EDC Science Weekly, Sept. 12-18, 2025 – HEEDS

EDC Science Weekly, Sept. 12-18, 2025

Post author:HEEDS
Post published:September 18, 2025
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Sept. 18 webinar: Chemicals & Children’s Health: The Need for Action [CHE Alaska]

Sept. 22: Plastics, Human Health, and Solutions Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

Sept. 29 conference: REACH revision 2025: simpler, faster, bolder, in Brussels [HEAL and CHEM Trust]

Oct. 1 webinar: Addressing Chemical Mixtures: Opportunities for the REACH revision [EDC Strategies Partnership]

Oct. 14 webinar: ToxicDocs: A database of once-secret chemical industry documents [CHE]

Oct. 8 – Nov. 19 class: Plastics, Microplastics, and Human Health [Physician and Scientist Network Addressing Plastics and Health (P-SNAP)]

Oct. 9: Children’s Environmental Health Day

Jan. 11-14: International Conference on Microplastics [in person in Santa Fe; abstracts due Oct. 1]

Note: HEEDS is now accepting applications for the Lou Guillette, Jr. Outstanding Young Investigator Award, due Sept. 30.

Methods/Tools/Screening

Physiologically based toxicokinetic models in aggregate exposure: a review.

Dose level selection for Developmental and Reproductive Toxicology (DART) studies: Insights from the EUROTOX 2024 Satellite Workshop

Replacing Fish Early Life Stage Toxicity Test: Performance of Three QSAR Tools for Recently Submitted REACH Data.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Endocrine circuitry in autism spectrum disorders: A systematic review of mechanistic insights and clinical implications.

Exposure Science and the exposome in relation to metabolic syndrome: a systematic review within the context of environmental health.

Environmental Endocrine Disrupting Chemicals: Disruptors of Central and Peripheral Clock Systems.

BPA/Phenols

Prenatal exposure to Bisphenol-A as a risk factor for infant neurodevelopment.

Phthalates

Research trends and hotspots of infertility and phthalate esters: a bibliometric and visualization analysis from 2001 to 2024.

PFAS

A scoping review on per- and poly-fluoroalkyl substances (PFAS) and colorectal cancer: Evidence from in vitro, animal, and epidemiological studies.

Global Serum Per- and Polyfluoroalkyl Substances Exposures and Their Correlation with Lipids: A Systematic Review and Meta-Analysis.

Evaluating health impacts of exposure to PFAS mixtures: a systematic review of epidemiological studies using mixture methods.

Pesticides

Chlormequat in our food: A potential hidden threat to health, highlighting the need for improved food safety practices.

Metals/Metalloids

Dose-response relationship of cadmium and pancreatic cancer risk: a meta-analysis.

The association between cadmium exposure and the risk of early liver disease: A systematic review and meta-analysis.

Microplastics/Nanomaterials

A systematic review and experimental study of micro/nanoplastic-induced endocrine disruption in rodents: Potential links to autism spectrum disorder.

Micro- and nano-plastic contamination in foods and potential risk to human health.

Health impacts of microplastic and nanoplastic exposure.

Nano- and Microplastics in the Brain: An Emerging Threat to Neural Health.

The never-ending story of dangerous ubiquitous particles: A meta-analysis of microplastics.

Synergistic effects of microplastics and bioaerosols: emerging trends in urban air pollution complexification and public health implications.

Exploring the complex interactions between microplastics and marine contaminants.

Perspectives on Eco-Friendly Food Packaging: Challenges, Solutions, and Trends.

Pharmaceuticals/Personal Care Products

Inventory of possible endocrine disrupting chemicals used in cosmetic products.

Comprehensive review of ensulizole toxicology data and human exposure assessment for personal care products.

Human Health Studies

Numerous Chemicals/Mixtures

Integrated chemical exposome-metabolome profiling of follicular fluid and associations with fertility outcomes during assisted reproduction.

BPA/Phenols

Urinary bisphenol levels and blood pressure after soda consumption from cans, PET and glass bottles.

Evaluation of Bisphenol A Levels in Children With Unprovoked Seizures.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The effect of polychlorinated biphenyls on type 2 diabetes risk is mediated via DNA methylation.

Prenatal exposure to polycyclic aromatic hydrocarbons and the risk of childhood overweight.

PFAS

Prenatal Per- and Polyfluoroalkyl Substances (PFAS) Exposures, Newborn Mitochondrial DNA Copy Number, and the Modifying Role of the Maternal Folate Level.

Flame Retardants

Associations between brominated and organophosphate flame retardant levels and inflammatory biomarkers in maternal blood, cord blood, and placental tissue at mid-gestation.

Pesticides

The association between urinary levels of organic phosphorus insecticide exposure and subclinical thyroid disorders.

Effects of children exposed to pyrethroid pesticides on their neurodevelopment at age two: A cohort study in rural Western China.

