EDC Science Weekly, Sept. 20-26, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Potential mammary carcinogens used in food contact articles: implications for policy, enforcement, and prevention
Harassed? Intimidated? Guidebook offers help to scientists under attack

Science summaries and highlights

Events

Sept. 30 and Oct. 1: Webinar on Next Round of Chemical Substances Being Considered for Prioritization Under TSCA [US EPA]

Oct. 1 webinar: Proposed Priorities for the Next U.S. President to Reduce Plastic Pollution [Beyond Plastics]

Oct. 7-8: Workshop on Advancing Quantitative Analysis in Human Health Assessments through Probabilistic Methods [US EPA]

Oct. 8: PFAS and Child Development: A Children’s Environmental Health Day Event (virtual) [Philadelphia Regional Center for Children’s Environmental Health]

Oct. 9 webinar: A Profitable Detox: Why safer chemistry makes financial sense [ChemSec]

Oct. 10: Children’s Environmental Health Day [Children’s Environmental Health Network]

Oct. 10 webinar: The impacts of PFAS on the immune system [Health and Environment Alliance]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC.

Oct. 15 workshop: State-of-the-Science and the Future of Cumulative Impact Assessment [National Academies]

Oct. 17 webinar: Male autism spectrum disorder & prenatal BPA exposure [EDC Strategies Partnership]

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

Oct. 29-30: 6th Annual Forum on Endocrine Disruptors [European Commission]

Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]

Nov. 21 webinar: Introduction to ECHA’s guidance on new CLP hazard classes [ECHA]

More events

Regulations/Policy

Potential mammary carcinogens used in food contact articles: implications for policy, enforcement, and prevention

Occupational exposure limits for reproductive toxicants – A comparative analysis

The New Paradigm in Animal Testing – “3Rs Alternatives”.

An industry perspective on the FDA modernization act 2.0/3.0: Potential next steps for sponsors to reduce animal use in drug development.

Harassed? Intimidated? Guidebook offers help to scientists under attack

Regulatory and practical considerations on the implementation of a mixture allocation factor in REACH

More EDC policy and regulations open for comment

Methods/Tools/Screening

Personalized mixture toxicity testing: A proof-of-principle in vitro study evaluating the steroidogenic effects of reconstructed contaminant mixtures measured in blood of individual adults.

TIRESIA and TISBE: Explainable Artificial Intelligence Based Web Platforms for the Transparent Assessment of the Developmental Toxicity of Chemicals and Drugs.

Derisking Future Agrochemicals before They Are Made: Large-Scale In Vitro Screening for In Silico Modeling of Thyroid Peroxidase Inhibition.

A conceptual framework for landscape-based environmental risk assessment (ERA) of pesticides.

Construction of an adverse outcome pathway for the cardiac toxicity of bisphenol a by using bioinformatics analysis.

Adverse Outcome Pathways Mechanistically Describing Hepatotoxicity.

The Potential of Molecular Docking for Predictive Toxicology.

Effect of per- and polyfluoroalkyl substances on neurodevelopment: Evidence-based risk assessment in the TRAEC strategy context.

Commentaries

Health Care Actions for Reducing Plastic Use and Pollution

Paraquat and Parkinson’s disease: has the burden of proof shifted?

Environmental Endocrine Disruptors: A Silent Threat to Public Health in India.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK – Breast Cancer Prevention Conference.

BPA/Phenols

Unveiling bisphenol A toxicity: human health impacts and sustainable treatment strategies.

Novel insights into the role of bisphenol A (BPA) in genomic instability.

Phthalates

Phthalate exposure as a hidden risk factor for uterine leiomyoma in adult women: Accumulated evidence from observational studies.

Extracellular Vesicles as a potential source of biomarkers for endocrine disruptors in MASLD: a short review on the case of DEHP.

PFAS

Contamination levels of per- and polyfluoroalkyl substances (PFAS) in recent North American precipitation events. A review.

Cross-cutting studies of per- and polyfluorinated alkyl substances (PFAS) in Arctic wildlife and humans.

Pesticides

Insight of neonicotinoid insecticides: Exploring Exposure, Mechanisms in Non-Target Organisms, and Removal Technologies.

Metals/Metalloids

Cadmium exposure and risk of hypertension: a systematic review and dose-response meta-analysis.

Microplastics/Nanomaterials

A state-of-the-art review of environmental behavior and potential risks of biodegradable microplastics in soil ecosystems: Comparison with conventional microplastics.

