EDC Science Weekly, Sept. 29 – Oct. 6, 2023 – HEEDS

EDC Science Weekly, Sept. 29 – Oct. 6, 2023

Post author:HEEDS
Post published:October 6, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Science highlights

Methods/Tools/Screening

Identifying priority PBT-like compounds from emerging PFAS by nontargeted analysis and machine learning models.

Suspect and nontarget screening of per- and polyfluoroalkyl substances based on ion mobility mass spectrometry and machine learning techniques.

Toward Nano-Specific In Silico NAMs: How to Adjust Nano-QSAR to the Recent Advancements of Nanotoxicology?

Commentaries

Infection Prevention, Planetary Health, and Single-Use Plastics

Discussion. Has the human population become an sentinel for the adverse effects of PFAS contamination on wildlife health and endangered species?

Reviews

Numerous Chemicals/Mixtures

The Mechanisms of Plastic Food-Packaging Monomers’ Migration into Food Matrix and the Implications on Human Health.

A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome.

Human semen quality and environmental and occupational exposure to pollutants: A systematic review.

Review of emerging contaminants in green stormwater infrastructure: Antibiotic resistance genes, microplastics, tire wear particles, PFAS, and temperature.

Synthetic Chemicals: What We Have Learned and Still Need to Learn About Their Associations with Childhood Allergy and Asthma. [phenols and phthalates]

Review of Endocrine Disrupting Compounds (EDCs) in China’s water environments: Implications for environmental fate, transport and health risks.

A systematic review on the current situation of emerging pollutants in Mexico: A perspective on policies, regulation, detection, and elimination in water and wastewater.

Multigenerational test on Daphnia spp.: A vision and new perspectives.

Combining computational tools and experimental studies towards endocrine disruptors mitigation: A review of biocatalytic and adsorptive processes.

BPA/Phenols

Relationship between prenatal and postnatal exposure to BPA and its analogues (BPS, BPF) and allergic diseases.

An integrated approach to remove endocrine-disrupting chemicals bisphenol and its analogues from the aqueous environment: a review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants (POPs) in marine crustaceans: Bioaccumulation, physiological and cellular responses.

Pollutants, including Organophosphorus and Organochloride Pesticides, May Increase the Risk of Cardiac Remodeling and Atrial Fibrillation: A Narrative Review.

Perfluoroalkyl Substances

The wide presence of fluorinated compounds in common chemical products and the environment: a review.

Interactions between biofilms and PFASs in aquatic ecosystems: Literature exploration.

The effects of per- and polyfluoroalkyl substances on environmental and human microorganisms and their potential for bioremediation.

[Health perspectives and handling of PFAS contamination in Denmark] [in Danish]

Pesticides

Literature landscape of neurodevelopment and pesticides: A scoping review of methodologies.

Glyphosate uses, adverse effects and alternatives: focus on the current scenario in Brazil.

The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides.

Metals/Metalloids

Heavy Metals in Foods and Beverages: Global Situation, Health Risks and Reduction Methods.

Human exposure to heavy metals and related cancer development: a bibliometric analysis.

Microplastics/Nanomaterials

From oceans to dinner plates: The impact of microplastics on human health.

Microplastics, a Global Issue: Human Exposure through Environmental and Dietary Sources.

Emergence of nanoplastics in the aquatic environment and possible impacts on aquatic organisms.

Pharmaceuticals/Personal Care Products

Towards Precision Ecotoxicology: Leveraging Evolutionary Conservation of Pharmaceutical and Personal Care Product Targets to Understand Adverse Outcomes Across Species and Life Stages.

Miscellaneous

The effect of polycyclic aromatic hydrocarbon biomarkers on cardiovascular diseases.

Endocrine Effect of Some Mycotoxins on Humans: A Clinical Review of the Ways to Mitigate the Action of Mycotoxins.

Human Health Studies

Numerous Chemicals/Mixtures

Co-exposure to organic UV filters and phthalates and their associations with oxidative stress levels in children: A prospective follow-up study in China.

Association of hair polychlorinated biphenyls and multiclass pesticides with obesity, diabetes, hypertension and dyslipidemia in NESCAV study.

Phthalates

Maternal concentrations of phthalates and Attention-Deficit Hyperactivity Disorder (ADHD-) related symptoms in children aged 2 to 4 years from Odense child cohort.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Impact of dioxin exposure on brain morphometry and social anxiety in men living in the most dioxin-contaminated area in Vietnam.

Association between cumulative airborne dioxin exposure and non-Hodgkin’s lymphoma risk in a nested case-control study within the French E3N cohort.