Metals/Metalloids

Hair levels of mercury, lead, and cadmium and their association with glycemic control in Egyptian children with type 1 diabetes.

Exposure to Metal Mixtures and Childhood Adiposity: An Examination of Periods of Heightened Susceptibility Between Gestation and Late Childhood.

Associations of Heavy Metals and Trace Elements with Gestational Diabetes Mellitus in the Boston Birth Cohort.

Association between blood metals exposure at early pregnancy and blood glucose homeostasis: Mediation by inflammatory blood cell parameters.

Arsenic in drinking water and prostate cancer: A population-based case-control study in Northern Chile.

Laboratory Studies

Numerous Chemicals/Mixtures

Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity.

Endocrine disruptors and male infertility: multi-omics identification of key genes in non-obstructive azoospermia.

Benzophenone-3 (BP3), bisphenol A (BPA), and their combination impair ovarian response to gonadotropin stimulation in a multi-exposure multiparity model.

Machine learning and SHAP-based identification of RNASE1 linking environmental endocrine-disrupting chemicals exposure to atherosclerosis.

BPA/Phenols

Multi-omics investigation of Bisphenol A in gastrointestinal carcinogenesis: a network toxicology and molecular docking approach.

Obesity aggravates neurotoxicity of bisphenol A in female rats via endoplasmic reticulum stress mediated death signals.

Mechanistic insights into bisphenol A – Induced liver fibrosis: Evidence of PPARγ downregulation and AKT1/FN1 signaling from multi-level analysis.

Maternal exposure to BPA during the perinatal period leads to imbalances in the testicular antioxidant enzymatic system and apoptosis in adult rat offspring.

Phthalates

Epigenetic signatures of phthalate exposure and potential risks: a DNA methylation analysis using Infinium MethylationEPIC BeadChip.

Di(2-Ethylhexyl) Phthalate Exposure Alters Hepatic Lipid Metabolism in Male SAMP8 Aged Mice.

Parabens/Triclosan/Antimicrobials

Transgenerational inheritance of diminished ovarian reserve triggered by prenatal propylparaben exposure in mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to an environmentally relevant mixture of polychlorinated biphenyls affects mitochondrial bioenergetics and plasticity.

PFAS

Perfluorooctanoic acid, perfluorobutanoic acid, and undecafluoro-2-methyl-3-oxahexanoic acid disrupt neurotransmitter release and cholinesterase activity.

Placentation Disruption by Perfluorooctanoic Acid and Perfluorooctanesulfonate in Human Trophoblast Organoids.

Flame Retardants

Developmental and Neurobehavioral Toxicity of Hexaphenoxycyclotriphosphazene: Implications for Its Safety as a Flame-Retardant Alternative to Triphenyl Phosphate.

Organotins

Tributyltin chloride alters the structural, genomic, and epigenomic integrity of postejaculatory mammalian sperm.

Pesticides

Neurological alterations in adult female rats developmentally exposed to a glyphosate-based herbicide: potential role of the immune system.

Protective effects of Melissa officinalis against Chlorpyrifos-induced hepatotoxicity in rat: a dose-dependent evaluation of biochemical, histological, and oxidative stress markers.

Developmental hepatotoxicity and lipid metabolic disruption induced by fluxapyroxad in zebrafish embryos: An integrative omics approach.

The role and mechanism of ERalpha(ERα) in atrazine-induced disorders of hepatic iron metabolism.

Microplastics/Nanomaterials

Dual impact of microplastic exposure in a mouse model: Impaired uterine receptivity and altered maternal-offspring metabolism.

Toxic effects of polystyrene and polyethylene microplastics on the zebrafish cardiovascular system and their differential mechanisms.

Polystyrene microplastics alter the toxicity of 6PPD to zebrafish (Danio rerio) larvae.

Comparative analysis of the toxicological and histopathological impact of microplastic fibers and microbeads in exposure associated with dibutyl phthalate in zebrafish (Danio rerio).

Metabolic effects of dietary exposure to polystyrene microplastic and nanoplastic in fruit flies.

Impacts of real microplastic leachates on the development and behavior of developing zebrafish (Danio rerio).

Novel insights into male reproductive toxicity: autophagy-dependent ferroptosis triggered by polylactic acid nanoplastics and copper sulfate.

Female exposure to microplastics in the atmospheric environment: Endocrine disrupting toxicity and its risk regulation strategies.

Pharmaceuticals/Personal Care Products

Impact of benzophenone-2 exposure on the reproductive outcomes in adult female mice.

Miscellaneous

Zearalenone at environmental levels promoted ER- positive breast cancer cell lines through the hedgehog pathway

Exposure/Environment Studies

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Release of Organochlorine Pollutants from Forest Fires: 1. Emission Factors and Revisiting Their Emissions in the Himalayan Regions
Release of organochlorine pollutants from forest fires: 2. Possible long-term migration from ash and burnt soil.

