EDC Science Weekly, Sept. 2-8, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Sept 22 webinar: Multi- and transgenerational outcomes of an exposure to a mixture of EDCs on puberty and maternal behavior in the female rat

For more upcoming events, see the August edition of HEEDS News and feel free to subscribe!

Methods/Tools/Screening

Reproducibility and robustness of high-throughput S1500+ transcriptomics on primary rat hepatocytes for chemical-induced hepatotoxicity assessment.

A Framework that Considers the Impacts of Time, Cost, and Uncertainty in the Determination of the Cost Effectiveness of Toxicity-Testing Methodologies.

Commentaries/Conference Summaries

Reflections on chemical risk assessment or how (not) to serve society with science.

Bridging the gap – University, startup, and industry partnership to destroy per- and polyfluoroalkyl substance (PFAS) forever chemicals.

Correction to The True Cost of PFAS and the Benefits of Acting Now.

Women in toxicology in the United States.

Reviews

Numerous EDCs

Pregnancy exposure to endocrine disrupting chemicals: implications for women’s health.

Environmental exposure during pregnancy and the risk of childhood allergic diseases.

[Pediatric exposure to endocrine disruptors and carcinogenic, mutagenic or reprotoxic substances by pharmaceutical forms intended for the cutaneous route: regulatory provisions in France, in Europe, and state of the art of scientific knowledge]. [in French]

BPA/Phenols

The hazardous threat of Bisphenol A: Toxicity, detection and remediation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants (POPs) in coastal wetlands: A review of their occurrences, toxic effects, and biogeochemical cycling.

Perfluoroalkyl Substances

PFAS and potential adverse impacts on bone and adipose tissue through interactions with PPAR-gamma.

Flame Retardants

The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review.

Pesticides

Chlorpyrifos and Δ⁹ Tetrahydrocannabinol exposure and effects on parameters associated with the endocannabinoid system and risk factors for obesity.

Peer review of the pesticide risk assessment of the active substance clofentezine.

Field-realistic neonicotinoid exposure has sub-lethal effects on non-Apis bees: A meta-analysis.

Potentially Toxic Elements

Health Repercussions of Environmental Exposure to Lead: Methylation Perspective.

Microplastics

Microplastics and Nanoplastics: Emerging Contaminants in Food.

Weathering pathways and protocols for environmentally relevant microplastics and nanoplastics: What are we missing?

Miscellaneous

Status of short-chain chlorinated paraffins in matrices and research gap priorities in Africa: a review.

Human Health Studies

Mixtures

Combined Exposure to Multiple Endocrine Disruptors and Uterine Leiomyomata and Endometriosis in US Women.

Phthalates

The association between maternal urinary phthalate metabolites concentrations and pregnancy induced hypertension: Results from the EDEN Mother-Child Cohort.

A Comprehensive Assessment of Associations between Prenatal Phthalate Exposure and the Placental Transcriptomic Landscape.

Prenatal phthalate exposure and early childhood wheeze in the SELMA study.

Parabens/Triclosan/Antimicrobials

In utero exposure to parabens and early childhood BMI z-scores – Associations between placental ethyl paraben, longitudinal BMI trajectories and cord blood metabolic biomarkers.

Perfluoroalkyl Substances

Exposure to Perfluoroalkyl Substances and Glucose Homeostasis in Youth.

Use of glioma to assess the distribution of patterns of perfluoroalkyl and polyfluoroalkyl substances in human brain.

Flame Retardants

The potential association of polybrominated diphenyl ether concentrations in serum to thyroid function in patients with abnormal thyroids: a pilot study.

Pesticides

Prenatal maternal pesticide exposure in relation to sleep health of offspring during adolescence.

Potentially Toxic Elements

Associations of multiple metals with bone mineral density: A population-based study in US adults.

Associations between rice consumption, arsenic metabolism, and insulin resistance in adults without diabetes.

Normal concentration range of blood mercury and bone mineral density: a cross-sectional study of National Health and Nutrition Examination Survey (NHANES) 2005-2010.

Laboratory Studies

Numerous Chemicals

Environmental obesogens (bisphenols, phthalates and parabens) and their impacts on adipogenic transcription factors in the absence of dexamethasone in 3T3-L1 cells.

BPA/Phenols

Hyperactivity of basolateral amygdala mediates behavioral deficits in mice following exposure to bisphenol A and its analogue alternative.

Mammary carcinoma in aged gerbil mothers after endocrine disruption in pregnancy and lactation.

BPA-induced prostatic hyperplasia in vitro is correlated to the unbalanced gene expression of AR and ER in the epithelium and stroma.

Phthalates

Gut microbiota may contribute to the postnatal male reproductive abnormalities induced by prenatal dibutyl phthalate exposure.

Toxicokinetics of di-isodecyl phthalate and its major metabolites in rats through the application of a developed and validated UHPLC-ESI-MS/MS method.

Dibutyl phthalate release from polyvinyl chloride microplastics: Influence of plastic properties and environmental factors.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Comparative transcriptomic analysis reveals reproductive impairments caused by PCBs and OH-PCBs through the dysregulation of ER and AR signaling.

Low-dose PCB126 exposure disrupts cardiac metabolism and causes hypertrophy and fibrosis in mice.

Simulation experiment on OH-PCB being ingested through daily diet: Accumulation, transformation and distribution of hydroxylated-2, 2′, 4, 5, 5′-pentachlorobiphenyl (OH-PCB101) in mice.

