EDC Science Weekly, Sept. 8-14, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

The Effect of Individual or Study-Wide Report-Back on Knowledge, Concern, and Exposure-Reducing Behaviors Related to Endocrine-Disrupting Chemicals. see related, Invited Perspective: Making the Implicit Explicit—Connecting Environmental Health Literacy and Exposure Report-Back

Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Placental single cell transcriptomics: Opportunities for endocrine disrupting chemical toxicology.

Making the Case for Quantum Mechanics in Predictive Toxicology─Nearly 100 Years Too Late?

Human Endocrine-Disrupting Effects of Phthalate Esters through Adverse Outcome Pathways: A Comprehensive Mechanism Analysis.

Predicting chemicals’ toxicity pathway of female reproductive disorders using AOP7 and deep neural networks.

Towards systematic read-across using Generalised Read-Across (GenRA).

Adding Depth to Microplastics.

More tools, reports, and resources

Commentaries

ChatGPT in the health sciences: pause and ponder.

Editorial: Molecules, environments, and neurological disorders. [Intro to a Research Topic in Frontiers in Endocrinology]

Reviews

Numerous Chemicals/Mixtures

A comprehensive review on environmental pollutants and osteoporosis: Insights into molecular pathways.

The influence of various endocrine disruptors on the reproductive system.

Phthalates

An insight into the critical role of gut microbiota in triggering the phthalate-induced toxicity and its mitigation using probiotics.

Flame Retardants

Review on typical organophosphate diesters (di-OPEs) requiring priority attention: Formation, occurrence, toxicological, and epidemiological studies.

Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer.

Toxic Effects and Mechanisms of Polybrominated Diphenyl Ethers.

Microplastics/Nanomaterials

Advances on micro/nanoplastics and their effects on the living organisms: A review.

Microplastics exposure and immunologic response.

Toxicity of microplastics and nanoplastics: invisible killers of female fertility and offspring health.

Air Pollution/PAHs

Lung cancer associated with combustion particles and fine Particulate Matter (PM_2.5) – the roles of Polycyclic Aromatic Hydrocarbons (PAHs) and the Aryl Hydrocarbon Receptor (AhR).

The association between exposure to polycyclic aromatic hydrocarbons and birth outcomes: A systematic review and meta-analysis of observational studies.

A Systematic Review of Polycyclic Aromatic Hydrocarbon Derivatives: Occurrences, Levels, Biotransformation, Exposure Biomarkers, and Toxicity.

Pharmaceuticals/Personal Care Products

Veterinary pharmaceutical as emerging contaminants in wastewater and surface water: An overview.

Miscellaneous

Early-life risk factors for food allergy: Dietary and environmental factors revisited.

Frontier of toxicology studies in zebrafish model.

Paternal effects on fetal programming.

Human Health Studies

BPA/Phenols

Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young children.

Bisphenol A accelerates the vascular complications in patients with Type 2 diabetes mellitus through vascular calcification-a molecular approach.

Phthalates

Exploring the relationship between urinary phthalate metabolites and Crohn’s disease via oxidative stress, and the potential moderating role of gut microbiota: A conditional mediation model.

Parabens/Triclosan/Antimicrobials

Exposure to parabens and semen quality in reproductive-aged men.

Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Blood Levels of Organochlorine Contaminants Mixtures and Cardiovascular Disease.

Perfluoroalkyl Substances

Adverse birth outcomes related to concentrations of per- and polyfluoroalkyl substances (PFAS) in maternal blood collected from pregnant women in 1960-1966.

PFAS concentrations in early and mid-pregnancy and risk of gestational diabetes mellitus in a nested case-control study within the ethnically and racially diverse PETALS cohort.

Per- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005-2014.

Pesticides

The Association Between Urinary Concentrations of Organophosphate Metabolites and Asthma-Related Outcomes Among Schoolchildren From Informal Settlements.

Vitamin D Intake Attenuated the Association between Pesticides Exposure and Female Infertility.

Metals/Metalloids

Prediagnostic Blood Metal Levels and the Risk of Parkinson’s Disease: A Large European Prospective Cohort.

Bioaccumulation of Non-Essential Trace Elements Detected in Women’s Follicular Fluid, Urine, and Plasma Is Associated with Poor Reproductive Outcomes following Single Euploid Embryo Transfer: A Pilot Study.

Association of co-exposure to metal(loid)s during pregnancy with birth outcomes in the Tibetan plateau.

Air Pollution

Ambient fine particulate matter and breast cancer incidence in a large prospective US cohort.

Impact of short-term exposure to ambient air pollution on osteoarthritis: a multi-city time-series analysis in Central-Eastern China.

Gestational age modifies the association between exposure to fine particles and fetal death: findings from a nationwide epidemiological study in the contiguous United States.

