EDC Science Weekly, Sept. 15 – 21, 2022 – HEEDS

EDC Science Weekly, Sept. 15 – 21, 2022

Post author:HEEDS
Post published:September 21, 2022
Post category:EDC Science Weekly

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A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Methods/Tools/Screening

Risk assessment for handling hazardous substances within the European industry: Available methodologies and research streams.

Use of new approach methodologies (NAMs) to meet regulatory requirements for the assessment of industrial chemicals and pesticides for effects on human health.

A guide to open science practices for animal research.

A high-throughput microplate toxicity screening platform based on Caenorhabditis elegans.

Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology.

High throughput embryonic zebrafish test with automated dechorionation to evaluate nanomaterial toxicity.

High throughput virtual screening (HTVS) of peptide library: Technological advancement in ligand discovery. [for pharmaceuticals but perhaps relevant to EDCs]

Reviews

Numerous Chemicals/Mixtures

Reviewing the variability in urinary concentrations of non-persistent organic chemicals:evaluation across classes, sampling strategies and dilution corrections.

Silicone wristbands as personal passive sampling devices: Current knowledge, recommendations for use, and future directions.

Emerging contaminants migration from pipes used in drinking water distribution systems: a review of the scientific literature.

Pesticides

Early exposure to agricultural pesticides and the occurrence of autism spectrum disorder: a systematic review.

An updated systematic review on the maternal exposure to environmental pesticides and invoved mechanisms of autism spectrum disorder (ASD) progression risk in children.

How pesticides affect neonates? – Exposure, health implications and determination of metabolites.

Effects of the herbicide glyphosate on fish from embryos to adults: a review addressing behavior patterns and mechanisms behind them.

Pesticide impacts on avian species with special reference to farmland birds: a review.

Metals/Metalloids

Mercury Exposure and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Exposure of metal toxicity in Alzheimer’s disease: An extensive review.

A systematic review and meta-analysis of the hyperuricemia risk from certain metals.

Arsenic as an immunotoxicant.

Overview of the cardiovascular effects of environmental metals: New preclinical and clinical insights.

Microplastics/Nanomaterials

Developmental and reproductive toxic effects of exposure to microplastics: A review of associated signaling pathways.

Sorption of pharmaceuticals over microplastics’ surfaces: interaction mechanisms and governing factors.

Pharmaceuticals/Personal Care Products

Metformin Contamination in Global Waters: Biotic and Abiotic Transformation, Byproduct Generation and Toxicity, and Evaluation as a Pharmaceutical Indicator.

Updated knowledge, partitioning and ecological risk of pharmaceuticals and personal care products in global aquatic environments.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents.

Phthalates

Association of phthalate exposure with low birth weight in couples conceiving naturally or via assisted reproductive technology in a prospective birth cohort.

Associations of individual and cumulative urinary phthalate and replacement biomarkers with gestational weight gain through late pregnancy.

Perfluoroalkyl Substances

Childhood exposure to per- and polyfluoroalkyl substances and neurodevelopment in the CHARGE case-control study.

Individual and mixture associations of perfluoroalkyl substances on liver function biomarkers in the Canadian Health Measures Survey.

Associations of exposure to perfluoroalkyl substances with serum uric acid change and hyperuricemia among Chinese women: Results from a longitudinal study.

Exposure to perfluoroalkyl substances and risk of hepatocellular carcinoma in a multiethnic cohort.

Flame Retardants

Childhood urinary organophosphate esters and cognitive abilities in a longitudinal cohort study.

Association of organophosphate ester exposure with cardiovascular disease among US adults: Cross-sectional findings from the 2011-2018 National Health and Nutrition Examination Survey.

Organophosphate ester exposure among Chinese waste incinerator workers: Urinary levels, risk assessment and associations with oxidative stress.

Correlates of Positive Thyroid Peroxidase Antibodies Among Firefighters: A Cross-Sectional-Study.

Pesticides

Non-carcinogenic health risk from carbamate pesticide exposure of toddlers living in agricultural areas of Thailand.

