New EDC articles, Aug. 21 – 27, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy/Screening, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

There are a few studies this week on replacements and lesser-known environmental chemicals:

Ionic Liquids: New Emerging Pollutants, Similarities with Perfluorinated Alkyl Substances (PFASs).
Genotoxicity and glucose tolerance induction by acetyltriethylcitrate, substitute plasticizer compared to di(2-ethylhexyl)phthalate.
C12-30 α-Bromo-Chloro “Alkenes”: Characterization of a Poorly Identified Flame Retardant and Potential Environmental Implications.

Regulations/Policy/Screening

A Class Approach to Hazard Assessment of Organohalogen Flame Retardants. [by the National Academies]

Screening

Understanding conditional associations between ToxCast in vitro readouts and the hepatotoxicity of compounds using rule-based methods.

Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)?

Miscellaneous

Environmental Stewardship in Nursing: Introducing the “WE ACT-PLEASE” Framework.

Reviews

Role of Obesogens in the Pathogenesis of Obesity. [this is the first article published as part of a special issue on endocrine disruptors in the journal Medicina; note that manuscript submissions are open until July 2020]

Scaling Up Solutions to Toxic Contamination in Communities. [Introduction to a special issue of Int J Environ Res Public Health on research translation and community engagement teams funded through the Superfund Research Program]

Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research.

Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions.

Primary prevention of ischaemic heart disease: populations, individuals, and health professionals. [Lancet]

Pollution in the Americas: a leading cause of disease burden and an opportunity for cancer prevention.

Distribution and Chemical Analysis of Pharmaceuticals and Personal Care Products (PPCPs) in the Environmental Systems: A Review.

Persistent Organic Pollutants

A new focus on legacy pollutants: Chlorinated Paraffins (CPs) and Polychlorinated Naphthalenes (PCNs). [editorial in Chemosphere]

Association between the persistent organic pollutants and polycystic ovary syndrome: A protocol for a systematic review and meta-analysis.

Pesticides

Gut microbiota and neurological effects of glyphosate

Micro/Nanoplastics

MODELPlastics workshop – Modelling Ocean Plastic Litter in a Changing Climate: Gaps and future directions.

Nanomaterials meet zebrafish: Toxicity evaluation and drug delivery applications.

Human Health Studies

BPA/Phenols

Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort.

Urinary bisphenol A and incidence of metabolic syndrome among Chinese men: a prospective cohort study from 2013 to 2017.

Phthalates

Environmental phthalate exposure and preterm birth in the PROTECT birth cohort.

Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China.

Parabens/Triclosan/Antimicrobials

Methyl Paraben May Increase the Risk of Pruritus in African Americans Whereas Triclosan Is Inversely Associated With Pruritus and Eczema.

Persistent Organic Pollutants

Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children.

Perfluoroalkyl Substances

Per- and Polyfluoroalkyl Substance Plasma Concentrations and Bone Mineral Density in Midchildhood: A Cross-Sectional Study (Project Viva, United States).

Pesticides

Urinary 3-phenoxybenzoic acid levels and the association with thyroid hormones in adults: Korean National Environmental Health Survey 2012-2014.

Environmental exposure to pesticides and risk of thyroid diseases.

DNA damage and adverse neurological outcomes among garlic farmers exposed to organophosphate pesticides.

Pesticide exposure and cognitive function: Results from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD).

Arsenic/Metals

Trace Minerals, Heavy Metals, and Preeclampsia: Findings from the Boston Birth Cohort.

Blood lead level and Helicobacter pylori infection in a healthy population: A cross-sectional study.

Blood Cadmium Level Is Associated with Short Progression-Free Survival in Nasopharyngeal Carcinoma.

Cardiovascular dysfunction and oxidative stress following human contamination by fluoride along with environmental xenobiotics (Cd & Pb) in the phosphate treatment area of Togo, West Africa.

Dietary cadmium intake and risk of cutaneous melanoma: An Italian population-based case-control study.

Association between urine lead levels and cardiovascular disease risk factors, carotid intima-media thickness and metabolic syndrome in adolescents and young adults.

Combined prenatal exposure to mercury and LCPUFA on newborn’s brain measures and neurodevelopment at the age of 18 months.

Air Pollution

Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark. also see: Air pollution as cause of mental disease: Appraisal of the evidence.

Acute air pollution exposure and the risk of violent behavior in the United States. also see: In Pursuit of Evidence in Air Pollution Epidemiology: The Role of Causally Driven Data Science.

Increased Outdoor PM2.5 Concentration Is Associated with Moderate/Severe Anemia in Children Aged 6-59 Months in Lima, Peru.

Air Pollution and Suicide in Mexico City: A Time Series Analysis, 2000-2016.

Acute air pollution exposure and NICU admission: a case-crossover analysis.

Effects of short-term exposure to fine and ultrafine particles from indoor sources on arterial stiffness – A randomized sham-controlled exposure study.

Combined toxicity of outdoor air pollution on kidney function among adult women in Mianyang City, southwest China.

Air pollution exposure associates with increased risk of neonatal jaundice.

