EDC Science Weekly, Sept. 1-7, 2023 – HEEDS

EDC Science Weekly, Sept. 1-7, 2023

Post author:HEEDS
Post published:September 7, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Note: HEEDS is accepting applications for the Lou Guillette, Jr. Outstanding Young Investigator Award, due Sept. 15!

Science highlights

Contents: Regulations/Policy, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Out of balance: conflicts of interest persist in food chemicals determined to be generally recognized as safe.

The Use of Alternatives Assessment in Chemicals Management Policies: Needs for Greater Impact.

Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny – Part IV: the ECETOC and CLE Proposal for a Thyroid Function-Related Neurodevelopmental Toxicity Testing and Assessment Scheme (Thyroid-NDT-TAS)

More EDC policy and regulations open for comment

Methods/Tools/Screening

Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo.

Environmental RNA as a Noninvasive Tool for Assessing Toxic Effects in Fish: A Proof-of-concept Study Using Japanese Medaka Exposed to Pyrene.

Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments.

Zebrafish as an emerging model to study estrogen receptors in neural development.

Developmental Toxicity Assessment Using Zebrafish-Based High-Throughput Screening.

More tools, reports, and resources

Reviews

Numerous Chemicals/Mixtures

Mechanisms Of Breast Cancer Progression Induced BY Environment-Polluting ARYL Hydrocarbon Receptor Agonists.

BPA/Phenols

New environmental factors related to diabetes risk in humans: Emerging bisphenols used in synthesis of plastics.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Biomonitoring, exposure routes and risk assessment of chlorinated paraffins in humans: a mini-review.

Perfluoroalkyl Substances

Exposure to perfluoroalkyl and polyfluoroalkyl substances and risk of stroke in adults: a meta-analysis.

Association between per- and polyfluoroalkyl substances and risk of hypertension: a systematic review and meta-analysis.

The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis.

Pesticides

Pesticides and insulin resistance-related metabolic diseases: Evidences and mechanisms.

Pesticide exposure and risk of Central Nervous System tumors in children: a systematic review with meta-analysis.

Metals/Metalloids

Role of Metals on SARS-CoV-2 Infection: a Review of Recent Epidemiological Studies.

Metabolic Derangement by Arsenic: a Review of the Mechanisms.

Challenges and Recommendations in Assessing Potential Endocrine Disrupting Properties of Metals in Aquatic Organisms.

Microplastics/Nanomaterials

Impacts of microplastic on fisheries and seafood security – Global analysis and synthesis.

A critical review of microplastics toxicity and potential Adverse Outcome Pathway in human gastrointestinal tract following oral exposure.

A comprehensive review of micro- and nano-plastics in the atmosphere: Occurrence, fate, toxicity, and strategies for risk reduction.

Metal Nanoparticles in Alzheimer’s Disease.

Approach to an answer to “How dangerous microplastics are to the human body”: A systematic review of the quantification of MPs and simultaneously exposed chemicals.

Air Pollution

Association between ambient air pollution and thyroid hormones levels: A systematic review and meta-analysis.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal exposures to mixtures of endocrine disrupting chemicals and sex-specific associations with children’s BMI and overweight at 5.5 years of age in the SELMA study.

Target Exposome for Characterizing Early Gestational Exposure to Contaminants of Emerging Concern and Association with Gestational Diabetes Mellitus.

BPA/Phenols

The association between maternal urinary Bisphenol A levels and neurodevelopment at age 2 years in Chinese boys and girls: A prospective cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Maternal exposure to organochlorine pesticides and anthropometrics of newborns – a hospital-based cross-sectional study in rural and urban settings in Armenia.

Perfluoroalkyl Substances

First observations of a potential association between accumulation of per- and polyfluoroalkyl substances in the central nervous system and markers of Alzheimer’s disease.

Association between a Mixture of Per- and Polyfluoroalkyl Substances (PFAS) and Inflammatory Biomarkers in the Atlanta African American Maternal-Child Cohort.

Per- and polyfluoroalkyl substances, gestational weight gain, postpartum weight retention and body composition in the UPSIDE cohort.

Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection.

Temporal decline in serum PFAS concentrations among metropolitan firefighters: Longitudinal study on post-exposure changes following PFAS foam cessation.

Trimester-specific hemodynamics of per- and polyfluoroalkyl substances and its relation to lipid profile in pregnant women.

Flame Retardants

Prenatal exposure to emerging and traditional organophosphate flame retardants: Regional comparison, transplacental transfer, and birth outcomes.

Pesticides

Exposure to multiple neonicotinoid insecticides, oxidative stress, and gestational diabetes mellitus: Association and potential mediation analyses.

Joint associations between established genetic susceptibility loci, pesticide exposures, and risk of prostate cancer.

Environmental exposure to pesticides and Amyotrophic Lateral Sclerosis in the South of Spain.

Association between urinary glyphosate levels and serum neurofilament light chain in a representative sample of US adults: NHANES 2013-2014.

Metals/Metalloids

Metal Exposure during Early Pregnancy and Risk of Gestational Diabetes Mellitus: Mixture Effect and Mediation by Phospholipid Fatty Acids.

Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice.

Microplastics/Nanomaterials

Microplastics in the Bronchoalveolar Lavage Fluid of Chinese Children: Associations with Age, City Development, and Disease Features.

Air Pollution

The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort.