Serum polychlorinated biphenyl levels and circulating miRNAs in non-obese women with and without polycystic ovary syndrome.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances in umbilical cord serum and body mass index trajectories from birth to age 10 years: Findings from a longitudinal birth cohort (SMBCS).

Associations between perfluoroalkyl substances and the severity of non-alcoholic fatty liver disease.

Association between per- and polyfluoroalkyl substances (PFAS) and depression in U.S. adults: A cross-sectional study of NHANES from 2005 to 2018.

Association between the dietary inflammatory index and serum perfluoroalkyl and polyfluoroalkyl substance concentrations: evidence from NANHES 2007-2018.

Flame Retardants

Higher HDL-C levels attenuated the association of plasma polybrominated diphenyl ethers with prediabetes and type 2 diabetes mellitus in rural Chinese adults.

Pesticides

Renal tubular dysfunction in greenhouse farmers exposed to pesticides unveiled by a panel of molecular biomarkers of kidney injury.

Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue.

Environmental exposure to organophosphate pesticides and effects on cognitive functions in elementary school children in a Middle Eastern area.

Metals/Metalloids

Genetic Susceptibility to Neurotoxicity Related to Prenatal Inorganic Arsenic Exposure in Young Spanish Children.

Associations of mixed urinary metals exposure with metabolic syndrome in the US adult population.

Exploring the association of metal mixture in blood to the kidney function and tumor necrosis factor alpha using machine learning methods.

Arsenic and fluoride exposure in drinking water caused human health risk in coastal groundwater aquifers.

Association between exposure to mixture of heavy metals and hyperlipidemia risk among U.S. adults: A cross-sectional study.

Effect of exposures to multiple metals on blood pressure and hypertension in the elderly: a community-based study.

Air Pollution

Uncertainty Reduction and Environmental Justice in Air Pollution Epidemiology: The Importance of Minority Representation.

Comparison of Particulate Air Pollution From Different Emission Sources and Incident Dementia in the US.

Exposure to Particulate Matter Air Pollution and Age of Menarche in a Nationwide Cohort of U.S. Girls.

Ambient PM2.5 Exposure and Bone Homeostasis: Analysis of UK Biobank Data and Experimental Studies in Mice and in Vitro.

Miscellaneous

Essential metals modified the effects of polycyclic aromatic hydrocarbons on the metabolic syndrome: Mediation effects of miRNA.

Cognitive decrements in 1991 Gulf War veterans: associations with Gulf War illness and neurotoxicant exposures in the Boston Biorepository, Recruitment, and Integrative Network (BBRAIN) cohorts.

Long-term effects of COVID-19 on the endocrine system – a pilot case-control study.

Laboratory Studies

Numerous Chemicals/Mixtures

Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining.

BPA/Phenols

Bisphenol A Alters the Levels of miRNAs That Directly and/or Indirectly Target Neuropeptide Y in Murine Hypothalamic Neurons.

Reproductive toxicity of bisphenol A, at environmentally relevant concentrations, on ovarian redox balance, maturational response, and intra-oocyte signalling events in Labeo bata.

Hydroxyl radical and UV-induced reactions of bisphenol analogues in water: Kinetics, transformation products and estrogenic activity estimation.

Phthalates

Reproductive toxicity following in utero and lactational exposure to a human-relevant phthalate mixture in rats.

Effects of Dibutylphthalate and Steroid Hormone Mixture on Human Prostate Cells.

Parabens/Triclosan/Antimicrobials

Exposure to Butylparaben Induces Craniofacial Bone Developmental Toxicity in Zebrafish (Danio rerio) Embryos.

Perfluoroalkyl Substances

Legacy and emerging per- and polyfluoroalkyl substances (PFAS) regulate steroidogenesis in the male gonad.

Significant Variability in the Developmental Toxicity of Representative Perfluoroalkyl Acids as a Function of Chemical Speciation.

Perfluorooctanoic acid induces behavioral impairment and oxidative injury in Nauphoeta cinerea nymphs.

Transcriptome analysis reveals the mechanism of the effect of perfluorocaproic acid exposure on brain injury in Carassius auratus.

Flame Retardants

Developmental Organophosphate Flame Retardant Exposure Disrupts Adult Hippocampal Neurogenesis in Wistar Rats.

Reproductive disorders linked to the interaction between sex steroid and thyroid hormonal activities, oxidative stress responses, and the rate of metabolism of tris (1,3-dichloro-2-propyl) phosphate (TDCPP) in zebrafish.

