EDC Science Weekly, Sept. 22 – 28, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

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Regulations/Policy

A Transformative Vision for an Omics-Based Regulatory Chemical Testing Paradigm.

Methods/Tools/Screening

A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target.

The potential of a data centred approach & knowledge graph data representation in chemical safety and drug design.

Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data.

Machine Learning Models for Identification and Prediction of Toxic Organic Compounds Using Daphnia magna Transcriptomic Profiles.

Ensemble learning for predicting ex vivo human placental barrier permeability.

A New Approach Methodology (NAM) Based Assessment of Butylated hydroxytoluene (BHT) for Endocrine Disruption Potential.

Estimating mixture effects and cumulative spatial risk over time simultaneously using a Bayesian index low-rank kriging multiple membership model.

Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells.

Molecular Screening and Toxicity Estimation of 260,000 Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) through Machine Learning.

Commentaries

Truth in the Serum? Estimating PFAS Relative Potency for Human Risk Assessment. [Science Selection in EHP]

Reviews

Numerous Chemicals/Mixtures

Contribution of common plastic-related endocrine disruptors to epithelial-mesenchymal transition (EMT) and tumor progression.

Molecular consequences of the exposure to toxic substances for the endocrine system of females.

Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk.

Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson’s Disease.

Three perspectives on the prediction of chemical effects in ecosystems.

Phthalates

Phthalate exposure and lung disease: the epidemiological evidences, plausible mechanism and advocacy of interventions.

Parabens/Triclosan/Antimicrobials

Bibliometric Analysis: The Effects of Triclosan on Human Health.

Perfluoroalkyl Substances

Human Evidence of Perfluorooctanoic Acid (PFOA) Exposure on Hepatic Disease: A Systematic Review and Meta-Analysis.

Pesticides

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans, and paths forward.

Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review.

Pesticide Pollution: Detrimental Outcomes and Possible Mechanisms of Fish Exposure to Common Organophosphates and Triazines.

Atrazine characterization: An update on uses, monitoring, effects, and environmental impact, for the development of regulatory policies in Argentina.

Metals/Metalloids

Epigenetic Dysregulations in Arsenic-Induced Carcinogenesis.

Meta-analysis of TLR4 pathway-related protein alterations induced by arsenic exposure.

Microplastics/Nanomaterials

Overview of microplastics in the environment: type, source, potential effects and removal strategies.

Microplastics in soil and freshwater: Understanding sources, distribution, potential impacts, and regulations for management.

Review of research on migration, distribution, biological effects, and analytical methods of microfibers in the environment.

Where and how? A systematic review of microplastic pollution on beaches in Latin America and the caribbean (LAC).

Air Pollution

Mitigating the impact of air pollution on dementia and brain health: Setting the policy agenda.

Human Health Studies

Numerous Chemicals/Mixtures

Using Latent Profile Analysis to Identify Associations Between Gestational Chemical Mixtures and Child Neurodevelopment.

Environmental Chemicals and their Association with Hyperparathyroidism.

BPA/Phenols

Use of high-resolution metabolomics to assess the biological perturbations associated with maternal exposure to Bisphenol A and Bisphenol F among pregnant African American women.

Phthalates

Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort.

Concurrent Assessment of Phthalates/HEXAMOLL^® DINCH Exposure and Wechsler Intelligence Scale for Children Performance in Three European Cohorts of the HBM4EU Aligned Studies.

Association of Exposure to Phthalate Metabolites With Sex Hormones, Obesity, and Metabolic Syndrome in US Women.

Mediation Effects of Placental Inflammatory Transcriptional Biomarkers on the Sex-Dependent Associations between Maternal Phthalate Exposure and Infant Allergic Rhinitis: A Population-Based Cohort Study.

Perfluoroalkyl Substances

Gestational per- and polyfluoroalkyl substances exposure and infant body mass index trajectory in the New Hampshire Birth Cohort Study.

Association of maternal perfluoroalkyl substance exposure with postpartum haemorrhage in Guangxi, China.

Flame Retardants

Associations between organophosphate esters concentrations and markers of liver function in US adolescents aged 12-19 years: A mixture analysis.

Metals/Metalloids

Paternal exposure to arsenic and sperm DNA methylation of imprinting gene Meg3 in reproductive-aged men.

Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes.

Methylation profiles of global LINE-1 DNA and the GSTP1 promoter region in children exposed to lead (Pb).

Relationships between urinary metals concentrations and cognitive performance among U.S. older people in NHANES 2011-2014.

Biochemical and Hematological Markers in Workers with Chronical Exposure to Lead and Cadmium in Colombia.

Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999-2018).

The association between exposure to multiple toxic metals and the risk of endometriosis: Evidence from the results of blood and follicular fluid.

Air Pollution

Joint effect of multiple air pollutants on cardiometabolic health in normal-weight and obese adults: A novel insight into the role of circulating free fatty acids.

Pharmaceuticals/Personal Care Products

Association of sleep problems with urinary concentrations of personal care and consumer product chemicals: a nationally representative, population-based study.