Pharmaceuticals/Personal Care Products

Exploring environmental obesogenous effects of organic ultraviolet filters on children from a case-control study.

Laboratory Studies

Numerous Chemicals/Mixtures

Estrogens and endocrine-disrupting chemicals differentially impact the bioenergetic fluxes of mammary epithelial cells in two- and three-dimensional models. [bisphenols, Tritan, glyphosate]

Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep.

BPA/Phenols

Continuous exposure to bisphenol S increases the accumulation of endogenous metabolic toxicants by obstructing the glucuronic acid pathway.

Gestational exposure to bisphenol S induces microvesicular steatosis in male rat offspring by modulating metaflammation.

Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model.

Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on Bisphenol A-induced murine nephrotoxicity.

Parabens/Triclosan/Antimicrobials

Mechanism-based understanding of the potential cellular targets of triclosan in zebrafish larvae.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Sex-specific effects of acute chlordane exposure in the context of steatotic liver disease, energy metabolism and endocrine disruption.

Adverse outcome pathway exploration of furan-induced liver fibrosis in rats: Genotoxicity pathway or oxidative stress pathway through CYP2E1 activation?

Agent Orange Causes Metabolic Dysfunction and Molecular Pathology Reminiscent of Alzheimer’s Disease.

Perfluoroalkyl Substances

Elevated Maternal Testosterone Levels Alter PFOA Elimination and Tissue Distribution in Pregnant Rats.

Effects of perfluorooctane sulfonate (PFOS) on cognitive behavior and autophagy of male mice.

Exploring the Accumulation Behavior and Heterogeneity of Perfluorooctanesulfonic Acid in Zebrafish Primary Organ Cells by Single-Cell Mass Cytometry.

Insights from metabolomics and transcriptomics studies on Perfluorohexanesulfonic acid (PFHxS) exposed zebrafish embryos.

Novel PFOS alternative OBS inhibits body growth of developing zebrafish by triggering thyroid function disorder and osteoclast differentiation.

Insight into the mechanisms of neuroendocrine toxicity induced by 6:2FTCA via thyroid hormone disruption. [PFOA substitute]

Flame Retardants

Anti-androgenic activity of novel flame retardants in mixtures: Newly identified contribution from tris(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO).

Pesticides

Chronic Paternal/Maternal Exposure to Environmental Concentrations of Imidacloprid and Thiamethoxam Causes Intergenerational Toxicity in Zebrafish Offspring.

Studies on immunotoxicity induced by emamectin benzoate in zebrafish embryos based on metabolomics.

Exploring the repairing mechanisms of reduced graphene oxide (rGo) on the dysregulation of Xenopus Laevis larva hypothalamus-pituitary-thyroid (HPT) axis caused by chiral triazole fungicide metconazole.

Behavioral effects of adult male mice induced by low-level acetamiprid, imidacloprid, and nicotine exposure in early-life.

A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism.

Metals/Metalloids

In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function.

Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development.

Prenatal cadmium exposure has inter-generational adverse effects on Sertoli cells through the follicle-stimulating hormone receptor pathway.

Microplastics/Nanomaterials

Oral exposure to polyethylene microplastics induces inflammatory and metabolic changes and promotes fibrosis in mouse liver.

Complex intestinal and hepatic in vitro barrier models reveal information on uptake and impact of micro-, submicro- and nanoplastics.

Polystyrene nanoplastics aggravated dibutyl phthalate-induced blood-testis barrier dysfunction via suppressing autophagy in male mice.

Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids.

Exposure to Polystyrene Microplastics Promotes the Progression of Cognitive Impairment in Alzheimer’s Disease: Association with Induction of Microglial Pyroptosis.

Uptake of Nanoplastic particles by zebrafish embryos triggers the macrophage response at early developmental stage.

Pharmaceuticals/Personal Care Products

Developmental reprogramming of myometrial stem cells by endocrine disruptor linking to risk of uterine fibroids. [DES]

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Toxic trespassers: Uncovering phthalates and organophosphate flame retardants in children’s rooms and their health implications.

Assessment of the plasticizer exposure of hospital workers regularly handling medical devices: A pilot study.

Uncovering the impact of agricultural activities and urbanization on rivers from the Piracicaba, Capivari, and Jundiaí basin in São Paulo, Brazil: A survey of pesticides, hormones, pharmaceuticals, industrial chemicals, and PFAS.

Perfluoroalkyl Substances

Factors associated with per- and polyfluoroalkyl substances (PFAS) serum concentrations in residents of New Hanover County, North Carolina: The GenX exposure study.

Are PFBS, PFHxS, and 6:2FTSA more friendly to the soil environment compared to PFOS? A new insight based on ecotoxicity study in soil invertebrates (Eisenia fetida).

Accumulation and dietary risks of perfluoroalkyl substances in fish and shellfish: A market-based study in Barcelona.

Biomonitoring equivalents for perfluorooctanoic acid (PFOA) for the interpretation of biomonitoring data.

Time trends in per- and polyfluoroalkyl substances (PFAS) concentrations in the Danish population: A review based on published and newly analyzed data.

Target and nontarget analysis of per- and polyfluoroalkyl substances in surface water, groundwater and sediments of three typical fluorochemical industrial parks in China.

Study of Perfluoroalkyl Acids (PFAA) in High-Protein Food Products.

Pesticides

Bees exposed to climate change are more sensitive to pesticides.

Metals/Metalloids

Toxic element contaminations of prenatal vitamins.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.