EDC Science Weekly, Sept. 16 – 22, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Sept. 23 committee meeting: Variability and Relevance of Current Laboratory Mammalian Toxicity Tests and Expectations for New Approach Methods (NAMs) for Use in Human Health Risk Assessment [The National Academies]

Oct 6-8 online workshop: Different perspectives on food contact materials: working together to make Food Contact Materials (FCMs) safer [Food Packaging Forum]

Jan 10-13 online conference PPTox VII: International Conference on Prenatal Programming and Toxicity [registration is open; abstracts due Nov 29]

June 19-24 Gordon Research Conference: Environmental Endocrine Disruptors [registration is open]

Methods/Tools/Screening

A pragmatic approach to Adverse Outcome Pathway (AOP) development and evaluation.

Commentaries

Mixture toxicity, cumulative risk, and environmental justice in United States federal policy, 1980-2016 : Why, with much known, was little done?

Racial Inequalities in Drinking Water Lead Exposure: A Wake-Up Call to Protect Patients with End Stage Kidney Disease.

A Framework for Cumulative Risk Assessment: Exploring the Carcinogenic Effects of Chemical Mixtures. [Science Selection in EHP]

Biodegradable microplastics (BMPs): a new cause for concern?

Reviews

Numerous EDCs

Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures.

Menstrual cycle length and modern living: a review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Experimental Evidence of 2,3,7,8-Tetrachlordibenzo-p-Dioxin (TCDD) Transgenerational Effects on Reproductive Health.

Chlorinated paraffins – A historical consideration including remarks on their complexity.

Persistent organic pollutants: The trade-off between potential risks and sustainable remediation methods.

Environmental contamination and human exposure of polychlorinated biphenyls (PCBs) in China: A review.

Perfluoroalkyl Substances

Absorption, distribution, and toxicity of per- and polyfluoroalkyl substances (PFAS) in the brain: a review

Pesticides

Effects of agrochemicals on the beneficial plant rhizobacteria in agricultural systems.

Microplastics

Evidence of underestimation in microplastic research: A meta-analysis of recovery rate studies.

Unfolding the interaction between microplastics and (trace) elements in water: A critical review.

Analyzing microplastics with Nile Red: Emerging trends, challenges, and prospects.

Pharmaceuticals/Personal Care Products

Transformation products of pharmaceuticals in the environment: Their fate, (eco)toxicity and bioaccumulation potential.

A review on environmental occurrence, toxicity and microbial degradation of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).

Human Health Studies

Mixtures

Anti-androgenic compounds in breast milk and cryptorchidism among Norwegian boys in the HUMIS birth cohort.

BPA/Phenols

Pregnancy exposure to synthetic phenols and placental DNA methylation – An epigenome-wide association study in male infants from the EDEN cohort.

Phthalates

Modification of the association by sex between the prenatal exposure to di(2-ethylhexyl) phthalate and fat percentage in a cohort of Mexicans schoolchildren.

Perfluoroalkyl Substances

Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study.

Pregnancy exposure to perfluoroalkyl substances, prolactin concentrations and breastfeeding in the Odense Child Cohort.

Flame Retardants

Associations between the exposure to organophosphate flame retardants during early pregnancy and the risk of spontaneous abortion based on metabolomics combined with tandem mass spectrometry.

The associations between organophosphate esters and urinary incontinence in the general US population.

Potentially Toxic Elements

Association between heavy metals and metabolic syndrome in drinking water and surface soil: case-control study in Iran.

Miscellaneous

Precocious puberty in Korean girls with and without exposure to endocrine-disrupting chemicals in toy slime: a comparative analysis.

Mixture Analysis of Associations between Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Sperm Oxidative DNA Damage

Laboratory Studies

Numerous Chemicals/Mixtures

Characterization of the ERK1/2 phosphorylation profile in human and fish liver cells upon exposure to chemicals of environmental concern.

Toxicological assessment of low-dose bisphenol A, lead and endosulfan combination: chronic toxicity study in male rats.

Developmental alterations, teratogenic effects, and oxidative disruption induced by ibuprofen, aluminum, and their binary mixture on Danio rerio.

BPA/Phenols

Maternal exposure to bisphenol A induces fetal growth restriction via upregulating the expression of estrogen receptors.

Phthalates

A comparative study based on activity, conformation and computational analysis on the inhibition of human salivary aldehyde dehydrogenase by phthalate plasticizers: Implications in assessing the safety of packaged food items.

The ameliorative effect of ellagic acid on di-(2-ethylhexyl) phthalate-induced testicular structural alterations, oxidative stress, inflammation and sperm damages in adult mice.

