EDC Science Weekly, Sept. 1 – 7, 2022 – HEEDS

EDC Science Weekly, Sept. 1 – 7, 2022

Post author:HEEDS
Post published:September 7, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Environmental specimen banks and the European Green Deal.

What you don’t know can still hurt you – underreporting in EU pesticide regulation.

Methods/Tools/Screening

Developing human biomonitoring as a 21st century toolbox within the European exposure science strategy 2020-2030.

Use of systematic evidence maps within the US environmental protection agency (EPA) integrated risk information system (IRIS) program: Advancements to date and looking ahead.

Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.

Toxicokinetic Modeling of Per- and Polyfluoroalkyl Substance Concentrations within Developing Zebrafish (Danio rerio) Populations.

Reviews

Numerous Chemicals/Mixtures

The Intersection of Immigrant and Environmental Health: A Scoping Review of Observational Population Exposure and Epidemiologic Studies. [see related, Invited Perspective: Call to Action-Reduce Immigrants’ Disparities in Environmental Exposures and Health.]

Neurotoxic effects of environmental contaminants-measurements, mechanistic insight, and environmental relevance.

Multigenerational metabolic disruption: Developmental origins and mechanisms of propagation across generations.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A review of the mechanisms of by-product PCB formation in pigments, dyes and paints.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances exposure and its influence on the intestinal barrier: An overview on the advances.

Pesticides

DNA methylation as a mediator of genetic and environmental influences on Parkinson’s disease susceptibility: Impacts of alpha-Synuclein, physical activity, and pesticide exposure on the epigenome.

Cognitive Impairment and Neurodegenerative Diseases Development Associated with Organophosphate Pesticides Exposure: a Review Study.

Effects of glyphosate on zebrafish: a systematic review and meta-analysis.

Metals/Metalloids

Occupational and environmental mercury exposure and human reproductive health – a review.

Microplastics/Nanomaterials

Microplastics: Occurrences, treatment methods, regulations and foreseen environmental impacts.

Microplastics from agricultural plastic mulch films: A mini-review of their impacts on the animal reproductive system.

Nanoplastics: Focus on the role of microRNAs and long non-coding RNAs.

Micro(nano)plastics in food system: potential health impacts on human intestinal system.

Miscellaneous

Use of Zebrafish as a Model Organism to Study Oxidative Stress: A Review.

Human Health Studies

Numerous Chemicals/Mixtures

Associations between developmental exposure to environmental contaminants and spatial navigation in late adolescence.

Association between co-exposure to phenols and phthalates mixture and infertility risk in women.

BPA/Phenols

Association between urinary concentrations of bisphenol A substitutes and diabetes in adults.

Phthalates

The relationship between exposure to phthalate metabolites and adult-onset hypogonadism.

Parabens/Triclosan/Antimicrobials

Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes.

Metals/Metalloids

Risk prediction of autism spectrum disorder behaviors among children based on blood elements by nomogram: A cross-sectional study in Xinjiang from 2018 to 2019.

Influence of differential arsenic exposure on cellular redox homeostasis of exposed rural women of West Bengal.

Associations of multiple plasma metals with chronic kidney disease in patients with diabetes.

Comparative plasma metabolomic analysis to identify biomarkers for lead-induced cognitive impairment.

Air Pollution

Impacts of traffic-related particulate matter pollution on semen quality: A retrospective cohort study relying on the random forest model in a megacity of South China.

Laboratory Studies

Numerous Chemicals/Mixtures

Influence on the adult male Leydig cell biomarker insulin-like peptide 3 of maternal exposure to estrogenic and anti-androgenic endocrine disrupting compound mixtures: A retrospective study.

Endocrine disrupting chemicals interfere with decidualization of human primary endometrial stromal cells in vitro.

BPA/Phenols

Bisphenols induce human genomic damage and modulate HERVs/env expression.

Activation of peroxymonosulfate by palygorskite-mediated cobalt-copper-ferrite nanoparticles for bisphenol S degradation: Influencing factors, pathways and toxicity evaluation.

Effect of bromelain on sperm quality, testicular oxidative stress and expression of oestrogen receptors in bisphenol-A treated male mice.

Phthalates

Endocrine-disruptor endpoints in the ovary and thyroid of adult female rats exposed to realistic doses of di-(2-ethylhexyl) phthalate.

Disrupted microbiota-barrier-immune interaction in phthalates-mediated barrier defect in the duodenum.

Parabens/Triclosan/Antimicrobials

Chronic ex posure to butyl-paraben causes photosensitivity disruption and memory impairment in adult zebrafish.

Investigation of combined effects of propyl paraben and methyl paraben on the hypothalamic-pituitary-adrenal axis in male rats.

Perfluoroalkyl Substances

Cell cycle alterations due to perfluoroalkyl substances PFOS, PFOA, PFBS, PFBA and the new PFAS C6O4 on bottlenose dolphin (Tursiops truncatus) skin cell.

