EDC Science Weekly, Sept. 27 – Oct. 3, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Association of mixed exposure to microplastics with sperm dysfunction: a multi-site study in China.
Antibody response to SARS-CoV-2 mRNA vaccination in Danish adults exposed to per-and polyfluorinated substances: The ENFORCE study.

Science summaries and highlights

Events

Oct. 7-8: Workshop on Advancing Quantitative Analysis in Human Health Assessments through Probabilistic Methods [US EPA]

Oct. 8: PFAS and Child Development: A Children’s Environmental Health Day Event (virtual) [Philadelphia Regional Center for Children’s Environmental Health]

Oct. 9 webinar: A Profitable Detox: Why safer chemistry makes financial sense [ChemSec]

Oct. 10: Children’s Environmental Health Day [Children’s Environmental Health Network]

Oct. 10 webinar: The impacts of PFAS on the immune system [Health and Environment Alliance]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC.

Oct. 15 workshop: State-of-the-Science and the Future of Cumulative Impact Assessment [National Academies]

Oct. 17 webinar: Male autism spectrum disorder & prenatal BPA exposure [EDC Strategies Partnership]

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

Oct. 29-30: 6th Annual Forum on Endocrine Disruptors [European Commission]

Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]

Nov. 21 webinar: Introduction to ECHA’s guidance on new CLP hazard classes [ECHA]

More events

Regulations/Policy

State-Level Childhood Lead Poisoning Prevention Policies and Practices in the United States: 2022-2023. [see many more articles on lead in this supplement of the journal Pediatrics]

EPA News: Addition of Certain Per- and Polyfluoroalkyl Substances to the Toxics Release Inventory

More EDC policy and regulations open for comment

Methods/Tools/Screening

Do small effects matter more in vulnerable populations? an investigation using Environmental influences on Child Health Outcomes (ECHO) cohorts

A Chemical Toolbox to Unveil Synthetic Nature-Inspired Antifouling (NIAF) Compounds.

Ultrasensitive Electrochemical Biosensor for Rapid Screening of Chemicals with Estrogenic Effect.

How can exposure assessment for pesticides in epidemiological studies be improved? Insights from the IMPRESS project

Comprehensive Compilation of Congener Profiles to Support Health Assessment of Environmental Exposures to Polychlorinated Biphenyl Mixtures.

Use of cardiac cell cultures from salmonids to measure the cardiotoxic effect of environmental pollutants.

Adverse outcome pathway networks as the basis for the development of new approach methodologies: liver toxicity as a case study

A new database contains 520 studies investigating the carcinogenicity data of 238 pharmaceuticals across 14 ATC classifications.

Commentaries

Reconceptualizing and Defining Exposomics within Environmental Health: Expanding the Scope of Health Research and related Invited Perspective: The Exposome-An Exciting Opportunity for Collaboration, Not Competition.

Double Trouble: Unravelling the Health Hazards of Microplastics and Heavy Metals.

Impact of Microplastics and Nanoplastics on Human Health.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Endocrine-Disrupting Chemicals and the Development of Diabetes Mellitus Type 1: A 5-Year Systematic Review.

Endocrine Disruptors in Pregnancy: Effects on Mothers and Fetuses-A Review.

The role of epigenetics in women’s reproductive health: the impact of environmental factors.

Neuroinflammation and Brain Health Risks in Veterans Exposed to Burn Pit Toxins.

Phthalates

Di (2-ethyl hexyl) phthalate and its metabolite-induced metabolic syndrome: a review of molecular mechanisms.

Parabens/Triclosan/Antimicrobials

Parabens as the double-edged sword: Understanding the benefits and potential health risks.

PFAS

Per- and Polyfluoroalkyl Substances (PFAS) Affect Female Reproductive Health: Epidemiological Evidence and Underlying Mechanisms.

Flame Retardants

Advanced Understanding of the Polybrominated Diphenyl Ethers (PBDEs): Insights from Total Environment to Intoxication.

Pesticides

A systematic review of herbicide safener toxicity.

Metals/Metalloids

Toxic Metals and Metalloids in Food: Current Status, Health Risks, and Mitigation Strategies.