Miscellaneous

Effects of polycyclic aromatic hydrocarbons on gestational hormone production in a placental cell line: Application of passive dosing to in vitro tests.

Laboratory Studies

Numerous Chemicals/Mixtures

Transfer pattern of hormesis into personal care product mixtures from typical hormesis-inducing compounds.

Combined toxicities of cadmium and five agrochemicals to the larval zebrafish (Danio rerio).

BPA/Phenols

Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering mTOR/CRTC2/SREBP1 in male rat offspring.

Juvenile Exposure to BPA Alters the Estrous Cycle and Differentially Increases Anxiety-like Behavior and Brain Gene Expression in Adult Male and Female Rats.

Predicting bioconcentration factor and estrogen receptor bioactivity of bisphenol a and its analogues in adult zebrafish by directed message passing neural networks.

Effects of Oral Exposure to Low-Dose Bisphenol S on Allergic Asthma in Mice.

Dietary zinc deficient condition increases the Bisphenol A toxicity in diabetic rat testes.

Grifola frondosa Extract Containing Bioactive Components Blocks Skin Fibroblastic Inflammation and Cytotoxicity Caused by Endocrine Disrupting Chemical, Bisphenol A.

Bisphenol A induces testicular oxidative stress in mice leading to ferroptosis.

Bisphenol A interacts with DLGAP5 and regulates IL-6/JAK2/STAT3 signaling pathway to promote tumorigenesis and progression of osteosarcoma.

Effects of 4-n-nonylphenol in liver of male and female viviparous fish (Poecilia vivipara).

Phthalates

Dose-response mapping of MEHP exposure with metabolic changes of trophoblast cell and determination of sensitive markers.

Eucalyptol relieves the toxicity of diisobutyl phthalate in Ctenopharyngodon idellus kidney cells through Keap1/Nrf2/HO-1 pathway: Apoptosis-autophagy crosstalk and immunoregulation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126).

Perfluoroalkyl Substances

Perfluorooctanoic acid (PFOA) promotes follicular growth and alters expression of genes that regulate the cell cycle and the Hippo pathway in cultured neonatal mouse ovaries.

Perfluorooctane Sulfonate Induces Dysfunction of Human Umbilical Vein Endothelial Cells via Ferroptosis Pathway.

Investigation of the Interaction between Human Serum Albumin and Branched Short-Chain Perfluoroalkyl Compounds.

Photodynamic Priming Overcomes Per- and Polyfluoroalkyl Substance (PFAS)-Induced Platinum Resistance in Ovarian Cancer.

An Environmentally Relevant Mixture of PFOS and PFHxS Does Not Conform to Additivity in Northern Leopard Frogs Exposed Through Metamorphosis.

Application of High-Resolution Mass Spectrometry to Evaluate UV-Sulfite-Induced Transformations of Per- and Polyfluoroalkyl Substances (PFASs) in Aqueous Film-Forming Foam (AFFF).

Flame Retardants

Organophosphate esters cause thyroid dysfunction via multiple signaling pathways in zebrafish brain.

Probiotics protect against hepatic steatosis in tris (2-chloroethyl) phosphate-induced metabolism disorder of mice via FXR signaling.

BDE-47 disturbs the immune response of lymphocytes to LPS by downregulating NF-κB pathway.

Hepatic Gene Expression Profiling of American Kestrels (Falco sparverius) Exposed In Ovo to Three Alternative Brominated Flame Retardants.

Determination of Apoptotic Mechanism of Action of Tetrabromobisphenol A and Tetrabromobisphenol S in Human Peripheral Blood Mononuclear Cells: A Comparative Study.

Vascular Response of Tetrabromobisphenol a in Rat Aorta: Calcium Channels Inhibition and Potassium Channels Activation.

Integration of transcriptomic and proteomic reveals the toxicological molecular mechanisms of decabromodiphenyl ethane (DBDPE) on Pleurotus ostreatus.

Pesticides

Commercial Fungicide Toxic Effects on Terrestrial Non-Target Species Might Be Underestimated When Based Solely on Active Ingredient Toxicity and Standard Earthworm Tests.

Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure-Preliminary In Vivo Study.

Life Cycle Exposure to Cyhalofop-Butyl Induced Reproductive Toxicity in Zebrafish.

Gut microbiota dysbiosis involves in host non-alcoholic fatty liver disease upon pyrethroid pesticide exposure.

Metals/Metalloids

2-Aminoethoxydiphenyl-borate reduces arsenic-induced cardiotoxicity in rats.

Can Bioactive Compounds in Beetroot/Carrot Juice Have a Neuroprotective Effect? Morphological Studies of Neurons Immunoreactive to Calretinin of the Rat Hippocampus after Exposure to Cadmium.

Differential Effects of Arsenic in Drinking Water on Mouse Hepatic and Intestinal Heme Oxygenase-1 Expression.

Embryonic Arsenic Exposure Triggers Long-Term Behavioral Impairment with Metabolite Alterations in Zebrafish.

Zinc supplementation prevents mitotic accumulation in human keratinocyte cell lines upon environmentally relevant arsenic exposure.

