New EDC articles, Apr. 10 – 16, 2019 – HEEDS

New EDC articles, Apr. 10 – 16, 2019

Post author:HEEDS
Post published:April 16, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Regulations/Policy

Probable carcinogenicity of glyphosate. [editorial in BMJ]

A restatement of the natural science evidence base on the effects of endocrine disrupting chemicals on wildlife.

Reviews

Current Research Approaches and Challenges in the Obesogen Field. [This is part of the Frontiers research topic, Endocrine Disruptors and Metabolism, all of which is well worth reading]

Endocrine Disrupting Chemicals: Effects on Endocrine Glands.

Mechanistic insights into environmental and genetic risk factors for systemic lupus erythematosus.

Climate Change, Human Health, and Social Stability: Addressing Interlinkages. [Commentary]

Populations, decreasing fertility, and reproductive health. [Letter]

BPA/Phenols/Phthalates/Parabens

A Review of Biomonitoring of Phthalate Exposures.

Prenatal exposure to parabens and anthropometric birth outcomes: A systematic review.

Selective citation in scientific literature on the human health effects of bisphenol A.

Arsenic

Arsenic in cooked rice foods: Assessing health risks and mitigation options.

Human Health Studies

BPA/Phenols

Bisphenol A and adiposity measures in peripubertal boys from the INMA-Granada cohort.

Prenatal Bisphenol A exposure and early childhood neurodevelopment in Shandong, China.

Bisphenol A differentially affects male reproductive function biomarkers in a reference population and agro pesticides users from Djutitsa, Cameroon.

Phthalates

Racial disparity in maternal phthalates exposure; Association with racial disparity in fetal growth and birth outcomes.

Phthalates and other endocrine-disrupting chemicals: the 21st century’s plague for reproductive health. [Commentary on: Follicular fluid concentrations of phthalate metabolites are associated with altered intrafollicularreproductive hormones in women undergoing in vitro fertilization]

Persistent Organic Pollutants

Commentary on “Hypospadias in offspring is associated with chronic exposure of parents to organophosphate and organochlorine pesticides”.

Perfluoroalkyl Substances

Maternal serum concentrations of perfluoroalkyl substances and birth size in British boys.

Pesticides

Longitudinal investigation of haematological alterations among permethrin-exposed pesticide applicators in the Biomarkers of Exposure and Effect in Agriculture study.

Para-occupational exposure to pesticides, PON1 polymorphisms and hypothyroxinemia during the first half of pregnancy in women living in a Mexican floricultural area.

Agricultural Exposures and Breast Cancer among Latina in the San Joaquin Valley of California.

Arsenic/Metals

Exploring telomere length in mother-newborn pairs in relation to exposure to multiple toxic metals and potential modifying effects by nutritional factors.

Sex-Specific Differences in Cognitive Abilities Associated with Childhood Cadmium and Manganese Exposures in School-Age Children: a Prospective Cohort Study.

TCE

Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards.

Miscellaneous

Exposure to disinfection byproducts and risk of type 2 diabetes: a nested case-control study in the HUNT and Lifelines cohorts. [trihalomethanes and brominated trihalomethanes]

Laboratory Studies

Screening

The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity.

Multiplex Analysis Platform for Endocrine Disruption Prediction Using Zebrafish.

Prêt-à-porter nanoYESα and nanoYESβ bioluminescent cell biosensors for ultrarapid and sensitive screening of endocrine-disrupting chemicals.

The use of 3D cultures of MCF-10A and MCF-12A cells by high content screening for effect-based analysis of non-genotoxic carcinogens.

BPA/Phenols

Inhibitory effect of Bisphenol A on in vitro feline uterine contractions.

Bisphenol A attenuates thyroxine-induced apoptosis in ovarian granulosa cells of pigs.

Bisphenol A disrupts mitotic progression via disturbing spindle attachment to kinetochore and centriole duplication in cancer cell lines.

Persistent Organic Pollutants

The influence of high doses of α-tocopherol on the content of selected trace elements in the liver of developing chicken embryos in experimentally induced 2,3,7,8-tetrachlorodibenzo-p-dioxin intoxication.

Polychlorinated biphenyl quinone induces caspase 1-mediated pyroptosis through the induction of pro-inflammatory HMGB1-TLR4-NLRP3-GSDMD signal axis.

Role of Aryl Hydrocarbon Receptor (AhR) in the Regulation of Immunity and Immunopathology During Trypanosoma cruzi Infection.

Flame Retardants

The organophosphorus flame retardants impaired intracellular lipid metabolic function in human hepatocellular cells.

Aryl-phosphorus-containing flame retardants induce oxidative stress, the p53-dependent DNA damage response and mitochondrial impairment in A549 cells.

Pesticides

Parental exposure to tebuconazole causes thyroid endocrine disruption in zebrafish and developmental toxicity in offspring.

Bioaccumulation, behavior changes and physiological disruptions with gender-dependent in lizards (Eremias argus) after exposure to glufosinate-ammonium and l-glufosinate-ammonium.

Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase.

Toxicity of binary mixtures of pesticides to the marine microalgae Tisochrysis lutea and Skeletonema marinoi: Substance interactions and physiological impacts.

Development and application of a multispecies toxicity test with tropical freshwater microalgae.

Atrazine exposure shifts activity but has minimal effects on courtship in an agrobiont spider.

Deltamethrin-induced Immunotoxicity and its protection by Quercetin: An experimental study.

Lethal and sublethal synergistic effects of a new systemic pesticide, flupyradifurone (Sivanto®), on honeybees.