The effect of chronic exposure to a low concentration of perfluorooctanoic acid on cognitive function and intestinal health of obese mice induced by a high-fat diet.

Per- and Polyfluoroalkyl Substances (PFASs) Impair Lipid Metabolism in Rana nigromaculata: A Field Investigation and Laboratory Study.

A rapid assessment bioaccumulation screening (RABS) study design for emerging per-and polyfluoroalkyl substances in mice exposed to industrially impacted surface water.

Does persistent organic pollutant PFOS (perfluorooctane sulfonate) negative impacts on the aquatic invertebrate organism, Astacus leptodactylus [Eschscholtz, 1823].

Flame Retardants

Decabromodiphenyl ethane induced hyperactivity in developing zebrafish at environmentally relevant concentrations.

Organotins

Tributyltin exposure disrupted the locomotor activity rhythms in adult zebrafish (Danio rerio) and the mechanism involved.

Pesticides

Reproductive and neurobehavioral effects of maternal exposure to dinotefuran in the F₁ -generation mice.

A mixture of pyrethroids induces reduced fecundity and increased testicular genotoxicity in rats.

Atrazine and estradiol effects on development of Acris blanchardi (Blanchard’s cricket frog) exposed in outdoor enclosures.

Cypermethrin inhibits proliferation of Sertoli cells through AR involving DAB2IP/PI3K/AKT signaling pathway in vitro.

Transcriptomic signaling in zebrafish (Danio rerio) embryos exposed to environmental concentrations of glyphosate.

Chlorpyrifos and parathion regulate oxidative stress differentially through the expression of paraoxonase 2 in human neuroblastoma cell.

Bromuconazole exposure induces cardiotoxicity and lipid transport disorder in larval zebrafish.

Metals/Metalloids

PIN1-mediated ROS production is involved in antagonism of N-acetyl-L-cysteine against arsenic-induced hepatotoxicity.

As3MT-mediated SAM consumption, which inhibits the methylation of histones and LINE1, is involved in arsenic-induced male reproductive damage.

Microplastics/Nanomaterials

Fire releases micro- and nanoplastics: Raman imaging on burned disposable gloves.

Polystyrene microplastics mitigate the embryotoxic damage of metformin and guanylurea in Danio rerio.

Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Occurrence of emerging organic contaminants and endocrine disruptors in different water compartments in Mexico – A review.

Disparities in chemical exposures among pregnant women and neonates by socioeconomic and demographic characteristics: A nontargeted approach.

An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant.

Suspect and non-targeted screening-based human biomonitoring identified 74 biomarkers of exposure in urine of Slovenian children.

Occurrence and risk assessment of endocrine-disrupting compounds in fish muscle: The case study of the Douro River (North East Atlantic Ocean).

BPA/Phenols

Determination of multiple bisphenol analogues and their metabolites in human serum by liquid chromatography tandem mass spectrometry.

Phthalates

Phthalate acid esters and polycyclic aromatic hydrocarbons concentrations with their determining factors among Chinese pregnant women: A focus on dietary patterns.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Time trends of PCDDs, PCDFs, DL-PCBs, and NDL-PCBs in Italian women from biomonitoring studies.

POPs in Antarctic ecosystems: is climate change affecting their temporal trends?

Perfluoroalkyl Substances

Association between fish oil supplements use and serum per- and polyfluoroalkyl substances (PFAS): Results from the National Health and Nutrition Examination Survey.

Identification of novel polyfluoroalkyl substances in surface water runoff from a chemical stockpile fire.

Assessment of PFAS in collocated soil and porewater samples at an AFFF-impacted source zone: Field-scale validation of suction lysimeters.

Flame Retardants

Unintentional formation of mixed chloro-bromo diphenyl ethers (PBCDEs), dibenzo-p-dioxins and dibenzofurans (PBCDD/Fs) from pyrolysis of polybrominated diphenyl ethers (PBDEs).

Dietary intake assessment of known and unknown organophosphate esters (OPEs) in foodstuffs via high-resolution mass spectrometry.

Pesticides

Racial and social disparities in Ventura County, California related to agricultural pesticide applications and toxicity.

Urinary metabolites of diazinon and chlorpyrifos in sprayer operators and farm workers of a potato farm.

Atrazine pollution in groundwater and raw bovine milk: Water quality, bioaccumulation and human risk assessment.

Metals/Metalloids

Fat rather than health – Ecotoxic responses of Bufo raddei to environmental heavy metal stress during the non-breeding season.

Microplastics/Nanomaterials

Prevalence and risk assessment of microplastics in the Nile Delta estuaries: “The Plastic Nile” revisited.

Miscellaneous

Exposure to melamine and its derivatives and aromatic amines among pregnant women in the United States: The ECHO program.

Investigation of free and conjugated estrogen fate and emission coefficients in three duck farms.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.