Pharmaceuticals/Personal Care Products

Low and very low lithium levels: Thyroid effects are small but still require monitoring.

Miscellaneous

Associations between Urinary Concentrations of Disinfection Byproducts and in Vitro Fertilization Outcomes: A Prospective Cohort Study in China.

Laboratory Studies

Numerous Chemicals/Mixtures

Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender.

Long exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions.

Generational effects and abnormalities in craniofacial chondrogenesis in zebrafish (Danio rerio) embryos upon maternal exposure to estrogen endocrine disrupting chemicals.

BPA/Phenols

Mystery of bisphenol F-induced nonalcoholic fatty liver disease-like changes: Roles of Drp1-mediated abnormal mitochondrial fission in lipid droplet deposition.

Curcumin Attenuates Nonylphenol-Induced Toxicity In Brain Development; An Experimental Study.

Curcumin protects against bisphenol A-induced hepatic steatosis by inhibiting cholesterol absorption and synthesis in CD-1 mice.

Ameliorative Effects of Zinc Oxide, in Either Conventional or Nanoformulation, Against Bisphenol A Toxicity on Reproductive Performance, Oxidative Status, Gene Expression and Histopathology in Adult Male Rats.

Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3β-hydroxysteroid dehydrogenases: structure-activity relationship and in silico molecular docking analysis.

Effects of bisphenol A on murine salivary glands and human tumor cell lines.

Quality of fresh and cryopreserved bovine sperm is reduced by BPA and BPF exposure.

Probing the bioconcentration and metabolism disruption of bisphenol A and its analogues in adult female zebrafish from integrated AutoQSAR and metabolomics studies.

Phthalates

Are New Phthalate Ester Substitutes Safer than Traditional DBP and DiBP? Comparative Endocrine-Disrupting Analyses on Zebrafish Using In Vivo, Transcriptome, and In Silico Approaches.

Integrated transcriptome and proteome analysis indicates potential biomarkers of prostate cancer in offspring of pregnant rats exposed to a phthalate mixture during gestation and lactation.

Combined cytotoxicity of phthalate esters on HepG2 cells: A comprehensive analysis of transcriptomics and metabolomics.

Parabens/Triclosan/Antimicrobials

Risk assessment of parabens in a transcriptomics-based in vitro test.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Altered splicing factor and alternative splicing events in a mouse model of diet- and polychlorinated biphenyl-induced liver disease.

Perfluoroalkyl Substances

Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring.

Dermal bioaccessibility of perfluoroalkyl substances from household dust; influence of topically applied cosmetics.

Flame Retardants

The effects and mechanisms of the new brominated flame retardant BTBPE on thyroid toxicity.

Developmental toxicity in early chicken embryos on exposure to an organophosphorus flame retardant, tris(2-chloroisopropyl) phosphate.

Involvement of Estrogen Receptor Alpha (Erα) and Impairment of Steroidogenesis After Exposure to tris(2,3-dibromopropyl) Isocyanurate (TBC) in Mouse Spermatogenic (GC-1 spg) Cells in vitro.

BDE-209-induced genotoxicity, intestinal damage and intestinal microbiota dysbiosis in zebrafish (Danio Rerio).

2-Ethylhexyl Diphenyl Phosphate Causes Obesity in Zebrafish by Stimulating Overeating via Inhibition of Dopamine Receptor D2.

Organotins

Short-term triphenyltin exposure alters microbial homeostasis in the silkworm (Bombyx mori) midgut.

Pesticides

Dimethenamid promotes oxidative stress and apoptosis leading to cardiovascular, hepatic, and pancreatic toxicities in zebrafish embryo.

Adverse effects of bifenthrin exposure on neurobehavior and neurodevelopment in a zebrafish embryo/larvae model.

Imidacloprid increases the prevalence of the intestinal parasite Lotmaria passim in honey bee workers.

Metals/Metalloids

Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen.

Effects of Gestational Arsenic Exposures on Placental and Fetal Development in Mice: The Role of Cyr61 m6A.

Metformin alleviates sodium arsenite-induced hepatotoxicity and glucose intolerance in mice by suppressing oxidative stress, inflammation, and apoptosis.

Arsenic exposure caused male infertility indicated by testis and sperm metabolic dysfunction in SD rats.

Combined Effects of Fluoride and Dietary Seleno-L-Methionine at Environmentally Relevant Concentrations on Female Zebrafish (Danio rerio) Liver: Histopathological Damages, Oxidative Stress and Inflammation.

Co-administration of L-Ascorbic Acid and α-Tocopherol Alleviates Arsenic-Induced Immunotoxicities in the Thymus and Spleen by Dwindling Oxidative Stress-Induced Inflammation.