Twenty years of microplastics pollution research-what have we learned?

Environmental toxicology of microplastic particles on fish: A review.

Pharmaceuticals/Personal Care Products

Benzotriazole ultraviolet stabilizers in the environment: A review of occurrence, partitioning and transformation.

Miscellaneous

A review of liquid crystal monomers (LCMs) as emerging contaminants: Environmental occurrences, emissions, exposure routes and toxicity.

Human Health Studies

Numerous Chemicals/Mixtures

Children’s exposure to chemical contaminants: Demographic disparities and associations with the developing basal ganglia.

Prenatal co-exposure to phthalate metabolites and bisphenols among non-syndromic cleft lip and/or palate in offspring.

BPA/Phenols

Association of same-day urinary phenol levels and cardiac electrical alterations: analysis of the Fernald Community Cohort.

Phthalates

Association Between Phthalates Exposure and All-Cause Mortality Among Diabetic Cases: A Prospective Study.

Di-2-ethylhexyl phthalate (DEHP) Exposure increase female infertility.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The association of organochlorine pesticides and polychlorinated biphenyls exposure with dyslipidemia and blood lipids: The mediating effect of white blood cell counts.

PFAS

Associations between per- and poly-fluoroalkyl substance (PFAS) exposure and immune responses among women in the California Teachers study: A cross-sectional evaluation.

Role of per- and polyfluoroalkyl substances in the cardiorenal system: Unraveling crosstalk from the network of pollutants and phenotypes.

Sex and obesity influence the relationship between perfluoroalkyl substances and lean body mass: NHANES 2011-2018.

Flame Retardants

Identification of Primary Organophosphate Esters Contributing to Enhanced Risk of Gestational Diabetes Mellitus Based on a Case-Control Study.

Organotins

Organotin exposure and DNA methylation in non-syndromic cleft lip and palate: Integrating findings from case-control studies and animal experiments.

Pesticides

A study protocol for a randomized clinical trial on exposure and effects of pesticides consumption – the PEST-EXPO Brazil study.

Relationship between organophosphate and pyrethroid pesticides and metabolic syndrome in Korean farmers.

Air Pollution

A longitudinal study on the effect of PM_2.5 components on blood pressure in the hypertensive patients from 2011 to 2019.

Laboratory Studies

Numerous Chemicals/Mixtures

Exploring the impact of estrogenic endocrine disruptors on cervical cancer progression: A transcriptome analysis and prognostic model development.

BPA/Phenols

Gestational exposure to BPA alters the expression of glucose and lipid metabolic mediators in the placenta: role in programming offspring for obesity.

Evaluating the Effects of Perinatal Exposures to BPSIP on Hepatic Cholesterol Metabolism in Female and Male Offspring ICR Mice.

Safe concentration, unsafe effects: Impact of BPA on antioxidant function in the hepatopancreas and ovarian gene expression in oriental river prawns (Macrobrachium nipponense).

Establishment of tumor microenvironment following bisphenol A exposure in the testis.

Elucidating the Molecular Interactions and Immune Modulation of Bisphenols Exposure in the Pathogenesis of Polycystic Ovary Syndrome.

Bisphenol A-induced oxidative stress increases the production of ovarian cancer stem cells in mice.

Sub-acute bisphenol A exposure induces proteomic alterations and impairs male reproductive health in mice.

Bisphenol H exposure disrupts Leydig cell function in adult rats via oxidative stress-mediated m6A modifications: Implications for reproductive toxicity.

Phthalates

Di-(2-ethylhexyl) phthalate induces prepubertal testicular injury through MAM-related mitochondrial calcium overload in Leydig and Sertoli cell apoptosis.

Calcium homeostasis imbalance mediates DEHP induced mitochondrial damage in cerebellum and the antagonistic effect of lycopene.

Toxicity of Dibutyl phthalate (DBP) toward isolated human blood lymphocytes: Apoptosis initiated from intracellular calcium enhancement and mitochondrial/lysosomal cross talk.

Di-(2-ethylhexyl) phthalate exposure induces ferroptosis by regulating the Nrf2-mediated signaling pathway in mouse ovaries.

PFAS

Longitudinal tracking of perfluorooctanoic acid exposure on mammary epithelial cell spheroids by dynamic optical coherence tomography.

Chronic environmental level exposure to Perfluorooctane Sulfonate overshadows Graphene Oxide to induce apoptosis through activation of the ROS-p53-caspase pathway in marine medaka Oryzias melastigma.

