin lightening products.
Air Pollution
Air pollution and female fertility: a systematic review of literature.
The Aryl Hydrocarbon Receptor as an Immune-Modulator of Atmospheric Particulate Matter-Mediated Autoimmunity.
Human Health Studies
BPA/Phthalates
Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children.
Early pregnancy bisphenol and phthalate metabolite levels, maternal hemodynamics and gestational hypertensive disorders.
Positive association of low-level environmental phthalate exposure with sperm motility was mediated by DNA methylation: A pilot study.
Exposure to phthalate metabolites, phenols and organophosphate pesticide metabolites and blood pressure during pregnancy.
Parabens/Triclosan/Antimicrobials
Association between urinary parabens and gestational diabetes mellitus across prepregnancy body mass index categories.
Persistent Organic Pollutants
Organochlorine pesticides and polychlorinated biphenyls (PCBs) in early adulthood and blood lipids over a 23-year follow-up.
Prevalence of heart attack and stroke and associated risk factors among Inuit in Canada: A comparison with the general Canadian population.
Association of brain heptachlor epoxide and other organochlorine compounds with Lewy pathology.
Perfluoroalkyl Substances
Selective Associations of Recent Low Concentrations of Perfluoroalkyl Substances With Liver Function Biomarkers: NHANES 2011-2014 Data on US Adults Aged ≥ 20 Years.
Arsenic/Metals
Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh.
Air Pollution
Prenatal exposure to air pollution, maternal diabetes and preterm birth.
Short-term exposure to sulfur dioxide and the risk of childhood hand, foot, and mouth disease during different seasons in Hefei, China.
Uranium
Elevated serum chemokines are independently associated with both endometriosis and uranium exposure.
Laboratory Studies
BPA/Phenols
Binary Mixtures of Selected Bisphenols in the Environment: Their Toxicity in Relationship to Individual Constituents.
Systems analysis of the liver transcriptome in adult male zebrafish exposed to the non-ionic surfactant nonylphenol.
Prenatal Bisphenol A Exposure in Mice Induces Multi-tissue Multi-omics Disruptions Linking to Cardiometabolic Disorders.
[Effects of IL-17 antibody on inflammation of adipose tissue in obese mice induced by bisphenol A].
Bisphenol AF exerts estrogenic activity in MCF-7 cells through activation of Erk and PI3K/Akt signals via GPER signaling pathway.
Effects of maternal bisphenol A on behavior, sex steroid and thyroid hormones levels in the adult rat offspring.
Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model.
Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors.
Metabolic treatment of syndrome linked with Parkinson’s disease and hypothalamus pituitary gonadal hormones by turmeric curcumin in Bisphenol-A induced neuro-testicular dysfunction of wistar rat.
Perinatal High-Fat Diet and Bisphenol A: Effects on Behavior and Gene Expression in the Medial Prefrontal Cortex.
Bisphenol A, Bisphenol AF, Di-n-butyl Phthalate, and 17β-estradiol have shared and unique dose-dependent effects on early embryo cleavage divisions and development in Xenopus laevis.
Interactions between Microcystis aeruginosa and coexisting bisphenol A at different phosphorus levels.
Bisphenol A disturbed the lipid metabolism mediated by sterol regulatory element binding protein 1 in rare minnow Gobiocypris rarus.
Diets contaminated with Bisphenol A and Di-isononyl phtalate modify skeletal muscle composition: A new target for environmental pollutant action.
Phthalates
Maternal di-(2-ethylhexyl) phthalate exposure alters hepatic insulin signal transduction and glucoregulatory events in rat F1 male offspring.
Toxicity of phthalate esters to lettuce (Lactuca sativa) and the soil microbial community under different soil conditions.
Melatonin alleviates meiotic defects in fetal mouse oocytes induced by Di (2-ethylhexyl) phthalate in vitro.
Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver.
Simulated digestion of polystyrene foam enhances desorption of diethylhexyl phthalate (DEHP) and In vitro estrogenic activity in a size-dependent manner.