Microplastics/Nanomaterials

Differential developmental and proinflammatory responses of zebrafish embryo to repetitive exposure of biodigested polyamide and polystyrene microplastics.

Effect of an environmental microplastic mixture from the Seine River and one of the main associated plasticizers, dibutylphthalate, on the sentinel species Hediste diversicolor.

Melatonin Alleviates Intestinal Barrier Damaging Effects Induced by Polyethylene Microplastics in Albino Rats.

Prenatal High-Fat Diet Combined with Microplastic Exposure Induces Liver Injury via Oxidative Stress in Male Pups.

Biological interactions of polystyrene nanoplastics: Their cytotoxic and immunotoxic effects on the hepatic and enteric systems.

Plasticiser leaching from polyvinyl chloride microplastics and the implications for environmental risk assessment.

Air Pollution

Effects of exposure to PM_2.5 during pregnancy on the multigenerational reproductive outcomes of male mouse offspring and the role of Sertoli cells.

Pharmaceuticals/Personal Care Products

TGFβ signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells. [DES]

Flunitrazepam and its metabolites exposure disturb the zebrafish gut-liver axis: Combined microbiome and metabolomic analysis.

Miscellaneous

Integration approach of transcriptomics and metabolomics reveals the toxicity of Anthracene and its chlorinated derivatives on human hepatic cells.

Effects of sub-chronic exposure to microcystin-LR on the endocrine system of male rats.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Pesticide, allergen, PCB, and lead measurements in childcare centers located on tribal lands in the Pacific Northwest, United States.

Exposure profiles in pregnant women from a birth cohort in a highly contaminated area of southern Italy.

A data-derived reference mixture representative of European wastewater treatment plant effluents to complement mixture assessment.

Endocrine disrupting chemicals in wastewater treatment plants in Kenya, East Africa: Concentrations, removal efficiency, mass loading rates and ecological impacts.

Phthalates

Analysis and contamination levels of ten phthalic acid esters (PAEs) in Chinese commercial bubble tea: a comparison with commercial milk.

Parabens/Triclosan/Antimicrobials

Human health risk assessment of Triclosan in water: spatial analysis of a drinking water system.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorines as contaminants in butter and other shortenings: occurrence and exposure assessment.

Perfluoroalkyl Substances

Exposure to per- and polyfluoroalkyl substances in women with twin pregnancies: Patterns and variability, transplacental transfer, and predictors.

Impact of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) on secondary sludge microorganisms: removal, potential toxicity, and their implications on existing wastewater treatment regulations in Canada.

Effects of Drinking Water Treatment Residual Amendments to Biosolids on Plant Uptake of Per- and Polyfluoroalkyl Substances.

Target and Suspect Screening Integrated with Machine Learning to Discover Per- and Polyfluoroalkyl Substance Source Fingerprints.

Retention and transport of PFOA and its fluorinated substitute, GenX, through water-saturated soil columns.

Perfluoroalkyl substances in food contact materials: preliminary investigation in Vietnam and global comparison.

Per- and polyfluoroalkyl substances and organofluorine in lakes and waterways of the northwestern Great Basin and Sierra Nevada.

Flame Retardants

PM_2.5-Bound Organophosphate Flame Retardants in Hong Kong: Occurrence, Origins, and Source-Specific Health Risks.

Pesticides

Comparing Longitudinal Measures of Cholinesterase as Biomarkers for Insecticide Exposure Among Latinx Children in Rural Farmworker and Urban Non-Farmworker Communities in North Carolina.

Metals/Metalloids

A regional comparison of children’s blood cadmium, lead, and mercury in rural, urban and industrial areas of six European countries, and China, Ecuador, and Morocco.

Change in Values of Illegal Miners and Inhabitants and Reduction in Environmental Pollution after the Cessation of Artisanal and Small-Scale Gold Mining: A Case of Bunikasih, Indonesia.

Rural Knowledge Transformation in Terms of Mercury Used in Artisanal Small-Scale Gold Mining (ASGM)-A Case Study in Gorontalo, Indonesia.

Mercury at the top of the world: A 31-year record of mercury in Arctic char in the largest High Arctic lake, linked to atmospheric mercury concentrations and climate oscillations.

Microplastics/Nanomaterials

Microplastics and phthalate esters release from teabags into tea drink: occurrence, human exposure, and health risks.

Microplastic pollution in organic farming development cannot be ignored in China: Perspective of commercial organic fertilizer.

Floating plastics as integrative samplers of organic contaminants of legacy and emerging concern from Western Mediterranean coastal areas.

Pharmaceuticals/Personal Care Products

Evaluating Neighborhood-Level Differences in Hair Product Safety by Environmental Working Group Ratings among Retailers in Boston, Massachusetts.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!