EDC Science Weekly, Oct. 8-13, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week. Starting this week, I’ll be sending these out on Thursdays instead of Wednesdays.

Contents: Events, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Happy Children’s Environmental Health Day!

Webinar Oct. 19: CHE Cafe: Cancer & the Environment

CHE anniversary event Nov 12: Celebrating 20 Years of Amplifying Science for Health

Methods/Tools/Screening

Novel machine learning models to predict endocrine disruption activity for high-throughput chemical screening.

Modeling the transplacental transfer of small molecules using machine learning: a case study on per- and polyfluorinated substances (PFAS).

Wikipedia on the CompTox Chemicals Dashboard: Connecting Resources to Enrich Public Chemical Data.

Using in vitro bioassays to guide the development of safer bio-based polymers for use in food packaging.

Reviews

Numerous Chemicals/Mixtures

Roles of estrogens, estrogen-like compounds, and endocrine disruptors in adipocytes.

Environmental pollution and attention deficit hyperactivity disorder: A meta-analysis of cohort studies.

Groundwater contamination pathways of phthalates and bisphenol A: origin, characteristics, transport, and fate – A review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Systematic review of associations of polychlorinated biphenyl (PCB) exposure with declining semen quality in support of the derivation of reference doses for mixture risk assessments.

Metals/Metalloids

A systematic literature review on the association between exposures to toxic elements and an autism spectrum disorder.

Microplastics/Nanomaterials

Effects of temperature on the toxicity of waterborne nanoparticles under global warming: Facts and mechanisms.

Miscellaneous

The injustice of risk avoidance: the limitations of fish consumption restrictions as institutional controls for superfund sites.

Environmental risk, toxicity, and biodegradation of polyethylene: a review.

Human Health Studies

Numerous Chemicals/Mixtures

Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study.

Exposure to a mixture of personal care product and plasticizing chemicals in relation to reproductive hormones and menarche timing among 12-19 years old girls in NHANES 2013-2016.

Estimated daily intake of phthalates, parabens, and bisphenol a in hospitalised very low birth weight infants.

Parabens/Triclosan/Antimicrobials

Implications of triclosan for female fertility: results from the National Health and Nutrition Examination Survey, 2013-2016. and related Everyday endocrine disruptors: challenges in investigation and interpretation.

Effect of Maternal Triclosan Exposure on Neonatal Thyroid-Stimulating Hormone Levels: A Cross-Sectional Study.

Serum parabens and its correlations with immunologic and cellular markers in Southern Taiwan industrialized city systemic lupus erythematosus patients.

Perfluoroalkyl Substances

Association of serum per- and polyfluoroalkyl substances and gestational anemia during different trimesters in Zhuang ethnic pregnancy women of Guangxi, China.

Flame Retardants

Gestational exposure to organophosphate esters and infant anthropometric measures in the first 4 weeks after birth.

Early exposure to flame retardants is prospectively associated with anxiety symptoms in adolescents: A prospective birth cohort study.

Pesticides

Associations of bifenthrin exposure with glucose homeostasis and type 2 diabetes mellitus in a general Chinese population: Roles of protein carbonylation.

Urinary concentrations of fungicide carbendazim’s metabolite and associations with oxidative stress biomarkers in young children.

Glyphosate exposure in early pregnancy and reduced fetal growth: a prospective observational study of high-risk pregnancies.

Metals/Metalloids

Associations of lead and cadmium co-exposure with fasting plasma glucose and type 2 diabetes in Chinese adults.

Parathyroid hormones in relation to serum cadmium and lead: the NHANES 2003-2006.

Air Pollution

Liquefied Petroleum Gas or Biomass for Cooking and Effects on Birth Weight.

Breast cancer incidence in relation to long-term low-level exposure to air pollution in the ELAPSE pooled cohort.

Association of long-term air pollution exposure with the risk of prediabetes and diabetes: Systematic perspective from inflammatory mechanisms, glucose homeostasis pathway to preventive strategies.

Acute and chronic maternal exposure to fine particulate matter and prelabor rupture of the fetal membranes: A nation-wide survey in China.

Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case-control study in Tianjin, China.

Pharmaceuticals/Personal Care Products

Associations between Benzophenone-3 and Sex Steroid Hormones among United States Adult Men.

Laboratory Studies

Numerous Chemicals/Mixtures

SAHmap: Synergistic-antagonistic heatmap to evaluate the combined synergistic effect of mixtures of three pesticides on multiple endpoints of Caenorhabditis elegans.

BPA/Phenols

Single and combined effect of bisphenol A with high sucrose diet on the diabetic and renal tubular dysfunction phenotypes in Drosophila melanogaster.

Antagonistic mechanisms of bisphenol analogues on the estrogen receptor α in zebrafish embryos: Experimental and computational studies.

Bisphenol A impairs renal function by reducing Na⁺/K⁺-ATPase and F-actin expression, kidney tubule formation in vitro and in vivo.

Mito-TEMPO protects against Bisphenol-A-induced testicular toxicity: An in vivo study.

Phthalates

Phthalate plasticizer decreases the prion-like protein doppel essential for structural integrity and function of spermatozoa.