Metabolome-wide association study of the relationship between chlorpyrifos exposure and first trimester serum metabolite levels in pregnant Thai farmworkers.

Metals/Metalloids

Associations of nickel exposure and kidney function in U.S. adults, NHANES 2017-2018.

Exposure to Metal Mixtures and Neuropsychological Functioning in Middle Childhood.

A cross-sectional examination of the early-onset hypertensive disorders of pregnancy and industrial emissions of toxic metals using Kentucky birth records, 2008-2017.

Laboratory Studies

Numerous Chemicals/Mixtures

Effects of single or combined exposure to bisphenol A and mono(2-ethylhexyl)phthalate on oxidant/antioxidant status, endoplasmic reticulum stress, and apoptosis in HepG2 cell line.

BPA/Phenols

Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine-rich protein 2.

Effects of bisphenol AF on growth, behavior, histology and gene expression in marine medaka (Oryzias melastigma).

Effect of bisphenol F on sexual performance and quality of offspring in Male Wistar rats.

Bisphenol S induces cardiovascular toxicity by disturbing the development of the common cardinal vein and myocardial contractility in zebrafish embryos.

Environmental estrogens inhibit insulin-like growth factor (IGF) receptor mRNA expression, IGF binding, and IGF signaling ex vivo in rainbow trout (Oncorhynchus mykiss).

Environmental concentrations of 2, 4-DTBP cause immunotoxicity in zebrafish (Danio rerio) and may elicit ecological risk to wildlife.

Phthalates

Lipophilic phthalic acid esters impair human sperm acrosomal reaction through the likely inhibition of phospholipase A₂-signaling pathway.

Parabens/Triclosan/Antimicrobials

Growth, ROS accumulation site, and photosynthesis inhibition mechanism of Chlorella vulgaris by triclosan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Gestational PCB52 exposure induces hepatotoxicity and intestinal injury by activating inflammation in dam and offspring mice: A maternal and progeny study.

Perfluoroalkyl Substances

Young fecal transplantation modulates the visual toxicity of perfluorobutanesulfonate in aged zebrafish recipients.

Effects of gestational low dose perfluorooctanoic acid on maternal and “anxiety-like” behavior in dams.

Perfluorooctane sulfonic acid disrupts protective tight junction proteins via protein kinase D in airway epithelial cells.

Structure-activity relationship analysis of perfluoroalkyl carbonic acids on human and rat placental 3β-hydroxysteroid dehydrogenase activity.

PFOS disrupts key developmental pathways during hiPSC-derived cardiomyocyte differentiation in vitro.

Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice.

Flame Retardants

Chlorinated organophosphorus flame retardants-induced mitochondrial abnormalities and the correlation with progesterone production in mLTC-1 cells.

Pesticides

Digestive tract toxicity associated with exposure to 2,4-dichlorophenoxyacetic acid in rats.

Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.

Paraquat induces apoptosis, programmed necrosis, and immune dysfunction in CIK cells via the PTEN/PI3K/AKT axis.

Perinatal exposure to a glyphosate pesticide formulation induces offspring liver damage.

Anxiety-related behavior and associated brain transcriptome and epigenome alterations in adult female zebrafish exposed to atrazine during embryogenesis.

Evolutionary consequences of pesticide exposure include transgenerational plasticity and potential terminal investment transgenerational effects.

Early pregnancy exposure to beta-cypermethrin compromises endometrial decidualisation in mice via downregulation of cyclin D3, CDK4/6, and p21.

Toxicity effects of chlorantraniliprole in zebrafish (Danio rerio) involving in liver function and metabolic phenotype.

Metals/Metalloids

Cadmium-induced preeclampsia-like phenotype in the rat is related to decreased progesterone synthesis in the placenta.

Lead exposure induces structural damage, digestive stress, immune response and microbiota dysbiosis in the intestine of silver carp (Hypophthalmichthys molitrix).

Exposure to low-dose arsenic caused teratogenicity and upregulation of proinflammatory cytokines in zebrafish embryos.

In utero and lactational exposure to methylmercury elicits physical-chemical and morphological damages in the alveolar bone of offspring rats: The first toxicological findings.