The effects of Roundup® in embryo development and energy metabolism of the zebrafish (Danio rerio).

Long-term exposure of Daphnia magna to carbendazim: how it affects toxicity to another chemical or mixture.

Repeated bifenthrin exposure alters hippocampal Nurr-1/AChE and induces depression-like behavior in adult rats.

Comparative analyses of the neurobehavioral, molecular, and enzymatic effects of organophosphates on embryo-larval zebrafish (Danio rerio).

Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells.

Low-dose pesticide mixture induces accelerated mesenchymal stem cells aging in vitro.

The possible alleviating effect of saffron on chlorpyrifos experimentally induced cardiotoxicity: Histological, immunohistochemical and biochemical study.

Mancozeb fungicide-induced genotoxic effects, metabolic alterations, and histological changes in the colon and liver of Sprague Dawley rats.

Arsenic/Metals

Copper caused reproductive endocrine disruption in zebrafish (Danio rerio).

Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.

Cadmium-induced oxidative stress, histopathology, and transcriptome changes in the hepatopancreas of freshwater crayfish (Procambarus clarkii).

Genetic, epigenetic, and developmental toxicity of Chironomus riparius raised in metal-contaminated field sediments: A multi-generational study with arsenic as a second challenge.

Exposure to arsenic during embryogenesis impairs olfactory sensory neuron differentiation and function into adulthood.

Inhibition of autophagy alleviates cadmium-induced mouse spleen and human B cells apoptosis.

Pharmaceuticals

Bioconcentration of the antiepileptic drug carbamazepine and its physiological and biochemical effects on Daphnia magna.

Stereoisomeric profiling of chiral pharmaceutically active compounds in wastewaters and the receiving environment – A catchment-scale and a laboratory study.

Glucocorticoid mixtures of fluticasone propionate, triamcinolone acetonide and clobetasol propionate induce additive effects in zebrafish embryos.

Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure.

Oral exposure of rats to dienestrol during gestation and lactation: Effects on the reproductive system of male offspring.

Microplastics

Toxicity of 10 organic micropollutants and their mixture: Implications for aquatic risk assessment.

Wildlife/Environment/Exposure Studies

BPA/Parabens

Concentrations of bisphenol A and parabens in socks for infants and young children in Spain and their hormone-like activities.

Phthalates

Risk assessment of phthalates in pharmaceuticals.

Dermal bioaccessibility of plasticizers in indoor dust and clothing.

Estimates of dietary exposure of Spanish population to packaging contaminants from cereal based foods contained in plastic materials.

Plastic film mulching increased the accumulation and human health risks of phthalate esters in wheat grains.

Health risk of phthalates in water environment: Occurrence in water resources, bottled water, and tap water, and burden of disease from exposure through drinking water in tehran, Iran.

Persistent Organic Pollutants

Measurement of Dioxin Emissions from a Small-Scale Waste Incinerator in the Absence of Air Pollution Controls.

Perfluoroalkyl Substances

Incorporating perfluoroalkyl acids (PFAA) into a geochemical index for improved delineation of legacy landfill impacts on groundwater.

Dietary intake, drinking water ingestion and plasma perfluoroalkyl substances concentration in reproductive aged Chinese women.

Does water temperature influence the distribution and elimination of perfluorinated substances in rainbow trout (Oncorhynchus mykiss)?

Occurrence and characteristics of perfluoroalkyl substances (PFASs) in electroplating industrial wastewater.

Flame Retardants

Halogenated and organophosphorus flame retardants in cetaceans from the southwestern Indian Ocean.

Spatial Distribution of Organophosphorus and Brominated Flame Retardants in Surface Water, Sediment, Groundwater, and Wild Fish in Chengdu, China.

Characterizing PBDEs in fish, poultry, and pig feeds manufactured in China.

Human exposure pathways to organophosphate flame retardants: Associations between human biomonitoring and external exposure.

Pesticides

Improvement of diet sustainability with increased level of organic food in the diet: findings from the BioNutriNet cohort.

A survey and risk assessment of neonicotinoids in water, soil and sediments of Belize.

Widespread occurrence and spatial distribution of glyphosate, atrazine, and neonicotinoids pesticides in the St. Lawrence and tributary rivers.

Ecological risk assessment of the increasing use of the neonicotinoid insecticides along the east coast of China.

From laboratory to the field: Validating molecular markers of effect in Folsomia candida exposed to a fungicide-based formulation.

tau-Fluvalinate and other pesticide residues in honey bees before overwintering.

Arsenic/Metals

Maternal exposure to arsenic and mercury in small-scale gold mining areas of Northern Tanzania.

Inorganic arsenic in food products on the Swedish market and a risk-based intake assessment.

An assessment of arsenic hazard in groundwater-soil-rice system in two villages of Nadia district, West Bengal, India.

Health risk apportionment of arsenic from multiple exposure pathways in Paracatu, a gold mining town in Brazil.

Waterpipe tobacco smoke: Characterization of toxicants and exposure biomarkers in a cross-sectional study of waterpipe employees.

Spatial and interspecies differences in concentrations of eight trace elements in wild freshwater fishes at different trophic levels from middle and eastern China.

Variation of heavy metal contamination between mushroom species in the Copperbelt province, Zambia: are the people at risk?

Microplastics

Review of micro- and nanoplastic contamination in the food chain.

Miscellaneous

Chemical mixtures and fluorescence in situ hybridization analysis of natural microbial community in the Tiber river.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed.

Compiled by Sarah Howard, Diabetes and Environment Program at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.