Microplastics/Nanomaterials

Uptake, Transport, and Toxicity of Pristine and Weathered Micro- and Nanoplastics in Human Placenta Cells.

Polyvinyl Chloride Microplastics Leach Phthalates into the Aquatic Environment over Decades.

Polystyrene microplastics inhibit the neurodevelopmental toxicity of mercury in zebrafish (Danio rerio) larvae with size-dependent effects.

Size-Dependent Effects of Polystyrene Nanoparticles (PS-NPs) on Behaviors and Endogenous Neurochemicals in Zebrafish Larvae.

Microplastics as potential carriers of viruses could prolong virus survival and infectivity.

Anti-predator behavioral responses of Italian agile frog tadpoles (Rana latastei) exposed to microplastics.

Fluoride enhances polystyrene nanoparticles cytotoxicity in colonocytes in vitro model.

Miscellaneous

Effects of polycyclic aromatic hydrocarbons on gestational hormone production in a placental cell line: Application of passive dosing to in vitro tests.

Acute toxicity testing of the tire rubber-derived chemical 6PPD-quinone on Atlantic salmon (Salmo salar) and brown trout (Salmo trutta).

Xenobiotic estradiol-17ß alters gut microbiota of hatchling American Alligators (Alligator mississippiensis).

Exposure/Environment Studies

Numerous Chemicals/Mixtures

A probabilistic hazard and risk assessment of exposure to metals and organohalogens associated with a traditional diet in the Indigenous communities of Eeyou Istchee (northern Quebec, Canada).

Priority screening of contaminant of emerging concern (CECs) in surface water from drinking water sources in the lower reaches of the Yangtze River based on exposure-activity ratios (EARs).

Detection of endocrine and metabolism disrupting xenobiotics in milk-derived fat samples by fluorescent protein-tagged nuclear receptors and live cell imaging.

Co-occurrence of phthalate esters and perfluoroalkyl substances affected bacterial community and pathogenic bacteria growth in rural drinking water distribution systems.

BPA/Phenols

Ten bisphenol analogs were abundantly found in swine and bovine urines collected from two Chinese farms: concentration profiles and risk evaluation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Designing optimal food safety monitoring schemes using Bayesian network and integer programming: The case of monitoring dioxins and DL-PCBs.

Perfluoroalkyl Substances

Per- and Polyfluoroalkyl Substances in North American School Uniforms.

Serum concentration trends and apparent half-lives of per- and polyfluoroalkyl substances (PFAS) in Australian firefighters.

Waxing activity as a potential source of exposure to per- and polyfluoroalkyl substances (PFAS) and other environmental contaminants among the US ski and snowboard community.

Flame Retardants

Monitoring Human Exposure to Organophosphate Esters: Comparing Silicone Wristbands with Spot Urine Samples as Predictors of Internal Dose.

Occurrence, distribution, and ecological risk of organophosphorus flame retardants and their degradation products in water and upper sediment of two urban rivers in Shenzhen, China.

Pesticides

National Assessment of Long-Term Groundwater Response to Pesticide Regulation.

Long-term trends of second generation anticoagulant rodenticides (SGARs) show widespread contamination of a bird-eating predator, the Eurasian Sparrowhawk (Accipiter nisus) in Britain.

Exploring China stepping into the dawn of chemical pesticide-free agriculture in 2050.

An assessment of exposure to several classes of pesticides in pet dogs and cats from New York, United States.

Prioritizing Pesticides of Potential Concern and Identifying Potential Mixture Effects in Great Lakes Tributaries Using Passive Samplers.

Metals/Metalloids

The Human Right to Water: A 20-Year Comparative Analysis of Arsenic in Rural and Carceral Drinking Water Systems in California. [see related Invited Perspective: Uncovering Harmful Exposures in Carceral Environments.]

Estimation of the Frequency and Time of Human Exposure to Arsenic by Single Hair Analysis.

Toxic Metals and Metalloids in Infant Formulas Marketed in Brazil, and Child Health Risks According to the Target Hazard Quotients and Target Cancer Risk.

Microplastics/Nanomaterials

Deeply in Plasticenta: Presence of Microplastics in the Intracellular Compartment of Human Placentas.

Microplastics in take-out food: Are we over taking it?

Co-contaminants of microplastics in two seabird species from the Canadian Arctic.

Microplastic contamination and risk assessment in blue shark (Prionace glauca) from the eastern tropical Pacific Ocean.

Relevance of tyre wear particles to the total content of microplastics transported by runoff in a high-imperviousness and intense vehicle traffic urban area.

Pharmaceuticals/Personal Care Products

Accumulation and risk prioritization of psychoactive substances in the critically endangered Yangtze finless porpoise.

Miscellaneous

Direct evidence on occurrence of emerging liquid crystal monomers in human serum from E-waste dismantling workers: Implication for intake assessment.

The longitudinal biomonitoring of residents living near the waste incinerator of Turin: Polycyclic aromatic hydrocarbon metabolites after three years from the plant start-up.

Fish Fingerprinting: Identifying Crude Oil Pollutants Using Bicyclic Sesquiterpanes (Bicyclanes) in the Tissues of Exposed Fish.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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