Parabens/Triclosan/Antimicrobials

Triclosan elicited biochemical and transcriptomic alterations in Labeo rohita larvae.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Angiotensin II type 1 receptor is involved in hypertension and vascular alterations caused by environmental toxicant hexachlorobenzene.

Perfluoroalkyl Substances

Exposure to Perfluoro-Octanoic Acid Associated With Upstream Uncoupling of the Insulin Signaling in Human Hepatocyte Cell Line.

Flame Retardants

Bis(2-ethylhexyl)-tetrabromophthalate induces zebrafish obesity by altering the brain-gut axis and intestinal microbial composition.

Life Cycle Exposure to Environmentally Relevant Concentrations of Diphenyl Phosphate (DPhP) Inhibits Growth and Energy Metabolism of Zebrafish in a Sex-Specific Manner.

Polybrominated diphenyl ethers BDE-47 and BDE-99 modulate murine melanoma cell phenotype in vitro.

Pesticides

Estrogen receptor: A potential linker of estrogenic and dopaminergic pathways in zebrafish larvae following deltamethrin exposure.

Azole fungicides: (Bio)degradation, transformation products and toxicity elucidation.

Multigeneration toxicity of Geunsami® (a glyphosate-based herbicide) to Allonychiurus kimi (Lee) (Collembola) from sub-individual to population levels.

Exposure to glyphosate and tetrachlorvinphos induces cytotoxicity and global DNA methylation in human cells.

Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.

Prenatal exposure to paraquat and nanoscaled TiO₂ aerosols alters the gene expression of the developing brain.

Glyphosate-induced gut microbiota dysbiosis facilitates male reproductive toxicity in rats.

Combined effects of maternal exposure to fungicides on behavioral development in F₁ -generation mice: 3. Fixed-dose study of imazalil.

Resistance and Vulnerability of Honeybee (Apis mellifera) Gut Bacteria to Commonly Used Pesticides.

Cardenolide, Potassium, and Pyrethroid Insecticide Combinations Reduce Growth and Survival of Monarch Butterfly Caterpillars (Lepidoptera: Nymphalidae).

Bioconcentration and toxicological impacts of fipronil and 2,4-D commercial formulations (single and in mixture) in the tropical fish, Danio rerio.

Microplastics

Size effects of polystyrene microplastics on the accumulation and toxicity of (semi-)metals in earthworms.

Microplastics from miscellaneous plastic wastes: Physico-chemical characterization and impact on fish and amphibian development.

Effects of sizes and concentrations of different types of microplastics on bioaccumulation and lethality rate in the green mussel, Perna viridis.

Size-dependent impact of polystyrene microplastics on the toxicity of cadmium through altering neutrophil expression and metabolic regulation in zebrafish larvae.

Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats.

Pharmaceuticals/Personal Care Products

Multi-omic approach to evaluate the response of gilt-head sea bream (Sparus aurata) exposed to the UV filter sulisobenzone.

MiR-17-5p/FOXL2/CDKN1B signal programming in oocytes mediates transgenerational inheritance of diminished ovarian reserve in female offspring rats induced by prenatal dexamethasone exposure.

Miscellaneous

The effect of benzo[a]pyrene on the gut microbiota of Nile tilapia (Oreochromis niloticus).

Exposure/Environment Studies

Numerous Chemicals

Combined chemical exposure using exposure loads on human biomonitoring data of the 4th Flemish Environment and Health Study (FLEHS-4).

Chemical mixtures in human post-mortem tissues assessed by a combination of chemical analysis and in vitro bioassays after extraction with silicone.

BPA/Phenols

Direct LC-MS/MS and indirect GC-MS/MS methods for measuring urinary bisphenol A concentrations are comparable.

Bisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue.

Urinary levels of dimethoate, bisphenol A and benzo[a]pyrene in first-year students of Hohai University from different geographical regions.

Investigation of the migration of bisphenols from baby bottles and sippy cups.

Phthalates

Accumulation of phthalates under high versus low nitrogen addition in a soil-plant system with sludge organic fertilizers instead of chemical fertilizers.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Risk assessment of PBDEs and PCBs in dust from an e-waste recycling area of China.

Hazardous pollutants in the environment: Fish host-parasite interactions and bioaccumulation of polychlorinated biphenyls.

Development and validation of a multi-residue method for the simultaneous analysis of brominated and organophosphate flame retardants, organochlorine pesticides, and polycyclic aromatic compounds in household dust.

