EDC Science Weekly, Sept. 23 – 29, 2021

Post author:HEEDS
Post published:September 29, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

International Consortium to Advance Cross Species Extrapolation of the Effects of Chemicals in Regulatory Toxicology.

Suggestions for a Systematic Regulatory Approach to Ocean Plastics.

Attack on Sunscreens Continues.

Methods/Tools/Screening

A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles.

Estimating perinatal critical windows of susceptibility to environmental mixtures via structured bayesian regression tree pairs.

Bayesian multiple index models for environmental mixtures.

Assessment of micropollutants toxicity by using a modified Saccharomyces cerevisiae model.

Artificial Intelligence Meets Marine Ecotoxicology: Applying Deep Learning to Bio-Optical Data from Marine Diatoms Exposed to Legacy and Emerging Contaminants.

Commentaries

Environmental Racism and Climate Change – Missed Diagnoses.

It’s Time to End Lead Poisoning in the United States.

Emerging questions in exposure, regulation, and remediation of PFAS [interview]

Unpacking the relationship between perfluoroalkyl substances and placental hormones in lactation.

Reviews

Numerous EDCs

Key Characteristics of Cardiovascular Toxicants.

Endocrine-Disrupting Chemicals and Child Health.

Endocrine-disrupting chemicals and their effects on puberty.

Perinatal exposure to endocrine disrupting chemicals and neurodevelopment: How articles of daily use influence the development of our children.

Concentrations of bisphenols, parabens, and benzophenones in human breast milk: A systematic review and meta-analysis.

Toxicity in Peripheral Nerves: An Overview.

Impacts of endocrine-disrupting chemicals on prostate function and cancer.

Combined Effects of Different Endocrine-Disrupting Chemicals (EDCs) on Prostate Gland.

A cross-species comparative approach to assessing multi- and transgenerational effects of endocrine disrupting chemicals.

A Review of Chemical Contaminants in Marine and Fresh Water Fish in Nigeria.

Effects of Diesel, Heavy Metals and Plastics Pollution on Penguins in Antarctica: A Review.

[Environmental endocrine disruptors and fertility.]. [in French]

BPA/Phthalates

Phthalate exposure and risk of diabetes mellitus: Implications from a systematic review and meta-analysis.

Phthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans.

Triclosan/Antimicrobials

Gestational triclosan exposure and infant birth weight: A systematic review and meta-analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in food and human dietary intake: An update of the scientific literature.

Perfluoroalkyl Substances

Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review.

Early-Life Exposure to Per- and Poly-Fluorinated Alkyl Substances and Growth, Adiposity, and Puberty in Children: A Systematic Review.

Nothing lasts forever: understanding microbial biodegradation of polyfluorinated compounds and perfluorinated alkyl substances.

Flame Retardants

A review of organophosphate esters in soil: Implications for the potential source, transfer, and transformation mechanism.

Pesticides

Mechanisms of Neurotoxicity Associated with Exposure to the Herbicide Atrazine.

Insecticide Exposure and Risk of Asthmatic Symptoms: A Systematic Review and Meta-Analysis.

Chlorpyrifos in environment and food: a critical review of detection methods and degradation pathways.

Insect Epigenetic Mechanisms Facing Anthropogenic-Derived Contamination, an Overview.

Impact of Pesticide Exposure among Rural and Urban Female Population. An Overview.

Potentially Toxic Elements

Arsenic and other metals as phenotype driving electrophiles in carcinogenesis.

Molecular Mechanism of Arsenic-Induced Neurotoxicity including Neuronal Dysfunctions.

Mercury (Hg) use and pollution assessment of ASGM in Ghana: challenges and strategies towards Hg reduction.

Molecular Mechanisms of Environmental Metal Neurotoxicity: A Focus on the Interactions of Metals with Synapse Structure and Function.

DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium.

Environmental and occupational exposure of metals and female reproductive health.

Impact of Heavy Metals on Human Male Fertility-An Overview.

Microplastics/Nanoplastic

Environmental microplastic and nanoplastic: Exposure routes and effects on coagulation and the cardiovascular system.

Biofilm-Developed Microplastics As Vectors of Pollutants in Aquatic Environments.

Microplastics: A review of analytical methods, occurrence and characteristics in food, and potential toxicities to biota.

How fast, how far: Diversification and adoption of novel methods in aquatic microplastic monitoring.

Air Pollution

Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature.

Pharmaceuticals/Personal Care Products

A Systematic Review on Occurrence and Ecotoxicity of Organic UV Filters in Aquatic Organisms.

Miscellaneous

Developing and implementing core competencies in children’s environmental health for students, trainees and healthcare providers: a narrative review.