Subchronic exposure to environmentally relevant concentrations of di-(2-ethylhexyl) phthalate differentially affects the colon and ileum in adult female mice.

H3K4me3 as a target of di(2-ethylhexyl) phthalate (DEHP) impairing primordial follicle assembly.

Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Single cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice.

Perfluoroalkyl Substances

An unexpected synergistic toxicity caused by competitive bioconcentration of perfluoroalkyl acid mixtures to Daphnia magna: Further promoted by elevated temperature.

PFOA-induced ovotoxicity differs between lean and obese mice with impacts on ovarian reproductive and DNA damage sensing and repair proteins.

Flame Retardants

Tetramethyl bisphenol A stimulates proliferation but inhibits fetal Leydig cell function in male rats by targeting estrogen receptor α after in utero exposure.

Exposure to melamine cyanuric acid in adult mice caused motor activity and skeletal muscle energy metabolism disorder.

Metabolite alterations in zebrafish embryos exposed to hydroxylated polybrominated diphenyl ethers.

Pesticides

Field-realistic acute exposure to glyphosate-based herbicide impairs fine-color discrimination in bumblebees.

Atrazine-induced oxidative damage via modulating xenobiotic-sensing nuclear receptors and cytochrome P450 systems in cerebrum and antagonism of lycopene.

Mechanism of 2,4-Dichlorophenoxyacetic acid-induced damage to rat testis via Fas/FasL pathway and the protective effect of Lycium barbarum polysaccharides.

Effects of thiacloprid exposure on microbiota-gut-liver axis: Multiomics mechanistic analysis in Japanese quails.

Chemical Constituents of Cyperus esculentus Leaves and The Protective Effect Against Agricultural Fungicide-Induced Hepatotoxicity.

Tannic acid through ROS/TNF-α/TNFR 1 antagonizes atrazine induced apoptosis, programmed necrosis and immune dysfunction of grasscarp hepatocytes.

Metals/Metalloids

Developmental adverse effects of trace amounts of lead: Evaluation using zebrafish model.

Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells.

Microplastics/Nanomaterials

Adverse effects of polystyrene microplastics in the freshwater commercial fish, grass carp (Ctenopharyngodon idella): Emphasis on physiological response and intestinal microbiome.

Stress responses of bivalve mollusc Unio tumidus from two areas to ibuprofen, microplastic and their mixture.

Polybrominated diphenyl ethers as hitchhikers on microplastics: Sorption behaviors and combined toxicities to Epinephelus moara.

Nanoplastics induce molecular toxicity in earthworm: Integrated multi-omics, morphological, and intestinal microorganism analyses.

Air Pollution

Effects of urban particulate matter on gut microbiome and partial schizophrenia-like symptoms in mice: Evidence from shotgun metagenomic and metabolomic profiling.

Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells.

Miscellaneous

Sex-specific thyroid disruption caused by phenanthrene in adult zebrafish (Danio rerio).

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Suspect screening of pharmaceuticals, illicit drugs, pesticides, and other emerging contaminants in Argentinean Piaractus mesopotamicus, a fish species used for local consumption and export.

BPA/Phenols

Assessment of BPA and BPS exposure in the general population in Guangzhou, China – Estimation of daily intakes based on urinary metabolites.

A holistic assessment of the sources, prevalence, and distribution of bisphenol A and analogues in water, sediments, biota and plastic litter of the Ebro Delta (Spain).

Phthalates

Human exposure to phthalate esters in soils embodied in interregional food trade in China.

Parabens/Triclosan/Antimicrobials

Pharmacokinetics of transdermal methyl-, ethyl-, and propylparaben in humans following single dermal administration.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Coming ecological risks of organochlorine pesticides and novel brominated flame retardants in the Yellow River Basin.

Sources of polychlorinated biphenyls to Upper Hudson River fish post-dredging.

Perfluoroalkyl Substances

Simulated leaching of PFAS from land-applied municipal biosolids at agricultural sites.

Flame Retardants

Distribution of flame retardants among indoor dust, airborne particles and vapour phase from Beijing: spatial-temporal variation and human exposure characteristics.

A global survey of organophosphate esters and their metabolites in milk: Occurrence and dietary intake via milk consumption.

Pesticides

Simple and rapid method for 336 multiresidual pesticide analysis in saliva, determination of their chemical stabilities, and biomonitoring of farmers.

Metals/Metalloids

Interrelationships among feather mercury content, body condition and feather corticosterone in a Neotropical migratory bird, the Purple Martin (Progne subis subis).

The timing and magnitude of anthropogenic mercury pollution: A 200-year record from multi-lake sediment cores in northeast China.

Microplastics/Nanomaterials

Plastic pollution of four understudied marine ecosystems: a review of mangroves, seagrass meadows, the Arctic Ocean and the deep seafloor.

Air Pollution

Optimized environmental justice calculations for air pollution disparities in Southern California.

Environmental justice analysis of wildfire-related PM_2.5 exposure using low-cost sensors in California.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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Sarah Howard

she/her/hers

Program Manager

Healthy Environment and Endocrine Disruptor Strategies (HEEDS)

Diabetes and the Environment

Environmental Health Sciences