Air Pollution Exposure and Cognitive Function in Taiwanese Older Adults: A Repeated Measurement Study.

Ambient Air Pollution and the Risk of Atrial Fibrillation and Stroke: A Population-Based Cohort Study.

Laboratory Studies

BPA/Phenols

BPA interferes with StAR-mediated mitochondrial cholesterol transport to induce germline dysfunctions.

Environmental chemicals differentially affect epigenetic-related mechanisms in the zebrafish liver (ZF-L) cell line and in zebrafish embryos. [bisphenols, PFAS, pesticides]

Nonylphenol acts on prostate adenocarcinoma cells via estrogen molecular pathways.

Phthalates

Ecotoxicological and biochemical effects of environmental concentrations of the plastic-bond pollutant dibutyl phthalate on Scenedesmus sp.

Alterations in oocytes and early zygotes following oral exposure to di(2-ethylhexyl) phthalate in young adult female mice.

Acute effects on human sperm exposed in vitro to cadmium chloride and diisobutyl phthalate.

Parabens/Triclosan/Antimicrobials

Antimicrobial agent triclosan suppresses mast cell signaling via phospholipase D inhibition.

Persistent Organic Pollutants

Catalpol protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytotoxicity in osteoblastic MC3T3-E1 cells.

A Human Relevant Defined Mixture of Persistent Organic Pollutants (POPs) Affects In Vitro Secretion of Glucagon-Like Peptide 1 (GLP-1), but Does not Affect Translocation of its Receptor.

Comparative Lethality of In ovo Exposure to PCB 126, PCB 77 and Two Environmentally Relevant PCB Mixtures in Japanese Quail (Coturnix japonica).

Perfluoroalkyl Substances

Perfluorooctane sulfonate (PFOS) produces dopaminergic neuropathology in C. elegans.

Perfluorooctanoic acid-induced toxicities in chicken embryo primary cardiomyocytes: Roles of PPAR alpha and Wnt5a/Frizzled2.

Exposure to perfluorooctane sulfonate based on circadian rhythm changes the fecundity and expression of certain genes on the hypothalamic-pituitary-gonadal-liver axis of female zebrafish.

Flame Retardants

Tetrabromobisphenol A inhibits carboxylesterase activity of marine organisms from different trophic levels.

Toxicological, gene expression and histopathological evaluations of environmentally realistic concentrations of polybrominated diphenyl ethers PBDE- 47, PBDE-99 and PBDE-209 on zebrafish embryos.

Pesticides

Development of a questionnaire-based insecticide exposure assessment method and comparison with urinary insecticide biomarkers in young Australian children.

Blood pharmacokinetic of 17 common pesticides in mixture following a single oral exposure in rats: implications for human biomonitoring and exposure assessment.

Biophysical and biomechanical properties of neural progenitor cells as indicators of developmental neurotoxicity.

Hemotoxic effects of some herbicides on juvenile of Nile tilapia Oreochromis niloticus.

DNA damage in liver cells of the tilapia fish Oreochromis mossambicus larva induced by the insecticide cyantraniliprole at sublethal doses during chronic exposure.

Oxidative stress and inflammation following sub-lethal oral exposure of cypermethrin in rats: mitigating potential of epicatechin.

Lethal and sublethal effects of acetamiprid on Eisenia andrei: Behavior, reproduction, cytotoxicity and oxidative stress.

Arsenic/Metals

Reproductive disorders in female rats after prenatal exposure to sodium arsenite.

Insights into the heavy metal-induced immunotoxic and genotoxic alterations as health indicators of Clarias gariepinus inhabiting a rivulet.

Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis.

Chronic lead exposure induces histopathological damage, microbiota dysbiosis and immune disorder in the cecum of female Japanese quails (Coturnix japonica).

TCE

Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice.

Cytochrome P450 2E1-deficient MRL+/+ mice are less susceptible to trichloroethene-mediated autoimmunity: Involvement of oxidative stress-responsive signaling pathways.

Micro/Nanoplastics

Nanopolystyrene at predicted environmental concentration enhances microcystin-LR toxicity by inducing intestinal damage in Caenorhabditis elegans.

Effects of microplastics and attached heavy metals on growth, immunity, and heavy metal accumulation in the yellow seahorse, Hippocampus kuda Bleeker.

Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their F1 and F2 offspring.

Miscellaneous

Role of endoplasmic reticulum stress and oxidative stress in vinyl chloride-induced hepatic steatosis in mice.

Prenatal testosterone excess disrupts placental function in a sheep model of polycystic ovary syndrome.

Damsels in distress: Oil exposure modifies behavior and olfaction in bicolor damselfish (Stegastes partitus).

Wildlife/Environment/Exposure Studies

BPA/Phenols

Overexposure to Bisphenol A and Its Chlorinated Derivatives of Patients with End-Stage Renal Disease during Online Hemodiafiltration.

Distribution patterns and ecological risk of endocrine-disrupting chemicals at Qingduizi Bay (China): A preliminary survey in a developing maricultured bay.