Assessing the Effects of Fluorine-Free and PFAS-Containing Firefighting Foams on Development and Behavioral Responses Using a Zebrafish-Based Platform.

Comparing the obesogenic effect and regulatory mechanisms of long-term exposure to per/polyfluoroalkyl substances with different terminal groups in Caenorhabditis elegans.

Flame Retardants

Flame retardant tetrabromobisphenol A (TBBPA) disrupts histone acetylation during zebrafish maternal-to-zygotic transition.

Pesticides

Alterations in microbiota-metabolism-circRNA crosstalk in autism spectrum disorder-like behaviours caused by maternal exposure to glyphosate-based herbicides in mice.

Melatonin prevents glyphosate-induced hepatic lipid accumulation in roosters via activating Nrf2 pathway.

Long-term exposure to environmental concentration of dinotefuran disrupts ecdysis and sex ratio by dysregulating related gene expressions in Chironomus kiinensis.

Roundup-Induced Gut Dysbiosis, Irrelevant to Aromatic Amino Acid Deficiency, Impairs the Gut Function in Rats.

Chlorpyrifos modulates the mouse gut microbiota and metabolic activity.

Metals/Metalloids

Evaluation of cadmium effects on the glucose metabolism on insulin resistance HepG2 cells.

Microplastics/Nanomaterials

Nanoplastics exposure-induced mitochondrial dysfunction contributes to disrupted stem cell differentiation in human cerebral organoids.

Intergenerational neurotoxicity of polystyrene nanoplastics in offspring mice is mediated by dysfunctional microbe-gut-brain axis.

Eco-corona enhanced the interactive effects of nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonate in zebrafish embryos.

Pharmaceuticals/Personal Care Products

Antidepressants as new endocrine disruptors? – transcriptomic profiling in gonads of Mytilus trossulus exposed to norfluoxetine.

Miscellaneous

Tire Rubber Based Microplastic Particles Cause Adverse on Quality Parameters of Rainbow Trout Sperm Cells.

Environmentally Relevant Concentrations of S-6PPD-Quinone Caused More Serious Hepatotoxicity Than R-Enantiomer and Racemate in Oncorhynchus mykiss.

Zearalenone promotes endometrial cancer cell migration and invasion via activation of estrogen receptor-mediated Rho/ROCK/PMLC signaling pathway.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Evaluation of dermal exposure to phthalates and parabens resulting from the use of hair relaxers.

Exposure and potential risks of thirteen endocrine- disrupting chemicals in pharmaceuticals and personal care products for breastfed infants in China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Trend analyses of persistent organic pollutants in human milk from first-time mothers in Norway between 2002 and 2021.

Exploring global oceanic persistence and ecological effects of legacy persistent organic pollutants across five decades.

PFAS

Mapping Per- and Polyfluoroalkyl Substance Footprint from Cosmetics and Carpets across the Continental United States.

Per- and polyfluoroalkyl substances (PFAS) in floor dust from different indoor environments in Australia: Levels, variation, and human exposure risks.

Per- and polyfluoroalkyl substances contamination of drinking water sources in Africa: Pollution sources and possible treatment methods.

Distribution and ecological risk assessment of perfluoroalkyl carboxylic acids (PFCAs) in the coastal river, China.

Atmospheric concentrations of per- and polyfluoroalkyl substances and their emissions at a waste recycling facility producing refuse-derived paper and plastics densified fuel.

Flame Retardants

Urinary Concentrations of Organophosphate Flame-Retardant Metabolites in the US Population.

Source identification and human exposure assessment of organophosphate flame retardants and plasticisers in soil and outdoor dust from Nigerian e-waste dismantling and dumpsites.

Organophosphate Ester Exposure in Nail Salons: Health Implications for Workers.

Organotins

Imposex incidence in gastropod species from the Colombian Caribbean Coast reveals continued and widespread tributyltin contamination after its global ban.

Pesticides

Widespread occurrence of glyphosate and aminomethylphosphonic acid in indoor dust from urban homes across the United States and its contribution to human exposure.

Microplastics/Nanomaterials

Microplastics in indoor air from Birmingham, UK: Implications for inhalation exposure.

Impact of seasonal changes and environmental conditions on suspended and inhalable microplastics in urban air.

Contamination of consumer composts by metals, microplastics and other microscopic debris.

Microplastic injection? Identification and quantification of plastic particles in medical injections.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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