Discriminative influence of persistent organic pollutants on nesting green sea turtles through genotoxicity, oxidative stress and reproductive related markers.

PFAS

Characteristics of Spatial Distribution, Health Risk Assessment, and Regulation of PFAS in Global Drinking Water.

Unmasking per- and polyfluoroalkyl substances (PFAS) in facemasks: Occurrence and leaching implications.

A province-wide mapping of per- and polyfluoroalkyl substances (PFAS) in surface waters of the St. Lawrence River watershed, Québec, Canada.

Seasonal distribution and ec ological risk of bisphenols in the Indo-Pacific humpback dolphin habitats from the Northern South China Sea.

Poly- and perfluoroalkyl substances (PFAS) in marine and freshwater fish muscle tissue from Shandong Province and implications for human exposure.Maternal exposure to BPA during the perinatal period leads to imbalances in the testicular antioxidant enzymatic system and apoptosis in adult rat offspring.

Per- and polyfluoroalkyl substances (PFAS) in landfill leachate, condensate, and groundwater: Characterization by landfill age and evaluation of activated carbon, ion exchange, and electrochemical treatment.

Field Measurement of PFAS Leaching at a Long-Term Land-Applied Biosolids Site.

Nonpolymeric Per- and Polyfluoroalkyl Substances (PFAS) and Side-Chain Fluorinated Polymers in Canadian Building Products.

First evidence of aerobic microbial degradation of HFPO-DA in soils adjacent to fluorochemical plant: Degradation pathways, and potential functional genes and hosts.

Flame Retardants

Discovery of novel spiro-pentaerythritol and dominant organophosphate esters in indoor dust via automated non-targeted screening.

Metals/Metalloids

Longitudinal Nephrotoxic Metal Exposure in a Cohort of Farm Workers in Sonora, Mexico.

Microplastics/Nanomaterials

UV weathering alters toxicity and chemical composition of consumer plastic leachates.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Gordon Research Conference on environmental endocrine disruptors
by Sarah Howard on January 16, 2026 at 4:02 pm
This year's Gordon Research Conference on endocrine disruptors will be held June 28-July 3, with the accompanying Gordon Research Seminar on June 27-28, in Newry, Maine. These conferences bring together graduate students, post-docs, professors, and researchers who work on endocrine disrupting chemicals, and are an invaluable source of discussion. Apply to attend and submit your abstract by January 20th if you would like to be considered for one of these short talks using this link.
National PFAS Conference
by Sarah Howard on January 15, 2026 at 10:15 pm
The University of Arizona is hosting the National PFAS Conference, in person in Tucson on June 8-10, 2026.
Webinar recording: Effects of chemical mixtures on ovarian function
by Sarah Howard on January 15, 2026 at 7:07 pm
In this Feb. 12 webinar, Dr. Shuo Xiao introduced his lab research that focuses on integrating in vivo, in vitro, and in silico models to study the impacts of real-world mixtures of endocrine disrupting chemicals (EDCs) on female ovarian function, reproductive outcomes, and the molecular mechanisms involved. Dr. Xiao is the 2025 winner of the Lou Guillette, Jr Outstanding Young Investigator Award from Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences. Sponsored by the EDC Strategies Partnership and Young EDC Scientists Showcase (YESS).

EHN EHN

Every stage of plastic use — from production to disposal — harms human health
by Environmental Health Sciences Staff on March 6, 2026 at 2:36 pm
In a recent study published by The Lancet Planetary Health, researchers examined the health costs of pollutants released by plastics across their full lifecycle and emphasized the need for international policy that reduces plastic production.
Babies are exposed to more forever chemicals in utero than previously thought
by EHN Curators on March 6, 2026 at 12:10 pm
New research into umbilical cord blood shows a startling number of PFAS.
Study links cell tower and cell phone radiation to changes in blood cells tied to immune health
by Environmental Health Sciences Staff on February 27, 2026 at 2:24 pm
A recent study published in Electromagnetic Biology and Medicine found people living close to cell towers and wireless base station network antennas had higher radiofrequency (RF) radiation exposures, along with measurable changes in certain white blood cells, suggesting a biological stress response and altered immune activity.

EHN EHN

After years of gains, GOP pushes to roll back chemical regulations
by EHN Curators on March 6, 2026 at 12:15 pm
In Texas, environmental activists and experts raise the alarm about the impact on the state's petrochemical industry.
Senate GOP backs speedier chemical reviews; Dems cite health risks
by EHN Curators on March 5, 2026 at 12:20 pm
Proposed changes to the nation’s premier chemical safety law are necessary for American competitiveness, Senate Republicans said in a hearing on Wednesday, as Democrats warned the changes will harm public health.
Former EPA staff detail expanding pollution risks under Trump
by EHN Curators on March 4, 2026 at 6:00 pm
The Trump administration’s relentless rollback of public health and environmental protections has allowed widespread toxic exposures to flourish, warn experts who helped implement safeguards now under assault.