Developmental exposure to DEHP alters hepatic glucose uptake and transcriptional regulation of GLUT2 in rat male offspring.
Parabens
Assessment of hepatotoxicity and dermal toxicity of butyl paraben and methyl paraben using HepG2 and HDFn in vitro models.
Persistent Organic Pollutants
Combined effects of pentachlorophenol and its byproduct hexachlorobenzene on endocrine and reproduction in zebrafish.
The sonic hedgehog signaling pathway is suppressed following PCB1254 exposure during retinal development.
Combined effects of DDE and hyperlipidic diet on metallothionein expression and synthesis in rat tissues.
Maternal care modulates transgenerational effects of endocrine-disrupting chemicals on offspring pup vocalizations and adult behaviors. [PCBs and vinclozolin]
Perfluoroalkyl Substances
Effects of Perfluorooctanoic Acid on the Associated Genes Expression of Autophagy Signaling Pathway of Carassius auratus Lymphocytes in vitro.
Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo.
Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice.
Flame Retardants
NTP Research Report on In Vivo Repeat Dose Biological Potency Study of Triphenyl Phosphate (CAS No. 115-86-6) in Male Sprague Dawley Rats (Hsd: Sprague Dawley SD) (Gavage Studies): Research Report 8 [Internet].
Hepatic transcriptional dose-response analysis of male and female Fischer rats exposed to hexabromocyclododecane.
Pesticides
Microcystin and pyriproxyfen are toxic to early stages of development in Rhamdia quelen: An experimental and modelling study.
Chronic exposure of bumblebees to neonicotinoid imidacloprid suppresses the entire mevalonate pathway and fatty acid synthesis.
The herbicide quinclorac as potent lipase inhibitor: discovery via virtual screening and in vitro/in vivo validation.
Chlorothalonil Inhibits Mouse Ovarian Development through Endocrine Disruption.
Effects on tadpole snail gene expression after exposure to vinclozolin.
The MEK/ERK/CREB signaling pathway is involved in atrazine induced hippocampal neurotoxicity in Sprague Dawley rats.
Interaction of insecticides with heteromeric GABA-gated chloride channels from zebrafish Danio rerio (Hamilton).
Effects of penthiopyrad on the development and behaviour of zebrafish in early-life stages.
Arsenic/Metals
Sodium arsenite exposure impairs B cell proliferation and enhances vascular inflammation in Plasmodium berghei mouse model.
Chronic cadmium exposure aggravates malignant phenotypes of nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway via hypermethylation of the casein kinase 1α promoter.
Acute diethyl nitrosamine and cadmium co-exposure exacerbates deficits in endocrine balance, sperm characteristics and antioxidant defence mechanisms in testes of pubertal rats.
The gut microbiome is required for full protection against acute arsenic toxicity in mouse models.
Joint effects of chronic exposure to environmentally relevant levels of nonylphenol and cadmium on the reproductive functions in male rockfish Sebastiscus marmoratus.
PAHs
Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro.
Pharmaceuticals
Altered non-reproductive behavior and feminization caused by developmental exposure to 17α-ethinylestradiol persist to adulthood in three-spined stickleback (Gasterosteus aculeatus).
Metformin-induced endocrine disruption and oxidative stress of Oryzias latipes on two-generational condition.
Fertilization and male fertility in the rotifer Brachionus calyciflorus in the presence of three environmental endocrines.
Behavioural effects of psychoactive pharmaceutical exposure on European perch (Perca fluviatilis) in a multi-stressor environment.
Bitumen/Coal
Cytochrome P450 1A transcript is a suitable biomarker of both exposure and response to diluted bitumen in developing frog embryos.
Assessment of growth, survival, and organ tissues of caged mussels (Bivalvia: Unionidae) in a river-scape influenced by coal mining in the southeastern USA.
Miscellaneous
Endocrine disruption, oxidative stress and lipometabolic disturbance of Bufo gargarizans embryos exposed to hexavalent chromium.
Uptake of nanopolystyrene particles induces distinct metabolic profiles and toxic effects in Caenorhabditis elegans.