Chlordane exposure causes developmental delay and metabolic disorders in Drosophila melanogaster.

Perfluoroalkyl Substances

Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model.

Flame Retardants

Triphenyl phosphate delayed pubertal timing and induced decline of ovarian reserve in mice as an estrogen receptor antagonist.

Effects of bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate on liver injury in Balb/c mice.

Pesticides

Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats.

Bumblebees Exposed to a Neonicotinoid Pesticide Make Suboptimal Foraging Decisions.

Juvenile hormone and transcriptional changes in honey bee worker larvae when exposed to sublethal concentrations of thiamethoxam.

In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors.

Detrimental effects of 6 months exposure to very low doses of a mixture of six pesticides associated with chronic vitamin deficiency on rats.

Potentially Toxic Elements

Integrated metabolomics coupled with pattern recognition and pathway analysis to reveal molecular mechanism of cadmium-induced diabetic nephropathy.

Prenatal cadmium exposure does not induce greater incidence or earlier onset of autoimmunity in the offspring.

Chronic mercury exposure induces oxidative stress in female rats by eNOS uncoupling and COX-2 activation, without affecting estrogen receptor function.

Micro/Nanoplastics

Parental exposure to sulfamethazine and nanoplastics alters the gut microbial communities in the offspring of marine madaka (Oryzias melastigma).

Early developmental nanoplastics exposure disturbs circadian rhythms associated with stress resistance decline and modulated by DAF-16 and PRDX-2 in C. elegans.

Polystyrene nanoplastics exacerbated the ecotoxicological and potential carcinogenic effects of tetracycline in juvenile grass carp (Ctenopharyngodon idella).

Investigation of the impact caused by different sizes of polyethylene plastics (nano, micro, and macro) in common carp juveniles, Cyprinus carpio L., using multi-biomarkers.

Pharmaceuticals/Personal Care Products

Toxic effects of a mixture of five pharmaceutical drugs assessed using Fontinalis antipyretica Hedw.

Mixtures

Prediction of adverse effects of effluents containing phenolic compounds in the Ba River on the ovary of fish (Hemiculter leucisculus) using transcriptomic and metabolomic analyses.

Profile occurrences and in vitro effects of toxic organic pollutants in metal shredding facilities in Wallonia (Belgium).

Miscellaneous

Exposure to an Environmental Mixture of Polycyclic Aromatic Hydrocarbons Induces Hepatic Cytochrome P450 Enzymes in Mice.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Tooth biomarkers to characterize the temporal dynamics of the fetal and early-life exposome. [phthalates, parabens, PFAS]

Risk assessments of emerging contaminants in various waters and changes of microbial diversity in sediments from Yangtze River chemical contiguous zone, Eastern China.

BPA/Phenols

Long-term elution of bisphenol A from dental composites.

Parabens/Triclosan/Antimicrobials

Environmental risk assessment of parabens in surface water from a Brazilian river: the case of Mogi Guaçu Basin, São Paulo State, under precipitation anomalies.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Mixtures of persistent organic pollutants are found in vital organs of late gestation human fetuses.

Monitoring temporal trends of dioxins, organochlorine pesticides and chlorinated paraffins in pooled serum samples collected from Northern Norwegian women: The MISA cohort study.

Concentrations and human health risk of organochlorines in farmed freshwater aquatic products: fish ponds around the Changsha, China.

Human health risks and benefits assessment based on OCPs, PCBs, toxic elements and fatty acids in the pelagic fish species from the Adriatic Sea.

Ten Bird Species, Six Guilds, Three Habitats, and 59 Chlorinated and Brominated POPs: What do 64 Eggs from the Largest Economic Hub of Southern Africa tell us?

Perfluoroalkyl Substances

Source apportionment of perfluoroalkyl substances in Great Lakes fish.

Occurrence, distribution, and risk assessment of perfluoroalkyl acids in drinking water sources from the lower Yangtze River.

Perfluoroalkyl substances in precipitation from the Tibetan Plateau during monsoon season: Concentrations, source regions and mass fluxes.

Comparative characterization of microbial communities that inhabit PFAS-rich contaminated sites: A case-control study.

Air monitoring with passive samplers for perfluoroalkane substances in developing countries (2017-2019).

Underlying mechanisms for the impacts of molecular structures and water chemistry on the enrichment of poly/perfluoroalkyl substances in aqueous aerosol.

Is HFPO-DA (GenX) a suitable substitute for PFOA? A comprehensive degradation comparison of PFOA and GenX via electrooxidation.

Flame Retardants

Spatiotemporal distribution and mass loading of organophosphate flame retardants (OPFRs) in the Yellow River of China (Henan segment).

Potentially Toxic Elements

Arsenic Bioaccumulation and Identification of Low-Arsenic-Accumulating Food Fishes for Aquaculture in Arsenic-Contaminated Ponds and Associated Aquatic Ecosystems.

Mercury accumulation in muscle and liver tissue and human health risk assessment of two resident freshwater fish species in Flanders (Belgium): a multilocation approach.

Microplastics

Occurrence and characterization of microplastic content in the digestive system of riverine fishes.

Pharmaceuticals/Personal Care Products

Human health risk assessment of selected pharmaceuticals in the five major river basins, China.

Miscellaneous

Changes in Latina Women’s Exposure to Cleaning Chemicals Associated with Switching from Conventional to “Green” Household Cleaning Products: The LUCIR Intervention Study.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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