Evaluating the Level of Pesticides in the Blood of Small-Scale Farmers and Its Associated Risk Factors in Western Ethiopia.

Hazardous pollutants in the environment: Fish host-parasite interactions and bioaccumulation of polychlorinated biphenyls.

Perfluoroalkyl Substances

Source apportionment and crop bioaccumulation of perfluoroalkyl acids and novel alternatives in an industrial-intensive region with fluorochemical production, China: Health implications for human exposure.

Urban proximity while breeding is not a predictor of perfluoroalkyl substance contamination in the eggs of brown pelicans.

Perfluorooctanoic Acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) in Surface Water of China: National Exposure Distributions and Probabilistic Risk Assessment.

Flame Retardants

Bioaccumulation and potential risk of organophosphate flame retardants in coral reef fish from the Nansha Islands, South China Sea.

Mixed bromine/chlorine transformation products of tetrabromobisphenol A: Potential specific molecular markers in e-waste dismantling areas.

Current pollution status, spatial features, and health risks of legacy and emerging halogenated flame retardants in agricultural soils across China.

Seasonal variation, source identification, and risk assessment of organophosphate ester flame retardants and plasticizers in surficial sediments from Liao River estuary wetland, China.

Pesticides

Validation of exposure indexes to pesticides through the analysis of exposure and effect biomarkers in ground pesticide applicators from Argentina.

Utilizing High-Throughput Screening Data, Integrative Toxicological Prioritization Index Score, and Exposure-Activity Ratios for Chemical Prioritization: A Case Study of Endocrine-Active Pesticides in Food Crops.

Molecular biomarkers as tool for early warning by chlorpyrifos exposure on Alpine chironomids.

Pollen nutrition fosters honeybee tolerance to pesticides.

Analysis of honey bee exposure to multiple pesticide residues in the hive environment.

A pilot nationwide baseline survey on the concentrations of Neonicotinoid insecticides in tap water from China: Implication for human exposure.

Potentially Toxic Elements

Before the Dam: A Fish-Mercury Contamination Baseline Survey at the Xingu River, Amazon Basin Before the Belo Monte Dam.

Arsenic contamination in widely consumed Caribbean sharpnose sharks in southeastern Brazil: Baseline data and concerns regarding fisheries resources.

Identifying schools at high-risk for elevated lead in drinking water using only publicly available data.

Three Gorges Dam alters the footprint of particulate heavy metals in the Yangtze Estuary.

Eurasian otter (Lutra lutra) as sentinel species for the long-term biomonitoring of the Guadiamar River after the Aznalcóllar mine spill.

Assessing Children’s Lead Exposure in an Active Mining Community Using the Integrated Exposure Uptake Biokinetic Model.

Novel Application of Machine Learning Algorithms and Model-Agnostic Methods to Identify Factors Influencing Childhood Blood Lead Levels.

Adapting a drinking water treatment technology for arsenic removal to the context of a small, low-income California community.

Arsenic contribution of poultry manure towards soils and food plants contamination and associated cancer risk in Khyber Pakhtunkhwa, Pakistan.

Correlation between concentrations of four heavy metals in cord blood and childhood blood of Jamaican children.

Total mercury concentrations in invasive lionfish (Pterois volitans/miles) from the Atlantic coast of Florida.

Microplastics

Microplastics in a Remote Lake Basin of the Tibetan Plateau: Impacts of Atmospheric Transport and Glacial Melting.

Ecological interception effect of mangroves on microplastics.

Insights into the interaction of microplastic with silver nanoparticles in natural surface water.

Microplastics and trace metals in fish species of the Gulf of Mannar (Indian Ocean) and evaluation of human health.

Cross-oceanic distribution and origin of microplastics in the subsurface water of the South China Sea and Eastern Indian Ocean.

The current state of microplastic pollution in the world’s largest gulf and its future directions.

Mixtures

Evaluation of estrogenic and antiestrogenic activity in sludge and explanation of individual compound contributions.

Assessment of a wide array of organic micropollutants of emerging concern in wastewater treatment plants in Greece: Occurrence, removals, mass loading and potential risks.

An integrated approach for chemical water quality assessment of an urban river stretch through Effect-Based Methods and emerging pollutants analysis with a focus on genotoxicity.

Comparison of Estrogenic, Spectroscopic, and Toxicological Analyses of Pilot-Scale Water, Wastewaters, and Processed Wastewaters at Select Military Installations.

Miscellaneous

Responses of steroid estrogen biodegradation to cyanobacterial organic matter biodegradability in the water column of a eutrophic lake.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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