Microplastics/Nanomaterials

The missing link: A systematic review of microplastics and its neglected role in life-cycle assessment.

Perspectives on the Toxic Effects of Micro- and Nanoplastics on the Environment: A Bibliometric Analysis of the 2014 to 2023 Period.

Air Pollution

Examining the Link between Air Quality (PM, SO₂, NO₂, PAHs) and Childhood Obesity: A Systematic Review.

Prenatal exposure to air pollution and maternal and fetal thyroid function: a systematic review of the epidemiological evidence.

Miscellaneous

The critical elements of digital health in diabetes and cardiometabolic care.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal and childhood exposure to endocrine-disrupting chemicals and early thelarche in 8-year-old girls: A prospective study using Bayesian kernel regression.

Environmental Contaminants, Sex Hormones and SHBG in an Elderly Population.

The Association between Maternal Endocrine-Disrupting Chemical Exposure during Pregnancy and the Incidence of Male Urogenital Defects: A Systematic Review and Meta-Analysis.

Association between dietary exposure to chemical contaminants and risk of dementia in older persons.

BPA/Phthalates

Associations between Urinary Phthalate Metabolites with BDNF and Behavioral Function among European Children from Five HBM4EU Aligned Studies.

Relationship between phthalate exposure and kidney function in Taiwanese adults as determined through covariate-adjusted standardization and cumulative risk assessment.

Evaluation of Exposure to Bisphenol A, Bisphenol F, and Phthalates in Patients with Phenylketonuria and Its Differences According to Dietary Status.

Pilot study: Unveiling the impact of bisphenol A and phthalate exposure on women with asthma.

Glycolysis mediates the association between phthalate exposure and the prevalence of childhood asthma: The National Health and Nutrition Examination Survey 2009-2018.

PFAS

Antibody response to SARS-CoV-2 mRNA vaccination in Danish adults exposed to per-and polyfluorinated substances: The ENFORCE study.

Prenatal exposure to PFAS and the association with neurobehavioral and social development during childhood.

Interaction between the oxidative balance score and serum per- and poly-fluoroalkyl substances (PFASs) on liver health: analysis of the NHANES 2007-2018 dataset.

Association of perfluoroalkyl substances (PFAS) with liver function biomarkers in the highly exposed population of the Veneto Region.

Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk.

Pesticides

Health status of Italian children living close to cultivations sprayed with pesticides.

Metals/Metalloids

Associations between metal/metalloid exposure during pregnancy and placental growth characteristics: Findings from the Hangzhou birth cohort study II.

Association of maternal blood mercury concentration during the first trimester of pregnancy with birth outcomes.

Investigating the relationship of co-exposure to multiple metals with chronic kidney disease: An integrated perspective from epidemiology and adverse outcome pathways.

Low-Level, Early Life Lead Exposure and School Behavior. [see many more articles on lead in this supplement of the journal Pediatrics]

Microplastics/Nanomaterials

Association of mixed exposure to microplastics with sperm dysfunction: a multi-site study in China.

Air Pollution

Associations between Changes in Exposure to Air Pollutants due to Relocation and the Incidence of 14 Major Disease Categories and All-Cause Mortality: A Natural Experiment Study. [see related Invited Perspective: Changing Places-How Moving Histories Can Help Map the Health Impacts of People’s Environmental Exposures.]

Air pollution exposure during preconception and first trimester of pregnancy and gestational diabetes mellitus in a large pregnancy cohort, Hebei Province, China.

Miscellaneous

An Evaluation of In Utero Polycyclic Aromatic Hydrocarbon Exposure on the Neonatal Meconium Microbiome.

Laboratory Studies

Numerous Chemicals/Mixtures

Transcriptomic and functional effects from a chemical mixture based on the exposure profile in Baltic Sea salmon, on metabolic and immune functions in zebrafish embryo.

Epigenetic Changes in the HTR8 and 3A-sub E placental Cell Lines Exposed to Bisphenol A and Benzyl Butyl Phthalate.

BPA/Phenols

Cytotoxic Impacts of Seven Alternative Bisphenols on Human In Vitro Cellular Models.