Human Health Studies

BPA/Phthalates

Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study.

Prenatal maternal phthalate exposures and trajectories of childhood adiposity from four to twelve years.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants distribution in plasma lipoprotein fractions.

Exposure to organochlorine pesticides as a predictor to breast cancer: A case-control study among Ethiopian women.

Upregulation of CCL7, CCL20, CXCL2, IL-1β, IL-6 and MMP-9 in Skin Samples of PCB Exposed Individuals-A Preliminary Study.

Perfluoroalkyl Substances

No association between maternal and child PFAS concentrations and repeated measures of ADHD symptoms at age 2½ and 5 years in children from the Odense Child Cohort.

Perfluoroalkyl substances are linked to incident chronic spontaneous urticaria: A nested case-control study.

Suspect and non-target screening of ovarian follicular fluid and serum – identification of anthropogenic chemicals and investigation of their association to fertility. [PFAS and more]

Flame Retardants

Prenatal exposure to a mixture of organophosphate esters and intelligence among 8-year-old children of the HOME Study.

Pesticides

Pesticides applied to crops and amyotrophic lateral sclerosis risk in the U.S.

[Mortality and cancer risk in agricultural nursery workers: a cohort study in Tuscany Region (Central Italy)]. [in Italian]

Potentially Toxic Elements

Association of blood heavy metal levels with osteocalcin abnormality and incidence of osteoporosis in Saudi subjects.

Metal exposure and oxidative stress biomarkers in a Brazilian agricultural community.

Blood and Stool Arsenic Levels Are Decisive for Diagnosing Children’s Functional Gastrointestinal Disease (FGD).

The Relationship between Metabolic Syndrome and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms.

Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction.

Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women

Effects of heavy metals on hypertension during menopause: a Korean community-based cross-sectional study.

Associations of plasma multiple metals with risk of hyperuricemia: A cross-sectional study in a mid-aged and older population of China.

Positive Association between Endothelium-Platelet Microparticles and Urinary Concentration of Lead and Cadmium in Adolescents and Young Adults.

Laboratory Studies

BPA/Phenols

Multi-Systemic Alterations by Chronic Exposure to a Low Dose of Bisphenol A in Drinking Water: Effects on Inflammation and NAD⁺-Dependent Deacetylase Sirtuin1 in Lactating and Weaned Rats.

Effects of 4-nonylphenol on adipogenesis in 3T3-L1 preadipocytes and C3H/10T1/2 mesenchymal stem cells.

Embryotoxic effects of tribromophenol on early post-implantation development of mouse embryos in vitro.

Phthalates

Di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) alters transcriptional profiles, lipid metabolism and behavior in zebrafish larvae.

Subacute Exposure to an Environmentally Relevant Dose of Di-(2-ethylhexyl) Phthalate during Gestation Alters the Cecal Microbiome, but Not Pregnancy Outcomes in Mice.

Effects of Prenatal Phthalate Exposure and Childhood Exercise on Maternal Behaviors in Female Rats at Postpartum: A Role of Oxtr Methylation in the Hypothalamus

Parabens/Triclosan/Antimicrobials

Multibiomarker responses in Danio rerio after exposure to sediment spiked with triclosan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Combined exposure to polychlorinated biphenyls and high-fat diet modifies the global epitranscriptomic landscape in mouse liver.

The Bladder Is a Novel Target of Developmental Polychlorinated Biphenyl Exposure Linked to Increased Inflammatory Cells in the Bladder of Young Mice.

Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish.

Potential Environmental Risk Characteristics of PCB Transformation Products in the Environmental Medium.

Immunotoxicity of polychlorinated biphenyls (PCBs) to the marine crustacean species, Scylla paramamosain.

Maternal 3,3-Dimethyl-1-Butanol Therapy Protects Adult Male Rat Offspring against Hypertension Programmed by Perinatal TCDD Exposure.

Perinatal Resveratrol Therapy to Dioxin-Exposed Dams Prevents the Programming of Hypertension in Adult Rat Offspring.

Mixed Exposure of Persistent Organic Pollutants Alters Oxidative Stress Markers and Mitochondrial Function in the Tail of Zebrafish Depending on Sex.

Perfluoroalkyl Substances

Perfluorooctane sulfonate affects mouse oocyte maturation in vitro by promoting oxidative stress and apoptosis induced bymitochondrial dysfunction.

Comparison of bioconcentration and kinetics of GenX in tilapia Oreochromis mossambicus in fresh and brackish water.

Exposure to GenX and its novel analogs disrupts fatty acid metabolism in male mice.

Metabolomics analysis of the 3D L-02 cell cultures revealing the key role of metabolism of amino acids in ameliorating hepatotoxicity of perfluorooctanoic acid.