Microplastics/Nanomaterials

The fate and risk of microplastic and antibiotic sulfamethoxazole coexisting in the environment.

Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice.

Probiotics ameliorate polyethylene microplastics-induced liver injury by inhibition of oxidative stress in Nile tilapia (Oreochromis niloticus).

Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio).

Intake of polyamide microplastics affects the behavior and metabolism of Drosophila.

Pharmaceuticals/Personal Care Products

Early- and whole-life exposures to florfenicol disrupts lipid metabolism and induces obesogenic effects in zebrafish (Danio rerio).

Miscellaneous

Measurement of hair thyroid and steroid hormone concentrations in the rat evidence endocrine disrupting potential of a low dose mixture of polycyclic aromatic hydrocarbons.

Interaction of Polycyclic Aromatic Hydrocarbon compounds in fish primary hepatocytes: From molecular mechanisms to genotoxic effects.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Profiling of phthalates, brominated, and organophosphate flame retardants in COVID-19 lockdown house dust; implication on the human health.

Characterisation of plasmatic B-esterases in bottlenose dolphins (Tursiops truncatus) and their potential as biomarkers of xenobiotic chemical exposures.

Transplacental transfer of plasticizers and flame retardants in fin whales (Balaenoptera physalus) from the North Atlantic Ocean.

BPA/Phenols

A probabilistic approach to model bisphenol A (BPA) migration from packaging to meat products.

Phthalates

Clinical and in vitro evaluation of red blood cells collected and stored in a non-DEHP plasticized bag system.

Phthalate migration and its effects on poly(vinyl chloride)-based footwear: pathways, influence of environmental conditions, and the possibility of human exposure.

Impact of mold growth on di(2-ethylhexyl) phthalate emission from moist wallpaper.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exploring lipid affinities of persistent organic pollutants and MeO-PBDEs in blubber of marine mammals.

Perfluoroalkyl Substances

Source apportionment of serum PFASs in two highly exposed communities.

Distribution of per- and poly-fluoroalkyl substances and their precursors in human blood.

A new method for determining PFASs by UHPLC-HRMS (Q-Orbitrap): Application to PFAS analysis of organic and conventional eggs sold in Italy.

Characterization of per- and polyfluoroalkyl substances on fire suppression system piping and optimization of removal methods.

Seasonal trends of per- and polyfluoroalkyl substances in river water affected by fire training sites and wastewater treatment plants.

Perfluoroalkyl acids (PFAAs) in water along the entire coastal line of China: Spatial distribution, mass loadings, and worldwide comparisons.

Optimization and validation of a fast supercritical fluid chromatography tandem mass spectrometry method for the quantitative determination of a large set of PFASs in food matrices and human milk.

Flame Retardants

Silicone wristband- and handwipe-based assessment of exposure to flame retardants for informal electronic-waste and end-of-life-vehicle recycling workers and their children in Vietnam.

Organophosphate esters in UK diet; exposure and risk assessment.

Organophosphate tri-esters and di-esters in drinking water and surface water from the Pearl River Delta, South China: Implications for human exposure.

Spatiotemporal transitions of organophosphate esters (OPEs) and brominated flame retardants (BFRs) in sediments from the Pearl River Delta, China.

Legacy and novel brominated flame retardants in air of Ny-Ålesund, Arctic from 2011 to 2019.

Pesticides

Pesticide drift mitigation measures appear to reduce contamination of non-agricultural areas, but hazards to humans and the environment remain.

Metals/Metalloids

Correlates of whole blood metal concentrations among reproductive-aged Black women.

Environmental risks from consumer products: Acceptable drinking water quality can produce unacceptable indoor air quality with ultrasonic humidifier use.

Toxic metal and trace element status in the breast milk of Turkish new-born mothers.

Microplastics/Nanomaterials

Detection of various microplastics in placentas, meconium, infant feces, breastmilk and infant formula: A pilot prospective study.

Children’s playgrounds contain more microplastics than other areas in urban parks.

The neglected potential source of microplastics from daily necessities: A study on protective mobile phone cases.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.