Persistent Organic Pollutants

Using Birth Cohort Data to Estimate Prenatal Chemical Exposures for All Births around the New Bedford Harbor Superfund Site in Massachusetts. [POPs, metals]

Spatial and temporal trends of PCDD/Fs in sediment and bivalves along the Korean coasts during 2001-2012.

Occurrence and Toxicological Risk Evaluation of Organochlorine Pesticides from Suburban Soils of Kenya.

Contamination pathways of polychlorinated biphenyls (PCBs) – From the worker to the family.

Investigation of the Presence of 22 Organochlorine Pesticide Residues in Ginseng from Jilin Province, China.

Polybrominated diphenyl ethers and polychlorinated biphenyls in mangrove sediments of Shantou, China: Occurrence, profiles, depth-distribution, and risk assessment.

Dichlorodiphenyltrichloroethane (DDT) levels in rat livers collected from a malaria vector control region.

On the effectiveness of tributyltin ban: Distribution and changes in butyltin concentrations over a 9-year period in Klaipėda Port, Lithuania.

Perfluoroalkyl Substances

Sociodemographic and behavioral determinants of serum concentrations of per- and polyfluoroalkyl substances in a community highly exposed to aqueous film-forming foam contaminants in drinking water.

Flame Retardants

Polybrominated diphenyl ethers (PBDE) and hexabromocyclododecane (HBCD) in liver of checkered puffer (Sphoeroides testudineus) from Ria Lagartos, Yucatan, Mexico.

Bioaccumulation and biomagnification of PBDEs in a terrestrial food chain at an urban landfill.

Pesticides

Paraquat Degradation From Contaminated Environments: Current Achievements and Perspectives.

Effects of chronic pesticide exposure on an epibenthic oyster reef community.

Monitoring of 49 Pesticides and 17 Mycotoxins in Wine by QuEChERS and UHPLC-MS/MS Analysis.

Bioconcentrations of herbicides used in sugarcane crops in tilapia (Oreochromis niloticus) and the risk for human consumption.

Neonicotinoid insecticides limit the potential of spiders to re-colonize disturbed agroecosystems when using silk-mediated dispersal.

Characteristics of neonicotinoid imidacloprid in urine following exposure of humans to orchards in China.

New relevant pesticide transformation products in groundwater detected using target and suspect screening for agricultural and urban micropollutants with LC-HRMS.

Arsenic/Metals

The concentration distribution and pollution assessment of heavy metals in surface sediments of the Bohai Bay, China.

Mercury in sediment cores from the southern Gulf of Mexico: Preindustrial levels and temporal enrichment trends.

Childhood lead poisoning from domestic products in China: A case study with implications for practice, education, and policy.

A multi-elemental approach to assess potential contamination in tourist beaches: The case of Loreto Bay (Marine Protected Area), NW Mexico.

The ecological risk assessment of soil contamination with Ti and Fe at military sites in Ukraine: avoidance and reproduction tests with Folsomia candida.

Human Blood Lead Levels and the First Evidence of Environmental Exposure to Industrial Pollutants in the Amazon.

Dietary determinants of inorganic arsenic exposure in the Strong Heart Family Study.

Arsenic bioaccumulation in subarctic fishes of a mine-impacted bay on Great Slave Lake, Northwest Territories, Canada.

Oral Bioavailability of As, Pb, and Cd in Contaminated Soils, Dust, and Foods based on Animal Bioassays: a Review.

Ecological and human health risk assessment of heavy metal contamination in road dust in the National Capital Territory (NCT) of Delhi, India.

A Global Look at Mercury Exposures: Supporting the Goals of the Minamata Convention.

Metal Exposure Risk Assessment for Tree Sparrows at Different Life Stages via Diet from a Polluted Area in Northwestern China.

Dietary Lead Exposure and Associated Health Risks in Guangzhou, China.

Air Pollution

Vehicular Air Pollution in Houston, Texas: An Intra-Categorical Analysis of Environmental Injustice.

Assessing Agreement in Exposure Classification between Proximity-Based Metrics and Air Monitoring Data in Epidemiology Studies of Unconventional Resource Development.

Microplastics

Microplastics as vectors of contaminants.

Microplastics in special protected areas for migratory birds in the Bay of Biscay.

Hudson River juvenile Blueback herring avoid ingesting microplastics.

Microplastic accumulation and biomagnification in a coastal marine reserve situated in a sparsely populated area.

Tiny, shiny, and colorful microplastics: Are regular glitters a significant source of microplastics?

Is this your glitter? An overlooked but potentially environmentally-valuable microplastic.

Microplastics in grey seal (Halichoerus grypus) intestines: Are they associated with parasite aggregations?

Environmental implications of microplastic pollution in the Northwestern Pacific Ocean.

Sorption of tri-n-butyl phosphate and tris(2-chloroethyl) phosphate on polyethylene and polyvinyl chloride microplastics in seawater.

[there are many more articles on microplastics in Marine Pollution Bulletin]

Miscellaneous

Occurrence and risk assessment of antibiotics in the Xi’an section of the Weihe River, northwestern China.

Occurrence and mass balance of sixty-two progestins in a municipal sewage treatment plant.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.