Flame Retardants

Establishment of baseline cytology metrics in nestling American kestrels (Falco sparverius): Immunomodulatory effects of the flame retardant isopropylated triarylphosphate isomers.

Lipid metabolism dysfunction and toxicity of BDE-47 exposure in white adipose tissue revealed by the integration of lipidomics and metabolomics.

AhR-mediated CYP1A1 and ROS overexpression are involved in hepatotoxicity of decabromodiphenyl ether (BDE-209).

Transcriptomic Analysis of the Differential Nephrotoxicity of Diverse Brominated Flame Retardants in Rat and Human Renal Cells.

Pesticides

Impact of Glyphosate-Roundup® in the Ileal Structure of Male and Female Rats: A Morphological and Immunohistochemical Study.

A Glyphosate-Based Formulation but Not Glyphosate Alone Alters Human Placental Integrity.

Astaxanthin Mitigates Thiacloprid-Induced Liver Injury and Immunotoxicity in Male Rats.

Comparative analysis on the photolysis kinetics of four neonicotinoid pesticides and their photo-induced toxicity to Vibrio Fischeri: Pathway and toxic mechanism.

Exposure to fipronil induces cell cycle arrest, DNA damage, and apoptosis in porcine trophectoderm and endometrial epithelium, leading to implantation defects during early pregnancy.

Identification of hub genes and key pathways of paraquat-induced human embryonic pulmonary fibrosis by bioinformatics analysis and in vitro studies.

Antioxidant and Anti-Inflammatory Potential of Thymoquinone and Lycopene Mitigate the Chlorpyrifos-Induced Toxic Neuropathy.

Multi Species Analyses Reveal Testicular T3 Metabolism and Signalling as a Target of Environmental Pesticides.

Potentially Toxic Elements

Understanding the hepatoxicity of inorganic mercury through guts: Perturbance to gut microbiota, alteration of gut-liver axis related metabolites and damage to gut integrity.

Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis.

Microplastics/Nanomaterials

Pre-fertilization exposure of sperm to nano-sized plastic particles decreases offspring size and swimming performance in the European whitefish (Coregonus lavaretus).

Combined lead and zinc oxide-nanoparticles induced thyroid toxicity through 8-OHdG oxidative stress-mediated inflammation, apoptosis, and Nrf2 activation in rats.

Polystyrene microplastics increase estrogenic effects of 17α-ethynylestradiol on male marine medaka (Oryzias melastigma).

Subchronic toxicity of dietary sulfamethazine and nanoplastics in marine medaka (Oryzias melastigma): Insights from the gut microbiota and intestinal oxidative status.

Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids.

Effects of synthetic and natural microfibers on Daphnia magna-Are they dependent on microfiber type?

Polystyrene Microplastics Exposure: An Insight into Multiple Organ Histological Alterations, Oxidative Stress and Neurotoxicity in Javanese Medaka Fish (Oryzias javanicus Bleeker, 1854).

Air Pollution

Simulated Wildfire Smoke Significantly Alters Sperm DNA Methylation Patterns in a Murine Model.

An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models.

Pharmaceuticals/Personal Care Products

Effects of Diethylstilbestrol on Zebrafish Gonad Development and Endocrine Disruption Mechanism.

Benzophenone-3 breaches mouse Sertoli cell barrier and alters F-actin organization without evoking apoptosis.

Levonorgestrel and dydrogesterone affect sex determination via different pathways in zebrafish.

Mixtures

Single and Combined Effects of Microplastics and Cadmium on the Cadmium Accumulation and Biochemical and Immunity of Channa argus.

Predicting cytotoxicity of binary pollutants towards a human cell panel in environmental water by experimentation and deep learning methods.

Prediction on the combined toxicities of stimulation-only and inhibition-only contaminants using improved inverse distance weighted interpolation.

Miscellaneous

Assessing the estrogenic activity of chemicals present in resin based dental composites and in leachates of commercially available composites using the ERα-CALUX bioassay.

Exposure/Environment Studies

BPA/Phthalates

Comparison of Daily Bisphenol A Intake Based on Dietary and Urinary Levels in Breastfeeding Women.

Lifestyle Habits and Exposure to BPA and Phthalates in Women of Childbearing Age from Northern Italy: A Pilot Study.

Dietary correlates of urinary phthalate metabolite concentrations in 6-19 Year old children and adolescents.

Air Phthalate Emitted from Flooring Building Material by the Micro-Chamber Method: Two-Stage Emission Evaluation and Comparison.

Strategies to Protect Dialysis Patients against Bisphenol A.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Biomonitoring of 89 POPs in blood serum samples of Czech city policemen.