Bisphenol A Disrupts Ribosome Function during Ovarian Development of Mice.

Effects of bisphenol A, bisphenol S, and tetramethyl bisphenol F on male fertility in Caenorhabditis elegans.

A multichannel microfluidic device for revealing the neurotoxic effects of Bisphenol S on cerebral organoids under low-dose constant exposure

Bisphenol A triggers activation of ocular immune system and aggravates allergic airway inflammation.

Bisphenol A induces lipid metabolism disorder and impairs hepatopancreas of Sesarmops sinensis.

The pro-atherogenic effects and the underlying mechanisms of chronic bisphenol S (BPS) exposure in apolipoprotein E-deficient mice.

Phthalates

The Impact of Dibutyl Phthalate on Insulin Signaling in Human Skeletal Muscle Cells.

DEHP regulates ferritinophagy to promote testicular ferroptosis via suppressing SIRT1/PGC-1α pathway.

Effect of Bis (methyl glycol) Phthalate on Endoplasmic Reticulum Stress in Endothelial Cells.

Effects of di-(2-ethylhexyl) phthalate and its metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells.

Quantitative label-free proteomic analysis of mouse ovarian antral follicles following oral exposure to a human-relevant mixture of three phthalates.

Sulforaphane substantially impedes testicular ferroptosis in adult rats exposed to di-2-ethylhexyl phthalate through activation of NRF-2/SLC7A11/GPX-4 trajectory.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Developmental origins of Parkinson’s disease risk: perinatal exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in the mouse midbrain.

The Impact of Polychlorinated Biphenyls on the Development of Zebrafish (Danio rerio).

PFAS

Molecular Mechanism of Immunotoxicity: Binding Interaction between Perfluorinated Compounds and Human Immunoglobulin G.

Environmentally relevant concentrations of perfluorobutane sulfonate impair locomotion behaviors and healthspan by downregulating mitophagy in C. elegans.

Itaconic Acid Alleviates Perfluorooctanoic Acid-Induced Oxidative Stress and Intestinal Damage by Regulating the Keap1/Nrf2/Ho-1 Pathway and Reshaping the Gut Microbiota.

Inulin alleviates GenX-induced intestinal injury in mice by modulating the MAPK pathway, cell cycle, and cell adhesion proteins

Per- and Polyfluoroalkyl (PFAS) Disruption of Thyroid Hormone Synthesis.

In vitro and in silico characterization of the transport of selected perfluoroalkyl carboxylic acids and perfluoroalkyl sulfonic acids by human organic anion transporter 1 (OAT1), OAT2 and OAT3.

Flaxseed oil attenuates PFOS-induced testicular damage by regulating RNA alternative splicing.

Flame Retardants

Insights into brominated flame retardant neurotoxicity: mechanisms of hippocampal neural cell death and brain region-specific transcriptomic shifts in mice.

Different Cytotoxicity Induced by Hexabromocyclododecanes on Mouse Neuroblastoma N2a Cells via Oxidative Stress and Mitochondrial Apoptotic Pathway.

Pesticides

Sequential pesticide exposure: Concentration addition at high concentrations – Inhibition of hormesis at ultra-low concentrations.

Maternal exposure to pesticides induces perturbations in the gut microbiota and blood-brain barrier of dams and the progeny, prevented by a prebiotic.

Lysosomal disruption, mitochondrial impairment, histopathological and oxidative stress in rat’s nervous system after exposure to a neonicotinoid (imidacloprid).

Prenatal Exposure to Herbicide 2,4-Dichlorophenoxyacetic Acid (2,4D) Exacerbates Zika Virus Neurotoxicity In Vitro and In Vivo.

Serum N-Glycan Changes in Rats Chronically Exposed to Glyphosate-Based Herbicides.

Glyphosate and a glyphosate-based herbicide dysregulate the epigenetic landscape of Homeobox A10 (Hoxa10) gene during the endometrial receptivity in Wistar rats.

Metals/Metalloids

Targeting Nrf2/HO-1 signaling by crocin: role in attenuation of arsenic trioxide-induced neurotoxicity in mice.

Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors.

Selenium Improves Arsenic-Induced Male Reproductive Dysfunction by Regulating H3K14ac Level.

Microplastics/Nanomaterials

Impact of Microplastic Exposure on Blood Glucose Levels and Gut Microbiota: Differential Effects under Normal or High-Fat Diet Conditions.

Long-term nanoplastics exposure contributes to impaired steroidogenesis by disrupting the hypothalamic-testis axis: Evidence from integrated transcriptome and metabolome analysis.

Biodistribution of synthesized polyethylene terephthalate fibers in adult zebrafish, their sex hormone disruption effect, and mitigation using natural organic matter

Consumption and Digestion of Plastics by Greater Hive Moth Larvae.

Investigation of interaction mechanism between polyvinyl chloride microplastics and phthalate acid esters using APGC-MS/MS.

Ecotoxicological Risk of Co-Exposure to Fosthiazate and Microplastics on Earthworms (Eisenia fetida): Integrating Biochemical and Transcriptomic Analyses.

Pharmaceuticals/Personal Care Products

Minor changes to circulating steroid hormones in female rats after perinatal exposure to diethylstilbestrol or ketoconazole.

Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links.

Prenatal Exposure to Low Doses of Benzophenone-3 Elicits Disruption of Cortical Vasculature in Fetuses through Perturbations in Wnt/β-catenin Signaling Correlating with Depression-like Behavior in Offspring Mice.

Vulnerable periods for the mouse mammary gland: comparison of the effects of ethinyl estradiol exposures during two early stages of development.

Miscellaneous

Protective role of ghrelin against 6PPD-quinone-induced neurotoxicity in zebrafish larvae (Danio rerio) via the GHSR pathway.

The Chronic Toxicity of Endocrine-Disrupting Chemical to Daphnia magna: A Transcriptome and Network Analysis of TNT Exposure.

Thyroid Endocrine Disruption and Mechanism of the Marine Antifouling Pollutant 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one.

Chemically recyclable polyvinyl chloride-like plastics.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Edible vegetables grown in the vicinity of electronic wastes: A study of potential health risks and DNA damage in consumers.

PFAS

Per- and Polyfluoroalkyl Substances in the Duluth, Minnesota Area: Exposure to and Biomarker Responses in Tree Swallows Relative to Known Fire-Fighting Foam Sources.

A 20-Year study reveal decrease in per- and polyfluoroalkyl substances (PFAS) in a pelagic seabird from the Western Mediterranean.

Per- and Polyfluoroalkyl Substances (PFAS) Accumulation, Reproductive Impairment, and Associations with Nestling Body Condition in Great (Parus major)- and Blue Tits (Cyanistes caeruleus) Living near a Hotspot in Belgium.

Fate of per- and polyfluoroalkyl substances at a 40-year dedicated municipal biosolids land disposal site

Determination of per- and polyfluoroalkyl substances (PFAS) in six different fish species from Swiss lakes.

Tissue distribution and temporal and spatial assessment of per- and polyfluoroalkyl substances (PFAS) in smallmouth bass (Micropterus dolomieu) in the mid-Atlantic United States.

Flame Retardants

Occupational Exposure of On-Shift Ottawa Firefighters to Flame Retardants and Polycyclic Aromatic Hydrocarbons.

Distribution Characteristics and Ecological Risk Assessment of Organophosphate Esters in Surface Soils of China.

Variation profiles, formation mechanisms, and emission risks of brominated flame retardant compounds during cement kiln co-processing of hexabromocyclododecane-containing waste.

Pesticides

Residential proximity to agricultural herbicide and fungicide applications and dust levels in homes of California children.

Identification of pesticide mixtures to which French agricultural workers and farm-owners are exposed: Results from the Agriculture and Cancer (AGRICAN) cohort study.

Microplastics/Nanomaterials

Microplastics detected in three types of female reproductive organs using micro-Raman spectroscopy.

Micro-nanoplastics: a serious threat to whales’ health and conservation.

How much do we know about the microplastic distribution in the Mediterranean Sea: A comprehensive review.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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