Trichloroethene metabolite dichloroacetyl chloride induces apoptosis and compromises phagocytosis in Kupffer Cells: Activation of inflammasome and MAPKs.
Exposure to microplastics reduces attachment strength and alters the haemolymph proteome of blue mussels (Mytilus edulis).
Wildlife/Environment/Exposure Studies
BPA/Phenols
Dental Sealants Part 4: Bisphenol A: What dentists should know.
Hot topic: Bisphenol A in cow milk and dietary exposure at the farm level.
Phthalates
Phthalate esters in indoor dust from several regions, China and their implications for human exposure.
Exposure to commonly-used phthalates and the associated health risks in indoor environment of urban China.
Triclosan
Formation of dioxins from triclosan with active chlorine: A potential risk assessment.
Persistent Organic Pollutants
Combining flux monitoring and data reconstruction to establish annual budgets of suspended particulate matter, mercury and PCB in the Rhône River from Lake Geneva to the Mediterranean Sea.
Preliminary release inventories of unintentionally generated dl-PCB and HCB from sources in China: Base year 2015.
Occurrences and patterns of residual organochlorine pesticides (OCPs) in cultured Chinese mitten crab (Eriocheir sinensis) in China: concentrations, sources, and a human health risk assessment.
Data relating to emissions of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) from industrial boilers.
Environmental characterization of 4,4′-dichlorobenzophenone in surface waters from Macao and Hong Kong coastal areas (Pearl River Delta) and its toxicity on two biological models: Artemia salina and Daphnia magna.
Plasma concentrations of organohalogenated contaminants in white-tailed eagle nestlings – The role of age and diet.
EStimating Contaminants tRansfers Over Complex food webs (ESCROC): An innovative Bayesian method for estimating POP’s biomagnification in aquatic food webs.
Four decades since the ban, old urban wastewater treatment plant remains a dominant source of PCBs to the environment.
Perfluoroalkyl Substances
Cord blood perfluoroalkyl substances in mothers exposed to the World Trade Center disaster during pregnancy.
Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study.
The PFOA substitute GenX detected in the environment near a fluoropolymer manufacturing plant in the Netherlands.
Reaction of Perfluorooctanoic Acid with Criegee Intermediates and Implications for the Atmospheric Fate of Perfluorocarboxylic Acids.
Modelling the transport of shipborne per- and polyfluoroalkyl substances (PFAS) in the coastal environment.
Flame Retardants
Trends in hexabromocyclododecanes in the UK and North America.
Temporal Trends of Decabromodiphenyl Ether and Emerging Brominated Flame Retardants in Dust, Air and Window Surfaces of Newly Built Low-Energy Preschools.
Electronics, interior decoration and cleaning patterns affect flame retardant levels in the dust from Dutch residences.
Distribution of polybrominated diphenyl ethers (PBDEs) in feather and muscle of the birds of prey from Beijing, China.
Releases of brominated flame retardants (BFRs) from microplastics in aqueous medium: Kinetics and molecular-size dependence of diffusion.
Arsenic/Metals
Assessment of chemical fractionations and mobilization potentials for heavy metals in wastes and other solid matrices in a mining site in the inland Aegean Region in Turkey.
Seasonal microbial variation accounts for arsenic dynamics in shallow alluvial aquifer systems.
Evaluating internal exposure of sea turtles as model species for identifying regional chemical threats in nearshore habitats of the Great Barrier Reef.
Geographical variation of arsenic distribution in paddy soil, rice and rice-based products: A meta-analytic approach and implications to human health.
Organotins
Urgent caution to trace organometal pollution: Occurrence, distribution and sources of methyltins, butyltins and phenyltins in sediments from South Hangzhou Bay, China.
Miscellaneous
Synthetic turf pitches with rubber granulate infill: are there health risks for people playing sports on such pitches?
Target screening analysis of 970 semi-volatile organic compounds adsorbed on atmospheric particulate matter in Hanoi, Vietnam.
This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program at Commonweal.