Honey as a bioindicator of environmental organochlorine insecticides contamination.

Dioxins and PCBs contamination in milk and dairy products from Province of Taranto (Puglia Region, Southern Italy): a six years spatio-temporal monitoring study.

Metabolic Disrupting Effects of Polychlorinated Biphenyls Revealed by Long-Term Temporal Variations of Lipids in Detritivorous Fish from the Rio de la Plata Basin.

Rain Amplification of Persistent Organic Pollutants.

Organochlorine pesticide residues in raw and grilled freshwater fish (Oreochromis niloticus) collected from various locations along the Nile basin in Egypt.

Continuing Persistence and Biomagnification of DDT and Metabolites in Northern Temperate Fruit Orchard Avian Food Chains.

Perfluoroalkyl Substances

Perfluorobutanoic acid (PFBA): No high-level accumulation in human lung and kidney tissue.

Evaluation, optimization, and application of three independent suspect screening workflows for the characterization of PFASs in water.

Presence and biodistribution of perfluorooctanoic acid (PFOA) in Paracentrotus lividus highlight its potential application for environmental biomonitoring.

Assessment of per- and polyfluoroalkyl substances in Biscayne Bay surface waters and tap waters from South Florida.

Occurrence and transport of perfluoroalkyl acids (PFAAs) in a Yangtze River water diversion project during water diversion and flooding.

Perfluoroalkyl Substances (PFAS) Contamination Levels of Pike (Esox lucius L.) and Roach (Rutilus rutilus L.) from Selected Masurian Lakes in Eastern Europe.

Flame Retardants

Organophosphate esters in surface soils from a heavily urbanized region of Eastern China: Occurrence, distribution, and ecological risk assessment.

Modeling of Flame Retardants in Typical Urban Indoor Environments in China during 2010-2030: Influence of Policy and Decoration and Implications for Human Exposure.

Changes in human hair levels of organic contaminants reflecting China’s regulations on electronic waste recycling.

Atmospheric concentrations of polychlorinated biphenyls, brominated flame retardants, and novel flame retardants in Lagos, Nigeria indicate substantial local sources.

Pesticides

Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphate pesticides in the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE).

Bluebirds Experience Impaired Hatching Success in Conventionally Sprayed Apple Orchard Habitats: A 31-Year Study.

Varroa mite and deformed wing virus infestations interactively make honey bees (Apis mellifera) more susceptible to insecticides.

Potentially Toxic Elements

Health Risk Assessments of Selected Trace Elements and Factors Associated with Their Levels in Human Breast Milk from Pretoria, South Africa.

Cumulative Risk Assessment of Exposure to Heavy Metals through Aquatic Products in China.

Impact of modernization on urinary concentrations of arsenic, cadmium, lead, and selenium in rural residents of Northern Laos.

Geographical distribution of dioxins, cadmium, and mercury concentrations in reindeer liver, kidneys, and muscle in the Russian Far North.

Mercury Bioaccumulation in Benthic Invertebrates: From Riverine Sediments to Higher Trophic Levels.

Effect of trophic position on mercury concentrations in bottlenose dolphins (Tursiops truncatus) from the northern Gulf of Mexico.

Bats are an excellent sentinel model for the detection of genotoxic agents. Study in a Colombian Caribbean region.

Trends in mercury concentrations and methylation in Minamata Bay, Japan, between 2014 and 2018.

Microplastics

Microplastics in beluga whale (Delphinapterus leucas) prey: An exploratory assessment of trophic transfer in the Beaufort Sea.

Air Pollution

Personal exposure levels to O₃, NO_x and PM₁₀ and the association to ambient levels in two Swedish cities.

Pharmaceuticals/Personal Care Products

Diagnosing Down-the-Drain Disposal of Unused Pharmaceuticals at a River Catchment Level: Unrecognized Sources of Environmental Contamination That Require Nontechnological Solutions.

Dosing the Coast: Leaking Sewage Infrastructure Delivers Large Annual Doses and Dynamic Mixtures of Pharmaceuticals to Urban Rivers.

Mixtures

Endocrine disruption in the sub Antarctic fish Patagonotothen tessellata (Perciformes, Notothenidae) from Beagle Channel associated to anthropogenic impact.

Miscellaneous

Toxicokinetic Models for Bioconcentration of Organic Contaminants in Two Life Stages of White Sturgeon (Acipenser transmontanus).

Quantitative Determination and Environmental Risk Assessment of 102 Chemicals of Emerging Concern in Wastewater-Impacted Rivers Using Rapid Direct-Injection Liquid Chromatography-Tandem Mass Spectrometry.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.