Pesticides

Histopathological and Behavioral Impairments in Zebrafish (Danio rerio) Chronically Exposed to a Cocktail of Fipronil and Pyriproxyfen.

Exposure to Roundup and Antibiotics Alters Gut Microbial Communities, Growth, and Behavior in Rana berlandieri Tadpoles.

Adverse developmental impacts in progeny of zebrafish exposed to the agricultural herbicide atrazine during embryogenesis.

Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches.

Time- and region-dependent blood-brain barrier impairment in a rat model of organophosphate-induced status epilepticus.

Metals/Metalloids

Metabolomics Analysis and Biochemical Profiling of Arsenic-Induced Metabolic Impairment and Disease Susceptibility.

D-Limonene Alleviates Oxidative Stress Injury of the Testis Induced by Arsenic in Rat.

Maternal exposure to dietary uranium causes oxidative stress and thyroid disruption in zebrafish offspring.

Microplastics/Nanomaterials

Transgenerational adaptation to ocean acidification determines the susceptibility of filter-feeding rotifers to nanoplastics.

Polyethylene nanoplastics cause reproductive toxicity associated with activation of both estrogenic hormone receptor NHR-14 and DNA damage checkpoints in C. elegans.

Air Pollution

PM_2.5 induced liver lipid metabolic disorders in C57BL/6J mice.

Pharmaceuticals/Personal Care Products

Can Pharmaceutical Excipients Threaten the Aquatic Environment? A Risk Assessment Based on the Microtox^® Biotest.

Mitigating abortion risk of synthetic musk-contained body wash in pregnant women: Risk assessment and mechanism analysis.

Miscellaneous

Disruption of dopamine metabolism by exposure to 6-PPD quinone in Caenorhabditis elegans.

Uptake and Biotransformation of the Tire Rubber-derived Contaminants 6-PPD and 6-PPD Quinone in the Zebrafish Embryo (Danio rerio).

The toxicity effects of the individual and combined exposure of methyl tert-butyl ether (MTBE) and tire rubber powder (RP) on Nile tilapia fish (Oreochromis niloticus).

Insights from the maternal lineage of the F2 generation after exposure to an environmentally relevant dose of benzo(a)pyrene in the male rats of F0 generation.

Adverse effect of environmental androgenic compounds Galaxolide and Irgacure 369 on the male reproductive system.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

A One-Health environmental risk assessment of contaminants of emerging concern in London’s waterways throughout the SARS-CoV-2 pandemic.

Ecological risk assessment of pharmaceuticals and endocrine disrupting compounds in Brazilian surface waters.

Dataset comprising pesticides, pharmaceuticals and personal care products, and industrial chemicals detected in streams and rivers of Central Chile.

Steroid metabolites as overlooked emerging contaminants: Insights from multimedia partitioning and source-sink simulation in an estuarine environment.

Perfluoroalkyl Substances

Development and application of an interactive generic physiologically based pharmacokinetic (igPBPK) model for adult beef cattle and lactating dairy cows to estimate tissue distribution and edible tissue and milk withdrawal intervals for per- and polyfluoroalkyl substances (PFAS).

Relationship between the Consumption of Fermented Red Beetroot Juice and Levels of Perfluoroalkyl Substances in the Human Body’s Fluids and Blood Parameters.

Per and polyfluoroalkyl substances in water treatment residuals: Occurrence and desorption.

Burning questions: Current practices and critical gaps in evaluating removal of per- and polyfluoroalkyl substances (PFAS) during pyrolysis treatments of biosolids.

Perfluoroalkyl acid depuration from the edible tissues of a migratory recreationally fished species.

Per- and polyfluoroalkyl substances (PFAS) in grocery store foods: method optimization, occurrence, and exposure assessment.

Flame Retardants

Patterns of urinary organophosphate ester metabolite trajectories in children: the HOME Study.

Dechlorane Plus in environmental samples and human serum samples from new and old electronic waste dismantling areas in East China: Levels, composition profiles, and human exposure.

Metals/Metalloids

A regional approach for health risk assessment of toxicants in plastic food containers.

Methylation of arsenic in rice: Mechanisms, factors, and mitigation strategies.

Microplastics/Nanomaterials

Adsorption of Per- and Polyfluoroalkyl Substances (PFAS) and Microcystins by Virgin and Weathered Microplastics in Freshwater Matrices.

Air Pollution

An environmental justice analysis of air pollution in India.

Miscellaneous

Nontargeted analysis and comparison strategies for volatile and semivolatile substances in toys made of different materials.

Discovery and occurrence of organophosphorothioate esters in food contact plastics and foodstuffs from South China: Dietary intake assessment.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.